Gordon Research Conferences
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Conference Program
 
Barriers of the CNS
Blood/Brain Interfaces in Health and Disease
June 20-25, 2010
Colby-Sawyer College
New London, NH
Chair:
Gert Fricker

Vice Chair:
Quentin Smith

Related Meeting Information
The Barriers of the CNS Gordon Research Conference was held in conjunction with the Barriers of the CNS Gordon-Kenan Research Seminar. Please refer to the Barriers of the CNS GKRS web page for more information.

The Gordon Research Conference on “Barriers of the Central Nervous System” will be held at Colby Sawyer College, New Hampshire, on June 20-25, 2010. Its overall goal is to increase the understanding of the basic mechanisms underlying the function of the blood brain barrier (BBB) / neurovascular unit (NVU) and the Choroid Plexus in health and disease. One major topic of this conference is to provide information how these barriers prevent therapeutics from entering the brain of patients suffering from diseases of the CNS. Therefore, alterations of the NUV and the Choroid Plexus under pathological conditions are central themes of this conference. The conference covers a specialized area of research, which brings together basic scientists as well as clinicians, who will both benefit from the collaborative effort to approach and solve the problems being related to the treatment of CNS diseases because of our very limited knowledge about the Blood/CNS barriers.

The program will include 2 keynote lectures and 8 sessions, that address tight junction molecules and signaling at the BBB, developmental biology of the cerebral vascular system and early and late stages of ageing of the BBB, Blood/CNS Barrier alterations in metabolic/genetic diseases, Blood/CNS Barriers in inflammatory disease states, BBB changes in stroke, trauma and epilepsy, molecular biology and regulation of the blood-CSF barrier / choroid plexus, transporter function and regulation at the blood / CNS barriers and BBB from an industrial perspective-Drug delivery to the CNS.

The Conference will be accompanied by a preceding Gordon Research Seminar from June 19-20, 2010, in Colby Sawyer College, New Hampshire. Graduate students, PostDocs and Junior faculty are particularly encouraged to participate in the Seminar, the focus of which is on methodological approaches towards BBB studies, and to present and discuss their data.


