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Cell Death
August 22-27, 2010
Salve Regina University
Newport, RI
Chair:
Richard J. Youle

Vice Chair:
John M. Abrams

The 2010 Gordon Conference on Cell Death will present cutting-edge research on programmed cell death spanning from molecular mechanisms to disease treatment. The Conference will feature a wide range of topics, such as caspase activation, Bcl-2 family protein mechanisms, alternate cell death pathways including necrosis and autophagy, mitochondrial dynamics, cancer treatment and apoptosis in the immune system. Invited speakers represent a variety of scientific disciplines, including biochemistry, structural biology, cell biology, imaging, developmental biology, immunology and disease mechanism and treatment. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings at the beautiful campus of Salve Regina University on the Atlantic ocean in Newport, RI, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Karen Vousden (Beatson Institute for Cancer Research)
7:40 pm - 8:20 pmGuy Salvesen (The Burnham Institute)
"The Space Between Proliferation and Death"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Xiaodong Wang (UT Southwestern)
"Biochemical pathway of necrosis"
9:15 pm - 9:30 pm Discussion
9:30 pm Reception / Poster Session: Group A (Last name A-K)
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBcl-2 Family Mechanisms
Discussion Leader: Eileen White (Rutgers University)
9:00 am - 9:20 amDavid Andrews (McMaster University)
"The Life and Death Consequences of Bcl-2 family protein interactions with membranes"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amDavid Huang (WEHI)
"Molecular mechanisms to initiate cell death"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break / Group Photo
10:30 am - 10:55 amDon Newmeyer (La Jolla Institute for Allergy and Immunology)
"Bax-dependent pore formation in the mitochondrial outer membrane"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 amMarie Hardwick (Johns Hopkins School of Medicine)
"Inner mitochondrial membrane functions of Bcl-2 proteins"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pmDoug Green (St. Jude Children’s Research Hospital)
"Give and take in the Bcl-2 family"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Group A (Last name A-K)
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Mechanisms
Discussion Leader: Sally Kornbluth (Duke University)
7:30 pm - 7:50 pmIngrid Wertz (Genentech)
"Cell Death Mechanisms of Anti-tubulin Chemotherapeutics"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Pascal Meier (Chester Beatty Laboratories)
"Ubiquitin-mediated regulation of cell survival'"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmHyung Don Ryoo (New York University School of Medicine)
"The mechanism of endoplasmic reticulum stress-induced apoptosis in Drosophila neurodegenerative disease models"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmEli Arama (Weizmann Inst.)
"Gradients of a Ubiquitin E3 Ligase Inhibitor and a Caspase Inhibitor Determine the Differentiation or Death in Spermatids"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAlternate Death Pathways and Autophagy
Discussion Leader: Eric Baehrecke (University of Massachusetts Medical School)
9:00 am - 9:20 am Kevin Ryan (Beatson Institute for Cancer Research)
"Interplay between apoptosis and autophagy in the control of tumor cell death"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amKim McCall (Boston University)
"Non-canonical cell death pathways in Drosophila oogenesis"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 am Junying Yuan (Harvard Medical School)
"Regulation of cell death: from apoptosis to necroptosis"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 amEileen White (Rutgers University)
"Oncogene activation causes autophagy addiction"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pmMichael Lenardo (NIAID)
"Molecular regulation of alternative forms of cell death"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Group A (Last name A-K)
6:00 pmDinner
7:30 pm - 9:30 pmMetabolism and Signaling
Discussion Leader: Kim McCall (Boston University)
7:30 pm - 7:45 pmScott Dixon (Columbia)
"Mitochondrial iron efflux triggers a novel form of non-apoptotic cell death"
7:45 pm - 7:55 pm Discussion
7:55 pm - 8:15 pmWan-Jin Lu (UT Southwestern)
"Turning it on in the germ line: meiotic activation of the p53 network"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:45 pmJeff Rathmell (Duke University)
"Glucose metabolism in regulation of Bcl-2 family proteins"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:15 pmEric Baehrecke (University of Massachusetts Medical School)
"The role of autophagy in bioenergetics and growth control"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular Mechanisms
Discussion Leader: Guy Salvesen (The Burnham Institute)
9:00 am - 9:20 am Matthew Bogyo (Stanford University School of Medicine)
"Applications of small molecules probes to study the function of caspases"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Frank Edlich (NINDS)
"Retrotranslocation of Bax from the mitochondria to the cytosol"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 am Zheng Li (NIMH)
"A mechanism of generating a non-lethal dose of caspase-3 in long-term synaptic depression"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Monica Driscoll (Rutgers University)
"Unconventional roles for conventional killers: CED-3 and CED-4 promote neuronal regeneration consequent to axotomy"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Brent Stockwell (Columbia University)
"Modulatory Profiling of Cell Death Mechanisms"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Group B (Last name L-Z)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmMitochondrial Dynamics and Cell Death
Discussion Leader: Marie Hardwick (Johns Hopkins School of Medicine)
7:30 pm - 7:45 pm Natalie Niemi (Van Andel Research Institute)
"MK-STYX, a catalytically inactive phosphatase regulating mitochondrial dependent apoptosis"
7:45 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Jean-Claude Martinou (University of Geneva)
"Mitochondrial dynamins, Bcl-2 family members and mitochondrial membrane permeabilization"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:45 pm Jodi Nunnari (UC Davis)
"The soluble form of Bax stimulates mitochondrial fusion via a MFN2-specific mechanism"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:15 pm Barbara Conradt (Dartmouth)
"A molecular switch that governs the balance between mitochondrial fusion and fission"
9:15 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCancer Therapeutics
Discussion Leader: Doug Green (St. Jude Children’s Research Hospital)
9:00 am - 9:20 amHuseyin Mehmet (Merck Research Laboratories)
"Proteomic identification of cell surface biomarkers of apoptosis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amVucic Domagoj (Genentech)
"Targeting IAPs in tumors: TNFa, NF-kB and ubiquitin connections"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 amSally Kornbluth (Duke University)
"Inhibition of apoptotic pathways in lapatinib-resistant breast cancer"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 amAnthony Letai (Dana-Farber Cancer Institute)
"Mitochondrial determination of chemotherapy response in vitro and in the clinic"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Karen Vousden (Beatson)
"Regulation of Cell Death and Survival by p53"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Group B (Last name L-Z)
6:00 pmDinner
7:30 pm - 9:30 pmImmunity and disease
Discussion Leader: Michael Lenardo (NIAID)
7:30 pm - 7:50 pmPhilippe Bouillet (WEHI)
"ABT737 and Bim: New twists in the story"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Nico Tjandra (NHLBI)
"Structural insights into cytomegalovirus resistance to apoptosis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmCraig Walsh (UC Irvine)
"A complex interplay between autophagy, apoptosis and necrotic signals promotes T cell homeostasis"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:15 pmSolange Desagher (Université Montpellier)
"The E3 ligase Trim17 is required for neuronal apoptosis"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by 1 R13 CA153310-10 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Last Updated: August 17, 2010
 
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