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Lysosomes & Endocytosis
Gordon Research Conference

Dates

June 20-25, 2010

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Frances Brodsky

Vice Chair:
Michael Marks

Meeting Description

The Gordon Research Conference on Lysosomes and Endocytosis covers recent advances in understanding the function of the endocytic pathway and lysosomes. Endosomes and lysosomes play important roles in the physiology of cells and organisms. Many inherited and somatic diseases result from defects in endocytic and lysosomal pathways. Some pathogens are destroyed by these pathways, while others subvert their function during infection. Moreover, these pathways play key roles in both the stimulation and implementation of immune responses. Recent developments reveal that endocytosis and endocytic organelles play critical roles in controlling oncogenesis, glucose metabolism and muscle and stem cell development.

Topics of focus for the 2010 meeting include molecular mechanisms and cell biology of endocytic and degradative pathways, as well as their role in human health and disease. Sessions will cover molecular features of endocytic membrane traffic such as coat formation, lipid regulation and motor activity, and cell physiology including endosomal and lysosomal membrane traffic, autophagy and lysosomal secretion. Other sessions will focus on the roles of endocytic pathways in infection and immunity, cancer, diabetes and muscle disease. The conference will continue to feature a session on 'New Directions' in which novel technical and conceptual developments in the field will be discussed.

