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Biomolecular Interactions & Methods
Protein Interaction Dynamics: Theory Method & Practice
January 17-22, 2010
Hotel Galvez
Galveston, TX
Chairs:
Karen Fleming & Gideon Schreiber

Vice Chairs:
Linda K. Nicholson & Justin E. Molloy
Related Meeting Information
The Biomolecular Interactions & Methods Gordon Research Conference was held in conjunction with the Biomolecular Interactions & Methods Gordon-Kenan Research Seminar. Please refer to the Biomolecular Interactions & Methods GKRS web page for more information.

This meeting explores the central role that protein structural mobility plays in biomolecular interactions as well as the dynamics of protein interactions themselves. Bringing together quantitative methodologies and key problems in biology, sessions include (1) Protein Interactions and Disease; (2) Intrinsically unstructured proteins and conformational diversity in complexes; (3) Advances in Physical Methods; (4) Macromolecular Assemblages and Machines; (5) Network Dynamics; (6) Advances in Computational Methods; (7) Single Molecule Biophysics; and (8) Kinetics & Thermodynamics. This conference remains true to the central goal of its founding RASMB meeting: to bring together experts in biophysical methodologies and those in biological problems ripe for quantitative analysis. In addition to invited presenters, speakers will be selected from poster abstracts. The 2010 GRC in Biomolecular Interactions & Methods will continue its strong tradition of encouraging the participation of younger scientists; in addition, we have an accompanying Gordon Research Seminar that we invite students and postdoctoral scientists to attend.

