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Diffraction Methods in Structural Biology
July 18-23, 2010
Bates College
Lewiston, ME
Chair:
Andrew G.W. Leslie

Vice Chair:
Ana Gonzales

Advances in basic methodologies have played a major role in the dramatic progress in macromolecular crystallography over the past decade, both in terms of overall productivity and in the increasing complexity of the systems being successfully tackled.

The 2010 Gordon Research Conference on Diffraction Methods in Structural Biology will, as in the past, focus on the most recent developments in methodology, covering all aspects of the process from crystallization to model building and refinement, complemented by examples of structural highlights and complementary methods. Extensive discussion will be encouraged and it is hoped that all attendees will participate by giving oral or poster presentations, the latter using the excellent poster display area available at Bates College.

The relatively small size and informal atmosphere of the meeting provides an excellent opportunity for all participants, especially younger scientists, to meet and exchange ideas with leading methods developers.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmMACROMOLECULAR STRUCTURES: PUSHING THE BOUNDARIES
7:35 pm - 7:40 pm Discussion Leader: Michael Rossmann (Purdue University, USA)
7:40 pm - 8:25 pm Doug Rees (Caltech/HHMI, USA)
"Adventures in membrane protein crystallography"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:20 pm Kiyoshi Nagai (MRC -LMB, Cambridge, England)
"Architecture of the spliceosomal snRNPs: Interpreting a low resolution map using heavy atom markers"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCRYSTALLISATION AND THE DIFFRACTION EXPERIMENT
9:00 am - 9:05 am Discussion Leader: Bob Sweet (Brookhaven National Laboratory, USA)
9:05 am - 9:40 am Seth Harris (Genentech, San Francisco, USA)
"Acoustic Liquid Transfer: Applications in small volume crystallization"
9:40 am - 9:50 am Discussion
9:50 am - 10:15am Coffee Break / Group Photo
10:15 am - 10:50 am Todd Yeates (University of California at Los Angeles, USA)
"Identifying and overcoming lattice translocation disorders"
10:50 am - 11:00 am Discussion
11:00 am - 11:35 am James Holton (University of California at San Francisco / Lawrence Berkeley National Laboratory, USA)
"MLFSOM: simulating the diffraction experiment from first principles"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Gwyndaf Evans (Diamond Light Source, UK)
"Microcrystallography: Choosing your weapon"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRADIATION DAMAGE AND DATA COLLECTION STRATEGIES
7:30 pm - 7:35 pm Discussion Leader: Vivian Stojanoff (Brookhaven National Laboratory, USA)
7:35 pm - 8:05 pm Martin Weik (Institut de Biologie Structurale, Grenoble, France)
"Radiation damage in MX: what's new?"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Y. Zou Finfrock (Physics department, University of Washington, USA)
"Spatial dependence and mitigation of MX radiation damage by focusing"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9.25 pm Marcus Mueller (Swiss Light Source, Paul Scherer Institut, Switzerland)
"Data collection strategies for single photon counting pixel detectors"
9:25 pm - 9.30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSYNCHROTRON DEVELOPMENTS AND AUTOMATED DATA PROCESSING
9:00 am - 9:05 am Discussion Leader: Thomas Schneider (EMBL Hamburg, Germany)
9:05 am - 9:40 am Sean McSweeney (ESRF, Grenoble, France)
"Advanced sample evaluation and experiment planning"
9:40 am - 9:50 am Discussion
9:50 am - 10:25 am Janet Smith (University of Michigan / GM/CA CAT, USA)
"Small and smaller beams for ordinary and extraordinary experiments at GM/CA CAT"
10:25 am - 10:35 am Discussion
10:35 am - 11:00 am Coffee Break
11:00 am - 11:35 am Graeme Winter (Diamond Light Source, UK)
"Automated data reduction: Xia2 and Chef"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Clemens Vonrhein (Global Phasing Ltd, UK)
"Automated (and non-automated) data processing with autoPROC"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCOMPLEMENTARY TECHNIQUES
