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Conference Program
 
Microbial Stress Response
July 18-23, 2010
Mount Holyoke College
South Hadley, MA

The 2010 Gordon Research Conference on Microbial Stress Responses provides an open and exciting forum for the exchange of scientific discoveries on the remarkable mechanisms used by microbes to survive in nearly every niche on the planet. Understanding these stress responses is critical for our ability to control microbial survival, whether in the context of biotechnology, ecology, or pathogenesis. From its inception in 1994, this conference has traditionally employed a very broad definition of stress in microbial systems. Sessions will cover the major steps of stress responses from signal sensing to transcriptional regulation to the effectors that mediate responses. A wide range of stresses will be represented. Some examples include (but are not limited to) oxidative stress, protein quality control, antibiotic-induced stress and survival, envelope stress, DNA damage, and nutritional stress. The 2010 meeting will also focus on the role of stress responses in microbial communities, applied and environmental microbiology, and microbial development. This conference brings together researchers from both the biological and physical sciences investigating stress responses in medically- and environmentally relevant microbes, as well as model organisms, using cutting-edge techniques. Computational, systems-level, and biophysical approaches to exploring stress responsive circuits will be integrated throughout the sessions alongside the more traditional molecular, physiological, and genetic approaches. The broad range of excellent speakers and topics, together with the intimate and pleasant setting at Mount Holyoke College, provide a fertile ground for the exchange of new ideas and approaches.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmControl of Stress-Responsive Gene Expression
Discussion Leader: Amy Vollmer (Swarthmore College)
7:40 pm - 8:20 pmSusan Gottesman (National Cancer Institute)
"Integrating multiple inputs to regulate RpoS synthesis: sRNAs and antiadaptors"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:50 pmRichard Gourse (University of Wisconsin-Madison)
"The original stress response: Control of rRNA and other promoters by DksA, NTPs, and ppGpp"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmSunney Xie (Harvard University)
"Single-cell E. coli proteome and transcriptome with single-molecule sensitivity"
9:20 pm - 9:30 pm Discussion
9:30 pm Reception, Willits-Hallowell Conference Center
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pmSignal Sensing and Processing
Discussion Leader: Mark Goulian (University of Pennsylvania)
9:00 am - 9:25 amRegine Hengge (Freie Universität Berlin)
"Role of the small regulatory RNA RprA in the RpoS/CsgD/Rcs biofilm control network of E. coli"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Hendrik Szurmant (Scripps Institute)
"Resolution of Protein Domain Complexes that Drive Bacterial Signaling"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 am Stefan Klumpp (Max Planck Institute of Colloids and Interfaces)
"Growth-rate dependent global effects on gene expression in bacteria"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:10 amMichael Laub (MIT)
"Post-transcriptional regulation of the Caulobacter cell cycle"
11:10 am - 11:15 am Discussion
11:15 am - 11:40 amEduardo Groisman (Washington University, Saint Louis)
"RNA-mediated control of magnesium homeostasis"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Peter Lund (University of Birmingham)
"High throughput methods shed light on how E. coli senses and responds to acid stress"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Anna Staron (Ludwid-Maximilians-Univeristy Munich)
"The LsdRS-AB and BceRS-AB Detoxification Modules: Specificity and Insulation in Sensing Peptide Antibiotics"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Tim Miyashiro (University of Wisconsin, Madison)
"Examining the evolutionary context of small RNAs in a quorum-sensing pathway"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMicrobial Communities and Interactions with the Environment
7:30 pm - 7:40 pmDiscussion Leader: John Kirby (University of Iowa)
Introduction
7:40 pm - 8:05 pmCameron Currie (University of Wisconsin-Madison)
"Bacterial mediation of insect-fungal mutualisms"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Julie Segre (NHGRI, Bethesda)
"Genomic Examination of the Human Skin Microbiome"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmGeorge O’Toole (Dartmouth)
"To Build a Biofilm"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pmErik Zinser (University of Tennessee)
"Heterotrophic bacteria protect the marine cyanobacterium, Prochlorococcus, from oxidative damage"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Damage Control
Discussion Leader: Tim Donohue (University of Wisconsin-Madison)
9:00 am - 9:25 amHeran Darwin (New York University)
"Proteolysis and Pathogenesis by M. tuberculosis"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 amTania Baker (MIT)
"Interplay between the sHSPs and the AAA+ Proteases in Protein Quality Control"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 am William Navarre (University of Toronto)
"PoxA, YjeK and Elongation Factor P Coordinately Modulate Resistance to Multiple Unrelated Stressors"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:10 amJulie Maupin-Furlow (University of Florida)
"Ubiquitin-like Small Archaeal Modifier Proteins (SAMPs) and their Conjugation to Proteins in Haloferax volcanii"
11:10 am - 11:15 am Discussion
11:15 am - 11:40 amMiroslav Radman (Université Paris Descartes)
"Desiccation and radiation stress responses in bacteria"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Marion Dorer (Fred Hutchinson Cancer Research Institute)
