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Conference Program
 
Host-Parasite Interactions, Biology of
June 27 - July 2, 2010
Salve Regina University
Newport, RI

The 2010 GRC conference on Biology of Host-Parasite Interactions will present the latest findings on the biology of protozoan parasites and their vectors, with special emphasis on human and animal diseases such as malaria, toxoplasmosis, African and American trypanosomiasis, leishmaniasis, trichomoniasis, giardiasis and entamoebiasis. The Conference will feature a wide range of topics, such as invasion and egress, systems biology, transmission, genetic and phenotypic variation, cell cycle, immune responses and novel intervention strategies.

The aim of the meeting is to bring together scientists from a variety of disciplines in order to define the current state of this dynamic field and to discuss and set future research agendas. This GRC conference offers the unique opportunity for junior investigators and graduate students to get together and exchange ideas with leaders in the field in a friendly and relaxed atmosphere at the Salve Regina University Campus, Newport. Some submitted abstracts will be selected for short talks. The success of this meeting would be considerably strengthened by the participation of students and post-docs who are strongly encouraged to apply. We are making a special effort to obtain funds to provide individuals from endemic countries with travel awards.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pm Transmission of parasites
Discussion Leader: David Sacks (NIH, Bethesda, USA)
7:35 pm - 7:55 pmSacks, David (NIH, Bethesda, USA)
"The cell biology of parasite-vector interactions in Leishmaniasis"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Bates, Paul (Liverpool School of Tropical Medicine, UK)
"Transmission mechanisms of leishmaniasis"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pmTait, Andy (University of Glasgow, UK)
"Genetic exchange in African Trypanosomes"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:30 pm Short Talks
9:05 pm - 9:15 pmSmith, Nick (University of Sydney, Australia)
"The molecular basis for the transition from gametocyte to oocyst in coccidian parasites"
9:15 pm - 9:18 pm Discussion
9:18 pm - 9:28 pmMorahan, Belinda (NIAID/NIH, Bethesda, USA)
"Plasmodium falciparum Gametocytogenesis"
9:28 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Phenotypic variation, RNA and gene expression
Discussion Leader: Elisabetta Ullu (Yale University, USA)
9:00 am - 9:20 amUllu, Elisabetta (Yale University, USA)
"RNA interference and gene regulation in Trypanosoma brucei"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amLlinas, Manuel (Princeton University, USA)
"Stage-specific transcriptional regulation by ApiAP2 proteins"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 10:50 amLujan, Hugo (University of Cordoba, Argentina)
"The RNAi machinery controls antigenic variation in the intestinal parasite Giardia lamblia"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amSingh, Upinder (Stanford University, USA)
"An unusual repertoire of small RNAs and RNAi genes regulate gene expression in Entamoeba histolytica"
11:20 am - 11:30 am Discussion
11:30 am - 12:30 pm Short Talks
11:30 am - 11:40 amChene, Arnaud (Institut Pasteur, France)
"A new family of DNA-binding proteins in P. falciparum"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 amKishore, Sandeep (Cornell University, USA)
"A primate malaria parasite-specific pathway for epigenetic memory of multi-copy virulence genes"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmLe Roch, Karine (University of California Riverside, USA)
"Genome-wide nucleosome positioning and DNA methylation in the human malaria parasite: Insights into differentiation and virulence"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmRoditi, Isabel (University of Berne, Switzerland)
"Sequence-specific mRNP isolation identifies a translational repressor in T. brucei"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Host and parasite genetic variation in disease
Discussion Leader: Xin-zhuan Su (NIAID/NIH, USA)
7:30 pm - 7:50 pmSu, Xin-zhuan (NIAID/NIH, USA)
"Genetic variation and genetic mapping genes contributing to drug response and virulence in malaria parasites"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmHajduk, Stephen (University of Georgia, USA)
