| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:45 pm | Comments by GRC Staff / Shukti Chakravarti: Conference overview and welcome |
| 7:45 pm - 9:30 pm | Development, structure and function |
| 7:45 pm - 7:50 pm | Discussion Leader: John R. Hassell (University of South Florida)
"Introduction" |
| 7:50 pm - 8:20 pm | David Birk (University of South Florida)
"Developmental regulation of stromal structure and function" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Andrew Quantock (Cardiff University, Wales)
"Structural collagen alterations in human corneas with abnormal proteoglycan populations" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Peter Lwigale (Rice University)
"Building the cornea with Semaphorin3A/Neuropilin-1 signaling" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Genetics, Genomic & Proteomic Approaches |
| 9:00 am - 9:05 am | Discussion Leader: Alexander V. Ljubimov (Cedars-Sinai Medical Center)
"Introduction" |
| 9:05 am - 9:35 am | Sarah S. Murray (Scripps Genomic Medicine)
"Complex disease genetics: role of common variation in diseases of the eye" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Akhilesh Pandey (Johns Hopkins University)
"Mass Spectrometry: From Proteins to Pathways" |
| 10:15 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Albert Jun (Johns Hopkins University)
"In vivo and in vitro analysis of alpha 2 collagen VIII mutations causing Fuchs endothelial corneal dystrophy" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Elizabeth Fini (University of Southern California)
"Genetic/genomic approaches to identify corneal protective responses" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Yaron Rabinowitz (Cedars-Sinai Medical Center)
"Genetic studies of keratoconus" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Barrier Functions and Secretion |
| 7:30 pm - 7:35 pm | Discussion Leader: Ilene Gipson (Schepens Eye Institute Harvard University)
"Introduction" |
| 7:35 pm - 8:05 pm | Bogi Andersen (University of California, Irvine)
"Transcriptional control of barrier formation in cornea and epidermis" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Pablo Argueso (Schepens Eye Institute Harvard University)
"Galectin-3 is a component of the ocular surface epithelial barrier" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Arpitha Parthasarathy (George Washington University School of Medicine)
"Cdk5 Regulates Stability of E-cadherin in Corneal Epithelial Cell-Cell Junctions" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Ilene Gipson (Schepens Eye Institute Harvard University)
"Goblet Cell Differentiation in the Conjunctiva" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Wound healing response |
| 9:00 am - 9:05 am | Discussion Leader: James D. Zieske (Schepens Eye Institute, Harvard University)
"Introduction" |
| 9:05 am - 9:30 am | Robert M. Lavker (Northwestern University)
"The Role of microRNAs in Maintaining Corneal Epithelial Homeostasis" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Shizuya Saika
"Modulation of TGF beta/Smad signals by tenascin C and osteopontin in corneal wound healing and fibrosis" |
| 10:00 am - 10:05 am | Discussion |
| 10:05 am - 10:25 am | Coffee Break |
| 10:25 am - 10:50 am | Mary Ann Stepp (George Washington University)
"MMP expression and recurrent erosions in the mouse cornea" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:30 am | Dennis Roop (University of Colorado)
"Signaling pathways that regulate stem cell maintenance in the epidermis and their relevance to cornea" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Fu-Shin Yu (Wayne State University / Kresge Eye Institute)
"Epithelial wound healing response in normal and diabetic corneas" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Inna Maltseva (University of California, San Francisco)
"The role of the Sulfs, heparan sulfate glucosamine 6-O-endosulfatases, in wound repair of the cornea" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Microbial and Viral Infections |
| 7:30 pm - 7:35 pm | Discussion Leader: Sally Atherton (Medical College of Georgia)
"Introduction" |
| 7:35 pm - 8:00 pm | Linda Hazlett (Wayne State University)
"Pseudomonas Keratitis: Immune Regulation is Key" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Todd Margolis (UCSF)
"Establishment of Latent HSV Infection" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Alison M. McDermott (University of Houston)
