Gordon Research Conferences
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Conference Program
 
Myelin
February 14-19, 2010
Ventura Beach Marriott
Ventura, CA

The Gordon Conference on Myelin is a longstanding meeting that has drawn together the leaders of the field with many junior investigators to discuss the newest questions in this research area. The 2010 Gordon Conference on Myelin will present cutting-edge research on the development of myelinating cells, the signaling pathways that mediate myelination, the consequences of demyelination and the potential for remyelination. The role of myelin in neurologic and psychiatric disease will be discussed. Invited speakers represent a variety of scientific disciplines, ranging from molecular biologists to clinicians focused on remyelination. Thus this meeting will integrate studies on basic mechanisms of nervous system development and repair with clinically relevant issues of brain function. As in other years, senior investigators will be session speakers and also discussion leaders who provide overviews of the field. A number of speakers will be investigators at the junior faculty level. This will allow young investigators a unique opportunity to present their work, and become known to their scientific peers. This meeting has been well attended by junior investigators, and as funds are available, we will support some trainee and junior faculty attendance. All attendees should plan to present their work, and some abstracts will be selected for oral presentation.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmWhat are the obstacles for validation of remyelination therapies?
Discussion Leader: James Salzer (NYU Medical Center)
7:40 pm - 8:20 pm Steven Goldman (University of Rochester)
"Human glial progenitor cell-based treatment and modeling of myelin disease"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Timothy Vartanian (Harvard Medical School)
"Non-invasive imaging and ascertainment of demyelination/remyelination"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGene expression in the oligodendrocyte lineage
Discussion Leader: Ben Barres (Stanford University School of Medicine)
9:00 am - 9:25 am Ben Emery (Stanford University School of Medicine)
"Myelin Gene Regulatory Factor: Transcriptional control of CNS myelination"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am David Rowitch (U.C. San Francisco)
"Oligodendrocyte gene expression and regulation during remyelination"
10:00 am - 10:10 am Discussion
10:10 am - 10:45 am Coffee Break / Group Photo
10:45 am - 11:10 am Nicole Schaeren-Wiemers (Basel)
"Altered expression pattern of oligodendrocytes in Multiple Sclerosis"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Mikael Simons (Max-Planck Institute for Experimental Medicine)
"Regulation of myelin membrane sheet formation"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Hauke Werner (Max-Planck Institute for Experimental Medicine)
"Proteomic analysis of CNS myelin"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell migration in brain development
Discussion Leader: Jonah Chan (USC Medical School)
7:30 pm - 7:40 pm Maria Smith (Cleveland Clinic)
"BT4 cells generate dynamic, migratory cell populations in the developing mouse brain"
7:40 pm - 7:45 pm Discussion
7:45 pm - 8:10 pm Shumin Duan (Chinese Academy of Sciences)
"GABA-induced migration of NG2 glial cells through activation of Na+ channels and Na+/Ca2+ exchangers"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Emma Frost (University of Manitoba)
"Tyrosine kinase receptor regulation of oligodendrocyte progenitor cell migration in the developing brain"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Elek Molnar (University of Bristol)
"The role of GABAB and metabotropic glutamate receptors in oligodendrocyte migration and development"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling mechanisms regulating myelination
Discussion Leader: Vittorio Gallo (Children's National Medical Center)
9:00 am - 9:25 am Gerald Crabtree (Stanford University School of Medicine)
"Calcineurin/NFAT signaling regulating Schwann cell differentiation"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Charles ffrench-Constant (University of Edinburgh)
"Integrins and the initiation of myelination in the CNS"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Babette Fuss (Virginia Commonwealth University)
"Autotaxin and P2Y12: regulators of oligodendrocyte morphology"
10:35 am - 10:45 am Discussion
10:45 am - 11:15 am Coffee Break
11:15 am - 11:40 am Sandra Goebbels (Max-Planck Institute for Experimental Medicine)
"Role of PI3 kinase in myelination"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Teresa Wood (University of Medicine and Dentistry of New Jersey)
"Targets of mTOR signaling and oligodendrocyte differentiation"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetic control of myelination
