Conference Program
 
Craniofacial Morphogenesis & Tissue Regeneration
April 11-16, 2010
Il Ciocco Hotel and Resort
Lucca (Barga), Italy
Chair:
Paul Trainor

Vice Chair:
Robert Maxson

Application Deadline
Applications for this meeting must be submitted by March 21, 2010. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Applications will still be accepted for oversubscribed meetings. However, they will only be considered by the Conference Chair if more seats become available due to cancellations.
Related Meeting Information
The Craniofacial Morphogenesis & Tissue Regeneration Gordon Research Conference will be held in conjunction with the Craniofacial Morphogenesis & Tissue Regeneration Gordon-Kenan Research Seminar. Those interested in attending both meetings must submit an application for the GKRS in addition to an application for the GRC. Please refer to the Craniofacial Morphogenesis & Tissue Regeneration GKRS web page for more information.

Craniofacial development is an extremely complex morphogenetic process requiring the proper integration of many specialized organs and tissues. This includes eyes, ears and teeth, together with bone, cartilage, muscle, connective and nervous system tissues. The size, shape, number and structure of craniofacial elements vary dramatically as a consequence of evolutionary selection. Abnormalities in the development of craniofacial tissues and organs are associated with approximately one-third of all congenital birth defects. Rapid advances in our understanding of the molecular, cellular and genetic mechanisms underlying craniofacial development and evolution are now being translated into novel approaches for disease prevention and repair via tissue regeneration and bioengineering.

The 2010 Gordon Conference on Craniofacial Morphogenesis and Tissue Regeneration will bring together a collection of leading investigators to present cutting-edge research on the molecular, cellular and genetic aspects of craniofacial development, evolution, disease and regeneration. Session topics will include neural crest cells and placodes, development of interactions between skeletal and connective tissues, signaling pathways mediating cell communication, animal models and genome wide association studies of human disease, advances in regenerative stem cell biology and replacement of craniofacial tissues through tissue engineering.

The collegial atmosphere of this Conference together with scheduled opportunities for informal gatherings and poster presentations provides numerous opportunities for interactive discussions. Furthermore, the Conference will provide platform opportunities for junior scientists to present their work. A number of abstracts will be selected for oral presentation. In addition, a Gordon-Kenan Research Seminar is being held in conjunction with the Conference. This provides a special additional platform opportunity for post-doctoral scientists and students to present their work amongst their peers.

Applications for this meeting must be submitted by March 21, 2010. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Applications will still be accepted for oversubscribed meetings. However, they will only be considered by the Conference Chair if more seats become available due to cancellations. Abstracts to be considered for oral presentation selection must be received before December 10, 2009.


