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Conference Program
 
Fibroblast Growth Factors in Development & Disease
March 14-19, 2010
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Fibroblast growth factors (FGFs) comprise a large family of growth and differentiation factors with essential functions in development, metabolism, and repair of various tissues and organs. Reflective of their pleiotropic roles, aberrations in FGF signaling are associated with a wide variety of human diseases, including several developmental/genetic diseases, metabolic disorders, and malignancies.

The meeting will include an introductory overview on the FGF family, followed by sessions on mechanistic aspects of FGF secretion and signaling, roles of FGFs in development, metabolism, tissue repair and remodeling, cooperation between FGF signaling and other signaling pathways, and on the roles of FGFs in genetic/developmental disease, metabolic diseases, and cancer. The recent discovery of the endocrine-acting FGF subfamily’s critical roles in bile acid, lipid, glucose, phosphate, and vitamin D homeostasis has sparked renewed interest in the therapeutic applications of FGFs, and this aspect will also be covered.

In addition to long presentations by invited speakers, a few abstracts will be selected for shorter oral presentation. This will ensure that the program includes exciting new topics emerging in the weeks preceding the conference.

It is the goal of this conference to bring together a diverse group of researchers working in the FGF field in a single forum to discuss new research results and to target future research areas. Since FGF researchers come from different fields such as biochemistry, cell biology, endocrinology, developmental biology, pharmacology and clinical medicine, they usually do not meet at other conferences. Therefore, this meeting will provide a unique opportunity for basic scientists, clinicians and colleagues from industry to exchange knowledge and to initiate and strengthen collaborations. Young investigators are particularly encouraged to apply to the meeting, and we will make every effort to include them into the program.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote presentations: The FGF family
Discussion Leaders: Sabine Werner (ETH Zurich, Switzerland) and Moosa Mohammadi (New York University School of Medicine, New York, USA)
7:40 pm - 8.00 pm Judith Abraham (Novartis Institutes for BioMedical Research, Emeryville, USA)
"Key events of the 'early days' of FGF research"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Joseph Schlessinger (Yale University, New Haven, USA)
"Regulatory mechanisms underlying FGF receptors and other receptor tyrosine kinases"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:10 pm Steven Kliewer (University of Texas, Dallas, USA)
"Endocrine FGFs: From feast to famine"
9:10 pm - 9:20 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmBiochemistry of FGFs, FGF signaling
Discussion Leader: Jeremy Turnbull (University of Liverpool, UK)
9:00 am - 9:20 am Jeremy Turnbull (University of Liverpool, UK)
"Extracellular regulation of FGF signalling - Roles of anosmin and heparan sulfates"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am David Fernig (University of Liverpool, UK)
"Tracking of individual FGFs on living cells reveals novel modes of molecular diffusion at the cell surface and of oligomerisation of signalling complexes"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Walter Nickel (University of Heidelberg, Germany)
"Molecular analysis of the unconventional secretory pathway of FGF2"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am John Heath (University of Birmingham, UK)
"Architecture and dynamics of the FGF signaling pathway(s)"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Akira Imamoto (University of Chicago, USA)
"Probing protein-protein interactions for an FGFR1/2 signaling feedforward loop"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Andrew Beenken (New York University, School of Medicine, USA)
"Structural basis for FGF-FGFR binding specificity and promiscuity"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Arno Muller (University of Dundee, UK)
"The Drosophila nesthocker mutation reveals a novel link between O-GlcNAcylation and Fibroblast Growth Factor signalling"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInteractions of FGFs with other signaling pathways
Discussion Leader: Gail Martin (University of California, San Francisco, USA)
7:30 pm - 7:50 pm Claudio Basilico (New York University School of Medicine, New York, USA)
"FGF induces Sox2 to promote osteoblast self-renewal"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Hichem Miraoui (INSERM U606, Paris, France)
"Increased EGF and PDGF-alpha receptor signaling by mutant FGF receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm Toru Imamura (National Institute of Advanced Industrial Science and Technology, Tsukaba, Japan)
"Association between FGF18 signaling and resting phase of hair growth"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Irma Thesleff (University of Helsinki, Finland)
"Integration of FGF and other signal pathways during tooth development"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm David Ornitz (Washington University, St. Louis, USA)
"Intracellular FGFs: conserved structure, unique function"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFGFs in Development
Discussion Leader: David Ornitz (Washington University, St. Louis, USA)
9:00 am - 9:20 am Olivier Pourquié (Institute of Genetics and Molecular and Cellular Biology, Strasbourg, France)
"Role of FGF signaling in patterning the vertebrate embryonic axis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Joseph Yost (University of Utah, Salt Lake City, USA)
"FGF signaling pathways and HSPG fine structures regulate cilia functions in development"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Deborah Yelon (University of California, San Diego, USA)
"Effects of FGF signaling on the zebrafish heart fields"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 am Judith Neugebauer (University of Utah, Salt Lake City, USA)
"FGF signaling controls brain laterality in early embryo development"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 am Angela Stathopoulos (Caltech, Pasadena, USA)
"Mesoderm migration in Drosophila is a multi-step process requiring two FGF ligands"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am Gail Martin (University of California, San Francisco, USA)
"Regulation of oriented cell division by FGF signaling in airway morphogenesis"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Sung-Ho Huh (Washington University, St. Louis, USA)