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmPROTEIN INTERACTIONS AND DISEASE
Discussion Leader: Brian Shoichet (UCSF)
7:40 pm - 7:50 pm Brian Shoichet (UCSF)
Session Introduction
7:50 pm - 8:15 pmJeremy Jenkins (Novartis Institutes for Biomedical Research)
"Molecular interaction networks: proteins, drugs, and phenotypes"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmDiane Joseph-McCarthy (AstraZeneca R&D Boston)
"Fragment-Based Lead Discovery and Design"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:00 pm Xiayang Qiu (Pfizer Central Research)
"Deep knowledge of Drug Targets Using Integrated Biomolecular Interaction Methods"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pmBrian Shoichet (UCSF)
"Predicting new ligands for old targets and new targets for old drugs"
9:25 pm - 9:30 pm Discussion
9:30 Poster Session
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmINTRINSICALLY UNSTRUCTURED PROTEINS AND CONFORMATIONAL DIVERSITY
Discussion Leader: Vince Hilser (UTMB Galveston)
9:00 am - 9:10 amVince Hilser (UTMB Galveston)
Session Introduction
9:10 am - 9:35 amTerry Oas (Duke University)
"Using the Concept of Flux to Determine Coupled Folding/Binding Mechanisms"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am David J. Scott (University of Nottingham, UK)
"Determining the Structures of Intrinsically Disordered Domains involved in Plasmid Partitioning"
10:00 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 11:00 amDavid Eliezer (Weill Cornell Medical College)
"Conformational transitions of free and membrane-bound alpha-synuclein"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 amVince Hilser (UTMB Galveston)
"Intrinsic disorder, local unfolding, and allostery in an ensemble"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Elisar Barbar (Oregon State University)
"Multivalency in the Assembly of LC8 with Intrinsically Disordered Proteins"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Carlos Camacho (University of Pittsburgh)
"On the Origins of Disorder in Protein Interactions"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General discussion on the session topic
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmADVANCES IN BIOPHYSICAL METHODS
Discussion Leader: Colin Kleanthous (University of York)
7:30 pm - 7:40 pmColin Kleanthous (University of York)
Session Introduction
7:40 pm - 8:05 pmHelen Saibil (Birbeck College, London)
"Electron microscopy studies of molecular and cellular machines"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmMarius Clore (NIH-NIDDK)
"Probing transient, low-population states of macromolecules and their complexes by paramagnetic relaxation enhancement"
8:35 pm - 8:40 pm Discussion
8:40 pm - 8:55 pm Daniel I Some (Wyatt Technologies, Inc.)
"Quantifying Protein Interactions via Composition-Gradient Static Light Scattering"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pmColin Kleanthous (University of York)
"Disulfide entrapment of a weak protein-protein interaction"
9:25 pm - 9:30 pm Discussion
9:30 Poster Session
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMACROMOLECULAR MACHINES AND ASSEMBLAGES
Discussion Leader: Keiichi Namba (Osaka University)
9:00 am - 9:10 amKeiichi Namba (Osaka University)
Session Introduction
9:10 am - 9:35 amRobert Sauer (MIT)
"Allosteric control of proteolytic activity"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am Grant Pearce (University of Canterbury, New Zealand)
"Developing Thermostable Building Blocks using Non-native Quaternary Structures"
10:00 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 11:00 amKiyoshi Nagai (MRC Laboratory of Molecular Biology)
"Architecture of the spliceosomal snRNPs"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 amKeiichi Namba (Osaka University)
"Molecular mechanisms of self-assembly, switching and motion of the bacterial flagellum"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Dongping Zhong (Ohio State University)
"Protein hydration dynamics and molecular mechanismof coupled water-protein fluctuations"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Thomas M. Laue (University of New Hampshire)
"The Open AUC Project"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General discussion on the session topic
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmADVANCES IN COMPUTATIONAL METHODS
Discussion Leader: Gideon Schreiber (Weizmann Institute)
7:30 pm - 7:40 pmGideon Schreiber (Weizmann Institute)
Session Introduction
7:40 pm - 8:05 pmAngel Garcia (Rensselaer Polytechnic Institute)
"Atomic simulations of the folding/unfolding thermodynamics of proteins"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmBrian Kuhlman (UNC Chapel Hill)
"Computational Design of Protein Interfaces and Switches"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Julia Shifman (Hebrew University)
"Tradeoff between Stability and Multi-specificity in the Design of Promiscuous Protein Sequences"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Yaakov Levy (Weizmann Institute)
"Ubiquitin: Not Just a Tag?"
9:25 pm - 9:30 pm Discussion
9:30 pm Poster Session
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSINGLE MOLECULE DYNAMICS
Discussion Leader: David Warshaw (University of Vermont)
9:00 am - 9:10 amDavid Warshaw (University of Vermont)
Session Introduction
9:10 am - 9:35 amJustin Molloy (MRC National Institute for Medical Research)
"Imaging single myosins as they move around the cell"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am Jennifer Potts (University of York)
"Inside-out Protein-Protein Recognition Underpins Redox Sensing by the ZAS anti-Sigma Factor RsrA"
10:00 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 11:00 amJoseph Puglisi (Stanford University Medical School)
"Dynamics of translation"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 amDavid Warshaw (University of Vermont)
"Myosin Molecular Motors: Transporting Cargo in All Directions"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Danette D. Hartzell (Promega Corp)
"Characterization of Macromolecular Complex Interactions and Function using New Surface Display and Imaging Technology"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Swagata Dasgupta (Indian Institute of Technology)
"Interactions of Biomacromolecules with Naturally Occuring Polyphenols: Prospects for Inhibitor Design"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General discussion on the session topic
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMOLECULAR NETWORK DYNAMICS
Discussion Leader: Luis Serrano (CRG EMBL Systems Biology Unit)
7:30 pm - 7:40 pmLuis Serrano (CRG EMBL Systems Biology Unit)
Session Introduction
7:40 pm - 8:05 pmForest White (MIT)
"Biological Insights from quantitative analysis of signaling networks"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmGianni Cesareni (University of Rome Tor Vergata)
"Domain Networks and Human Diseases"
8:35 pm - 8:40 pm Discussion
8:40 pm - 8:55 pm Brian M. Baker (University of Notre Dame)
"T Cell Receptor Crossreactivity Directed by Antigen-dependent Tuning of Peptide/MHC Molecular Flexibility"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pmLuis Serrano (CRG EMBL Systems Biology Unit)
"Structural Systems Biology and the EGF Map Kinase pathway"
9:25 pm - 9:30 pm Discussion
9:30 pm Poster Session
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmKINETICS & THERMODYNAMICS
Discussion Leader: Madeline Shea (Univ. Iowa)
9:00 am - 9:10 amMadeline Shea (Univ. Iowa)
Session Introduction
9:10 am - 9:35 amLinda Nicholson (Cornell University)
"The Kinetics and Thermodynamics of the cis/trans Isomerase Pin1 Revealed by NMR and ITC"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am Eric J. Sundberg (Boston Biomedical Research Institute)
"Dissecting protein-protein interactions using directed evolution"
10:00 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 11:00 amEnrique De La Cruz (Yale University)
"Pathway of ATP hydrolysis and duplex rRNA unwinding by the DEAD box helicase DbpA"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 amMadeline Shea (Univ. Iowa)
"Molecular Recognition by Calmodulin: Balancing Bending and Binding"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Borries Demeler (Univ. Texas Health Science Center San Antonio)
"Investigation of Reversible Protein Dynamics with Analytical Ultracentrifugation"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Chun Tang (University of Missouri)
"Characterizing Dynamic Protein-Protein Interactions Using Differentially Scaled Paramagnetic Relaxation Enhancement"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General discussion on the session topic
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmKEYNOTE LECTURE
Discussion Leader: Karen Fleming (Johns Hopkins University)
7:30 pm - 8:30 pmJames R. Williamson (The Scripps Research Institute)
"Dynamics of Ribosome Assembly, in vitro and in Cells, Using Mass Spectrometry"
8:30 pm - 9:00 pm Discussion
9:00 pm Closing Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this conference was made possible (in part) by 1 R13 GM 090452 - 01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Last Updated: July 22, 2010
 
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