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Conference Program
 
Mechanisms of Epilepsy & Neuronal Synchronization
Dynamics, Development and Dysregulation
August 8-13, 2010
Colby College
Waterville, ME
Chair:
John Huguenard

Vice Chair:
Carolyn R. Houser

The study of epilepsy entails two major questions. What are the mechanisms underlying seizures, i.e. the pathological synchronous electrical discharges in neuronal networks? How does epileptogenesis occur, i.e. what are the mechanisms through which changes in neural function transform normally functioning circuits into pathological ones? Both questions focus on dynamic properties of neural circuits. The first focuses on short term network dynamics and how seizures arise suddenly (in seconds) from a normal electrical background. The second focuses on maladaptive changes in circuits that occur over a longer period of time (days to years) in response to, for example, genetic defects or injury. Improved understanding of these two issues will lead to enhanced treatment of patients with epilepsy and in new therapies that may ultimately prevent the development of epilepsy following brain injury.

The 2010 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization will present cutting edge research on the theme of dynamics of circuit function. The issue will be addressed at multiple levels of analysis, from function of single molecules, neurons, microcircuits, brain region and the entire brain. Studies utilizing a variety of modern approaches including neurophysiology, imaging, molecular biology, genetics, developmental neurosciences, and neuroanatomy will be presented. The purpose of this conference is to bring together specialists in these fields to discuss the complex issues that arise in the processes of seizure generation and progression. It is expected that a synthesis of current ideas will result and inform the critical next stage of experimental epilepsy research. Topics to be covered include microcircuit dynamics & emergence of synchrony, inhibitory neuron function and dysfunction, neuroinflammation, circuit homeostasis and short term dynamics, epigenetics & gene regulation, circuit development, neural progenitor cells, occult epileptogenic mechanisms, and epileptic ion channels and synaptic proteins.

