Conference Program
 
Immunochemistry & Immunobiology
May 16-21, 2010
Les Diablerets Conference Center
Les Diablerets, Switzerland
Chair:
Caetano Reis E Sousa

Vice Chair:
Cynthia J. Guidos
Application Deadline
Applications for this meeting must be submitted by April 25, 2010. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Applications will still be accepted for oversubscribed meetings. However, they will only be considered by the Conference Chair if more seats become available due to cancellations.

There probably is no tissue or organ with a greater impact on human health than the immune system. The last decades have seen an explosion of knowledge regarding the functioning of the immune system both in health and disease.The GRC on Immunochemistry and Immunobiology has been held regularly since 1966. Its small size and broad coverage of cutting edge Immunology distinguish it from larger conferences focussed on more specialised topics within the field. The 2010 GRC on Immunochemistry and Immunobiology will cover those areas of Immunology currently receiving the most intense investigation, both on the basic and applied front. The meeting will be divided into nine half-day sessions, with approximately 36 invited speakers who are internationally recognised for their contributions. Several slots will additionally be allotted for platform presentations selected from submitted abstracts. An intimate setting in the Swiss mountains, ample time for discussion and a maximum of 150 attendees will combine to favour an intense exchange of ideas and to help advance knowledge in the field. As usual, there will be poster sessions and many opportunities for informal interactions among participants throughout the week. Past GRCs on Immunochemistry and Immunobiology have been a great success and the 2010 meeting is likely to be oversubscribed. Early application is highly recommended.

Contributors
SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmINNATE IMMUNITY AND INFLAMMATION
Discussion Leader: Ruslan Medzhitov (Yale University & HHMI, USA)
7:40 pm - 8:00 pmMax Cooper (Emory Vaccine Centre, USA)
"Immune mechanisms in jawless vertebrates"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmJürg Tschopp (University of Lausanne, Switzerland)
"The inflammasomes: sensors of metabolic danger?"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmRuslan Medzhitov (Yale University & HHMI, USA )
"Innate control of adaptive immune responses"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pmYasmine Belkaid (NIH, USA)
"Roles of retinoic acid in protective immunity"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLYMPHOID STRESS-SURVEILLANCE RESPONSES
Discussion Leader: Adrian Hayday (London Research Institute, UK)
9:00 am - 9:20 amAdrian Hayday (London Research Institute, UK)
"Exploring the lymphoid stress-surveillance response"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short talk to be selected
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short talk to be selected
9:55 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:50 amMitch Kronenberg (La Jolla Institute for Allergy & Immunology, USA)
"Innate-like responses to microbes by natural killer T cells"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amEric Vivier (Luminy Centre for Immunology of Marseille, France)
"Activation of natural killer cells"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short talk to be selected
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pmAngela Santoni (Sapienza University of Rome, Italy)
"NK cell recognition of drug-induced senescent tumor cells"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short talk to be selected
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #1
5:30 pm - 7:30 pmLEUKOCYTE DEVELOPMENT
Discussion Leader: Cynthia Guidos (Toronto University, Canada)
5:30 pm - 5:50 pmJim P. Di Santo (Institut Pasteur, France)
"Roles for diverse NK cell subsets in tissue homeostasis and immune defense"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pmCindy Guidos (Toronto University, Canada)
"Functions of Notch signaling in T cell development and leukemogenesis"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmMeinrad Busslinger (Research Institute of Molecular Pathology, Austria)
"Transcriptional networks controlling early B cell development"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pmHarinder Singh (The University of Chicago/Genentech, USA)
"Gene regulatory networks regulating B cell development and function"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmANTIGEN PRESENTATION AND LYMPHOCYTE ACTIVATION
Discussion Leader: Doreen Cantrell (University of Dundee, UK)
9:00 am - 9:20 amSebastian Amigorena (Institut Curie, France)
"Antigen cross presentation and T cell activation by dendritic cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short talk to be selected
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short talk to be selected
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Michael Reth (Max-Planck Institute of Immunobiology, Germany)
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amMark Davis (Stanford University School of Medicine, USA)
"Micro- and macro-immunology: T cell recognition and approaches to human immunology"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short talk to be selected
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pmDoreen Cantrell (University of Dundee, UK)
"Protein kinase B/Akt programs T cell migration and differentiation but is dispensable for metabolism"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short talk to be selected
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #2
5:30 pm - 7:30 pmIMMUNE CELL INTERACTIONS
Discussion Leader: Marc Jenkins (University of Minnesota, USA)
5:30 pm - 5:50 pmMarc Jenkins (University of Minnesota, USA)
"How CD4+ T cells remember bacterial infections"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Michael Sixt (Max-Planck Institute of Biochemistry, Germany)
"Cytoskeletal dynamics of migrating leukocytes"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmRon Germain (NIH, USA)
"Dynamic intravital imaging of immune cell behavior in lymphoid and peripheral tissues"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Ellen Robey (UC Berkeley, USA)
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGENERATION OF EFFECTOR LYMPHOCYTES
Discussion Leader: Gitta Stockinger (National Institute of Medical Research, UK)
9:00 am - 9:20 amEd Palmer (Basel University, Switzerland)
"Affinity thresholds in T lineage cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short talk to be selected
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short talk to be selected
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amGitta Stockinger (National Institute of Medical Research, UK)
"Modulation of effector T cell development"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amSteve Reiner (University of Pennsylvania, USA)
"Inducing the diverse cell fates required for immunity"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short talk to be selected
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pmCarola Vinuesa (Australian National University, Australia)
"Disentangling the different types of T cell help for B cells"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short talk to be selected
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #3
5:30 pm - 7:30 pmIMMUNE REGULATION AND DYSFUNCTION
Discussion Leader: Diane Mathis (Harvard, USA)
5:30 pm - 5:50 pmDiane Mathis (Harvard, USA)
"Control of immunological tolerance"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pmSasha Rudensky (Sloan-Kettering Institute, USA)
"Molecular determinants of regulatory T cell differentiation and function"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmFederica Sallusto (Institute for Research in Biomedicine, Switzerland)
"T cell migration in immunity and autoimmunity"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pmDan Littman (NYU, USA)
"A cryptic innate response to HIV in human dendritic cells"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmIMMUNITY TO INFECTIONS
Discussion Leader: Antonio Lanzavecchia (Institute for Research in Biomedicine, Switzerland)
9:00 am - 9:20 am Antonio Lanzavecchia (Institute for Research in Biomedicine, Switzerland)
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short talk to be selected
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short talk to be selected
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Andrea Cooper (Trudeau Institute, USA)
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amAnnette Oxenius (ETH, Switzerland)
"Antibody-mediated protection against intracellular bacterial pathogens"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short talk to be selected
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pmClaude-Agnès Reynaud (Faculty of Medicine Necker-Paris Descartes, France)
"Multiple memory B cell subsets in the mouse"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short talk to be selected
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #4
5:30 pm - 7:30 pmTHE IMMUNE SYSTEM AT MUCOSAL SURFACES
Discussion Leader: Andrew Macpherson (University of Bern, Switzerland)
5:30 pm - 5:50 pmBart Lambrecht (Ghent University, Belgium)
"Activation of dendritic cells in asthma: the danger within"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pmLora Hooper (Dallas Southwestern Medical Center, USA)
"Commensal-host interactions at the mucosal surface"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmAndrew Macpherson (University of Bern, Switzerland)
"Mutalistic mucosal immune responses to commensal intestinal microbes"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Fiona Powrie (University of Oxford, UK)
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: January 18, 2010