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Conference Program
 
Bioorganic Chemistry
June 13-18, 2010
Proctor Academy
Andover, NH

The Gordon Research Conference on Bioorganic Chemistry was founded in 1992 to bring together scientists from a range of disciplines to present and discuss cutting-edge research at the interface between chemistry and biology. Both fundamental and applied research relevant to academia and industry are highlighted. To maintain a balance between these areas, the conference is organized by two co-chairs, one from academia and one from industry. The conference emphasizes the presentation of techniques or approaches that are broadly applicable across multiple areas of chemical and biological research. Traditionally, small molecules that probe, modulate, or mimic cellular components or processes as well as studies of biology at the molecular level have been of particular interest.

The meeting in 2010 will continue the tradition of showcasing interdisciplinary biological research in the areas of metabolomics, medicinal chemistry and drug discovery, infectious disease, cell signaling, natural products, nucleic acids, peptides, and biomaterials. All conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC web site. Eight poster presenters will be invited to present short talks. Given the popularity of this meeting, submission of applications by early 2010 is strongly encouraged.


Contributors
The Chairs of the 2010 Bioorganic Chemistry Gordon Research Conference would like to thank the following organizations for their generous contributions:

American Chemical Society Biological Chemistry Division
New England Biolabs, Inc.
Genentech,Inc.
American Chemical Society
Ash Stevens, Inc.
Eli Lilly and Company
Nature Chemical Biology
Cell Press