In addition to our invited speakers at the main meeting, 8 short talks will be selected from submitted abstracts one to two weeks prior to the start of the meeting.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmIntroductory Comments by GRC Site Staff
7:35 pm - 7:45 pmWelcome by John Huguenard and Carolyn Houser, Chair and Vice-Chair
7:45 pm - 9:30 pmEpileptic ion channels and synaptic proteins
7:45 pm - 7:50 pm Discussion Leader: Istvan Mody (UCLA)
"Introduction"
7:50 pm - 8:15 pm Heinz Beck (University of Bonn)
"Excitable properties of small caliber hippocampal dendrites"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:50 pm David Bredt (Eli Lily)
"Regulation of neuronal excitability by AMPA auxiliary subunits"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Hee-Sup Shin (Korea Inst. of Science and Tech.)
"R-type calcium channels in oscillatory burst discharges of nRT neurons and absence seizures"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cells and Epilepsy
9:00 am - 9:05 am Discussion Leader: Helen Scharfman (NYU)
"Introduction"
9:05 am - 9:30 am Jack Parent (Univ. Michigan)
"Reelin and seizure-induced neurogenesis and neuroblast migration"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Linda Overstreet-Wadiche (Universty of Alabama, Birmingham)
"Seizures and integration of adult-born neurons"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Lori Isom (University of Michigan)
"Na+ channel Beta 1B: a secreted cell adhesion molecule involved in human epilepsy"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Jenny Hsieh (UTSW)
"Seizure-induced epigenetic modifications alter adult neurogenesis"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Steve Danzer (Cincinnati Children's Hospital Med Ctr)
"Contributions of adult-generated granule cells to aberrant hippocampal circuitry and epileptogenesis"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm Elsa Rossignol (NYU)
"Defective cortical interneuronal signaling results in generalized seizures"
12:15 pm - 12:30 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInhibitory neurons: failure to deliver
7:30 pm - 7:35 pm Discussion Leader: Joseph LoTurco (University of Connecticut)
"Introduction"
7:35 pm - 7:55 pm Elizabeth Powell (University of Maryland)
"Functional consequences of altered forebrain interneuron ontogeny"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm John Rubenstein (UCSF)
"Molecular mechanisms regulating interneuron specification and migration"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Antoine Triller (INSERM, Paris)
"Activity-dependent GABA receptor trafficking"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Scott Baraban (UCSF)
"Seizures and altered inhibition in Dlx mutant mice"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCircuit Homeostasis, Analytical and Experimental approaches in Epilepsy
9:00 am - 9:05 am Discussion Leader: Ivan Soltesz (UC Irvine)
"Introduction"
9:05 am - 9:30 am Liset Menendez de la Prida (Instituto Cajal, Madrid)
"Hippocampal rhythms and epilepsy"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Carlos Aizenman (Brown University)
"Polyamine-mediated regulation of seizure threshold in a developmental model of epilepsy"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Helen Sabolek (Massachusetts General Hospital)
"GABAergic inhibition sculpts the spread of interictal activity"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Michael Sutton (University of Michigan)
"Local homeostatic control of synapse function"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Gina Turrigiano (Brandeis University)
"Network synaptic scaling in neocortex"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm Catherine Christian (Stanford University)
"Disruption of the GABAAR alpha3 subunit benzodiazepine binding site alters intra-thalamic inhibition and absence seizures"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetics, gene regulation and microRNAs in Epilepsy
7:30 pm - 7:35 pm Discussion Leader: Amy Brooks-Kayal (University of Colorado)
"Multiple levels and mechanisms of gene regulation in epilepsy: how do we sort it all out?"
7:35 pm - 7:55 pm Douglas Coulter (Children's Hospital of Pennsylvania)
"REST-regulation and epileptogenesis"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Eleanora Aronica (University of Amsterdam)
"Transcriptional and post-transcriptional regulation of gene expression during epileptogenesis"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Hongjun Song (Johns Hopkins University)
"Neuronal activity modifies the epigenetic DNA methylation landscape in the adult brain"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Raymond Dingledine (Emory University)
"Patterns of altered gene expression in experimental epilepsies"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCircuit development and function: basis for epileptic networks
9:00 am - 9:05 am Discussion Leader: Uwe Heineman (University of Berlin)
"Introduction"
9:05 am - 9:30 am Cagla Eroglu (Duke University)
"Astrocytic thrombospondin and synaptogenesis"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Hisashi Umemori (University of Michigan)
"Wiring the functional brain"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Rebecca Boumil (The Jackson Laboratory)
"A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Robert Wong (SUNY Downstate Medical Center)
"mGluR network plasticity and epilepsy"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am John Jefferys (University of Birmingham)
"High frequency activity in temporal lobe epilepsy"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm William Stacey (University of Michigan)
"Modulation of epileptiform activity with coupling and synaptic noise"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmMicrocircuit Dynamics: Emergence of synchrony
7:30 pm - 7:35 pm Discussion Leader: Kevin Staley (Mass. General Hospital)
"Introduction"
7:35 pm - 7:55 pm Michael Hausser (University College, London)
"Microcircuits and synchronization of cerebellar activity"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Rafa Yuste (Columbia University)
"Imaging and optically controlling epileptiform events"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Marlene Bartos (University of Aberdeen)
"Distance dependent inhibitory signalling - a new mechansims of cortical network synchronization"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Edward Boyden (MIT)
"New Optical Reagents and Strategies for Controlling Neural Circuit Dynamics"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeuroinflammation and Epilepsy
9:00 am - 9:05 am Discussion Leader: Karen Wilcox (University of Utah)
"Inflammatory remarks"
9:05 am - 9:30 am Annamaria Vezzani (Mario Negri Institute for Pharmacological Research)
"Brain inflammation, seizures and epileptogenesi"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Daniela Kaufer (UC Berkeley)
"TGF-beta signaling in epileptogenesis following BBB compromise"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Jerome Clasadonte (Tufts University)
"Astrocyte-dependent regulation of synaptic NMDA receptors modulates seizure activity"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Jean-Marc Fritschy (University of Zurich)
"Regulation of epileptogenesis and seizures by innate and adaptive immunity"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Rita Balice Gordon (University of Pennsylvania)
"Astrocytes secrete proteins that selectively modulate inhibitory axon length, branching and synapse formation"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm Sally Duarte (University of Rochester)
"Elucidating the neuronal and network mechanisms of ictogenesis"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpileptogenesis: occult and overt mechanisms
7:30 pm - 7:35 pm Discussion Leader Frances Jensen (Children's Hospital, HMS)
"Going 'outside the box' to search for novel antiepileptogenic targets"
7:35 pm - 7:55 pm Michael Wong (Washington University, St. Louis)
"The mammalian target of rapamycin (mTOR) pathway: a central mechanism of epileptogenesis in multiple types of epilepsy?"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Christophe Bernard (INSERM, Marseille)
"HCN alterations in the 'latent' period"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Ed Dudek (University of Utah)
"Challenges and strategies for studying acquired epileptogenesis"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Final Discussion & Summary
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The project described was supported by Award Number R13NS070313 from the National Institute Of Neurological Disorders And Stroke. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Neurological Disorders And Stroke or the National Institutes of Health.

 
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