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In Vivo Magnetic Resonance
Gordon Research Conference

Dates

July 25-30, 2010

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Risto A. Kauppinen

Vice Chair:
Greg J. Stanisz

Meeting Description

In Vivo applications of Magnetic Resonance (MR) continue to grow owing to technical advancements in several key domains of MR technology, including ultra-high magnetic field instrumentation, gradient and radio-frequency coils, image processing algorithms as well as contrast agents. All these advancements further promote MR as the most powerful single imaging modality to study living systems, spanning from anatomy and metabolic functions to detection and characterization of disease processes, and on spatial scales from individual cells to whole organs. The research field of in vivo MR is inherently interdisciplinary, bringing together scientists with backgrounds in physics, chemistry, engineering, biology and medicine. This conference focuses on the latest developments in both MR methodology and applications, providing a unique venue for exchanging ideas and developing collaborations. Young investigators and students are particularly encouraged to apply. In addition to the invited talks and poster presentations, the Hot Topics presentations - selected from the submitted abstracts - provide for inclusion of late-breaking developments. Topics to-be-covered include, but are not limited to: novel approaches for creating, detecting, and localizing the MR signal; applications of in vivo spectroscopy in disease and basic studies of metabolism; physical, chemical and biological mechanisms that affect the MR signal in vivo; development of new agents and approaches for manipulating the MR signal and contrast; functional MRI to study activation, blood flow and metabolism; and cellular function, from metabolism to gene expression to migration.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff / Welcome by Chair, Risto Kauppinen
7:40 pm - 9:30 pmFUTURE MR - LIGHTER AND FASTER
Discussion Leader: Peter Luijten (Utrecht University Medical Centre, Utrecht, Holland)
7:40 pm - 8:20 pmKlaas Pruessmann (ETH, Zurich, Switzerland)
"Mind the field: the promise of dynamic magnetometry for in vivo MR"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pmMark Griswold (Case Western Reserve University, Cleveland, OH, USA)
"Breaking the speed limits of MRI"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmADVANCES IN MR HARDWARE AND SIGNAL ENCODING
Discussion Leader: Tommy Vaughan (University of Minnesota, Minneapolis, MN, USA)
9:00 am - 9:40 amLawrence Wald (Martinos Imaging Center, Boston, MA, USA)
"Parallel transmit hardware, pulse design and SAR considerations for shaped excitations"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amAndrew Kiruluta (Harvard University, Boston, MA, USA)
"Traveling wave MR: From momentum in space to holography and beyond"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmMaxim Zaitsev (University of Freiburg, Germany)
"PatLoc: New approaches to spatial encoding in MRI"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmPUSHING THE LIMITS OF SPATIAL RESOLUTION
Discussion Leader: Greg Stanisz (Sunnybrook Health Sciences Center, Toronto, Canada)
7:30 pm - 8:10 pmRussel Jacobs (Caltech, Pasadena, CA, USA)
"Microscopic MRI: compromises, qualifications and applications in small animal imaging"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmChristian Degen (MIT, Boston, MA, USA)
"Nanoscale magnetic resonance imaging by force microscopy"
9:10 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMRS: FROM MICE TO MAN
Discussion Leader: Alena Horska (Johns Hopkins University, Baltimore, MD, USA)
9:00 am - 9:40 amJullie Pan (Yale University, New Haven, CT, USA)
"Developments in ultra high field MR: evaluating the human brain in health and disease"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amGulin Oz (University of Minnesota, Minneapolis, MN, USA)
"High field MR spectroscopy in spino-cerebellar ataxias: from mice to man"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmPratip Bhattacharya (Huntington Medical Research Institutes, Pasadena, CA, USA)
"Imaging tricarboxylic acid cycle metabolism in vivo by hyperpolarized 13C succinate"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmMAGNETIC PARTICLES AND NOVEL IMAGING APPLICATIONS
Discussion Leader: Chrit Moonen (University of Bordeaux, France)
7:30 pm - 8:10 pmBernhard Gleich (Philips Healthcare, Hamburg, Germany)
"Magnetic Particle Imaging"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmAlan Koretsky (NINDS, Bethesda, USA)
"Micron scale particles for tracking new neurons in the rodent brain"
9:10 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPRECLINICAL ADVANCEMENTS IN MR: NOVEL CONTRASTS AND BIOLOGICAL TARGETS
Discussion Leader: Timothy Duong (University of Texas, San Antonio, TX, USA)
9:00 am - 9:40 amKlaas Nicolay (Technical University of Eindhoven, Holland)
"Visualising the invisible: Is molecular and cellular MRI there to stay?"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amOlli Gröhn (University of Eastern Finland, Kuopio, Finland)
"Applications of spin-lock MRI contrast in vivo"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmRichard Carano (Genentech, South San Francisco, CA, USA)
"MRI of tumor angiogenesis: from mice to man"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmHOT TOPICS SESSION
Discussion Leader: Joel Garbow (Washington University, St Louis, MO, USA)
7:30 pm - 7:40 pmKarin Shmueli (NIH, Bethesda, MD, USA)
"Chemical Exchange as a Source of MRI Frequency Contrast in Brain"
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pmYong Chen (Case Western Reserve University, Cleveland, OH, USA)
"Functional Improvement in Stem Cell Treated Hearts after Myocardial Infarction Is Associated with Preserved Myofiber Structure"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:10 pmAlan Jasanoff (MIT, Boston, MA, USA)
"Engineered Protein-Based Neurotransmitter Sensors for Molecular-Level fMRI"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pmOvidiu Andronesi (MGH/Harvard Medical School, Boston, MA, USA)
"Multivoxel 2D Chemical Shift Correlation MR Spectroscopy of the Human Brain Using Low Power Adiabatic Pulses and Fast Spiral Spectroscopic Imaging"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pmYi Zhang (UT Health Science Center, San Antonio, TX, USA)
"Anatomical, Blood-Flow, and BOLD MRI of the Human Retina"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pmSilvia Mangia (University of Minnesota, Minneapolis, MN, USA)
"Non-BOLD isochronous mechanisms can substantially contribute to fMRI signals: a theoretical investigation"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmProdromos Parasoglou (New York University School of Medicine, NY, USA)
"In Utero Imaging of Vascular Development in the Mouse"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmPhillip Zhe Sun (MGH/Harvard Medical School, Boston, MA, USA)
"pH-Weighted MRI of Ischemic Acidosis: From Animal Models to Acute Stroke Patients"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmADVANCING NEURO-MR TECHNIQUES
Discussion Leader: Karla Miller (FMRIB, University of Oxford, UK)
9:00 am - 9:40 amXiang He (Washington University, St Louis, MO, USA)
"Biophysical mechanisms of phase contrast in gradient echo MRI: theory and validation"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amPenny Anne Gowland (University of Nottingham, UK)
"Why MR signals from grey and white matter differ?"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmJeff Duyn (NINDS, Bethesda, MD, USA)
"Origin and use of spontaneous BOLD fMRI fluctuations"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pmAPPLIED MR METABOLOMICS
Discussion Leader: Sabrina Ronen (UCSF, San Francisco, CA, USA)
7:30 pm - 8:10 pmXin Yu (Case Western Reserve University, Cleveland, OH, USA)
"The metabolomics of normal and disease hearts"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmJoe Ackerman (Washington University, St Louis, MO, USA)
"Plantae vs. Homo Sapiens: Secrets to survival revealed by 31P NMR"
9:10 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The project described was supported by Award Number R13EB011782 from the National Institute Of Biomedical Imaging And Bioengineering. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Biomedical Imaging And Bioengineering or the National Institutes of Health.
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