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Biocatalysis
July 11-16, 2010
Bryant University
Smithfield, RI
Chairs:
Uwe T. Bornscheuer & Jeffrey C. Moore

Vice Chairs:
Stefan Lutz & Hans-Peter Meyer

Biocatalysis encompasses the use of enzymes or whole cell systems for effecting the conversion of readily available, inexpensive starting materials to high value products. Enzymes frequently display exquisite selectivity, particularly chemo-, enantio- and regioselectivity, making them attractive catalysts for a wide range of chemical transformations. Enzymes also typically operate under mild conditions of pH and temperature leading to the formation of products of high purity. Modern tools of protein discovery and engineering aid the development of novel biocatalysts and their tailor-designed implementation into industrial processes. Consequently, they find wide application in the production of pharmaceutical intermediates, fine chemicals, agrochemicals, novel materials, diagnostics, biofuels and performance chemicals. The Biocatalysis Gordon Conference highlights the best science, technologies and case studies responsible for the understanding, development and incorporation of biocatalysts around the world.

Contributors
Almac Sciences
B.R.A.I.N. AG
Codexis, Inc.
E.I. DuPont de Nemours & Co
Eli Lilly and Company
F. Hoffmann-La Roche AG
Firmenich S.A.
Genencor International, Inc.
IEP GmbH
Itochu Chemicals America Inc
Johnson Matthey, Inc.
Kaneka America Corporation
Hans-Peter Meyer
Pfizer, Inc.
Syncore Laboratories (Shanghai) Co., Ltd.
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTrends in Biocatalysis
Discussion Leader: Jeffrey Moore (Merck & Co, US)
7:40 pm - 8:20 pmDavid Baker (Washington University, US)
"Computational design of novel enzyme catalysts"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pmScott Miller (Yale University, US)
"Biochemically Inspired Solutions to Organic Synthesis Challenges: a Minimized Peptide Catalyst Approach"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCatalytic Promiscuity
Discussion Leader: Romas Kazlauskas (Minnesota University, US)
9:00 am - 9:30 amJoseph P. Noel (Salk Institute, US)
"Recycling Metabolic ‘Waste’: Moonlighting Enzymes and the Evolution of Chemodiversity in Plant Specialized Metabolic Pathways"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amMarco Fraaije (Groningen University, NL)
"New Insights in Mechanistic and Structural Aspects of Flavoprotein Oxidases Facilitate Effective Redesign"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amFlorian Hollfelder (Cambridge University, UK)
"Multiple Catalytic Promiscuity"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmDaniel Herschlag (Stanford University, US)
"Catalytic Promiscuity as a Powerful Tool in Dissecting Enzymatic Catalysis"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmEnzyme Discovery and Application
Discussion Leader: Stefan Lutz (Emory University, US)
7:30 pm - 8:00 pmDonald Hilvert (ETH Zürich, CH)
"Creating New Enzymes by Design and Evolution"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmJürgen Eck (B.R.A.I.N. AG, DE)
"Learning from Nature: Tapping the Full Potential of Functional Sequence Space for Novel Enzymes and Artificial Operons"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmPaul Kamer (St. Andrews University, UK)
"Ligand Design in Homogeneous Catalysis: Rational Design, Combinatorial Approaches, and Artificial Enzymes"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEngineering Concepts and Tools
Discussion Leader: David Baker (Washington University, US)
9:00 am - 9:30 amHaruyuki Atomi (Kyoto University, JP)
"Novel Enzymes and Pathways in Hyperthermophilic Archaea"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amDavid Estell (Genencor Inc., US)
"Engineering Enzyme Surfaces: Beauty is Skin Deep"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amJiri Damborsky (Masaryk University, CZ)
"Structure and Activity of Dehalogenases in Organic Solvents"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmHenk-Jan Joosten (Bio-prodict, NL)
"3DM: Protein Engineering Super-Family Systems"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmApplied Protein Engineering
Discussion Leader: Jiri Damborsky (Brno University, CZ)
7:30 pm - 8:00 pmMichael Breuer (BASF AG, DE)
"Enzymatic Cyclisation Based on Acid-Base Catalysis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmDick Janssen (Groningen University, NL)
"Engineered Enzymes for β-Functionalized Alcohols and Carboxylic Acids"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmChris Savile (Codexis Inc., US)
"Engineering a Transaminase for the Manufacture of Sitagliptin"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnzymes in Organic Synthesis I
Discussion Leader: Manfred Schneider (Wuppertal University, DE)
9:00 am - 9:30 amJason Micklefield (Manchester University, UK)
"Structure-Guided Directed Evolution of Alkenyl and Arylmalonate Decarboxylases"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amKenji Miyamoto (Keio University, JP)
"Asymmetric Decarboxylation by Arylmalonate Decarboxylase and a Thermostable Esterase"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amCarlos Martinez (Pfizer Inc., US)
"New Trends in the Scale-up of Biocatalytic Reactions for the Synthesis of Pharmaceutical Intermediates"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmMei-Xiang Wang (Tsinghua University, CN)
"Enantioselective Nitrile Biotransformations and Their Applications in Organic Synthesis"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmBiocatalytic Routes to Chiral Amines and Alcohols
Discussion Leader: Uwe Bornscheuer (Greifswald University, DE)
7:30 pm - 8:00 pmOliver May (DSM, NL)
"Novel Omega-Transaminases and Improved Redox Enzymes for Industrial Applications"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmAndreas Bommarius (GeorgiaTech, US)
"Development of a Novel Dehydrogenase"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmGreg Hughes (Merck & Co, US)
"Insights into Pharmaceutical Biocatalysis: Discovery and Process Development"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMultiple Enzyme Reactions: Cascade Reactions and Pathway Engineering
Discussion Leader: Andreas Bommarius (GeorgiaTech, US)
9:00 am - 9:30 amPaul Dalby (University College London, UK)
"Integrated Process, Pathway and Enzyme Engineering for Chiral Keto- and Amino-Diols"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amStephan Lütz (Novartis, CH)
"Recent Developments in the Application of Oxidoreductases for Fine Chemical Synthesis"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amHarald Gröger (Erlangen-Nuremberg University, DE)
"Chemoenzymatic One-Pot Syntheses in Water"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmByung-Gee Kim (Seoul National University, SK)
"Di-Hydroxylation of (Iso)Flavonoids using P450s from Actinomycetes and its Host Development"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmEnzymes in Organic Synthesis II
Discussion Leader: Hans-Peter Meyer (Lonza, CH)
7:30 pm - 8:00 pmWolfgang Kroutil (Graz Technical University, A)
"Extending the Toolbox for Biocatalytic C-C Bond Formation"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Selected Poster Presentations I
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Selected Poster Presentations II
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: July 22, 2010
 
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