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNEURAL CREST CELLS
Discussion Leader: Paul Trainor (Stowers Institute, Kansas City, USA)
7:40 pm - 8:05 pmMarianne Bronner-Fraser (Caltech, Pasadena, USA)
"Formation of the cranial neural crest"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:30 pm Speaker TBA
8:30 pm - 8:35 pm Discussion
8:35 pm - 9:00 pmRoberto Mayor (University College, London, UK)
"Collective migration of neural crest cells"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Speaker TBA
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPLACODES
Discussion Leader: Marianne Bronner-Fraser (Caltech, Pasadena, USA)
9:00 am - 9:25 amAndrea Streit (King’s College London)
"Cell fate decisions in the cranial sensory nervous system"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Speaker TBA
9:55 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:55 am Speaker TBA
10:55 am - 11:05 am Discussion
11:05 am - 11:25 am Speaker TBA
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am Speaker TBA
11:50 am - 11:55 am Discussion
11:55 am - 12:20 pmIrma Thesleff (University of Helsinki, Finland)
"Placodes of teeth and other ectodemal appendages: regulation by signal pathways"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmDEVELOPMENTAL PATTERNING AND EVOLUTION
Discussion Leader: Chuck Kimmel (University of Oregon, Eugene, USA)
5:30 pm - 5:55 pmGerhard Schlosser (National University of Ireland, Galway, Ireland)
"Sense and sensibility - induction, specification and differentiation of cranial placodes"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:25 pm Speaker TBA
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Speaker TBA
6:50 pm - 6:55 pm Discussion
6:55 pm - 7:20 pmMichael Depew (King’s College London, UK)
"Cephalic ectodermal competence factors establish upper jaw pattern and morphology"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTISSUE INTERACTIONS AND MORPHOGENESIS
Discussion Leader: Andrea Streit (University College London, UK)
9:00 am - 9:25 amFred Relaix (UPMC-Paris VI, Paris, France)
"Analysis of Pax3 and Pax7 functions and downstream genetic networks in craniofacial development"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Speaker TBA
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 amEldad Tzahor (Weizmann Institute, Israel)
"Neural crest - mesoderm interactions and the role of p53"
10:55 am - 11:05 am Discussion
11:05 am - 11:25 am Speaker TBA
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am Speaker TBA
11:50 am - 11:55 am Discussion
11:55 am - 12:20 pmYang Chai (USC School of Dentistry, Los Angeles, USA)
"Cranial neural crest and myogenic progenitor interactions in tongue development"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmSIGNALING AND CELL COMMUNICATION
Discussion Leader: Michael Depew (King’s College, London, UK)
5:30 pm - 5:55 pmGary Landreth (Case Western, USA)
"Perturbation of the ERK-MAP Kinase pathway in Neuro-cardio-facial cutaneous syndromes"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:25 pm Speaker TBA
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Speaker TBA
6:50 pm - 6:55 pm Discussion
6:55 pm - 7:20 pmFilippo Rijli (Switzerland)
"Mapping the face in the somatosensory brain stem"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCRANIOFACIAL SYNDROMES AND DISORDERS: MODELS AND GENETICS I
Discussion Leader: Andrew Wilkie (Weatherall Institute, Oxford, UK)
9:00 am - 9:25 amDanny Huylebroeck (University of Leuven, Lueven, Belgium)
"Conditional Zfhx1b mutant mice for studying Mowat-Wilson syndrome"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Speaker TBA
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 amStan Lyonnet (Université Paris Descartes, Paris, France)
"Disruption of long-distance highly conserved non coding sequences at the SOX9 locus, in craniofacial neurocristopathies"
10:55 am - 11:05 am Discussion
11:05 am - 11:25 am Speaker TBA
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am Speaker TBA
11:50 am - 11:55 am Discussion
11:55 am - 12:20 pm Speaker TBA
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCRANIOFACIAL SYNDROMES AND DISORDERS: MODELS AND GENETICS II
Discussion Leader: Rob Maxson (USC, LA, USA)
5:30 pm - 5:55 pmMax Muenke (NIH Bethesda, USA)
"Holoprosencephaly: the genotype predicts the phenotype"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:25 pm Speaker TBA
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Speaker TBA
6:50 pm - 6:55 pm Discussion
6:55 pm - 7:20 pmAndy Copp (Institute Child Health, London, UK)
"Mechanisms of cranial neural tube closure - normal and abnormal"
7:20 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSTEMS CELLS, TISSUE ENGINEERING AND REGENERATION
Discussion Leader: Irma Thesleff (University of Helsinki, Finland)
9:00 am - 9:25 amPaul Sharp (King’s College, London, UK)
"Polycomb complex proteins regulate rodent incisor mesenchymal stem cells"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Speaker TBA
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 amPam Yelick (Tufts Univeristy, USA)
"Tooth and Dare"
10:55 am - 11:05 am Discussion
11:05 am - 11:25 am Speaker TBA
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am Speaker TBA
11:50 am - 11:55 am Discussion
11:55 am - 12:20 pm Speaker TBA
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKEYNOTES: EVOLUTION, DEVELOPMENT AND DISEASE
Discussion Leader: Paul Trainor (Stowers Institute, Kansas City, USA)
5:30 pm - 6:15 pmChuck Kimmel (University of Oregon, USA)
"Mechanisms of Craniofacial Variation and Evolution"
6:15 pm - 6:30 pm Discussion
6:30 pm - 7:15 pmAndrew Wilkie (Weatherall Institute, Oxford, UK)
"Future directions for research into the craniosynostoses"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Last Updated: December 18, 2009