"Alternative mRNA editing expands T. brucei mitochondrial protein diversity"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmBeverly, Steve (Washington University, USA)
"Genetic crossing as a tool for probing Leishmania virulence and tropisms"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:30 pm Short Talks
9:00 pm - 9:10 pmSterkers, Yvon (University of Montpellier, France)
"Generation of chromosome aneuploidy and mosaicism in Leishmania"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmTaraschi, Theodore (Thomas Jefferson University, USA)
"Malaria Drug Resistance is Associated with DNA Mismatch Repair Deficiency"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Invasion and egress from host cells
Discussion Leader: Alan Cowman (WEHI, Melbourne, Australia)
9:00 am - 9:20 amCowman, Alan (WEHI, Melbourne, Australia)
"Alternate merozoite invasion pathways used by P. falciparum to invade human erythrocytes"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amCarruthers, Vern (University of Michigan, Ann Arbor, USA)
"Cell to cell transmission of Toxoplasma gondii"
9:50 am - 10:00 am Discussion
10:00 am - 10:15 amCoffee Break
10:15 am - 10:35 amBlackman, Mike (National Institute of Medical Research, Mill Hill, UK)
"Malarial proteases in invasion and egress"
10:35 am - 10:45 am Discussion
10:45 am - 11:05 amSoldati, Dominique (University of Geneva, Switzerland)
"Mechanisms controlling glideosome function in apicomplexans"
11:05 am - 11:15 am Discussion
11:15 am - 12:30 pm Short Talks
11:15 am - 11:25 amDuraisingh, Manoj (Harvard University, USA)
"Genetic analyses of parasite and erythrocyte determinants of P. falciparum egress and invasion"
11:25 am - 11:30 am Discussion
11:30 am - 11:40 amSkillman, Kristen (Washington University, USA)
"Molecular Basis of Divergent Unstable Actins in Apicomplexan Parasites"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 amMartins, Rafael (Sao Paulo, Brazil)
"Molecular mimicry in the context of host cell invasion by T. cruzi"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmSinis, Photini (New York University, USA)
"Conformational Changes in the Circumsporozoite Protein Are Required for the Establishment of Malaria Infection"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmGreenbaum, Doron (University of Pennsylvania, USA)
"Apicomplexan parasites co-opt host calpain proteases for efficient egress from the host cell"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Systems biology
Discussion Leader: Elisabeth Winzeler (Genomics Institute of the Novartis Research Foundation, San Diego, USA)
7:30 pm - 7:50 pmWinzeler, Elisabeth (Genomics Institute of the Novartis Research Foundation, San Diego)
"Chemical and population genomics of malaria"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmKami, Kim (Albert Einstein College of Medicine, New York, USA)
"Using Epigenomics to Understand Gene Expression in Toxoplasma gondii"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmRoos, David (University of Pennsylvania, USA)
"Integrating diverse datasets to define key biological traits: Towards a systems biology of host-parasite interactions"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:30 pm Short Talks
9:00 pm - 9:10 pmMcNamara, Case (Genomics Institute of the Novartis Research Foundation, USA)
"Using systems approaches to discover the targets of small molecules with antimalarial activity"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmOlszewski, Kellen (Princeton University, USA)
"Metabolomic QTL analysis implicates PfCRT as a small peptide transporter"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Trafficking and organelle biogenesis
Discussion Leader: Boris Striepen (University of Georgia, Athens, USA)
9:00 am - 9:20 amStriepen, Boris (University of Georgia, Athens)
"Biology of the apicomplexan plastid"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amHaldar, Kasturi (University of Notre Dame, USA)
"The malaria secretome: from algorithms to essential functions"
9:50 am - 10:00 am Discussion
10:00 am - 10:15 amCoffee Break
10:15 am - 10:35 amBastin, Philippe (Institut Pasteur, Paris)
"Constructing the trypanosome flagellum: a puzzle of 300 proteins"
10:35 am - 10:45 am Discussion
10:45 am - 11:05 amBangs, Jay (University of Wisconsin-Madison, USA)
"GPI's, sphingolipids, and secretory trafficking in African trypanosomes"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 amDesai, Sanjay (NIAID/NIH, USA)
