Gordon Research Conferences
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Conference Program
 
Hemostasis
July 25-30, 2010
Waterville Valley Resort
Waterville Valley, NH
Chair:
Nigel Mackman

Vice Chair:
Sriram Krishnaswamy

Related Meeting Information
The Hemostasis Gordon Research Conference was held in conjunction with the Hemostasis Gordon-Kenan Research Seminar. Please refer to the Hemostasis GKRS web page for more information.

The Gordon Research Conference on Hemostasis is widely considered to be the premiere small meeting on the topics of blood coagulation, platelet biology, and anticoagulant pathways, enjoying both national and international reputation. First organized by hemostasis pioneers Earl W. Davie and Oscar Ratnoff in 1973, the meeting has been held biennially since then. The Hemostasis Gordon Conference has a unique focus, bringing together scientists interested in the biology, biochemistry and genetics of platelets and coagulation proteins, physicians involved in the treatment of bleeding and thrombotic diseases and biotechnologists from small and large pharma focused on the development of new therapies to address hemostatic problems.

The next conference will be held on July 25th - July 30th, 2010 at Waterville Valley Conference Center, Waterville Valley, New Hampshire, a new, comfortable, and inviting location that should provide an excellent venue for all participants. This Conference Center, surrounded by the White Mountains of New Hampshire, received the Pinnacle Award from Successful Meetings magazine in 2000, and provides over 15,000 square feet of flexible, highly functional space. Recreational facilities include ready access to biking hiking, golf, tennis, boating, and the Waterville Valley Arts Center. Waterville Valley is only two hours north of Boston, making travel to and from convenient for speakers and attendees from the US and overseas alike. All accommodations, dining hall, poster areas and meeting rooms are accessible to handicapped persons.

It is the goal of the conference organizers that nearly every person attending the conference participates either as a speaker, discussion leader, or poster presenter. At Waterville Valley, the venue for the 2010 Conference, there is space available for 30-40 posters at a session, and four poster sessions will be scheduled. The conference Vice-Chair, Sriram Krishnaswarmy, will be responsible for organizing the posters into sessions that are related to the meeting agenda.

Afternoons will be open for informal discussion among attendees and leisure activities aimed at increasing further interactions and intellectual exchange – traditionally a unique and important part of all Gordon Conferences. Poster presentations will be held before dinner on four of the five days. These are always very well-attended, and provide a dedicated, informal forum for interaction between junior and more senior scientists in the field.

The current draft program of the meeting is shown below. All attendees not currently on the Program who apply to the conference will be encouraged to submit an abstract for presentation at one of our four scheduled Poster Sessions, scheduled to be held in the afternoon Monday-Thursday.


