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Glycolipid & Sphingolipid Biology
Gordon Research Conference

Dates

February 7-12, 2010

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Lina M. Obeid

Vice Chair:
Yasuyuki Igarashi

Meeting Description

The Gordon Research Conference on Glycolipid and Sphingolipid Biology, the eleventh in this series, promises to be an exciting and instructive meeting on the cutting edge of the field. Important areas of focus will include: role of these lipids in membrane structure and function, regulation and structure of the enzymes of glycolipid and sphingolipid metabolism, involvement of these lipids in cellular transport mechanisms, role of bioactive sphingolipids in signal transduction, cell regulation, and in diseases such as neurodegeneration, diabetes, and cancer. In addition the meeting will cover exciting new developments in Lipidomics and sphingolipidology, including mass spectroscopy, systems biology, model organisms, knockout mouse models and translational sciences. With the help of all attendees, we'll try to cover the significant developments and the different perspectives in the field. In addition to invited presentations by leaders in the field, exciting abstracts will be selected for oral presentation, and stimulating posters will be selected for presentation as part of a “hot topics” session. We will have ample discussion after each talk, during the poster sessions, and during afternoon walks on the southern California beaches.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBIOPHYSICS AND BIOMEMBRANES
Session Chair: Howard Riezman
Discussion Leader: Toshihide Kobayashi
7:40 pm - 7:50 pm Gerritt Van Meer (Utrecht University, Utrecht, The Netherlands)
"Perspectives From Previous Gordon Research Conference"
7:50 pm - 7:55 pm Howard Riezman (University of Geneva, Geneva, Switzerland)
"Chair's Introduction"
7:55 pm - 8:15 pm Alicia Alonso (Unidad de Biofisica CSIC-UPV/EHU Universidad del Pais Vasco LEIOA, Spain)
"Ceramide and cholesterol. An unlikely couple"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:45 pm Alessandro Prinetti (The Medical School, University of Milano, Milano, Italy)
"Multiple Contributions of Sphingolipid Metabolism to Drug Resistant Phenotypes in Human Ovarian Cancer Cells: Crossroads, One-ways and Evacuation Routes"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:10 pm Liana Casquinha da Silva (Weizmann Institute of Science, Rehovot, Israel)
"Biophysics of Ceramide and Complex Sphingolipids"
9:10 pm - 9:20 pm Discussion
9:20 pm - 9:30 pm Discussion Leader
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGLYCOLIPID AND SPHINGOLIPID BIOCHEMISTRY: ENZYMES OF SPHINGOLIPID METABOLISM
Session Chair: Mariana Nikolova-Karakashian
Discussion Leader: Konrad Sandhoff
9:00 am - 9:05 am Mariana Nikolova-Karakashian (University of Kentucky College of Medicine, Lexington, KY)
"Chair's Introduction"
9:05 am - 9:25 am Teresa Dunn (Uniformed Services University of the Health Sciences, Bethesda, MD)
"Small Stimulatory Subunits of Serine Palmitoyltransferase"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Hiroko Hama (Medical University of South Carolina, Charleston, SC)
"FA2H Deficiency: Demyelination and Cerebellar Dysfunction in Mice and Men"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break / Group Photo
10:30 am - 10:50 am Toshiro Okazaki (Faculty of Medicine, Nish-Machi, Yonago, Japan)
"SMS1, but not SMS2, regulates intracellular degradation and recycling system in cell death and proliferation"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Makoto Ito (Kyushu University, Fukuoka, Japan)
"Structures and Functions of Sphingolipid-metabolizing Machinery"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Boaz Tirosh (Hebrew University, Jerusalem, Israel)
"XBP-1 promotes de novo ceramide synthesis in plasma cells by multiple post-translation mechanisms"
11:45 am - 11:55 am Discussion
11:55 am - 12:10 pm Leah Siskind (Medical University of South Carolina, Chrleston, SC)
"BAK regulates CerS and ceramide generation during apoptosis"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Discussion Leader