"The plasmodial surface anion channel: cloning and validation as an antimalarial target"
11:35 am - 11:45 am Discussion
11:45 am - 12:30 pm Short Talks
11:45 am - 11:55 amHehl, Adrian (University of Zurich, Switzerland)
"Indirect epigenetic control of a small set of genes drives encystation in Giardia lamblia"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmRobinson, Derrick (University of Bordeaux, France)
"The identification and characterization of flagellar pocket collar proteins in T. brucei"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmMatthews, Steve (Imperial College, UK)
"Atomic resolution basis for host cell recognition by apicomplexan parasites"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Cell cycle and development
Discussion Leader: Keith Matthews (University of Edinburgh, UK)
7:30 pm - 7:50 pmMatthews, Keith (University of Edinburgh, UK)
"Regulating transmission by African trypanosomes"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmBillker, Oliver (The Wellcome Trust Sanger Institute, Cambridge, UK)
"Regulation of malaria development in the mosquito"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmCoppens, Isabelle (Johns Hopkins University, Baltimore, USA)
"Apicomplexan parasites: Insights into the developmental transformations of the sporozoite stage"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:30 pm Short Talks
9:00 pm - 9:10 pmDobbelaere, Dirk (University of Berne, Switzerland)
"Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmDawson, Scott (Univesity of California, Davis, USA)
"Cytoskeleton and nuclear division in Giardia"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Host Innate and Adaptive Immune Response
Discussion Leader: Elena Levashina (Institute of Molecular Biology, CNRS, Strasbourg)
9:00 am - 9:20 amLevashina, Elena (Institute of Molecular Biology, CNRS, Strasbourg)
"Central role of complement in the mosquito responses against Plasmodium parasites"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amHunter, Christopher (University of Pennsylvania, Philadelphia, USA)
"Imaging the immune response to Toxoplasma gondii"
9:50 am - 10:00 am Discussion
10:00 am - 10:15 amCoffee Break
10:15 am - 10:35 amZavala, Fidel (Johns Hopkins University, Baltimore, USA)
"Homing and functional properties of liver-resident memory CD8+ T cells against malaria parasites"
10:35 am - 10:45 am Discussion
10:45 am - 11:05 amPays, Etienne (Université Libre de Bruxelles, Belgium)
"Molecular dialogue between Trypanosoma brucei and its mammalian hosts"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 amCrompton, Peter (NIAID/NIH, USA)
"New approaches to understanding the B cell response to malaria"
11:35 am - 11:45 am Discussion
11:45 am - 12:30 pm Short Talks
11:45 am - 11:55 amFentress, Sarah (Washington University, USA)
"Toxoplasma gondii ROP18 kinase thwarts host defenses by phosphorylating immunity- related GTPases"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmDzierszinski, Florence (McGill University, Canada)
"Post-translational regulation of MHC-II antigen presentation by Toxoplasma gondii"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmRaper, Jayne ( NYU School of Medicine, USA)
"Antimicrobial HDL-the good cholesterol?"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Novel intervention strategies
Discussion Leader: Mike Ferguson (University of Dundee, UK)
7:30 pm - 7:50 pmFerguson, Mike (University of Dundee, UK)
"Protein glycosylation in Trypanosoma brucei: host-parasite differences and therapeutic opportunities"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmWard, Stephen (Liverpool School of Tropical Medicine, UK)
"Targeting parasite uniqueness"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmKappe Stefan (Seattle Biomedical Research Institute, USA)
"Live-attenuated whole-cell malaria vaccine design"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:30 pm Short Talks
9:00 pm - 9:10 pmMalmquist, Nick (Institut Pasteur, France)
"Targeting the epigenetic machinery of P. falciparum"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmIstvan, Eva (Washington University, USA)
"Plasmodium falciparum isoleucyl-tRNA synthetases"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by (1 R13 AI088775-01) from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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