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Musculoskeletal Biology & Bioengineering
Musculoskeletal Science: From Organism to Organelle
August 1-6, 2010
Proctor Academy
Andover, NH
Chair:
Farshid Guilak

Vice Chair:
Kurt Spindler

The 2010 Gordon Research Conference on Musculoskeletal Biology and Bioengineering will present the latest findings on clinical and basic studies of musculoskeletal tissues. The overall theme of the conference is "Musculoskeletal Science: From Organism to Organelle”, to emphasize the broad scope of the research being performed in this field. Presentations will encompass the study of clinical diseases and injuries relevant to various musculoskeletal tissues, including bone, cartilage, intervertebral disc, muscle, nerve, meniscus, ligament, and tendon. The topics will also cut across multiple scientific areas of study, including cell and molecular biology, biomedical imaging and bioengineering, tissue engineering and biomaterials, systems biology, and the translation of basic research to clinical practice. As in previous years, the conference will bring together an outstanding group of leading clinicians, scientists, and bioengineers. Junior investigators, students, and fellows will have the chance to present their work in poster format, and a number of posters will be selected for oral presentation, with ample time scheduled for discussion. The conference allows many opportunities for collegial interactions with more senior colleagues in an environment that is conducive to formal and informal scientific discourse.

The conference will include sessions on the following topics, although posters presentations in all areas of musculoskeletal research are welcome:

  • Clinical aspects of musculoskeletal disease
  • Systemic and genetic regulation of the musculoskeletal system
  • Epigenetics
  • Mechanobiology and Bioengineering
  • Non-mammalian models of musculoskeletal development and disease
  • Stem cells and tissue engineering
  • High throughput analysis and systems approaches
  • Imaging of musculoskeletal tissues
Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmClinical aspects of musculoskeletal disease
Discussion Leader: Martha Murray (Children’s Hospital, Boston)
7:40 pm - 8:00 pmJoseph Buckwalter (University of Iowa)
"The etiopathogenesis of post-traumatic arthritis"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:25 pmGunnar Knutsen (University Hospital North Norway)
"Cartilage repair: Does anything work better than microfracture?"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pmLou Defrate (Duke University Medical Center)
"In vivo ACL strain and joint kinematics in patients with ACL reconstruction"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmJay Parvizi (Thomas Jefferson University)
"Prosthetic Joint Infection After Total Hip Arthroplasty: Risk Factors and Treatments"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSystemic and genetic regulation of the musculoskeletal system
Discussion Leader: Nancy Lane (University of California, Davis)
9:00 am - 9:20 amLynda Bonewald (University of Missouri, Kansas City)
"Osteocytes as Endocrine Cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amStephen Trippel (Indiana University)
"Role of growth factors in articular cartilage repair"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amDi Chen (University of Rochester)
"Beta-Catenin is A Key Mediator during the Development of Osteoarthritis and Intervertebral Disc Degeneration"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amTamara Alliston (University of California, San Francisco)
"Anabolic and anti-catabolic effects of TGF-beta in the skeleton"
11:20 am - 11:30 am Discussion
11:30 am - 12:30 pm Short talks from posters: TBA
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetic Influences on the Musculoskeletal System
Discussion Leader: Mary Goldring (Hospital for Special Surgery)
7:30 pm - 7:50 pmKo Hashimoto (Hospital for Special Surgery)
"Epigenetics and aberrant gene expression in osteoarthritis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmMin Du (University of Wyoming)
"Maternal Obesity, Inflammation, and Fetal Skeletal Muscle Development"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmRocky Tuan (University of Pittsburgh)
"Epigenetic regulation of mesenchymal stem cells"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Jeffrey Dilworth (Ottawa Hospital Research Institute)
"Epigenetic regulation of the skeletal muscle gene expression program"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanobiology and Bioengineering
Discussion Leader: Catherine Kuo (Tufts University)
9:00 am - 9:20 amRobert Sah (University of California, San Diego)
"Mechanobiology and bioengineering of articular cartilage and synovial joints"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amYi-Xian Qin (SUNY at Stony Brook)
"Bone adaptation as dependent on functional mechanobiological signals"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amStavros Thomopoulos (Washington University)
"The role of mechanobiology in the attachment of tendon to bone"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amJames Iatridis (University of Vermont)
"Asymmetric loading promotes early signs of intervertebral disc degeneration"
11:20 am - 11:30 am Discussion
11:30 am - 12:30 pm Short talks from posters: TBA
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNon-mammalian models of musculoskeletal development and disease
Discussion Leader: Linda Sandell (Washington University)
7:30 pm - 7:50 pmStephen F. Badylak (University of Pittsburgh)
"Epimorphic regeneration of functional musculotendinous tissue"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmEileen Shore (University of Pennsylvania)
"Activation of BMP-independent signaling in a zebrafish model of a human disease"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmCharles Archer (University of Cardiff)
"Notch signalling and other pathways in development and in OA"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmKelly Tseng (Tufts University)
"Pathways that regulate Xenopus appendage regeneration"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem cells and tissue engineering
Discussion Leader: Chris Evans (Brigham and Women's Hospital)
9:00 am - 9:20 amJohnny Huard (University of Pittsburgh)
"Regenerative medicine based on muscle stem cells: Potential for Tissue Regeneration & Repair"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amAndrés Garcia (Georgia Tech)
"Biomaterial strategies for enhanced bone repair"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amAnna Spagnoli (University of North Carolina)
"Mesenchymal stem cells and fracture healing"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amHelen Lu (Columbia University)
"Engineering the soft tissue to bone interface"
11:20 am - 11:30 am Discussion
11:30 am - 12:30 pm Short talks from posters: TBA
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmHigh throughput analysis and systems approaches
Discussion Leader: Lou Gerstenfeld (Boston University)
7:30 pm - 7:50 pmJohn Bateman (Murdoch Childrens Research Institute, Victoria Australia)
"Proteomics and microarray profiling to studying cartilage formation and disease"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmJason Burdick (University of Pennsylvania)
"High-throughput and Combinatorial Technologies for Tissue Engineering Applications"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmLeonidas Alexopoulos (National Technical University of Athens)
"Phosphoproteomic-based pathway analysis of cartilage degeneration"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmKurt Hankenson (University of Pennsylvania)
"Transcriptional network/systems biology in the musculoskeletal system"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImaging of Musculoskeletal Tissues
Discussion Leader: Roy Aaron (Brown University)
9:00 am - 9:20 amConnie Chu (University of Pittsburgh)
"New imaging methods for enhanced clinical assessment of cartilage injury and repair"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amHollis Potter (Hospital for Special Surgery)
"MRI of joint morphology, structure, and composition"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 pmBrian Snyder (Beth Israel Deaconess Medical Center)
"Predicting Pathologic Fracture Risk: Structure is more important than tissue mineral density"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amEdward Schwarz (University of Rochester)
"Imaging the reservoirs of bone infection"
11:20 am - 11:30 am Discussion
11:30 am - 12:30 pm Short talks from posters: TBA
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:00 pmShort Talks from Posters
Discussion Leader: Farshid Guilak (Duke University Medical Center)
7:30 pm - 9:00 pm (Speakers TBA)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by (1 R13AR059420-01) from NIAMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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