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGLYCOLIPID AND SPHINGOLIPID-BASED CHEMISTRY AND STRUCTURAL BIOLOGY APPROACHES
Session Chair: Gerhild van Echten-Deckert
Discussion Leader: Sarah Spiegel
7:30 pm - 7:35 pm Gerhild van Echten-Deckert (Kekulé-Institut fur Org. Chemie. & Biochemie, Bonn, Germany)
"Chair's Introduction"
7:35 pm - 7:55 pm Gemma Fabrias (iQAC, CSIC, Barcelona, Spain)
"Novel Inhibitors of Sphingolipid Pathways"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm James A. Shayman (University of Michigan, Ann Arbor, Michigan)
"The Structure and Function of 1-O-acylceramide Synthase"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Hiroko Ikushiro (Osaka Medical College, Osaka, Japan)
"Multifunctional Role of His159 in the Catalytic Reaction of Serine Palmitoyltransferase"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:20 pm Dominic J. Campopiano (School of Chemistry, Edinburgh, UK)
"Serine Palmitoyl Transferase; captured intermediates, HSAN1 mimics and novel inhibition mechanisms"
9:20 pm - 9:30 pm Discussion Leader
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCELL BIOLOGY: TRANSPORT AND CELL REGULATION
Session Chair: Walt Holleran
Discussion Leader: Akemi Szuki
9:00 am - 9:05 am Walt Holleran (UCSF & VA Medical Center, San Francisco, CA)
"Chair's Introduction"
9:05 am - 9:25 am Giovannin D'Angelo (Consorzio Mario Negri Sud, Chieti, Italy)
"Cellular Roles of the GlcCer Transfer Protein FAPP2"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Neale Ridgway (Dalhousie University, Halifax, Nova Scotia, Canada)
"Coordination of Cholesterol and Sphingomyelin Assembly in the Golgi Apparatus by Oxysterol-binding Protein"
9:55 am - 10:05 am Discussion
10:05 am - 10:30 am Coffee Break
10:30 am - 10:50 am Marion B. Sewer (Georgia Institute of Technology, Atlanta, GA)
"Sphingolipid Metabolic Enzymes as Nuclear Coregulatory Proteins"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Akio Kihara (Hokkaido University, Sapporo, Japan)
"Elucidation of the Pathway of Very Long-chain Fatty Acid Synthesis and its Relationship to Sphingolipid Metabolism"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Erhard Bieberich (Institute of Molecular Medicine and Genetics, Augusta, GA)
"The bright side of ceramide: novel function of a death lipid in cell polarity and ciliogenesis"
11:45 am - 11:55 am Discussion
11:55 am - 12:10 pm Reinhard Bauer (Limes institute, Bonn, Germany)
"Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Discussion Leader
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTRANSLATIONAL ASPECTS OF SPHINGOLIPID BIOLOGY (I): CANCER BIOLOGY AND THERAPY
Session Chair: Richard Kolesnick
Discussion Leader: Amy S. Paller
7:30 pm - 7:35 pm Richard Kolesnick (Memorial Sloan-Kettering Cancer Center, New York, NY)
"Chair's Introduction"
7:35 pm - 7:55 pm Besim Ogretman (Medical University of South Carolina, Charleston, SC)
"Sphingolipids and Cancer"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Myles Cabot (John Wayne Cancer Institute, Santa Monica, CA)
"Role of ABC Transporters Like P-glycoprotein in Regulating Cytotoxicity of Short-chain Ceramides"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Tzipora Goldkorn (University of California Davis School of Medicine, Davis, CA)
"nSMase2: Role and Molecular Mechanism in Lung Injury"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Charles Swanton (Cancer Research UK London Research Institute, London, UK)
"Molecular Roles for the Multi-Drug Sensitiser CERT, a Mediator of Prognosis and Outcome in Breast Cancer"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTRANSLATIONAL ASPECTS OF SPHINGOLIPID BIOLOGY (II): NEUROPATHOBIOLOGY
Session Chair: Mark Kester
Discussion Leader: Koichi Furukawa
9:00 am - 9:05 am Mark Kester (Penn State University, Hershey, PA)
"Chair's Introduction"
9:05 am - 9:25 am Ronald L. Schnaar (Johns Hopkins School of Medicine, Baltimore, MD)
"Ganglioside-mediated Signaling in Axon-myelin Interactions"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Wayne I. Lencer (Harvard Digestive Diseases Center, Boston, MA)
"Lipid Trafficking in Epithelial Cells: Structure-Function Studies on the Cholera Toxin Receptor Ganglioside GM1"
9:55 am - 10:05 am Discussion
10:05 am - 10:30 am Coffee Break