"FGF9 subfamily regulates organ of Corti development"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Albert Basson (King's College, London, UK)
"Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFGFs in the Nervous System
Discussion Leader: Klaus Unsicker (University of Freiburg, Germany)
7:30 pm - 7:50 pm Steve Wilson (University College London, UK)
"A role for FGF signalling in the establishment of brain asymmetry"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm James Li (University of Connecticut, Farmington, USA)
"Interactions among different FGF8 splice forms in the control of midbrain-hindbrain development"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Juha Partanen (University of Helsinki, Finland)
"FGF signalling and neuronal development in the embryonic midbrain"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Klaus Unsicker (University of Freiburg, Germany)
"Regulation of astroglial functions and neural progenitor cells by FGF2"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Mohammad Hajihosseini (School of Biological Sciences, Norwich, UK)
"FGF10 expressing tanycytes in the adult hypothalamus resemble neural stem cells and generate both neurons and glia in vivo"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndocrine FGFs
Discussion Leader: Steven Kliewer (University of Texas, Dallas, USA)
9:00 am - 9:20 am Wallace McKeehan (Texas A&M Health Science Center, Houston)
"Beta-Klotho directs FGFR4 and FGFR1 signaling to metabolism and tumor suppression"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Nobuyuki Itoh (Kyoto University, Japan)
"Roles of FGF21 signaling in energy metabolism"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:40 am Yang Li (Amgen Inc., South San Francisco, USA)
"FGF19 activates different FGFRs to control distinct biological responses"
10:40 am - 10:45 am Discussion
10:45 am - 11:05 am Beate Lanske (Harvard Medical School, Boston, USA)
"FGF23: an endocrine hormone derived from bone"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Makoto Kuro-O (University of Texas, Dallas, USA)
"Endocrine FGFs and Klothos"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pm Yo-Ishi Nabeshima (Kyoto University, Japan)
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Barbara Haenzi (Friedrich Miescher Laboratories, Basel, Switzerland)
"MEMO, a novel downstream effector of the FGFR pathway"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFGFs in Genetic / Developmental Disease
Discussion Leader: Bradley Olwin (University of Colorado Boulder, USA)
7:30 pm - 7:50 pm Marja Hurley (University of Connecticut, Farmington, USA)
"Nuclear FGF2 isoforms are novel regulators of phosphate homeostasis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Suzi Mansour (University of Utah, Salt Lake City, USA)
"Genetic rescue of hearing loss in a mouse model of Muenke syndrome (FGFR3 P244R)"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm Richard Grose (Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, UK)
"Insights from the FGF22 knockout mouse"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Andrew Wilkie (University of Oxford, UK)
"Selfish FGF receptor mutations and spermatogenesis"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Nelly Pitteloud (Massachusetts General Hospital, Boston, USA)
"Role of FGF signaling in the neuroendocrine control of reproduction"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFGFs in Tissue Repair, Regeneration and Remodelling
Discussion Leader: Andrew Wilkie (University of Oxford, UK)
9:00 am - 9:20 am Saverio Bellusci (University of Southern California, Los Angeles, USA)
"Expected and unexpected roles for fibroblast growth factor 10 in development and repair"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Michael Simons (Yale University, New Haven, USA)
"FGF signaling in the endothelium"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am George Cotsarelis (University of Pennsylvania, Philadelphia, USA)
"FGFs in hair follicle neogenesis following wounding"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 am Ariel Arthur (Glasgow Biomedical Research Center, Glasgow, UK)
"The role of fibroblast growth factor-9 in chronically demyelinated multiple sclerosis lesions"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 am Bradley Olwin (University of Colorado, Boulder, USA)
"A requirement for FGF Receptor 1 in skeletal muscle stem cell self-renewal and muscle regeneration"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Janet Bodmer (University of Cincinnati, USA)
"The alpha isoform of PKC is necessary for low molecular weight fibroblast growth factor 2-mediated cardioprotection"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Pierre Fons (Sanofi-Aventis, Toulouse, France)
"SAR106881, a fibroblast growth factor receptor agonist aimed at improving peripheral vascularization and wound healing and at reducing neuropathic pain"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Christoph Ladel (Merck Serono Research, Geneva, Switzerland)
"FGF18 evaluated in a translational dog model of osteoarthritis and relation to clinical settings"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:35 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
Afterwards: Introduction of an FGF website by Tomoko Iwata
7:35 pm - 9:30 pmFGFs in Cancer
Discussion Leader: Judith Abraham (Novartis Institutes for BioMedical Research, Emeryville, USA)
7:30 pm - 7:55 pm Fen Wang (Texas A&M Health Science Center, Houston, USA)
"The FGF signaling axis in prostate development and tumorigenesis"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:20 pmPamela Pollock (The Translational Genomics Research Institute, Phoenix, USA)
"FGFR2 in endometrial cancer - receptor activation, inhibition and resistance to FGFR tyrosine kinase inhibitors"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:35 pm Tomoko Iwata (University of Glasgow, UK)
"Towards the mouse model of bladder cancer with FGFR3 mutations; co-operators and tissue-specific signaling"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Jing Qing (Genentech Inc., South San Francisco, USA)
"Antibody targeting of FGFR3 in human cancer"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Adam Cheuk (NIH/NCI, Bethesda, USA)
"Activating mutations of FGFR4 in rhabdomyosarcoma"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

The project described was supported by Award Number R13HD063210 from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Eunice Kennedy Shriver National Institute Of Child Health & Human Development or the National Institutes of Health.

Last Updated: July 22, 2010
 
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