Discussion Leader: Patrizia Casaccia-Bonnefil (Mt. Sinai School of Medicine)
7:30 pm - 7:50 pm Sjef Copray (University Medical Center Groningen)
"The role of polycomb group proteins in the regulation of oligodendrocyte differentiaion"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Q. Richard Lu (University of Texas, Southwestern)
"Transcriptional and epigenetic regulation of oligodendrocyte myelination"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Mark Mehler (Albert Einstein College of Medicine)
"Long non-coding RNAs in oligodendrocyte maturation and myelination"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Lucia Notterpek (University of Florida School of Medicine)
"The role of miRNAs in regulating myelin gene expression in Schwann cells"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAxonal pathology in de/dysmyelinated tissue
Discussion Leader: Peter Brophy (University of Edinburgh)
9:00 am - 9:25 am Selva Baltan (University of Washington School of Medicine)
"Role of oligodendrocytes on axon dysfunction during ischemic injury"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Klaus Nave (Max-Planck-Institute for Experimental Medicine)
"Glial support of myelinated axons"
10:00 am - 10:10 am Discussion
10:10 am - 10:20 am Valeria Cavalli (Washington University)
"Regulation of axonal transport by neuronal damage"
10:20 am - 10:25 am Discussion
10:25 am - 10:35 am Emily Harrington (UC San Francisco)
"Oligodendrocyte PTEN is required for normal myelination and axonal integrity but not remyelination"
10:35 am - 10:40 am Discussion
10:40 am - 11:10 am Coffee Break
11:10 am - 11:35 am Martin Stangel (Medizinische Hochschule Hannover)
"Axonal and neuronal damage after demyelination: lessons learned from the cuprizone model"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Bruce Trapp (Cleveland Clinic)
"Axonal pathology in Multiple Sclerosis"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmMyelin involvement in psychiatric and neurologic disorders
Discussion Leader: Gabriel Corfas (Harvard School of Medicine)
7:30 pm - 7:50 pm George Bartzokis (UCLA School of Medicine)
"The myelin model of the human brain: Implications for treatment and prevention of neuropsychiatric disorders"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Vahram Haroutunian (Mt. Sinai School of Medicine)
"Indices of oligodendroglial, paranodal and cell cycle abnormalities in schizophrenia"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Eric Blalock (University of Kentucky College of Medicine)
"Myelin-related gene expression changes across the lifespan"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Peter Canoll (Columbia University Medical Center)
"Adult glial progenitors in glioma growth and progression"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRemyelination in the adult nervous system
Discussion Leader: Catherine Lubetzki (Hôpital de la Salpêtrière)
9:00 am - 9:25 am Regina Armstrong (Uniformed Services University of the Health Sciences)
"Modifying progenitor cell differentiation to promote CNS repair"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Rashmi Bansal (University of Connecticut School of Medicine)
"Fibroblast growth factor receptor signaling in axon-glial interactions"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Robin Franklin (University of Cambridge)
"Rejuvenating remyelination in the ageing CNS"
10:35 am - 10:45 am Discussion
10:45 am - 11:15 am Coffee Break
11:15 am - 11:40 am Gareth John (Mt. Sinai School of Medicine)
"Notch1 signaling regulates oligodendrocyte progenitor differentiation during CNS remyelination"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Tanja Kuhlmann (University Hospital Muenster)
"Remyelination in MS"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem cells vs. progenitor cells/transplantation vs endogenous repair: which is the most useful?
Discussion Leader: Ian Duncan (University of Wisconsin School of Veterinary Medicine)
7:30 pm - 7:50 pm Annick Baron van Evercooren (INSERM)
"The dual role of inflammatory demyelination on the stem cell niche"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Jeffrey Kocsis (Yale University School of Medicine)
"Olfactory ensheathing cells in repair"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Robert Miller (Case Western Reserve University School of Medicine)
"Stem cells in repair"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Andrea Mothe (University of Toronto)
"Endogenous and transplanted neural stem progenitor cells for spinal cord repair"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by (1R13NS067696-01) from the National Institute Of Neurological Disorders And Stroke and the National Institute Of Mental Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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