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Lipoprotein Metabolism
Lipid and Lipoprotein Metabolism in Health and Disease
June 20-25, 2010
Waterville Valley Resort
Waterville Valley, NH
Chair:
Ira Tabas

Vice Chair:
Robert O. Ryan

The Gordon Research Conference on Lipoprotein Metabolism is one of the long standing conferences in the GRC's 78 year history. The scientific content of our conference has continually evolved since the first meeting and it is traditionally the forum in our discipline for the presentation of high impact leading edge science. The program for the 2010 Conference on Lipoprotein Metabolism will communicate new and exciting advances in the field and will bring together a range of established investigators, new investigators, and trainees from around the world to present and discuss a spectrum of topics related to new developments in lipid and lipoprotein metabolism, particularly in those areas that impact upon human disease. Basic molecular and cell biological studies, animal models of metabolism, and genetic studies in humans will be presented. The topics include metabolism and clearance of triglyceride-rich lipoproteins; HDL and ABC transporters; cellular sterol trafficking and metabolism; the function of lipoproteins, apolipoproteins, and their receptors in the brain; cellular mechanisms and therapeutic potential related to LDL receptor regulation; lipid droplets and cellular lipid metabolism; therapeutic approaches to improving plasma lipoprotein profile; and hepatic lipid and lipoprotein metabolism. In addition, there will be a special keynote session on Thursday evening featuring two world-renowned National Academy of Science members discussing their work on new discoveries in lipid metabolism. In addition to outstanding leading-edge lectures and discussion, poster presentations represent an integral part of the scientific program. Additional Oral Sessions will be selected from among submitted abstracts.

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMetabolism and Clearance of Triglyceride-Rich Lipoproteins
Discussion Leader: Steve Young (University of California, Los Angeles)
7:40 pm - 8:00 pmSteve Young (University of California, Los Angeles)
"Mechanisms of Clearance of TG-Rich Lipoproteins"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmRobert Ryan (Children's Hospital Oakland Research Institute)
"Mechanisms of TG Lowering by Apo-AV"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmKevin Williams (Temple University)
"The Dysregulation of Remnant Lipoprotein Receptors in Diabetes Mellitus"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pmJeff Esko (University of California, San Diego)
"Proteoglycans and Lipoproteins: What They Do and Don't Do"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLipid Droplets and Cellular Lipid Metabolism
Discussion Leader: Robert Farese, Jr (Gladstone Institute, University of California, San Francisco)
9:00 am - 9:20 amRobert Farese, Jr (Gladstone Institute, UCSF)
"Recent Insights into Lipid Droplet Biology"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amMichael Czech (University of Massachusetts)
"Regulation of Energy Metabolism by Lipid Droplet Proteins"
9:50 am - 10:00 am Discussion
10:00 am - 10:15 am Monika Oberer (University of Graz)
"The N-Terminal Region of Comparative Gene Identification-58 (Cgi-58) is Important for Lipid Droplet Binding and Activation of Adipose Triglyceride Lipase"
10:15 am - 10:30 am Group Photo / Coffee Break
10:30 am - 10:50 amDawn Brasaemle (Rutgers University)
"Lipid Droplet Associated Proteins and the Control of Triacylglycerol Metabolism"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amSepp Kohlwein (University of Graz)
"The Good, the Bad and the Ugly - Fat Insights from Yeast"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Wilhelm Palm (Max Planck Institute of Molecular Cell Biology)
"Drosophila Lipophorin Requires Different Lipid Transfer Proteins for the Uptake of Dietary and Endogenous Lipids"
11:45 am - 12:05 pmMichael Welte (Rochester University)
"Fat, Flies and Videotape: Intracellular Motility of Lipid Droplets"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmLipoproteins and Cells: Cellular Sterol Trafficking and Metabolism
Discussion Leader: Fred Maxfield (Weill-Cornell Medical College)
7:30 pm - 7:50 pmFred Maxfield (Weill-Cornell Medical College)
"Cellular Sterol Trafficking and Metabolism"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmElina Ikonen (University of Helsinki)
"The Role of Rab Proteins and Cholesterol Efflux"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmRussell Debose-Boyd (University of Texas Southwestern Medical Center)
"Cholesterol homeostasis and ER-associated degradation of HMG CoA reductase"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmTY Chang (Dartmouth University)
"ACAT1 in Atherosclerosis and Alzheimer's Disease"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHDL and ABBC Transporters
Discussion Leader: Alan Tall (Columbia University)
9:00 am - 9:20 amAlan Tall (Columbia University)
"HDL, ABC Transporters, and the Regulation of Myeloid Cell Proliferations"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amMary Sorci Thomas (Wake Forest University)
"ApoA-I Structure and Function: Regulation of Cholesterol Homeostasis and Inflammation"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amCarlos Fernandez-Hernando (New York University)
"Control of Lipoprotein Metabolism by MicroRNA"
10:20 am - 10:30 am Discussion
10:30 am - 10:45 am Coffee Break
10:45 am - 11:05 amJay Heinecke (University of Washington)
"HDL Regulates Novel Macrophage Inflammatory Pathways"
11:05 am - 11:15 am Discussion
11:15 am - 11:30 am Soonkyu Chung (Wake Forest University)
"Adipocyte Specific Deletion of ABCA1 Decreases HDL-C but Induces Adipocyte Cholesterol Accumulation"
11:30 am - 11:50 amDan Rader (University of Pennsylvania)
"Lipoprotein Genetics and CAD in Humans"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmMarge Connelly (Johnson & Johnson)
"Endothelial Lipase, a Therapeutic Target for Raising HDL and Potentially Reducing CV risk"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmTherapeutic Approaches to Improving Plasma Lipoprotein Profile
Discussion Leader: Dan Rader (University of Pennsylvania)
7:30 pm - 7:50 pmAndy Taggart (Merck)
"What can novel niacin receptor agonists tell us? Lessons from preclinical and clinical studies"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmMargrit Schwartz (Amgen)
"PCSK9-Based Therapeutic Approaches to Lowering Plasma LDL"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmRosanne Crooke (Isis)
"Antisense Inhibition of Lipoproteins: From Bench to Clinic"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmHarry (Chip) Davis (Merck)
"Drug Discovery Challenges in Developing Novel Treatments for Dyslipidemia: Compensatory Mechanisms"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLipoproteins, Lipids, and the Brain
Discussion Leader: Cheryl Wellington (University of British Columbia)
9:00 am - 9:20 amCheryl Wellington (University of British Columbia)
"Central Nervous System Lipoproteins in Brain Health and Diseases"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amBill Rebeck (Georgetown University Medical Center)
"Lipid Redistribution in Chronic And Acute Brain Injuries"
9:50 am - 10:00 am Discussion
10:00 am - 10:15 am Joanna Karasinska (University of British Columbia)
"ABCA1 Influences Neuroinflammation and Susceptibility to Neuronal Death"
10:15 am - 10:30 am Coffee Break
10:30 am - 10:50 amGary Landreth (Case Western Reserve University School of Medicine)
"Roles of ApoE in the Pathogenesis of Alzheimer's Disease"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amJoachim Herz (University of Texas Southwestern Medical Center)
"ApoE Receptors - A New Class of Synaptic Signal Modulators"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Junichi Takagi (Osaka University)
"Ligand Binding Mechanism of Lipoprotein Receptor Family Proteins Revealed by Three-Dimensional Structure Analyses"
11:45 am - 12:05 pmGuojun Bu (Washington University School of Medicine)
"ApoE Receptor LRP1 in Brain Lipid Metabolism and Synaptic Functions"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmRegulation of Hepatic LDL Receptors and Plasma LDL
Discussion Leader: Jonathan Cohen (University of Texas Southwestern Medical Center)
7:30 pm - 7:50 pmJonathan Cohen (University of Texas Southwestern Medical Center)
"PCSK9, LDL Receptors, and Coronary Artery Disease"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmPeter Michaely (University of Texas Southwestern Medical Center)
"Lipoprotein-Specific Pathways of LDL Receptor Mediated Uptake"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmSek Kathiresan (Harvard University)
"From DNA Sequence Variant to Lipoprotein Phenotype at the Sortilin Locus"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmAnders Nykjaer (Aarhus University)
"Sortilin, a Novel Regulator of Hepatic Lipoprotein Production"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHepatic Lipid and Lipoprotein Metabolism
Discussion Leader: Jay Horton (University of Texas Southwestern Medical Center)
9:00 am - 9:20 amJay Horton (University of Texas Southwestern Medical Center)
"Molecular Mediators of Hepatic Steatosis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amHenry Ginsberg (Columbia University)
"Hepatic Steatosis - How Many Ways Can You Fill The Liver With Fat?"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amPeng Li (Tsinghua University, Beijing)
"Cide Proteins in Lipid Storage and Secretion"
10:20 am - 10:30 am Discussion
10:30 am - 10:45 am Coffee Break
10:45 am - 11:05 amEd Fisher (New York University Medical School)
"The Role of Autophagy in Hepatic Lipoprotein Secretion"
11:05 am - 11:15 am Discussion
11:15 am - 11:30 am Jorge Caviglia (Columbia University)
"Different Fatty Acids Regulate Hepatic Apolipoproteinb100 Secretion by Different Mechanisms: Endoplasmic Reticulum Stress, Ceramides, and Lipid Peroxidation"
11:30 am - 11:50 amMurray Huff (University of Western Ontario)
"ApoB Overproduction and Hyperinsulinemia: Regulation by Flavanoids"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmRob Hegele (University of Western Ontario)
"Genetic Insights into Hypertriglyceridemia and Triglyceride Clearance"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:10 pmKEYNOTE SESSION: New Discoveries in Lipid Metabolism
Discussion Leaders: Ira Tabas (Columbia University) & Jay Horton (University of Texas Southwestern Medical Center)
7:30 pm - 8:10 pmLaurie Glimcher (Harvard University)
"Transcription Factors that Control Lipogenesis"
Lecture in Honor of the Journal of Lipid Research 50th Anniversary
8:10 pm - 8:20 pm Discussion
8:20 pm - 9:00 pmMorris White (Harvard University)
"Regulation of hepatic mitochondrial function by the insulin-like signaling cascade"
9:00 pm - 9:10 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this conference was made possible (in part) by 1 R13 HL 102895-01 from the National Institutes of Health, National Heart, Lung & Blood Institute.
Last Updated: July 22, 2010
 
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