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Lasers in Medicine and Biology
Gordon Research Conference

Dates

July 25-30, 2010

Location

Holderness School
Holderness, NH

Organizers

Chairs:
Lihong V. Wang & Christoph K. Hitzenberger

Vice Chairs:
Brian W. Pogue & Rudolf M. Verdaasdonk

Meeting Description

The Gordon Research Conference on Lasers in Medicine and Biology (GRC-LMB) will be held on July 25-30, 2010 at the Holderness School, Holderness, New Hampshire. The objective of this conference is to bring together researchers from academia, hospitals and clinics, national laboratories, and industries to jointly examine how new photonic technologies can bring progresses to medical practices, biological understandings, and pharmaceutical development. Biophotonics is the science and engineering of light with applications in medicine and biology. The advance in biophotonics is therefore always a multidisciplinary endeavor requiring inputs from physicists, chemists, engineers, biologists and clinicians. Physicists explore biomedical applications of fundamental optical principles. Chemists create optical sensors and probes. Engineers translate basic advances into practical devices. New optical techniques allow biologists to better investigate and model different physiological systems. Ultimately, better devices and biological insights enable clinicians to develop new therapies and cures for patients.

This multidisciplinary approach is now bearing fruits in many fronts: microscopy and nanophotonics have enhanced our understanding of the normal physiology from cellular to organ level and our understanding of pathological physiology in disease such as angiogenesis in tumors; diffusive optical tomography allows better understanding of our cognition as well as provides insight into origin of diseases such as migraine headache; photoacoustic tomography improves the spatial resolution of diffuse optical tomography by combining light with ultrasound; optical spectroscopic assays based on light absorption, scattering, and endogenous luminescence signals has allowed continuous monitoring of tissue oxygenation and potentially allow non-invasive diagnosis of diseases such as cancer and atherosclerosis. Most importantly, a number of photonic techniques have successfully translated into the clinics and becoming standard methods of care for some patients including the treatment of some malignant lesions by photodynamic therapy and the diagnosis of glaucoma and macular degeneration by optical coherence tomography.

Nine technical sessions are scheduled to provide a broad and comprehensive coverage of the biophotonics field while giving in depth examination of several rapidly developing subfields. The titles of the sessions include Nerve stimulation and neural imaging, Microscopy, Therapy and manipulation, Photoacoustic microscopy and computed tomography, Diffuse optical imaging and spectroscopy, Optical coherence tomography, Contrast agents, Phase conjugation and super-resolution microscopy, and Microscopic endoscopy and cytometry in vivo.