7:30 pm - 7:35 pm Discussion Leader: Ana Gonzalez (Stanford Synchrotron Radiation Lightsource, USA)
7:35 pm - 8:05 pm Sriram Subramaniam (National Cancer Institute, USA)
"Visualizing cells and viruses at molecular resolution with 3D electron microscopy: Progress and challenges"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Tsutomu Matsui (Stanford Synchrotron Radiation Lightsource, USA)
"Recent advances in bio-SAXS: bringing back atomic-resolution structures into life"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Carrie Wilmot (University of Minnesota, USA)
"Linking single crystal spectroscopy to structure"
9.25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSTRUCTURE SOLUTION AND REFINEMENT
9:00 am - 9:05 am Discussion Leader: Paul Adams (Lawrence Berkeley Laboratory, USA)
9:05 am - 9:40 am Randy Read (Cambridge Institute for Medical Research, University of Cambridge, UK)
"Using SAD data in Phaser"
9:40 am - 9:50 am Discussion
9:50 am - 10:25 am Garib Murshudov (University of York, UK)
10:25 am - 10:35 am Discussion
10:35 am - 11:00 am Coffee Break
11:00 am - 11:35 am Tom Terwilliger (Los Alamos National Laboratory, USA)
"Automated structure determination with PHENIX"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Ethan Merritt (University of Washington School of Medicine, USA)
"TLS models: There's more to this than just a nice R-factor"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmCHALLENGING PROBLEMS/MEMBRANE PROTEINS
7:30 pm - 7:35 pm Discussion Leader: Michael C. Wiener (Department of Molecular Physiology and Biological Physics, University of Virginia, USA)
7:35 pm - 8:05 pm Martin Caffrey (Membrane Structural and Functional Biology Groups, Trinity College, Dublin, Ireland)
"Membrane protein structure determination using crystallography and lipidic mesophases - Recent advances and successes"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Stephen White (University of California at Irvine, USA)
"Exploring membranes by neutron diffraction"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Hao Wu (Weill Cornell Medical College, USA)
"Heterogeneity, low solubility and low resolution: structural pursuit on the ternary Myddosome complex in Toll-like receptor signaling"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:25 amTALKS SELECTED FROM POSTERS
9:00 am - 9:05 am Discussion Leader: Anastassis Perrakis (Netherlands Cancer Institute, The Netherlands)
9:05 am - 9:20 am TBA (to be selected from posters)
9:20 am - 9:25 am Discussion
9:25 am - 9:40 am TBA (to be selected from posters)
9:40 am - 9:45 am Discussion
9:45 am - 10:00 am TBA (to be selected from posters)
10:00 am - 10:05 am Discussion
10:05 am - 10:20 am TBA (to be selected from posters)
10:20 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 12:30 pmMAP IMPROVEMENT AND MODEL BUILDING
10:55 am - 11:00 am Discussion Leader: Anastassis Perrakis (Netherlands Cancer Institute, The Netherlands)
11:00 am - 11:35 am Paul Emsley (University of Oxford, UK)
"Low resolution model building using COOT"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Johan Hattne (EMBL Outstation Hamburg, Germany / UT Southwestern Medical Centre, USA)
"Modelling nucleic acids with ARP/wARP"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFUTURE METHODS: FELs AND DIFFRACTION IMAGING
7:30 pm - 7:35 pmDiscussion Leader: Ed Lattman (Hauptman-Woodward Medical Research Institute, Buffalo, USA)
7:35 pm - 7:55 pm Petra Fromme (Department of Chemistry and Biochemistry, Arizona State University, USA)
"Opportunities for membrane protein analysis with FELs - recent results from LCLS"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:35 pm Anton Barty (Center for Free-Electron Laser Science, Germany)
"Single-particle imaging with pulsed hard-Xray lasers"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:20 pm John C.H. Spence (Arizona State University and Lawrence Berkeley Laboratory, USA)
"Femtosecond nanocrystallography of membrane proteins using LCLS"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by 1 R13 GM 093355 - 01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Last Updated: July 22, 2010
 
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