The meeting will be divided into nine half-day sessions, comprising a mixture of invited speakers and those selected from abstracts. Attendance by under-represented minorities, students, postdoctoral fellows, junior faculty, and faculty from primarily undergraduate institutions is encouraged. If you are a student or postdoctoral researcher, it is very important to identify the principal investigator of your laboratory in your application. This conference is usually oversubscribed, so early application is advised with a suggested deadline of April 1, 2010, after which the conference may be filled. Applications received after the conference is full will be assigned to a waiting list.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmDIABETES, MUSCLE AND METABOLISM
Discussion Leader: Phil Stahl (Washington University)
7:40 pm - 8:00 pmTimothy McGraw (Cornell Medical College)
"Insulin-regulated membrane trafficking"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmNia Bryant (University of Glasgow)
"Insulin-regulated trafficking of GLUT4 in adipocytes; lessons from yeast"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmAmira Klip (University of Toronto)
"Rab molecules and actin dynamics regulating GLUT4 traffic"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pmElizabeth McNally (University of Chicago)
"IGF receptor recycling in muscle growth"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTRAFFICKING MECHANISMS
Discussion Leaders: Greg Payne (UCLA) and Linton Traub (University of Pittsburgh)
9:00 am - 9:20 amJim Hurley (NIDDK)
"Its all in the neck: How the ESCRTs make multivesicular bodies"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amSandy Schmid (The Scripps Research Institute)
"Dynamin-catalyzed membrane fission"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Mary Munson (University of Massachusetts)
"SNARE regulation by Sec1/Munc18 proteins"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amMark von Zastrow (UCSF)
"Hierarchical sorting of signaling receptors in the endocytic pathway"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amPaolo DiFiore (IFOM)
"A ubiquitin threshold controls non-clathrin EGFR endocytosis"
11:50 am - 12:00pm Discussion
12:00 pm - 12:20 pmPietro DeCamilli (Yale University)
"Phosphoinositide metabolism in the endocytic pathway"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLIPIDS AND CAVEOLAE
Discussion Leader: Beverly Wendland (Johns Hopkins University)
7:30 pm - 7:50 pmLudger Johannes (Institut Curie)
"Mechanisms of domain construction driving endocytic membrane invagination and scission"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmRob Parton (IMB, University of Queensland)
"New insights into the formation and function of caveolae"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmJitu Mayor (NCBS)
"Endocytic trafficking of GPI-anchored proteins, a class of lipid-tethered extrafacial proteins: a tale of surprises"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmSergio Grinstein (University of Toronto)
"Signaling phagocytosis: receptors and phosphoinositides"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPATHOGENESIS AND IMMUNITY
Discussion Leaders: Mark Marsh (MRC, University College London) & Graça Raposo (Institut Curie, Paris)
9:00 am - 9:20 amPaul Lehner (CIMR, Cambridge University)
"Viral downregulation of cell surface receptors"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amThierry Soldati (University of Geneva)
"Mycobacteria interference with host membrane traffic and cytoskeleton"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amPascale Cossart (Pasteur Institute)
"What Listeria teaches us about endocytosis, phagocytosis and trafficking"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 am Olivia Steele-Mortimer (Rocky Mountain Labs, NIH)
"Escape from the vacuole is an important step for intracellular Salmonella"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 amMike Brenner (Harvard Medical School)
"Arl8 directs lysosomal trafficking"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 amMarco Sardiello (TIGEM, Italy)
"Discovery of a gene network regulating lysosomal biogenesis and function"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmVojo Deretic (University of New Mexico)
"Autophagy and autolysosomes in health and disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLYSOSOMAL TRAFFIC, RELATED ORGANELLES AND AUTOPHAGY
Discussion Leader: Victor Faundez (Emory University)
7:30 pm - 7:50 pmDan Cutler (MRC, University College London)
"Formation and function of Weibel-Palade bodies, LROs of endothelial cells"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmEsteban Dell’Angelica (UCLA)
"Biogenesis of lysosome-related organelles in Drosophila"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmMarkus Babst (University of Utah)
"Starvation-response regulates the MVB pathway"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmAna Maria Cuervo (Albert Einstein College of Medicine)
"Chaperone-mediated autophagy: crossing the lysosomal membrane for final destruction"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSORTING PATHWAYS
Discussion Leaders: Liz Conibear (University of British Columbia) & Chris Burd (University of Pennsylvania)
9:00 am - 9:20 amRob Piper (University of Iowa)
"Ubiquitin recognition on endosomes"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amJean Gruenberg (University of Geneva)
"Dynamics of membranes in the endosomal lumen"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Tom Stevens (University of Oregon)
"Golgi/Endosomal Sorting of the Yeast V-ATPase Complexes"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amAlexander Sorkin (University of Pittsburgh)
"Role of ubiquitination in EGF receptor endocytosis"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Peter Cullen (University of Bristol, UK)
"Sorting nexins and retrograde endosome-to-Golgi transport"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Doug Boettner (University of Miami)
"A genome-wide screen suggests a mechanism for the clathrin light chain regulation of Sla2 (Hip1/R) during endocytosis"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmScott Emr (Cornell University)
"Arrestin-related adaptors required for PM protein endocytosis and down-regulation"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmNEW DIRECTIONS (PART I)
Discussion Leader: Mickey Marks (University of Pennsylvania)
7:30 pm - 7:50 pmBridget Wilson (University of New Mexico)
"High resolution imaging captures details of receptor diffusion, clustering and internalization"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmMarta Miaczynska (International Institute of Molecular and Cell Biology)
"Endocytic proteins in the regulation of transcription"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Gerard Apodaca (University of Pittsburgh)
"Integrin- and RhoA-dependent compensatory endocytosis in bladder umbrella cells"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Steve Royle (University of Liverpool, UK)
"The mitotic function of clathrin: stabilisation of kinetochore fibres by intertubule bridges"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmJennifer Lippincott-Schwartz (NICHD, NIH)
"Autophagosome biogenesis during starvation"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMIGRATION, MOTORS AND MORE
Discussion Leaders: Jim Keen (Thomas Jefferson University) & Julie Donaldson (National Institutes of Health)
9:00 am - 9:20 amJon Cooper (Fred Hutchinson Cancer Research Center)
"Clathrin-binding endocytic adaptors and cell migration"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amHarald Stenmark (Institute for Cancer Research)
"Endosomal sorting in control of cell signalling and migration"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Trina Schroer (Johns Hopkins University)
"Characterization of dynactin's cargo-binding domain"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amLois Weissman (Life Sciences Institute)
"A new view of how myosin V attaches to cargoes"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Joel Ybe (Indiana University)
"Structure of the clathrin trimerization domain reveals features of clathrin light chain function"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Lauren Jackson (CIMR, Cambridge, UK)
"Structure and function of AP2 at the plasma membrane"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmMiguel Seabra (Imperial College London)
"Mechanisms of Rab GTPase-dependent disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:20 pmNEW DIRECTIONS (PART II)
Discussion Leader: Frances Brodsky (UCSF)
7:30 pm - 7:45 pm Wouter den Otter (University of Twente, NL)
"Simulations of clathrin cage assembly"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:00 pm Phil Robinson (Children's Medical Research Institute)
"Building a better dynasore: A toolbox of mechanistically distinct dynamin inhibitors"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:15 pm Volker Haucke (Free University of Berlin, Germany)
"Pitstops, novel small molecule inhibitors of clathrin function and effects on synaptic vesicle recycling"
8:15 pm - 8:20 pm Discussion
8:20 pm - 9:30 pmKEYNOTE LECTURE: (In Honor of Alex Novikoff)
8:20 pm - 8:35 pmIntroduction and History
8:35 pm - 9:20 pmNorma Andrews (University of Maryland)
"The Secret Life of Lysosomes"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by R13 GM084519 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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