The GRC-LMB has been held biannually since 1960s and is one of the longest running meetings of our field. This meeting has served the biophotonics field in two important ways ever since. First, this meeting is routinely attended by most of the leading researchers of this field. The presentations of these experts always emphasize ongoing and unpublished works. Therefore, this conference serves as a vehicle where the biophotonics community can come together to identify the most promising future directions and jointly tackle the most difficult obstacles. Second, unlike many meetings that are attended by predominately senior researchers, many of the attendees of the conference are junior researchers, consisting of graduate students and postdoctoral fellows. The Gordon Conference brings together senior and junior researchers in a convivial environment that encourages in depth scientific exchanges. The conference is further organized such that oral presentations from senior researchers are followed with an ample and lively question-and-discussion period with the meeting participants. Finally, all junior meeting attendees participate in poster presentation where they can discuss their ongoing work with leaders of the field as well as their peers.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:45 pmWelcome / Introductory Comments by GRC Site Staff
7:45 pm - 9:30 pmNerve stimulation and neural imaging
Discussion Leader: E. Duco Jansen (Vanderbilt University)
7:45 pm - 8:10 pm Claus-Peter Richter (Northwestern University)
"Infrared nerve stimulation"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Elizabeth Hillman (Columbia University)
"Optical neuroimaging"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Christopher Fang-Yen (Harvard University)
"Optical spatiotemporal control of neural activity in freely moving animals"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pmMicroscopy
Discussion Leader: Emmanuel Beaurepaire (Ecole Polytechnique, France)
9:00 am - 9:30 am Chris Xu (Cornell University)
"Technologies for deep tissue multiphoton microscopy"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Sunny Xie (Harvard University)
"Raman microscopy"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Tony Wilson (Oxford University)
"Confocal microscopy"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Ricky Wang (Oregon Health & Science University)
"Optical microangiography: label-free visualization and quantification of microcirculations in vivo"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTherapy and manipulation
Discussion Leader: Steve Jacques (Oregon Health & Science University)
7:30 pm - 7:55 pm Alfred Vogel (University of Lübeck, Germany)
"Femtosecond and nanosecond laser nanosurgery: new perspectives for controlled nonlinear energy deposition"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Ed Boyden (MIT)
"Optogenetics: Targeted Control of Brain Circuits With Light"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Katarina Svanberg (Lund University, Sweden)
"Clinical advances in PDT"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhotoacoustic microscopy and computed tomography
Discussion Leader: Mark Anastasio (Illinois Institute of Technology)
9:00 am - 9:30 am Konstantin Maslov (Washington University in St. Louis)
"3D photoacoustic microscopy"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Paul Beard (University College London, UK)
"Optical-detection PAT"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Michael Pashley (Philips Research USA)
"Breast PAT"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Alexander A. Oraevsky (Fairway Medical Technologies, Inc.)
"Challenges and merits of optoacoustic tomography"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDiffuse optical imaging and spectroscopy
Discussion Leader: Quing Zhu (University of Connecticut)
7:30 pm - 7:55 pm Bruce Tromberg (University of California, Irvine)
"Monitoring of chemotherapy"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Martin van der Mark (Philips Research Europe, The Netherlands)
"Diffuse optical spectroscopy"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Ozzy Mermut (National Optics Institute, Canada)
"Using hybridized magneto-optic effects on luminescence for molecular imaging"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOptical coherence tomography
Discussion Leader: Maciej Wojtkowski (Nicolaus Copernicus University, Poland)
9:00 am - 9:30 am James G. Fujimoto (MIT)
"High-speed OCT"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Yoshiaki Yasuno (University of Tsukuba, Japan)
"Multi-contrast OCT of human eye"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Michael Pircher (Medical University of Vienna, Austria)
"Cellular resolution SLO/OCT for retinal imaging"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Stephen Boppart (University of Illinois at Urbana-Champaign)
"Novel diagnostic optical coherence imaging techniques"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmContrast agents
Discussion Leader: Samuel Achilefu (Washington University in St. Louis)
7:30 pm - 7:55 pm Xiaohu Gao (University of Washington)
"Development of multimodality imaging probes"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Younan Xia (Washington University in St. Louis)
"Gold nanocages: a new platform for cancer diagnosis and treatment"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Hisataka Kobayashi (National Institutes of Health)
"Activatable molecular probes for cancer diagnosis"
9:15 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmPhase conjugation and super-resolution microscopy
Discussion Leader: Irene Georgakoudi (Tufts University)
9:00 am - 9:30 am David Williams (University of Rochester)
"Adaptive optics imaging of the retina"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Changhuei Yang (Caltech)
"The science and applications of time-reversal based tissue turbidity suppression"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Xiaowei Zhuang (Harvard University)
"STORM: super-resolution microscopy"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Sam Hess (University of Maine)
"fPALM: super-resolution microscopy"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMicroscopic endoscopy and cytometry in vivo
Discussion Leader: Xingde Li (Johns Hopkins University)
7:30 pm - 7:55 pm Guillermo Tearney (MGH, Harvard Medical School)
"Spectral-encoded and OCT endoscopy"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Stanislav Emelianov (University of Texas at Austin)
"Intravascular photoacoustic imaging"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pm Charles Lin (MGH, Harvard Medical School)
"In vivo cytometry"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:30 pmPoster awards; LMB Traditional "Awards"; Closing remarks
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible, in part by 1 R13 EB011768-01 from the National Institute of Biomedical Imaging and Bioengineering and the National Cancer Institute. The views expressed in written conference materials or publications and by speakers or moderators do not necessarily reflect the official policies of the Department of Health; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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