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Microbial Toxins & Pathogenicity
July 11-16, 2010
Waterville Valley Resort
Waterville Valley, NH
Chair:
Joseph T. Barbieri

Vice Chair:
Ralph R. Isberg
Related Meeting Information
The Microbial Toxins & Pathogenicity Gordon Research Conference was held in conjunction with the Microbial Toxins & Pathogenicity Gordon Research Seminar. Please refer to the Microbial Toxins & Pathogenicity GRS web page for more information.

The 2010 Gordon Research Conference on Microbial Toxins and Pathogenicity is an outstanding forum to acquire cutting-edge knowledge on microbial pathogenesis. Conference organization includes seminars on the basic mechanisms of microbial pathogenesis, addressing primarily bacterial systems, with seminar sessions on toxin biochemistry and biogenesis, molecular and cellular pathogenesis, interactions of bacteria with plants and lower eukaryotes, and infection and immunity. Seminars will also be presented that translate knowledge of basic mechanisms into therapeutic advances. Speakers include both established and junior investigators. Seminar sessions are chaired by prominent researchers who will provide an overview of the session topic and place the speakers' work into the context of the session. Discussions provide an opportunity for the exchange of new ideas and perspectives. In addition to the seminar sessions, the conference includes well-attended and interactive poster sessions. The 2010 conference will be preceded by the Gordon Research Seminar (GRS) on Microbial Toxins and Pathogenicity. The GRS is planned by and for post-doctoral and pre-doctoral trainees who study microbial pathogenesis and provides an opportunity for our future leaders to present their research as seminars and posters in a collegial and interactive environment. Attendance at the GRS has added a great value to the Gordon Research Conference experience for these junior investigators.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKEYNOTE TALKS: MICROBIAL TOXINS AND PATHOGENICITY
7:40 pm - 7:50 pm Discussion Leader: John Mekalanos (Harvard Medical School)
7:50 pm - 8:25 pmPascale Cossart (Pasteur Institute)
"The intracellular bacterial pathogen Listeria monocytogenes: a multifaceted model"
8:25 pm - 8:40 pm Discussion
8:40 pm - 9:15 pmAlexander M. Cruickshank Lecture:
Jorge Galan (Yale School of Medicine)
"Interaction of Salmonella with host cells"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMECHANISMS OF TOXIN ACTION
9:00 am - 9:15 am Discussion Leader: Steve Blanke (University of Illinois-UC)
9:15 am - 9:40 amRodney Tweten (The University of Oklahoma Health Sciences Center)
"The Molecular Basis of Cellular Recognition by the Cholesterol- dependent Cytolysins"
9:40 am - 9:50 am Discussion
9:50 am - 10:15 amStephen Leppla (NIAID)
"Anthrax toxin receptor expression in specific tissues determines the susceptibility of mice to infection"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Group Photo / Coffee Break
10:50 am - 11:15 amKlaus Aktories (Albert-Ludwigs-Universität Freiburg)
"Actions of Photorhabdus luminescens toxins on the actin cytoskeleton"
11:15 am - 11:25 am Discussion
11:25 am - 11:50 amDara Frank (Medical College of Wisconsin)
"The Peculiar "Tail" of ExoU, a Bacterial A2 Phopholipase"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmC. Erec Stebbins (Rockefeller University School of Medicine)
"Diverse Virulence Uses for a Simple Catalytic Triad"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmINTERACTIONS OF BACTERIA WITH PLANTS AND LOWER EUKARYOTES
7:30 pm - 8:45 pm Discussion Leader: Joanne Engel (UC-San Francisco School of Medicine)
7:45 pm - 8:10 pmDavid Guttman (University of Toronto)
"Evolutionary Genomics of Innate Immunity Triggers"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmKaren Visick (Loyola University)
"Biofilms and colonization by Vibrio fischeri"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmRaffi Aroian (UC-San Diego)
"Pore-forming toxins and C. elegans: a "hole-istic" genome-wide approach to tackling cellular defenses against the largest class of bacterial virulence factors"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREGULATORY MECHANISMS OF BACTERIAL PATHOGENS
9:00 am - 9:15 am Discussion Leader: Scott Stibitz (FDA)
9:15 am - 9:25 amShelley Payne (University of Texas - Austin)
"Life in the intracellular environment: Shigella genes important for intracellular pathogenesis"
9:25 am - 9:50 am Discussion