"Antimicrobial Peptides: In Vivo Activity and Clinical Potential" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:25 pm | Danielle K. Augustin (University of California, Berkeley)
"Corneal Epithelial Barrier Function and Adaptation by P. aeruginosa" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Immune Response, Inflammation and Angiogenesis |
| 9:00 am - 9:05 am | Discussion Leader: Reza Dana (Schepens Eye Research Institute, Harvard University)
"Introduction" |
| 9:05 am - 9:35 am | Shigeru Kinoshita (Kyoto Prefectural University of Medicine, Japan)
"Ocular surface inflammation modulated by innate immunity" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Eric Pearlman (Case Western Reserve University)
"The role of Toll-Like Receptors in the Pathogenesis of Microbial Keratitis" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Coffee Break |
| 10:35 am - 11:05 am | Robert L. Hendricks (University of Pittsburgh)
"DCs, neurons, and HSV-1 induced corneal inflammation" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Daniel Saban (Schepens Eye Research Institute, Harvard University)
"Novel characterizations of dendritic cell subsets in the normal cornea" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:05 pm | Sunil Chauhan
"Th17 and Tregs are central to dry eye pathogenesis and ocular autoimmunity" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Nancy R. Reyes (UT Southwestern Medical Center)
"Innate T Cells are Necessary for Maximal Expression of Allergic Conjunctivitis" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Transplantation and immune modulation |
| 7:30 pm - 7:40 pm | Discussion Leader: Jerry Niederkorn (University of Texas Southwestern Medical Center)
"Introduction" |
| 7:40 pm - 8:05 pm | Junko Hori (Nippon Medical School, Japan)
"Molecular mechanisms of immune privilege in corneal transplantation" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Pedram Hamrah (MEEI Harvard Medical School)
"In vivo Imaging of Corneal Immune Responses" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Khrishen Cunnusamy
"IL-17 in promoting corneal allograft survival" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Johannes Schwartzkopff (University Eye Hospital, Frieiburg, Germany)
"Local Transfer of Naïve Regulatory T Cells Promotes Corneal Allograft Survival in Baby Rats" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Surgery Bioengineering and Biomimetics |
| 9:00 am - 9:10 am | Shigeto Shimmura (Keio University School of Medicine, Japan)
"Introduction" |
| 9:10 am - 9:35 am | Virendar Sangwan (LV Prasad Eye Institute, India)
"Cell based approach to ocular surface reconstruction" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Steven Wilson
"Corneal surgery and the myofibroblast in wound healing and complications" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:05 am | Noriko Koizumi (Doshisha University, Japan)
"Cultivated corneal endothelial transplantation in a primate for the future clinical application of corneal endothelial regenerative medicine" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Jennifer Elisseeff (Johns Hopkins University)
"Biomaterials in corneal repair" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Pallavi Deshpande (University of Sheffield, UK)
"Development of an alternative to the amniotic membrane for delivering cultured epithelial cells to the cornea using poly(lactide-co-glycolide) electrospun scaffolds" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Moritz Winkler (University of California, Irvine)
"Quantitative Analysis of Micro- and Macrostructural Organization of Collagen in Human Corneas using Non-linear Optical Imaging" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Stem Cell Biology and Applications |
| 7:30 pm - 7:35 pm | Graziella Pellegrini (University of Modena e Reggio Emilia, Italy)
"Introduction" |
| 7:35 pm - 8:00 pm | Utpal Banerjee (UCLA)
"Maintenance of stem cell fate: lessons from Drosophila blood development" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | James Funderburgh (University of Pittsburgh)
"Stem and Progenitor Cells of the stroma: Is the keratocyte an example of arrested development?" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Jesper Mikkel Lyngholm (Aarhus University Hospital)
"Proteomic analysis of limbal stem cell markers" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | Graziella Pellegrini (University of Modena e Reggio Emilia, Italy)
"Stem cell research in the cornea: where do we stand" |
| 9:30 pm | Discussion at Posters |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |