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Photosensory Receptors & Signal Transduction
Gordon Research Conference

Dates

April 18-23, 2010

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Kevin H. Gardner

Vice Chair:
Christian Fankhauser

Meeting Description

The 2010 Gordon Research Conference on Photosensory Receptors and Signal Transduction, held April 18-23 at the Il Ciocco Conference Center (Barga, IT), will provide a forum for discussions of the biological, chemical and physical aspects of the diverse group of proteins used throughout biology to convert light into signals controlling biological function. Aided by the explosion of newly-available photosensors provided by genomic sequencing efforts, this field has been joined by both new families of photoreceptors and a many new members of existing ones. Taken together, these provide a diverse array of model systems to answer fundamental questions in protein signaling: How can small molecule chromophores trigger allosteric changes to a surrounding protein? How are these changes transmitted to downstream effectors? How are the sensitivity, lifetime and other features of this process tuned to match the needs of the biological system?

This conference will provide insight into these issues with a program that offers comparative discussions of the families of natural photoreceptors. By combining data from in vitro studies and from bacteria, plants and animal systems, underlying similarities and differences among different photoreceptors will be highlighted. Additional sessions will focus on novel biophysical and biochemical research approaches to study the signaling properties of these proteins, along with discussions of the engineering of these proteins for biotechnological use.

Invited speakers will provide discussions of groundbreaking research from the range of disciplines in this diverse field, including biochemistry, biophysics, cell biology, physiology and chemistry. This meeting will assemble established investigators, junior scientists and graduate students working in the field. The formal program will include a mix of oral and poster presentations, with some poster presentations being selected for short talks. This program will be complemented by the new addition of a Gordon Research Seminar immediately preceding this meeting, providing additional opportunities for postdocs and graduate students to present their research in talks and posters. Combined with time for informal discussions throughout the meeting, this conference will provide ample chances for integration and cross-disciplinary collaborations in this exciting area.

Kevin Gardner, chair
Christian Fankhauser, vice-chair

Related Meeting

This GRC was held in conjunction with the "Photosensory Receptors & Signal Transduction" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:50 pm Opening Remarks: Kevin Gardner (UT Southwestern Medical Center)
7:40 pm - 9:30 pmVISUAL RHODOPSINS: MODELS FOR GPCR SIGNALING
Discussion Leader: Oliver Ernst (Charité - Universitätsmedizin Berlin)
7:50 pm - 8:20 pmOliver Ernst (Charité - Universitätsmedizin Berlin)
"Structural and spectroscopic studies on rhodopsin activation and interaction with G protein"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:50 pmGebhard Schertler (ETH Zürich)
"Structure of a constitutively active rhodopsin mutant: Insights into receptor activation"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:15 pmSpeaker TBA: To be selected from GRS talks (TBA)
9:15 pm - 9:20 pm Discussion
9:20 pm - 9:25 pm Speaker TBA: To be selected from GRS posters (TBA)
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPHYTOCHROME STRUCTURE/FUNCTION RELATIONSHIPS
Discussion Leader: J. Clark Lagarias (UC Davis)
9:00 am - 9:30 amJ. Clark Lagarias (UC Davis)
"Molecular Mechanisms of Light Perception by Phytochromes"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amRichard Vierstra (University of Wisconsin - Madison)
"Atomic Perspectives on Phytochrome Photoconversion"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break / Group Photo
10:45 am - 11:10 amLars-Oliver Essen (Phillips Universität - Marburg)
"Cph1 & Cph2: Two families of cyanobacterial photochromes"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amAndrew Ulijasz (University of Wisconsin - Milwaukee)
"The Cyanochromes: Phytochrome-Like Photoreceptors With An Unusual Blue-Green Twist"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Akira Nagatani (Kyoto University)
"Structural basis of phytochrome A specific functions"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCRYPTOCHROMES
Discussion Leader: Alfred Batschauer (Phillips Universität - Marburg)
5:30 pm - 5:35 pmAlfred Batschauer (Phillips Universität - Marburg)
"Open challenges in cryptochromes"
5:35 pm - 6:00 pmMargaret Ahmad (CNRS)
"Cryptochrome photoreceptor mechanisms of light activation"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmSteven Reppert (UMass Medical Center)
"Monarch butterfly cryptochromes mediate magnetoreception through an unconventional photochemical mechanism"
6:35 pm - 6:45 pm Discussion
6:45 pm - 7:10 pmDongping Zhong (Ohio State University)
"Ultrafast dynamics and anionic states of the flavin cofactor in cryptochrome"
7:10 pm - 7:20 pm Discussion
7:20 pm - 7:25 pm Speaker TBA: Promoted poster talk (TBA)
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMICROBIAL RHODOPSINS
Discussion Leader: Hartmut Luecke (UC Irvine)
9:00 am - 9:05 amHartmut Luecke (UC Irvine)
"Open challenges in microbial rhodopsins"
9:05 am - 9:30 amJohn Spudich (UT Houston Medical School)
"Microbial rhodopsins: Receptors, channels, and pumps from a single design"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amKlaus Gewert (Ruhr Universität - Bochum)
"Proton transfer via protein bound water molecules"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:10 amJoachim Heberle (Free University of Berlin)
"The vibrations of channelrhodopsin-2"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amPeter Hegemann (Humboldt University)
"Tailoring the Channelrhodopsin properties"
11:45 am - 11:55 am Discussion
11:30 am - 12:10 pmEd Boyden (MIT)
"Tools for controlling neural and biological processes enabled by ecological diversity of microbial opsins"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmBLUF DOMAINS
Discussion Leader: Ilme Schlichting (Max Planck Institute for Medical Research, Heidelberg)
5:30 pm - 6:00 pmIlme Schilchting (Max Planck Institute for Medical Research, Heidelberg)
"BLUF proteins: On downstream signaling"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmCarl Bauer (Indiana University)
"Defining dark and lit state of the BLUF photoreceptors AppA and PixD"
6:35 pm - 6:45 pm Discussion
6:45 pm - 7:10 pmMineo Iseki (Hayama Center for Advanced Studies)
"Single molecule studies of the structure and function of photoactivated adenylyl cyclase (PAC), a sensor for photomovement in Euglena"
7:10 pm - 7:20 pm Discussion
7:20 pm - 7:25 pm Speaker TBA: Promoted poster talk (TBA)
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBIOPHYSICAL METHODS AS APPLIED TO PHOTOSENSORS
Discussion Leader: Klaas Hellingwerf (University of Amsterdam)
9:00 am - 9:05 amKlaas Hellingwerf (University of Amsterdam)
"Open challenges for novel biophysical applications to photosensors"
9:05 am - 9:30 amKeith Moffat (University of Chicago)
"Optogenetics: The structure and function of natural and engineered photoreceptors"
9:30 am - 9:35 am Discussion
9:35 am - 10:00 amTom Sakmar (Rockefeller University)
"Using genetically-encoded non-natural amino acids to study rhodopsin structure and function"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break
10:30 am - 10:55 amWayne Hubbell (UCLA)
"Protein flexibility in signal transduction: A view from the EPR time window"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am Masahide Terazima (Kyoto University)
"Spectrally hidden reaction dynamics of photosensor proteins"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 amMarloes Groot (Vrije Universiteit, Amsterdam)
"The role of the protein in the isomerization reaction of photoactive yellow protein"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:25 pmJocelyne Vreede (University of Amsterdam)
"Predicting the reaction coordinates of millisecond light-induced conformational changes in Photoactive Yellow Protein"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmPHOTOSENSORY COMPONENTS OF BIOLOGICAL CLOCKS
Discussion Leader: Jay Dunlap (Dartmouth University School of Medicine)
5:30 pm - 5:35 pmJay Dunlap (Dartmouth University School of Medicine)
"Open challenges in biological clocks"
5:35 pm - 5:55 pmJennifer Loros (Dartmouth University School of Medicine)
"How the VVD photoreceptor works in Neurospora"
5:55 pm - 6:00 pm Discussion
6:00 pm - 6:20 pmDave Somers (Ohio State University)
"Post-translational regulation of the circadian clock"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:45 pmAmita Seghal (University of Pennsylvania)
"Photic entrainment of the circadian clock in Drosophila"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:10 pm Samer Hattar (Johns Hopkins University)
"Vision beyond image formation: The role of melanopsin cells in regulating mammalian physiology"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:20 pm Speaker TBA: Promoted poster talk (TBA)
7:20 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLOV DOMAINS: STRUCTURE, MECHANISM AND ENGINEERING
Discussion Leader: Aba Losi (University of Parma)
9:00 am - 9:30 amAba Losi (University of Parma)
"News and views for prokaryotic LOV proteins: From signaling to phylogeny"
9:30 am - 9:35 am Discussion
9:35 am - 10:00 amJohn Christie (University of Glasgow)
"Application of LOV domains as fluorescent reporters"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break
10:35 am - 11:00 amMasamitsu Wada (Kyushu University)
"Factors controlling the existence of chlorplast actin filaments involved in chloroplast movement"
11:00 am - 11:05 am Discussion
11:05 am - 11:30 amAndreas Möglich (University of Chicago)
"Signal integration in PAS histidine kinases"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pm Hartmut Luecke (UC Irvine)
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:25 pm Wolfgang Gärtner (Max Planck Institute for Bioinorganic Chemistry, Mülheim)
"Novel LOV domain proteins from screening data bases and environment"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmPHYTOCHROME SIGNALING
Discussion Leader: Eberhard Schaefer (University of Freiburg)
5:30 pm - 6:00 pmEberhard Schaefer (University of Freiburg)
"Early events in phy signaling and modeling of HIR"
6:00 pm - 6:05 pm Discussion
6:05 pm - 6:25 pmJorge Casal (University of Buenos Aires)
"Signalling by phytochrome A under sustained compared to transient excitation"
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Giltsu Choi (KAIST)
"Inhibition of PIFs by phytochromes"
6:50 pm - 6:55 pm Discussion
6:55 pm - 7:15 pm Chris Voigt (UC San Francisco)
"Fast, high-resolution induction of signaling networks using light"
7:15 pm - 7:20 pm Discussion
7:20 pm - 7:25 pm Speaker TBA: Promoted poster talk (TBA)
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 GM093350-01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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