| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Properties of DNA and Mutagenesis |
| Chair of Session: Jacqueline Barton (California Institute of Technology) |
| Discussion Leader: Kristin Eckert (Penn State Milton S. Hershey Medical Center) |
| 7:40 pm - 8:05 pm | Jacqueline Barton (California Institute of Technology)
"DNA-mediated Signaling of Damage and Repair" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Jean-Sebastien Hoffman (Groupe Instabilité Génétique et Cancer)
"New functional roles of Human TLS DNA polymerases during genomic DNA replication" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Kristin Eckert (Penn State Milton S. Hershey Medical Center)
"Replicative versus specialized DNA polymerases in replication: Lessons from studies of microsatellite DNA and common fragile sites" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Endogenous DNA Damage |
| Chair of Session: Sheila David (US Davis University of California) |
| Discussion Leader: Susan Wallace (University of Vermont) |
| 9:00 am - 9:25 am | Sheila David (UC Davis University of California)
"OG and Beyond: Recognition, Repair and Mutations" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Paul Doetsch (Emory University)
"Transcriptional mutagenesis and DNA repair systems" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break / Group Photo |
| 10:30 am - 10:55 am | Takehiko Nohmi (National Institute of Health Sciences)
"Nucleotide pool damage and Y-family DNA polymerases" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | John Tainer (The Scripps Research Institute)
"DNA repair machines, predictive biology, and insights for cancer interventions" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Susan Wallace (University of Vermont)
"Processing of Oxidative DNA Damage" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Eric Brown (University of Pennsylvania School of Medicine)
"Critical Functions of the ATR Checkpoint Pathway in the Suppression of Genomic Instability, Cancer and Aging" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DNA Repair and Cancer Therapy |
| Chair of Session: Peter Glazer (Yale University) |
| Discussion Leader: Helen Piwnica-Worms (Washington University) |
| 7:30 pm - 7:55 pm | Peter Glazer (Yale University)
"Manipulating DNA repair for cancer therapy" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Shindeng Bao (Cleveland Clinic)
"Targeting Cancer Stem Cells" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Helen Piwnica-Worms (Washington University)
"Checkpoint control in normal and caner cell cycles" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Joanne Weidhaas (Yale University)
"MicroRNAs and Cancer" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Conformational Dynamics and Polymerase Fidelity |
| Chair of Session: Catherine Joyce (Yale University) |
| Discussion Leader: Samuel Wilson (NIEHS) |
| 9:00 am - 9:25 am | Catherine Joyce (Yale University)
"Conformational transitions in the DNA polymerase reaction pathway" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Suse Broyde (New York University)
"Modeling of Y Family Polymerases" |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | F. Peter Guengerich (Vanderbilt University Medical Center)
"Interactions of Translesion DNA Polymerases with Carcinogen-modified DNA: Structures and Functions" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Samuel Wilson (NIEHS)
"Structural basis for nucleotide discrimination by DNA polymerase β" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | William G. Thilly (MIT)
"Metakaryotic mutator stem cells and cancer initiation in humans" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Ashok Bhagwat (Wayne State University)
"Interaction between Inhibitors of DNA-cytosine Methylation and DNA Repair" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Presentations: Genomic Predictors of Responses to Chemotherapy/MicroRNAs and Cancer |
| Session Chair: Joann Sweasy (Yale University) |
| 7:30 pm - 8:20 pm | Leona Samson (Massachusetts Institute of Technology)
"Complex Responses to DNA damaging agents" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Frank Slack (Yale University)
"MicroRNAs as novel cancer therapeutic targets" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Translesion Synthesis: Is It Ordered or Stochastic? |
| Chair of Session: Wei Yang (NIDDK, National Institutes of Health) |
| Discussion Leader: Myron Goodman (University of Southern California) |
| 9:00 am - 9:25 am | Wei Yang (NIDDK, National Institutes of Health)
"Human Translesion Polymerase XPV" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Graham Walker (Massachusetts Institute of Technology)
"Function and Control of Translesion DNA Polymerases" |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Alan Lehman (University of Sussex)
"Post-translational modifications of DNA polymerase eta" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Myron Goodman (University of Southern California)
"Captured Alive: the Active Form of Pol V Reveals the Mutagenic Mechanism of the RecA Nucleoprotein Filament" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Patricia Opresko (University of Pittsburgh)
"The environmental carcinogen Cr(VI) induces telomeric instability associated with defective DNA replication" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Sharon Cantor (University of Massachusetts School of Medicine)
"Evidence that the BRCA1-associated FANCJ functions in post-replication repair" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Chromatin Structure and DNA Repair |
| Chair of Session: Jac Nickoloff (Colorado State University) |
| Discussion Leader: Jessica Downs (University of Sussex) |
| 7:30 pm - 7:55 pm | Jac Nickoloff (Colorado State University)
"The Metnase Histone Methylase Regulates Non-homologous End-Joining and Replication Fork Restart" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Andrew Xiao (Yale University)
"Investigating new links between chromatin, genome integrity and transcription" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Jessica Downs (University of Sussex)
"Involvement of RSC and INO80 chromatin remodeling complexes in the DNA damage response" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Robert Hromas (University of New Mexico)
"Chk1 Regulation of the Histone Code for DNA repair" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Ranjit Bindra (Memorial Sloan Kettering Cancer Center)
"Development and characterization of a novel NHEJ assay for high-throughput screening in cancer cell lines" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mutagenesis and Cancer |
| Chair of Session: Bradley Preston (University of Washington) |
| Discussion Leader: Lawrence Loeb (University of Washington) |
| 9:00 am - 9:25 am | Bradley Preston (University of Washington)
"DNA Replication Fidelity and Cancer in Mice" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Polina Schberkova (University of Nebraska Medical Center)
"Mutator variants of replicative DNA polymerases and cancer" |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Carlo Maley (The Wistar Institute)
"Somatic evolution in cancer" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Lawrence Loeb (University of Washington)
"Mutator Phenotype in Cancer: Implications and Future Directions" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Jennifer Rahn (UTMDACC, Science Park Research Division)
"Molecular analysis of hyperrecombination in WRN-deficient CHO cells" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Nayun Kim (Duke University)
"Abasic lesion repair by Transcription Coupled Nucleotide Excision Repair" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Transcriptional and Translational Mutagenesis |
| Chair of Session / Discussion Leader: Andres Aguilera (Universidad de Sevilla-CSIC) |
| 7:30 pm - 7:55 pm | Andres Aguilera (Universidad de Sevilla-CSIC)
"Specific TFIIH mutations that lead to replication fork breakage and channeling of UV damage into DSB repair" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Mitsuko Masutani (National Cancer Institute, Japan)
"Role of PARP-1 in DNA Repair and Carcinogenesis" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | David Jones (University of Utah)
"Control of a DNA Demethylase System by the Adenomatous Polyposis Coli Tumor Suppressor" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Hani Zaher (John Hopkins)
"Dealing with Mistakes: The Ribosome's Response to Misincorporations" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |