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Endothelial Cell Phenotypes in Health & Disease
August 8-13, 2010
University of New England
Biddeford, ME
Chair:
Edward M. Conway

Vice Chair:
Susan Quaggin
Application Deadline
Applications are no longer being accepted for this meeting. If you have been instructed to apply by the Conference Chair, please contact your Conference Coordinator for further instructions.

Since its inception in 2004, this Gordon Research Conference has become recognized as the foremost venue for creating valuable interactions among scientists from many biological and medical fields, with a common interest in understanding the role of the vascular endothelium in health and disease. The aims of this conference are to i. provide a forum for direct and intense discussion in vital and emerging areas, ii. discuss the mechanisms that mediate phenotypic heterogeneity of the endothelium, iii. apply these considerations to an understanding of vascular disease states, and iv. encourage new avenues of research and development. The novel focus and cross-disciplinary nature of this meeting provides the much-needed opportunity to explore the distinct functions of endothelial cells at different developmental time points, in different organs and vascular beds, and as a crucial player in a range of pathologies and disease processes. This meeting is guaranteed to be stimulating, informative, thought-provoking and controversial!

Contributors
Amgen, Inc.
Carl Strom Underrepresented Minority Fellowships
Eli Lilly USA, LLC
Gordon Research Conferences
Imclone Systems, Inc.
Life Sciences Research Partners, VZW
National Institutes of Health (NHLBI)
Pfizer, Inc.
Signal Pharmaceutical, LLC
StemCell Technologies, Inc.
University of Leuven, VRC
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:50 pmIntroductory Comments by GRC Site Staff / Welcome by Conference Chair, Ed Conway
7:50 pm - 9:30 pmENDOTHELIUM - PAST AND FUTURE
Discussion Leader: William Aird (Harvard University)
7:50 pm - 8:25 pm Special Lecture: Jane Maienschein (Arizona State University, Tempe, Arizona)
"History of the Endothelium"
8:25 pm - 8:40 pm Discussion
8:40 pm - 9:15 pm Keynote Address: Stefanie Dimmeler (Goethe University, Frankfurt)
"MicroRNAs in the Endothelium - What are they doing?"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTHE EC IN THE PLACENTA, PREGNANCY AND ECLAMPSIA
Discussion Leader: S. Ananth Karumanchi (Harvard University)
9:00 am - 9:20 am S. Ananth Karumanchi (Harvard University)
"Angiogenic factors and preeclampsia"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Asif Ahmed (University of Edinburgh, UK)
"Role of hemoxygenases In placental vascular homeostasis"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Ralf Dechend (Charite Hospital, Berlin)
"Angiotensin II signaling in placental disorders"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Eli Keshet (Hadassah Hebrew University, Jerusalem)
"A novel primate specific VEGF inhibitor in pre-eclampsia"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Kirk Conrad (University of Florida)
"Relaxin in vascular health and in preeclampsia"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Hot Topic: Tina Shahani (University of Leuven)
"Activation of ECs from specific vascular beds induces release of a FVIII storage pool"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmINDUCIBLE PLURIPOTENT STEM CELLS AND EC PROGENITOR CELLS
Discussion Leader: Andras Nagy (Lunenfeld Institute, Toronto)
7:30 pm - 7:50 pm Andras Nagy (Lunenfeld Institute)
"piggyBac transposition for inducible pluripotent stem cells"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Yoshiaki Kubota (Keio University, Tokyo)
"M-CSF as a therapeutic target for tumor lymph/angiogenesis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Hiroshi Kataoka (RIKEN, Kobe, Japan)
"Development of hematopoietic stem cells and endothelial cells explained"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Mervin Yoder (Indiana University School of Medicine)
"Ontogeny of the endothelial progenitor cell"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmINFECTIOUS DISEASES AND THE ENDOTHELIUM
Discussion Leader: Kevin Kain (University of Toronto)
9:00 am - 9:20 am Gustavo Valbuena (University of Texas Medical Branch)
"Rickettsial infections and endothelial pathobiology"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Paul Kubes (University of Calgary)
"Intravascular immunity and bacterial infections"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am David Walker (University of Texas Medical Branch)
"Viral hemorrhagic fevers and endothelial pathobiology"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am W. Conrad Liles (University of Toronto)
"Endothelial activation in severe infections"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Kevin Kain (University of Toronto)