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNEW PERSPECTIVES IN BIOLOGICAL CATALYSIS
Discussion Leader: Irene Lee (Case Western Reserve University)
7:40 pm - 8:10 pmSquire Booker (Pennsylvania State University)
"C-H Bond Activation: Doing it in the Absence of Oxygen"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:35 pm Poster Talk #1: John Richard (University of Buffalo)
"A Role for Phosphate Gripper Loops in Enzymatic Catalysis"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:15 pmJoanne Stubbe (Massachusetts Institute of Technology)
"Biosynthesis of Metallo-cofactors in vitro and in vivo"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNOVEL METHODS AND CHEMICAL TOOLS
Discussion Leader: Erin Carlson (Indiana University)
9:00 am - 9:30 amGang-yu Liu (University of California, Davis)
"Design and Production of Architectures for Regulation of Cellular Signaling Processes"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amKate Carroll (University of Michigan)
"Painting the Cysteine Chapel: New Tools to Probe Redox Signal Transduction"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amAlan Saghatelian (Harvard University)
"Peptidomics Approaches to Endogenous Peptide Metabolism"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmKay Ahn (Pfizer)
"Discovery of Highly Selective Fatty Acid Amide Hydrolase (FAAH) Inhibitors for the Treatment of Inflammatory Pain"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Poster Talk #2: Junko Ohkanda (Osaka University)
"Module Assembly for Disruption and Detection of Protein-Protein Interactions"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBACTERIA: FRIEND OR FOE
Discussion Leader: David Ehmann (AstraZeneca)
7:30 pm - 8:00 pmMichelle Chang (University of California, Berkeley)
"Building New Chemical Function in E. coli"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmDouglas Weibel (University of Wisconsin, Madison)
"A Chemical Biological Approach to Studying Spatial Organization in Bacteria"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmShahriar Mobashery (University of Notre Dame)
"Bacterial Cell Wall Turnover"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA REPAIR AND THERAPEUTICS
Discussion Leader: Penny Beuning (Northeastern University)
9:00 am - 9:30 amAmanda Bryant-Friedrich (University of Toledo)
"The Interplay of Oxidative Damage and Protein-DNA Interactions"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amSheila David (University of California, Davis)
"The Good, the Bad and the Damaged: Mediation of Oxidative DNA Damage by Base Excision Repair Glycosylases"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amTheresa Reineke (Virginia Technological University)
"Glycopolymer Carriers for Nucleic Acid Delivery and Diagnostic Imaging"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Poster Talk #3: Nathan Luedtke (University of Zurich)
"Structure-Selective Fluorescent Probes for Nucleic Acids"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Poster Talk #4: Peter Andreana (Wayne State University)
"Targeting Cellular Immunity with Entirely Carbohydrate-based Constructs"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Poster Talk #5: Jeffery Gildersleeve (National Cancer Institute)
"Glycan Arrays and Cancer Vaccines: Partners for Life"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMOLECULAR SWITCHES
Discussion Leader: Jean-Paul Desaulniers (University of Ontario Institute of Technology)
7:30 pm - 8:00 pmBeatrix Suess (Goethe-Universität Frankfurt am Main)
"Engineered Riboswitches: An Alternative Means for Conditional Gene Expression"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmJustin Gallivan (Emory University)
"Reprogramming Bacteria with Small Molecules and RNA"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmDirk Trauner (Ludwig-Maximilians-Universität München)
"Controlling Neural Activity with Molecular Switches"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREMODELING PROTEIN FUNCTION
Discussion Leader: Minkui Luo (Memorial Sloan-Kettering Cancer Center)
9:00 am - 9:30 amJennifer Ottesen (The Ohio State University)
"Chemical Tools to Probe Histone Modification in the Nucleosome Core"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amHening Lin (Cornell University)
"The Enzymatic Activity of Sirtuins: Beyond NAD-Dependent Deacetylation"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amCarol Fierke (University of Michigan)
"Mechanism and Regulation of Metal-Dependent Deacetylases"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Poster Talk #6: Michael Acker (Harvard University)
"Biosynthesis of the Thiocillin Family of Thiopeptides: A Mutasynthetic Approach"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Poster Talk #7: Richard Gantt (University of Wisconsin)
"Exploiting Glycosyltransferase Reversibility for Nucleotide Diphosphate Sugar Synthesis"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Poster Talk #8: Emma Doud (Harvard University)
"TIM-Barrel Prenyltransferases in Bacteria"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmCHEMICAL BIOLOGY OF DISEASE
Discussion Leader: Rami Hannoush (Genentech, Inc.)
7:30 pm - 8:00 pmStephanie Leavitt (Gilead Sciences)
"The Combined Use of Label-free Binding Technologies During Lead Identification, Validation, and Optimization"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmThomas Hermann (University of California, San Diego)
"Targeting RNA with Synthetic Ligands of Natural Product-like Complexity"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmMichael Gelb (University of Washington, Seattle)
"Bioorganic Chemistry of Saving Babies From Devastating Enzyme Deficiency Diseases"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDESIGN, DEVELOP, DISCOVER
Discussion Leader: Samy Meroueh (Indiana University School of Medicine)
9:00 am - 9:30 amRobert Lazarus (Genentech, Inc.)
"Pseudo-proteases in Biology and Cancer Signaling Pathways"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amDustin Maly (University of Washington, Seattle)
"Small Molecule Control of Signaling-Enzyme Function"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 pmKen Houk (University of California, Los Angeles)
"Computational Design of New Enzymes"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Poster Talk #9: Brendan Orner (Nanyang Technological University)
"Toward an Understanding of the Self-Assembly of Protein Cages and Application to Inorganic Nano-materials"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Poster Talk #10: Greg Tochtrop (Case Western Reserve University)
"Metabolism and Signaling of Lipid Peroxidation Products"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Poster Talk #11: David Spiegel (Yale University)
"Small Molecule Modulators of Antibody Function"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFRONTIERS IN BIOORGANIC AND MEDICINAL CHEMISTRY
Discussion Leader: Timothy Dore (University of Georgia)
7:30 pm - 8:00 pmRussell Petter (Avila Therapeutics)
"Toward Digital Selectivity in Protease Inhibitors - Covalent Modification of a Non-catalytic Cysteine in HCV Protease"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmAndrew Judd (Abbott Laboratories)
"Industrial Applications of the RCM Reaction: From Twisted Amides to Productive Dimers"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmPaul Wender (Stanford University)
"The Chemistry-Medicine Continuum: New Approaches To Alzheimer's Disease, HIV/AIDS Eradication and Resistant Cancer"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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