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:45 pmIntroductory Comments by GRC Site Staff
Welcome by Conference Chair, Nigel Mackman (University of North Carolina at Chapel Hill, Chapel Hill, North Carolina)
7:45 pm - 9:30 pm Historical Views of Thrombosis and Hemostasis
Discussion Leader: David Ginsburg (University of Michigan)
7:45 pm - 8:15 pmKen Mann (University of Vermont)
"Discovery of thrombin and its central role in coagulation"
8:15 pm - 8:30 pm Discussion
8:30 pm - 9:00 pmShaun Coughlin (University of California San Francisco)
"Protease-activated receptors: discovery, physiology, and therapy"
9:00 pm - 9:15 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Platelet Biology
Discussion Leader: Jane Freedman (Boston University)
9:00 am - 9:25 amJoe Italiano (Harvard Medical School)
"Mechanistic insights into how platelets are produced and how they regulate angiogenesis"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amMichael Berndt (University College Cork, Ireland)
"A novel signaling pathway regulating early events in platelet adhesion"
10:05 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break / Group Photo
11:00 am - 11:25 amTatiana Byzova (Lerner Research Institute, Cleveland Clinic)
"Kindlin as a key component of integrin activation machinery"
11:25 am - 11:40 am Discussion
11:40 am - 12:05 pmAndy Weyrich (University of Utah)
"Synthetic Events Mediated by Platelets: Links to Thrombosis and Hemostasis"
12:05 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A
6:00 pmDinner
7:30 pm - 9:30 pm Atherothrombosis
Discussion Leader: Jose Lopez (Puget Sounds Blood Center)
7:30 pm - 7:55 pmMark Taubman (University of Rochester)
"Role of tissue factor in smooth muscle cell biology and thrombosis"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmLisa Jennings (University of Tennessee Health Science Center)
"Platelet function in atherothrombosis: critical factors for thrombus stability"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmSkip Brass (University of Pennsylvania)
"The biology of semaphorins in platelets and their role in atherothrombosis"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Blood Coagulation Factors
Discussion Leader: Paula Tracy (University of Vermont)
9:00 am - 9:25 amRodney Camire (University of Pennsylvania)
"The molecular basis of factor V procofactor activation"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amJim Huntington (Cambridge for Medical Research, United Kingdom)
"NMR studies on thrombin structure and interactions"
10:05 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 amJim Morrissey (University of Illinois at Urbana-Champaign)
"Nanoscale studies of protein-membrane interactions"
11:15 am - 11:30 am Discussion
11:30 am - 11:55 amAlisa Wolberg (University of North Carolina at Chapel Hill)
"Plasma and cellular influences on fibrin structure and stability"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:20 pmHongmin Sun (University of Missouri)
"Exploring the interaction of host hemostatic system and group A streptococcus to generate novel antimicrobial reagents"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A (continued)
6:00 pmDinner
7:30 pm - 9:30 pm Anticoagulants and Cross Talk Between Thrombosis and Inflammation
Discussion Leader: Charles Esmon (Oklahoma Medical Research Foundation)
7:30 pm - 7:55 pmGeorge Broze (Washington University, St. Louis)
"TFPI isoforms"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmJohn Griffin (The Scripps Research Institute)
"Protein C"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmDenisa Wagner (Immune Disease Institute and Harvard Medical School)
"Links between thrombosis and inflammation"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Platelet Signaling
Discussion Leader: Mark Ginsberg (University of California San Diego)
9:00 am - 9:25 amXiaoping Du (University of Illinois)
"MAPK signaling in platelets"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amWolfgang Bergmeier (Thomas Jefferson University)
"CalDAG-GEFI: At the nexus of calcium-dependent calcium signaling"
10:05 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 amLeslie Parise (University of North Carolina at Chapel Hill)
"Platelets, leukocytes and RBCs in sickle cell disease"
11:15 am - 11:30 am Discussion
11:30 am - 11:55 amSteve Watson (University of Birmingham, United Kingdom)
"Platelet activation by ITAM and ITAM-like receptors"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:20 pmGow Arepally (Duke University)
"Immune Pathogenesis of HIT"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Hot Topics
Discussion Leader: Sriram Krishnaswarmy (Children’s Hospital of Philadelphia)
7:30 pm - 7:40 pmFeng Ye (University of California-San Diego)
"Complete Reconstitution of GPIIb-IIIa Activation In Vitro"
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pmHeyu Ni (University of Toronto)
"Apolipoprotein A-IV is a ligand of platelet beta3 integrins and an endogenous inhibitor of thrombosis: A novel link between lipoprotein metabolism and platelet function"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:10 pmDominic W. Chung (University of Washington)
"Regulation of ADAMTS13 by a cofactor from human plasma"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pmParvathi Kamath (Children’s Hospital of Philadelphia)
"Ligand binding shuttles thrombin along a continuum of zymogen-like and proteinase-like states"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pmAlastair W. Poole (University of Bristol)
"Distinct regulation of calcium signaling by different PKC isoforms in platelets"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pmUmesh Desai (Virginia Commonwealth University)
"Desgined allosteric regulators of coagulation enzymes"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmAlec A. Schmaier (University of Pennsylvania)
"Platelet vs. thrombocyte function: aggregate formation under shear is unique to platelets"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmMikhail V. Ovanesov (Food and Drug Administration)
"Regulation of clot growth by Factor XI through the generation of thrombin inside the clot"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Biology of Von Willebrand Factor
Discussion Leader: X. Long Zheng (The Children's Hospital of Philadelphia and The University of Pennsylvania Medical Center)
9:00 am - 9:25 amTim Springer (Harvard University)
"Structure of the A2 domain of VWF and the cleavage by ADAMTS13"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amZaverio Ruggeri (The Scripps Research Institute)
"Von Willebrand factor and thrombin as GPIba ligands: structural aspects and physiopathological consequences"
10:05 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 amShaun Jackson (Monash University, Australia)
"Impact of flow disturbances on platelet aggregation and thrombus growth"
11:15 am - 11:30 Discussion
11:30 am 11:55 amDavid Motto (University of Iowa)
"VWF and ADAMTS13 in mouse models"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:20 pmJerry Ware (University of Arkansas)
"GP1ba and mouse models"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B (continued)
6:00 pmDinner
7:30 pm - 9:30 pm Microparticles and Anti-Thrombotic Drugs
Discussion Leader: Bruce Sullenger (Duke University)
7:30 pm - 7:55 pmAlok Khorana (University of Rochester Medical Center)
"Role of tissue factor and microparticles in venous thrombosis in cancer"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmJimmy Tcheng (Duke University)
"Antithrombotic Therapies in Coronary Artery Disease: Promises (Partially) Fulfilled"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmJeff Weitz (McMaster University, Canada)
"New anticoagulants: Is targeted therapy better therapy"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 HL102954-01 from the National Institutes of Health, National Heart, Lung and Blood Institute.

Last Updated: July 22, 2010
 
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