"DNA damage triggers genetic exchange in Helicobacter pylori"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Cari Vanderpool (University of Illinois at Urbana-Champaign)
"A dual-function small RNA regulator coordinates a metabolic stress response"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Tinya Fleming (UCSD)
"Dynamic assembly of the DNA translocase SpoIIIE around trapped DNA"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmCell Shape, Development, and Growth
7:30 pm - 7:40 pmDiscussion Leader: Alan Grossman (MIT)
Introduction
7:40 pm - 8:05 pmThomas Bernhardt (Harvard University)
"Cognate lipoprotein-PBP complexes are required for peptidoglycan biogenesis in Escherichia coli"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmMarie Elliot (McMaster University)
"Dormancy and resuscitation: the role of cell wall remodeling in Streptomyces coelicolor"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmPetra Levin (Washington University, Saint Louis)
"A look across species: Carbon availability and cell size in E. coli and B. subtilis"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pmTeuta Pilizota (Princeton University)
"Bacteria regulate turgor pressure in order to grow"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Envelope Stress
Discussion Leader: Thorsten Mascher (Karlsruhe Institute of Technology)
9:00 am - 9:25 amDiego de Mendoza (Universidad Nacional de Rosario)
"The Molecular Logic of Cold Sensation in Bacillus"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Carol Gross (UCSF)
"Phenotypic landscape of a bacterial cell"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 am Christopher Hayes (UCSB)
"A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:10 amNatacha Ruiz (Princeton University)
"Downregulation of envelope stress responses by YdcQ"
11:10 am - 11:15 am Discussion
11:15 am - 11:40 amAndrew Darwin (New York University)
"The phage-shock-protein stress response: a very complicated simple system"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Kevin Devine (Trinity College, Dublin)
"Regulation of cell wall synthesis by the WalRK(YycFG) and PhoPR two-component systems in Bacillus subtilis"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm James Weisshaar (University of Wisconsin, Madison)
"Single-cell, real-time study of LL-37 antimicrobial attack on live E. coli cells"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Errett Hobbs (NIH)
"A small protein required for antibiotic resistance in E. coli interacts with the AcrAB-TolC efflux pump"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmStress in Applied and Environmental Microbiology
Discussion Leader: Steve Finkel (University of Southern California)
7:30 pm - 7:55 pm Steve Finkel (University of Southern California)
"Long-term survival and evolution in biofilms"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pmDianne Newman (Caltech)
"Microbial hopanoids: no longer biomarkers of oxygenic photosynthesis, but rather, of stress"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Thomas Bobik (Iowa State)
"Sequestration of toxic metabolites by bacterial microcompartments"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pmDavid Stahl (University of Washington)
"Divergent lifestyles and stress response of Desulfovibrio and Nitrosomonas species"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOxidative Stress
Discussion Leader: Tricia Kiley (University of Wisconsin-Madison)
9:00 am - 9:25 amUrsula Jakob (University of Michigan)
"Oxidative Stress and Redox Regulation"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 amChris Kaiser (MIT)
"How the ER Moderates Oxidative Stress"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 am Ivan Gusarov (NYU School of Medicine)
"Nitric Oxide protects Gram-positive bacteria against a wide spectrum of antimicrobials"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:10 amJohn Helmann (Cornell University)
"Diverse roles of bacillithiol in Bacillus subtilis stress responses"
11:10 am - 11:15 am Discussion
11:15 am - 11:40 amTim Donohue (University of Wisconsin-Madison)
"Convergence of bacterial transcriptional responses to heat shock and singlet oxygen stress"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Jiqiang Ling (Yale University)
"Oxidative stress induced protein mistranslation"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Jean Francois Collet (de Duve Institute, Université catholique de Louvain)
"A periplasmic system protecting single cysteine residues from oxidation"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Jeannette Winter (Technische Universitaet Muenchen)
"YjiE - a novel HOCl-responsive transcription factor that protects Escherichia coli from oxidative stress"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pmAntimicrobial Stress and Survival
Discussion Leader: Sarah Ades (The Pennsylvania State University)
7:30 pm - 7:55 pmJennifer Leeds (Novartis)
"Unraveling novel mechanisms of antibacterial activity - a case study"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Roy Kishony (Harvard University)
"Evolution in multi-drug environment"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pmTerry Hwa (UCSD)
"Intrinsic feedback between cell growth and antibiotic resistance: growth transition, persistence, and rapid evolution"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Keith Poole (Queen’s University)
"Multidrug efflux systems as components of stress responses in Pseudomonas aeruginosa: implications for in vivo recruitment of efflux mechanisms and promotion of multidrug resistance"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1R13AI088776-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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