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTHE BLOOD / CNS BARRIERS AND BEYOND
Discussion Leader: Gert Fricker (University of Heidelberg, Germany)
7:40 pm - 8:20 pm David S. Miller (NIH/NIEHS, Research Triangle Park, NC)
"Signaling to ABC Transporters at the Blood-Brain Barrier: The Good News and the Bad"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm William Elmquist (University of Minnesota, Minneapolis, MN)
"Redundant Transport Systems in the BBB: Complex Impact on Drug Delivery"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDEVELOPMENTAL BIOLOGY AND AGEING AT THE CEREBRAL VASCULAR SYSTEM - EARLY AND LATE STAGES OF AGEING
Discussion Leader: Norman Saunders (University of Melbourne, AUS)
9:00 am - 9:20 am Norman Saunders (University of Melbourne, AUS)
"Barrier mechanisms and the control of the internal environment of the developing brain"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Daniel Anthony (University of Oxford, UK)
"Inflammation in the foetal brain"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Helen Stolp (University of Oxford, UK)
"Effect of environmental challenges on foetal cortical and vascular development"
10:20 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break / Group Photo
11:00 am - 11:20 am Daniela Virgintino (University of Bari, Italy)
"How does NG2 proteoglycan work during foetal brain development?"
10:20 am - 10:30 am Discussion
11:30 am - 11:50 am Whei Zeng (Purdue University, West Lafayette, IN)
"Age-Dependent Transport of Metals by the Blood-Cerebrospinal Fluid Barrier"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Zinaida Vexler (University California, San Francisco, CA)
"The blood-brain barrier after neonatal and adult stroke: impact of immaturity"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTIGHT JUNCTION MOLECULES AND SIGNALLING AT THE BBB
Discussion Leaders: Joerg Piontek (Leibnitz Institute of Mol. Phamacol., Berlin, Germany) and Tom Davis (University of Arizona, Tucson, AZ)
7:30 pm - 7:45 pm Monica Corada (University of Milan, Italy)
"Endothelial cell to cell junction organization and signaling at the BBB"
7:45 pm - 7:55 pm Discussion
7:55 pm - 8:10 pm David Antonetti (Penn State University, Hershey, PA)
"Phosphorylation of occludin contributes to cell cycle control"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:35 pm Anuska V. Andjelkovic (University of Michigan, Ann Arbor, MI)
"Crosstalk between tight junction proteins and RabGTPase"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:00 pm Carola Foerster (University of Würzburg, Würzburg, Germany)
"Glucocorticoid signalling and resistance at the BBB in central nervous system disorders"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Patrick Ronaldson (University of Arizona, Tuscon, AZ)
"Involvement of transforming growth factor-β (TGF-β) signaling on the regulation of ight junction proteins at the blood brain barrier during inflammatory pain"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBLOOD/CNS BARRIERS IN INFLAMMATORY AND INFECTIOUS DISEASE STATES
Discussion Leaders: Weihong Pan (Pennington Medical Res. Ctr., Baton Rouge, LA) and Pierre Olivier Couraud (Université Paris Descartes, Paris, France)
9:00 am - 9:20 am Yuri Persidsky (Temple University, USA)
"Blood brain abrrier dysfunction in HIV-1 CNS infection and alcohol abuse: Molecular mechanisms"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Elga deVries (VU Medical Center, Amsterdam, The Netherlands)
Altered function of the blood-brain barrier underlies multiple sclerosis"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Gary Rosenberg (University of New Mexico Health Sci. Center, Albuquerque, NM)
"Matrix Metalloproteinases in CSF Correlate with Opening of the Blood-Brain Barrier in Patients with Vascular Dementia"
10:20 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:20 am Monique Stins (Johns Hopkins University, Baltimore, ML)
"Plasmodium falciparum induced cerebral malaria: a highly proinflammatory environment at the blood brain barrier"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Stephen C. Jones (Allegheny-Singer Research Institute, Pittsburgh, PA)
"The Glia Limitans, the Other Barrier in Ischemic Stroke and Inflammation"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Pierre Olivier Couraud (Université Paris Descartes, Paris, France)
"Use of in vitro Cell Culture Model to Study Transporters at the human Blood-Brain Barrier"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBLOOD/CNS BARRIERS IN METABOLIC/GENETIC DISEASES
Discussion Leaders: Hans Joachim Galla (University of Münster, Münster, Germany)
7:30 pm - 7:45 pm David Begley (Kings College, London, UK)
"The blood-brain barrier and San Filippo Syndrome"
7:45 pm - 7:55 pm Discussion
7:55 pm - 8:10 pm Akihiko Urayama (Unversity of Texas, Galveston, TX)
"Pharmacological manipulation of lysosomal enzyme transport across the blood-brain barrier"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:35 pm Jason Huber (West Virginia University, Morgantown, WV)
"Role of BBB disruption in the development of cognitive disorders during diabetes"