10:30 am - 10:50 am Hugh J. Willison (University of Glasgow, Glasgow, Scotland)
"A Combinatorial Glycolipidomic Approach to Peripheral Nerve Autoimmunity"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Glyn Dawson (University of Chicago, Chicago, IL)
"Its hard to be neutral about Sphingomyelinases"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Mitsutoshi Setou (Hamamatsu University School of Medicine, Shizuoka, Japan)
"Imaging Mass Spectrometry of Glycolipid and Sphingolipid"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Thorsten Hornemann (Institute of Clinical Chemistry, Zurich, Switzerland)
"Accumulation of two atypical sphingolipids underlies the pathology in hereditary sensory neuropathy HSAN1"
12:15 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm Discussion Leader
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmTRANSLATIONAL ASPECTS OF SPHINGOLIPID BIOLOGY (III): STORAGE AND METABOLISM
Session Chair: Frances Platt
Discussion Leader: Julie Saba
7:30 pm - 7:35 pm Frances Platt (University of Oxford, Oxford, UK)
"Chair's Introduction"
7:35 pm - 7:55 pm Emyr Lloyd-Evans (Wolfson College, Oxford, UK)
"Salvaging Lysosomal Sphingosine; Essential Role of NPC1, The Protein Deficient in Niemann-Pick Type C Disease"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Rahm Gummuluru (Boston University School of Medicine, Boston, MA)
"Glycosphingolipid Requirement for HIV-1 Interactions with Dendritic Cells"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Roger Sandhoff (German Cancer Research Center, Heidelberg, Germany)
"Male Fertility Requires Sphingolipids With Very Long Chain-polyunsaturated Fatty Acids: New Insights"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Julie Saba (Children's Hospital Oakland Research Institute, Oakland, CA)
"Sphingosine Phosphate Lyase in Development and Physiology"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:00 amPOSTER TALKS
Discussion Leaders: Ashley Cowart (Medical University of South Carolina, Charleston, SC), Nigel Pyne (University of Strathclyde, Glasgow, Scotland, UK), and Tilla Worgall (Columbia University, New York, NY)
(Poster Talks TBA)
10:00 amCoffee Break
10:30 am - 12:30 pmLIPID MEDIATED SIGNALING
Session Chair: Thierry Levade
Discussion Leader: Tony Futerman
10:30 am - 10:35 am Thierry Levade (Lab de Biochimie Maladies Metabolique Chu Rangueil, Toulouse, France)
"Chair's Introduction"
10:35 am - 10:55 am Timothy Hla (Weill Cornell Medical College / Cornell University, New York City, NY)
"Sphingosine and S1P Signalling"
10:55 am -11:05 am Discussion
11:05 am - 11:25 am Stuart Pitson (Centre for Cancer Biology, Adelaide, Australia)
"The Critical Role of Protein Interactions in Sphingosine Kinase 1 Function"
11:25 am - 11:35 am Discussion
11:35 am - 11:55 am Susan Pyne (University of Strathclyde, Glasgow, Scotland, UK)
"Sphingosine 1-phosphate Signalling in Breast Cancer"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:25 pm Antonio Gomez-Munoz (University of the Basque Country, Bilbao, Spain)
"New Developments in Ceramide 1-phosphate Biology"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSPHINGOLIPIDOMICS AND MODEL SYSTEMS
Session Chair: Al Merrill
Discussion Leader: Yusuf Hannun
7:30 pm - 7:35 pm Al Merrill (Georgia Institute of Technology, Atlanta, GA)
"Chair's Introduction"
7:35 pm - 7:55 pm M. Cameron Sullards (Georgia Institute of Technology, Atlanta, GA)
"Sphingolipidomics: Emerging Tools and Techniques"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Robert Dickson (University of Kentucky, Lexington, KY)
"Regulation of mRNA Decay and P-body Formation by the LCB-Pkh1/2-Pkc1 Pathway"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Richard Proia (National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD)
"What knockout mice have taught us about sphingolipid biology"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:20 pm Xinghua Lu (MUSC, Charleston, SC)
"Modeling sphingolipid-mediated signal transduction in yeast gene expression systems"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by Grant # 1 R13 CA144310-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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