The Gordon-Kenan Research Seminar on Barriers of the CNS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of this meeting is to encourage young researchers exploring the field of blood-brain interfaces to display their research and methods they use and interact and gain valuable knowledge from the experts in this field. “Barriers of the CNS” is a platform where exhibiting research related to the CNS and its various barriers will lead to exchange of ideas and methodical approaches and eventually enhance the research in this field.
| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Lecture |
| 3:15 pm - 3:45 pm | Joan Abbott (King's College London, UK)
"History of blood-brain-barriers and important methods to study these barriers" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Perfusion/Microdialysis, Imaging techniques |
| Discussion Leaders: Danica Staminirovic (University of Ottawa, Canada) and Elisabeth de Lange (Leiden University, The Netherlands) |
| 7:30 pm - 7:50 pm | Olga Huber (University of Heidelberg)
"Use of single molecule localization microscopy to analyze the expression pattern of P-glycoprotein" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Sripad Ram (University of Texas Southwestern Medical Center)
"Understanding the mechanisms of antibody transport at the blood brain barrier" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Rachita K. Sumbria (Texas Tech University Health Sciences Center)
"Quantitative Estimation of Blood-Brain Barrier Opening Following Ischemia Reperfusion Using Intracerebral Microdialysis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Li Yang (Texas Tech University, Pharmaceutical Sciences Department)
"Characterization of the Neuroprotective Effects of Biphalin, a Potent Opioid Receptor Agonist, in Focal Brain Ischemia" |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | In vivo, ex vivo, in vitro models |
| Discussion Leaders: Hans-Joachim Galla (University of Muenster, Germany) and David Miller (NIH/NIEHS, North Carolina, USA) |
| 9:00 am - 9:20 am | Douglas N. Clarke (Texas A&M University Health Science Center)
"Perlecan Domain V enhances brain microvascular endothelial cell angiogenesis by interacting with the integrin a5β1, activating the ERK-(1/2) signaling pathway, and causing the release of VEGF" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Jisook Lee (University of California, San Diego)
"Conditional FAK deletion mediates blood-brain barrier remodeling in glioma" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Sagar Argawal (University of Minnesota)
"P-gp and BCRP 'Co-operate' at the BBB to Limit Brain Penetration of Tyrosine Kinase Inhibitors - Impact on Chemotherapy in Glioma" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Shameena Bake (Texas A&M Health Science Center)
"Sex differences in structural properties of the blood brain barrier and endothelial function: Role of reproductive aging" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jorge I. Alvarez (University of Montreal)
"The hedgehog pathway sustains blood-brain barrier properties and promotes CNS immune quiescence" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | John C. Peart (Laboratory of Toxicology and Pharmacology, NIH/NIEHS)
"Sphingosine-1-Phosphate (S1P) exposure reduces P-glycoprotein (P-gp) transport activity in rat brain capillaries" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 3:30 pm | Poster Session II |
| 3:30 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
Last Updated: April 20, 2010