9:50 am - 10:15 amD. Scott Merrell (Uniformed Services University)
"Role of the Helicobacter pylori Fur Regulatory Protein in Colonization and Virulence"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:15 amTheresa Koehler (University of Texas - Houston)
"Virulence Gene Regulation in Bacillus anthracis"
11:15 am - 11:25 am Discussion
11:25 am - 11:50 amMarcia Goldberg (Harvard Medical School)
"Mechanisms involved in the development of bacterial polarity"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmAimee Shen (Stanford School of Medicine)
"Probing the autoproteolytic activation of Clostridium difficile glucosylating toxins using small molecules"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmPATHOGENIC PROPERTIES OF MACROMOLECULAR MOLECULES
7:30 pm - 7:45 pm Discussion Leader: Michael Donnenberg (University of Maryland School of Medicine)
7:45 pm - 8:10 pmHungTon-That (University of Texas-Houston)
"Gram-positive pili: assembly and function"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Natalie Strynadka (University of British Columbia)
"Piecing together the Type III secretion system using structure-based approaches"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmWim Hol (University of Washington-Seattle)
"The fascinating properties and remaining mysteries of the Type 2 Secretion System"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCELLULAR MICROBIOLOGY
9:00 am - 9:15 am Discussion Leader: Beth McCormick (University of Massachusetts School of Medicine)
9:15 am - 9:40 amKirsten Sandvig (Institute for Cancer Research, Norway)
"Endocytosis and retrograde transport of Shiga toxin"
9:40 am - 9:50 am Discussion
9:50 am - 10:15 amJohn Leong (University of Massachusetts School of Medicine)
"Actin signaling by an extracellular pathogen promotes late-stage colonization"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:15 amTed Hackstadt (NIAID)
"Subversion of the Eukaryotic Host Cell by Secreted Chlamydia trachomatis is Effectors"
11:15 am - 11:25 am Discussion
11:25 am - 11:50 amJames Bliska (Stony Brook School of Medicine)
"Regulation of signaling and trafficking in macrophages by Yersinia"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmKathryn Monroe (UC-Berkeley)
"Induction of type I Interferon by Bacteria"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmTRANSLATING KNOWLEDGE OF MICROBIAL PATHOGENESIS
7:30 pm - 7:45 pm Discussion Leader: Drusilla Burns (FDA)
7:45 pm - 8:10 pmDavide Serruto (Novartis Corporation, Italy)
"From Reverse Vaccinology to Pathogenesis"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmCammie Lesser (Harvard Medical School)
"Yeast functional genomics provides new insights into mechanisms of bacterial pathogenesis"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmOlaf Schneewind (University of Chicago)
"Plague: studies towards a new vaccine"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHOST-PATHOGEN INTERACTIONS
9:00 am - 9:15 am Discussion Leader: Joan Mecsas (Tufts University School of Medicine)
9:15 am - 9:40 amJenifer Coburn (Medical College of Wisconsin)
"Interactions of pathogenic leptospires with host cells"
9:40 am - 9:50 am Discussion
9:50 am - 10:15 amEric Rubin (Harvard Medical School)
"Genome-wide protein domain mapping"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:15 amBrad Cookson (University of Washington-Seattle)
"Pyroptosis: coordinated host inflammatory responses to infection"
11:15 am - 11:25 am Discussion
11:25 am - 11:50 amWilliam Goldman (University of North Carolina-CH)
"Intracellular Survival Strategies of a Discreet Fungal Pathogen"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmMichele Swanson (University of Michigan- Ann Arbor)
"Inflammasome components coordinate macrophage autophagy and pyroptosis"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmMECHANISMS OF PATHOGENESIS
7:30 pm - 7:40 pm Discussion Leader: Samuel Miller (University of Washington-Seattle)
7:40 pm - 8:20 pmScott Hultgren (Washington University School of Medicine)
"E. coli Biofilms, Bottlenecks, and Host Responses in Urinary Tract Infection"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pmJeffrey Weiser (University of Pennsylvania School of Medicine)
"The Pneumococcus: Why a commensal misbehaves"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this conference was made possible [in part] by 1R13AI088764-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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