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Biopolymers
Gordon Research Conference

From Folding and Function to Engineering and Design

Dates

June 6-11, 2010

Location

Salve Regina University
Newport, RI

Organizers

Chairs:
Dorothy Beckett & Michael H. Hecht

Vice Chair:
Angel E. Garcia

Meeting Description

The focus of the 2010 Biopolymers Gordon Research Conference will be on understanding fundamental physical-chemical properties of biopolymers including their structures, folding, dynamics, stability, and interactions. The meeting will assemble leaders in the biopolymers field with junior scientists, postdocs and students in a five-day conference to discuss current approaches to elucidating the structures, function and folding of biopolymers and their complexes. The conference plays a unique role in fostering interdisciplinary interactions among scientists who apply a breadth of techniques to understanding a number of distinct systems. In addition to a keynote address that will be delivered by Dr. Peter Wright, the 2010 schedule includes the following exciting scientific sessions: RNA Structure, Folding and Dynamics; Molecular Machines Acting on Nucleic Acids; Binding, Allostery and Dynamics; Proteins from Birth to Death; Biopolymers by Design; Membrane Proteins: Structure, Folding and Function; Folding and Unfolding, Order and Disorder; and Amyloid (Death by Misfolding). The sessions have been designed so that each topic is addressed using a range of approaches and techniques including simulation, NMR spectroscopy, single molecule measurements, x-ray crystallography and traditional solution methods. As with all Gordon Research Conferences the Biopolymers conference will provide ample opportunities for informal interactions in the afternoons and evenings. Poster sessions will provide a venue for graduate students and postdocs to discuss their research with leaders in the field.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Conference Chairs
7:45 pm - 8:50 pmKEYNOTE LECTURE
Discussion Leader: Dorothy Beckett (University of Maryland)
7:45 pm - 8:35 pmPeter Wright (Scripps)
"Disorderly behavior: Promiscuous interactions of intrinsically disordered proteins"
8:35 pm - 8:50 pm Discussion
9:00 pm - Welcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRNA STRUCTURE, FOLDING, AND FUNCTION
9:00 am - 9:05 am Discussion Leader: Eric Westhof (University of Strassburg)
Introduction to Session
9:05 am - 9:35 amAdrian Ferre D’Amare (Fred Hutchinson)
"Small molecule recognition and catalysis by gene-regulatory RNAs"
9:35 am - 9:45 am Discussion
9:45 am - 10:15 amJuli Feigon (UCLA)
"Structure & dynamics of pseudoknots from telomerase and the preQ1 riboswitch"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Group Photo / Coffee Break
10:50 am - 11:20 amLois Pollack (Cornell University)
"Ions and RNA Folding"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmEric Westhof (University of Strassburg)
"The elementary modules of RNA architecture"
12:00 pm - 12:10 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMOLECULAR MACHINES
7:30 pm - 7:35 pm Discussion Leader: Steve Block (Stanford University)
Introduction to Session
7:35 pm - 8:05 pmTaekjip Ha (University of Illinois)
"Single molecule fluorescence and force analysis of protein dynamics on single stranded DNA"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmEnrique M. De La Cruz (Yale University)
"How cofilin severs and actin filament: Insights from biochemistry & mechanics"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmSteve Block (Stanford University)
"Riboswitch Dynamics and Folding Studied at the Single-Molecule Level"
9:20 pm - 9:30 pm Discussion
9:30 pm Refreshments
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:10 pmBIOPOLYMERS BY DESIGN
9:00 am - 9:05 am Discussion Leader: Alanna Schepartz (Yale University)
Introduction to Session
9:05 am - 9:35 amShohei Koide (University of Chicago)
"Design of protein interaction interfaces"
9:35 am - 9:45 am Discussion
9:45 am - 10:15 amPhil Bryan (CARB, UMBI)
"A minimal sequence code for switching protein structure and function"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:20 amAlexander M. Cruickshank Lecture:
Alanna Schepartz (Yale University)
"Protein design without alpha-amino acids"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmNed Seeman (New York University)
"DNA: Not Merely the Secret of Life"
12:00 pm - 12:10 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMEMBRANE PROTEINS: STRUCTURE, FOLDING AND FUNCTION
7:30 pm - 7:35 pm Discussion Leader: Jim Bowie (UCLA)
Introduction to Session
7:35 pm - 8:05 pmDan Rosenbaum (Stanford University)
"Structure of a GPCR: The Human beta2 Adrenergic Receptor"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmKatherine Henzler-Wildman (Washington University)
"The role of conformational exchange in multidrug resistance transport by EmrE"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmJim Bowie (UCLA)
"What drives membrane protein folding?"
9:20 pm - 9:30 pm Discussion
9:30 pm Refreshments
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:10 pmBINDING, ALLOSTERY AND DYNAMICS
9:00 am - 9:05 am Discussion Leader: Carol Post (Purdue University)
Introduction to Session
9:05 am - 9:35 amGideon Schreiber (Weizmann Institute)
"Binding in the crowd: a struggle between opposite forces"
9:35 am - 9:45 am Discussion
9:45 am - 10:15 amCarol Post (Purdue University)
"Phosphorylation and allosteric disorder in regulation of Syk-receptor interactions"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:20 amIvet Bahar (University of Pittsburgh)
"Intrinsic Dynamics vs Induced Dynamics: Insights from Computations"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmCharalampos Kalodimos (Rutgers University)
"Dynamic activation of protein function"
12:00 pm - 12:10 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmPROTEINS FROM BIRTH TO DEATH
7:30 pm - 7:35 pm Discussion Leader: George Lorimer (University of Maryland)
Introduction to Session
7:35 pm - 8:00 pmAda Yonath (Weizmann Institute)
"Chaperons assisting folding of nascent chains"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmOlke Uhlenbeck (Northwestern University)
"tRNA structural elements required for decoding"
8:30 pm - 8:35 pm Discussion
8:35 pm - 8:55 pmGeorge Lorimer (University of Maryland)
"Allosteric States and the Operation of the Chaperonin Machine"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pmBob Sauer (MIT)
"Allosteric machines: back to the future"
9:25 pm - 9:30 pm Discussion
9:30 pm Refreshments
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:10 pmAMYLOID (DEATH BY MISFOLDING)
9:00 am - 9:05 am Discussion Leader: M. Vendruscolo (Cambridge University)
Introduction to Session
9:05 am - 9:35 amJean Baum (Rutgers University)
"Characterization of transient encounter complexes of the intrinsically disordered protein alpha-synuclein by NMR": Implication for initiation of aggregation"
9:35 am - 9:45 am Discussion
9:45 am - 10:15 amRob Tycko (NIH)
"Unfolded and Misfolded Proteins: New Structural Insights from Solid State NMR"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:20 amMichele Vendruscolo (Cambridge University)
"Physico-Chemical Principles of Protein Aggregation"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmJijun Dong (MIT)
"Optical trapping of prion fibrils reveals unexpected unfolding behavior"
12:00 pm - 12:10 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFOLDING: IN VITRO AND IN VIVO
7:30 pm - 7:35 pm Discussion Leader: Gary Pielak (University of North Carolina)
Introduction to Session
7:35 pm - 8:05 pmHarold Scheraga (Cornell University)
"Dynamics of Protein Folding"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Jasna Brujic (New York University)
"Non-exponential kinetics may increase the robustness of mechanically active proteins"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pmGary Pielak (University of North Carolina)
"Diffusion & Stability of Proteins under Crowded Conditions"
9:25 pm - 9:30 pm Discussion
9:30 pm Refreshments
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 GM 093357 - 01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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