8:35 pm - 8:45 pm Discussion
8.45 pm - 9:00 pm Sven Sauer (University of Heidelberg, Heidelberg,Germany)
"Cerebral import and export of neurotoxic dicarboxylic acids in glutaric aciduria type I and methylmalonic aciduria"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Volkmar Gieselmann (University of Bonn, Bonn, Germany)
"The BBB in lysosomal storage diseases"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBBB CHANGES IN STROKE, TRAUMA AND EPILESPY
Discussion Leader: Heidrun Potschka (Ludwigs-Maximilian-University, Munich, Germany)
9:00 am - 9:20 am Adam Chodobski (Brown University, Providence, RI, USA)
"Vasopressin and the function of the gliovascular unit in brain injury"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Damir Janigro (Cleveland Clinic Foundation, Cleveland, OH, USA)
"BBB repair by steroids prevents pediatric seizures"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Alon Friedman (Ben-Gurion University of the Negev, Beer-Sheva, Israel)
"Blood brain barrier breakdown in stroke and its role in epileptogenesis"
10:20 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:20 am Marilyn Cipolla (University of Vermont College of Medicine, Burlington, VT)
"Role of the BBB in the eclamptic seizure"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Felix Schlachetzki (University of Regensburg, Regensburg, Germany)
"Ischemic stroke and the blood brain barrier - a clinical perspective"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Tom Abbruscato (Texas Tech University HSC, Amarillo, TX)
"BBB Sodium Dependent Glucose Cotransport: A Role in Ischemic Brain Injury"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmMOLECULAR BIOLOGY AND REGULATION OF THE BLOOD-CSF BARRIER/CHOROID PLEXUS
Discussion Leader: Joanna Chodobska (Brown University, Providence, RI) and Jean-François Ghersi-Egea (INSERM U842, Université Lyon, Lyon, France)
7:30 pm - 7:45 pm Patrizia Ferretti (UCL Institute of Child Health, London, UK)
"Developmental regulators in the choroid plexus"
7:45 pm - 7:55 pm Discussion
7:55 pm - 8:10 pm Federica Sallusto (Institute for Research in Biomedicine, Bellinzona, Switzerland)
"The CCR6-CCL20 axis in regulation of T lymphocytes traffic in the CNS"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:35 pm Nathalie Strazielle (INSERM U433 Faculté de Médecine Laennec, Lyon, France)
"Involvement of the blood-CSF barrier in chemoattraction and infiltration of immune cells in the CNS"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:00 pm Patricia D'Amore (Harvard Medical School, Boston, MS)
"Role of VEGF in the maintenance of vascular and non-vascular components of the choroid plexus"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Sumio Ohtsuki (Tohoku University, Sendai, Japan)
"Elimination system of amyloid beta peptide in the choroid plexus"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTRANSPORTER FUNCTION AND REGULATION AT THE CNS BARRIERS
Discussion Leader: Reina Bendayan (University of Toronto, Toronto, Canada) and Jean-Michel Scherrmann (Université Paris Descartes, Paris, France)
9:00 am - 9:20 am David Smith (University of Michigan, Ann Arbor, MI)
"Impact of PEPT2 on Glycylsarcosine and Cefadroxil Disposition in Brain of Wild-Type and Pept2 Null Mice Following ICV Administration"
9:20 am - 9:35 am Discussion
9:35 am - 9:55 am Xavier Declèves (INSERM U705 UMR CNRS 7157, Faculty of Pharmacy, Paris, France)
"Drug-metabolizing enzymes and ABC transporters in the human BBB: interactions with drugs of abuse"
9:55 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:00 am Martha O'Donnell (University of California, Davis, CA)
"Neurovascular Unit Ion Transporters as Therapeutic Targets for Ischemic Stroke"
11:00 am - 11:15 am Discussion
11:15 am - 11:40 am Paul Lockman (Texas Tech University HSC, Amarillo, TX)
"Drug Delivery to Metastatic Brain Tumors"
11:40 am - 11:55 am Discussion
11:55 am - 12:10 pm Michal Toborek (University of Kentucky, Lexington, KY)
"Modulation of blood-brain transporters in HIV-1"
12:10 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBLOOD BRAIN BARRIER FROM AN INDUSTRIAL PERSPECTIVE: DRUG DELIVERY TO THE CNS
Discussion Leader: Andreas Reichel (Bayer-Schering AG, Berlin, Germany) and Joerg Kreuter (University of Frankfurt, Frankfurt, Germany)
7:30 pm - 7:50 pm Reinhard Gabathuler (Biomarin, Montreal, Canada)
"Development of a new platform technology invoprorating a peptide Angiopep in small and large therapeutics for the treatment of brain disorders"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Svetlana Gelperina (University of Moskau, Moskau, Russia)
"Nanoparticles: Efficient carriers for drug delivery across the blood-brain barrier"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Margaretha Hammarlund-Udenaes (Uppsala University, Sweden)
"Drug delivery to the CNS - principles, methods and drug properties"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Haojing Rong (Pfizer, Groton, CT, USA)
"Prediction of human CNS penetration from preclinical information"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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