Gordon Research Conferences
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Conference Program
 
Biomineralization
August 15-20, 2010
Colby-Sawyer College
New London, NH
Chair:
Lia Addadi

Vice Chair:
Peter Fratzl

Application Deadline
Applications are no longer being accepted for this meeting. If you have been instructed to apply by the Conference Chair, please contact your Conference Coordinator for further instructions.

The objective of the Gordon Research Conference on Biomineralization is to explore the fundamental mechanisms that underlie biomineralization processes in all organisms, as well as their possible applications. The interest in this topic stems from the important role that biomineralization processes play in biology, biotechnology and medicine, and the inspiration that can derive from the understanding of biomineralization strategies in chemistry, interfacial science, materials science, and nanotechnology. The goal of this GRC is thus to foster discussion on fundamental and applied biomineralization aspects, by bringing together chemists, physicists, biologists, medical doctors and engineers who would otherwise not overlap on the conference circuit, in a setting that promotes cross-disciplinary fertilization of new ideas.

The specialty of biomineralization is in exercising control at many different hierarchical levels. Investigation on biomineralization thus covers the whole spectrum from the molecular level to the skeletal tissue, its properties and structure-function relations. Over the last few years we have witnessed exciting new developments originating from the realization that transient precursor phases play a fundamental role in the development of the mature mineralized material. Side by side, new experimental and modeling techniques are now available to explore the dynamics of the systems.

We anticipate that these and other avenues will be explored in an exciting meeting with invited oral presentations that will include, but not be limited to the subjects: Structure/function relations- from architecture to function, Mineralization mechanisms, Transient mineral precursor phases, Bioinspired materials, Mechanisms of crystal growth, Matrix/mineral interactions, Cellular and genetic control of mineralization.