"Malaria and endothelial based therapies"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Hot Topic: Nyall London (University of Utah)
"Targeting Robo4-dependent Slit signaling to survive the cytokine storm"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTISSUE ENGINEERING
Discussion Leader: Michael Sefton (University of Toronto)
7:30 pm - 7:50 pm Michael Sefton (University of Toronto)
"Modular tissue engineering"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Jordan Pober (Yale University)
"Vascular cell transplantation"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Shuichi Takayama (University of Michigan)
"Microfluidics"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm David Cheresh (University of California San Diego)
"MicroRNA-132 mediated loss of p120RasGAP activates quiescent endothelium to facilitate pathological angiogenesis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDIABETES AND THE METABOLIC SYNDROME CENTERED AROUND THE ENDOTHELIAL CELL
Discussion Leader: Peter Nawroth (University of Heidelberg)
9:00 am - 9:20 am Jon Graff (University of Texas)
"Vessels as a niche for adipose stem cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Michael Brownlee (Albert Einstein College of Medicine, New York)
"Hyperglycemic memory in endothelial cell"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Ulf J. Eriksson (Uppsala University)
"Redox regulation in endothelial cells"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Peter Nawroth (University of Heidelberg)
"Reactive metabolites and microvascular diabetic complications"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Triantfyllos Chavakis (Dresden University of Technology)
"Regulation of vasoproliferative retinopathy by inflammation"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Hot Topic: Nicholas Mordwinkin (University of Southern California)
"NO, the Mas receptor, angiotensin-(1-7) and bone marrow EPCs in diabetes"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 8:10 pmKEYNOTE ADDRESS
7:30 pm - 8:00 pm Mark Ginsberg (University of California San Diego)
"Dynamic regulation of adhesive signaling in the vasculature"
8:00 pm - 8:10 pm Discussion
8:10 pm - 9:30 pmTHE EYE AND THE VASCULAR ENDOTHELIUM
Discussion Leader: Martin Friedlander (Scripps Research Institute)
8:10 pm - 8:25 pm Lois Smith (Children's Hospital and Harvard Medical School)
"Hormone signaling and immune pathways in retinal EC function"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:50 pm Michael Dorrell (Point Loma Nazarene University)
"Effects of non-vascular cells on ECs during retinal angiogenesis"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Martin Friedlander (Scripps Research Institute)
"Cell based approaches to treating retinal vascular disease"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmENDOTHELIAL CELL-SPECIFIC SIGNALING PATHWAYS
Discussion Leader: William Aird (Harvard University)
9:00 am - 9:20 am Grietje Molema (University Medical Center Groningen)
"Inflammatory signaling in different microvascular segments"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Michael Simons (Yale University)
"FGF signaling"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Mark Kahn (University of Pennsylvania)
"Mechanisms underlying cerebral cavernous malformations"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Holger Gerhardt (University of London)
"Notch/Wnt signaling regulates endothelial cell sprouts"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Laura Benjamin (ImClone and Harvard Medical School)
"Akt signaling in vascular tumors and implications for tailoring pathway inhibitors"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Hot Topic: Natalie Kofler (Columbia University)
"The interaction of Notch1 and Foxo1 in regulating angiogenesis"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCROSS-TALK PATHWAYS
Discussion Leader: Susan Quaggin (University of Toronto)
7:30 pm - 7:50 pm Luisa Iruela-Arispe (University of California, Los Angeles)
"Instructive signaling from the vasculature to the liver parenchyma"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Angela Orecchia (Rome, Italy)
"Matrix, sFlt and and the endothelial cell"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Christiana Ruhrberg (University College London)
"Macrophages as bridge cells in angiogenesis"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Susan Quaggin (University of Toronto)
"New paradigms in pericyte-endothelial crosstalk"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this conference was made possible, in part by 1 R13 HL 102800-01 from the National Institutes of Health, National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers or moderators do not necessarily reflect the official policies of the Department of Health; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Last Updated: July 23, 2010
 
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