The oral sessions will be followed by the highly successful afternoon poster sessions, providing all conferees with the opportunity to present their latest research and to exchange ideas in a more informal setting. As in the past, discussions will continue during the social gathering in the poster hall following the evening lectures. Both posters and lectures should present work that has not been previously published to a significant extent. All conferees are encouraged to submit and present posters. We will select 8-10 of the best poster abstracts for short oral presentations.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmFROM ARCHITECTURE TO FUNCTION
7:40 pm - 8:00 pm Discussion Leader: William Landis (Northeastern Ohio Universities)
"Overview"
8:00 pm - 8:25 pm Steve Weiner (Weizmann Institute of Science, Israel)
"Teeth: From architecture to function"
8:25 pm - 8:40 pm Discussion
8:40 pm - 9:05 pm Henrik Birkedal (Aarhus University, Denmark)
"The byssus of the jingle shell (Anomia): a mineralized holdfast system"
9:05 pm - 9:20 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 9:40 amFROM ARCHITECTURE TO FUNCTION (continued)
9:00 am - 9:25 am Sunita Ho (UCSF)
"Bone-PDL-cementum complex of a load bearing fibrous joint"
9:25 am - 9:40 am Discussion
9:40 am - 12:30 pmMINERAL PHASES AND MINERAL GROWTH MECHANISMS
9:40 am - 10:00 am Discussion Leader: Peter Fratzl (Max Planck Inst. Potsdam, Germany)
"Overview"
10:00 am Coffee Break / Group Photo
10:30 am - 10:55 am Andrzej Wierzbicki (University of South Alabama)
"The interplay between experimental and computational approaches to biomineralization"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Fiona Meldrum (University of Leeds UK)
"Crystallisation within constrained environments"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Colin Brownlee (Marine Biological Association, Plymouth, UK)
"Intracellular calcification in coccolithophores - transport and homeostasis mechanisms"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPATHOLOGICAL ASPECTS OF BIOLOGICAL CRYSTALLIZATION
7:30 pm - 7:45 pm Discussion Leader: Marc McKee (McGill University, Canada)
"Overview"
7:45 pm - 8:10 pm Howard Kruth (NIH Bethesda)
"Monoclonal antibody detection of cholesterol microdomains functioning in cellular cholesterol efflux"
8:10 pm - 8:25 pm Discussion
8:25 pm - 8:50 pm Linda Demer (UCLA)
"Relationship between vascular and skeletal mineralization"
8:50 pm - 9:05 pm Discussion
9:05 pm - 9:15 pm Alexander Heiss (RWTH Aachen, Germany)
"Inhibition of calcium phosphate precipitation by the serum protein fetuin-A"
9:15 pm - 9:25 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTRANSIENT MINERAL PRECURSOR PHASES
9:00 am - 9:15 am Discussion Leader: Irit Sagi (Weizmann Institute of Science, Israel)
"Overview"
9:15 am - 9:40 am Marc Grynpas (Toronto University, Canada)
"The control of vertebrate mineralization by polyphosphates"
9:40 am - 9:55 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Helmut Colfen (Max Planck Inst. Potsdam, Germany)
"Pre-nucleation Clusters"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Jens Rieger (BASF, Germany)
"Precursor structures in bulk / interfacial crystallization of CaCO3"
11:35 am - 11:50 am Discussion
11:50 am - 12:00 pm Fabio Nudelman (TU Eindhoven, Netherlands)
"Collagen can directly control the formation of bone apatite"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Karina K. Sand (Copenhagen University, Denmark)
"The role of the OH bond and its relevance to biomineralization: Binding of ethanol on calcite"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPROTEIN/MINERAL INTERACTIONS
7:30 pm - 7:45 pm Discussion Leader: Frederic Marin (University of Bourgogne, France)
"Overview"
7:45 pm - 8:10 pm Kazuyoshi Endo (University of Tsukuba, Japan)
"In vitro functional analysis of molluscan shell matrix proteins"
8:10 pm - 8:25 pm Discussion
8:25 pm - 8:35 pm Michio Suzuki (University of Tokyo, Japan)
"Structural and functional analyses of a novel acidic matrix protein, Pif, from the nacreous layer of the Japanese pearl oyster, Pinctada fucata"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Lukmaan Bawazer (Univ. California, Santa Barbara)
"Directed Laboratory Evolution of Biomineralizing Enzymes"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:15 pm Elia Beniash (University of Pittsburgh)
"CryoTEM of Amelogein: self-assembly and mineralization"
9:15 pm - 9:25 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBIOINSPIRED NANO-FABRICATION
9:00 am - 9:15 am Discussion Leader: Trevor Douglas (Montana State University)
"Overview"
9:15 am - 9:40 am Joanna Aizenberg (Harvard University)
"Controlled inorganic precipitation on functionalized 2D and 3D substrates"
9:40 am - 9:55 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Shu Hong Yu (University of Science and Technology of China)
"Bioinspired synthesis of nanostructures and nanocomposites and their functionalities"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Lara Estroff (Cornell University)
"Crystals grown in gels: synthesis, structure, and properties"
11:35 am - 11:50 am Discussion
11:50 am - 12:00 pm Johanna Galloway (Univ. Leeds, UK)
"Arrays of Nanomagnets formed with the Biomineralizing protein Mms6"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Benjamin Hatton (Harvard University)
"Mineral Nucleation and Growth on a Superhydrophobic Surface - Topological Control of Bottom-up Assembly"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmMINERALIZATION MECHANISMS
7:30 pm - 7:45 pm Discussion Leader: Elaine DiMasi (Brookhaven National Laboratory)
"Overview"
7:45 pm - 8:10 pm Pupa Gilbert (University of Wisconsin-Madison)
"Co-orientation mechanisms in biominerals"
8:10 pm - 8:25 pm Discussion
8:25 pm - 8:50 pm Oskar Paris (Leoben University, Austria)
"Crystalline and amorphous phases in biomineralized tissues: lessons from scanning microbeam X-ray scattering"
8:50 pm - 9:05 pm Discussion
9:05 pm - 9:15 pm Asher Schmidt (Technion, Israel)
"Functionally tailored, biogenic materials: Understanding nature's strategies by solid state NMR"
9:15 pm - 9:25 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 9:40 amMINERALIZATION MECHANISMS (continued)
9:15 am - 9:25 am Jim De Yoreo (Lawrence Berkeley National Laboratory)
"The dynamics of organization and reorganization during protein self-assembly and mineralization"
9:25 am - 9:40 am Discussion
9:40 am - 12:30 pmCELLULAR AND MATRIX CONTROLS ON MINERALIZATION
9:40 am - 10:00 am Discussion Leader: Malcolm Snead (USC Los Angeles)
"Overview"
10:00 am Coffee Break
10:30 am - 10:55 am Benjamin Geiger (Weizmann Institute of Science, Israel)
"Mechanisms underlying adhesion-mediated surface sensing in fibroblasts and osteoclasts"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Bjorn Olsen (Harvard University)
"The role of polycystins in biomineralization"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Brian Cox (Teledyne Scientific Co)
"How strain stimulus can create spatial ordering in large cell populations"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKEYNOTE PRESENTATION
7:30 pm - 7:35 pm Discussion Leader: Lia Addadi (Weizmann Institute of Science, Israel)
"Introduction"
7:35 pm - 8:10 pm Fred Wilt (UC Berkeley)
"Genes, proteins, and minerals: how to make hard stuff"
8:10 pm - 8:25 pm Discussion
8:25 pm - 8:35 pm James Weaver (Univ California, Santa Barbara)
"Beasts in the Electron Microscope. A wrap-up show"
8:35 pm - 9:00 pm General Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Last Updated: July 27, 2010
 
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