Conference Program
 
Photosensory Receptors & Signal Transduction
April 18-23, 2010
Il Ciocco Hotel and Resort
Lucca (Barga), Italy

Application Deadline
Applications for this meeting must be submitted by March 28, 2010. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Applications will still be accepted for oversubscribed meetings. However, they will only be considered by the Conference Chair if more seats become available due to cancellations.
Related Meeting Information
The Photosensory Receptors & Signal Transduction Gordon Research Conference will be held in conjunction with the Photosensory Receptors & Signal Transduction Gordon-Kenan Research Seminar. Those interested in attending both meetings must submit an application for the GKRS in addition to an application for the GRC. Please refer to the Photosensory Receptors & Signal Transduction GKRS web page for more information.

The 2010 Gordon Research Conference on Photosensory Receptors and Signal Transduction, held April 18-23 at the Il Ciocco Conference Center (Barga, IT), will provide a forum for discussions of the biological, chemical and physical aspects of the diverse group of proteins used throughout biology to convert light into signals controlling biological function. Aided by the explosion of newly-available photosensors provided by genomic sequencing efforts, this field has been joined by both new families of photoreceptors and a many new members of existing ones. Taken together, these provide a diverse array of model systems to answer fundamental questions in protein signaling: How can small molecule chromophores trigger allosteric changes to a surrounding protein? How are these changes transmitted to downstream effectors? How are the sensitivity, lifetime and other features of this process tuned to match the needs of the biological system?

This conference will provide insight into these issues with a program that offers comparative discussions of the families of natural photoreceptors. By combining data from in vitro studies and from bacteria, plants and animal systems, underlying similarities and differences among different photoreceptors will be highlighted. Additional sessions will focus on novel biophysical and biochemical research approaches to study the signaling properties of these proteins, along with discussions of the engineering of these proteins for biotechnological use.

Invited speakers will provide discussions of groundbreaking research from the range of disciplines in this diverse field, including biochemistry, biophysics, cell biology, physiology and chemistry. This meeting will assemble established investigators, junior scientists and graduate students working in the field. The formal program will include a mix of oral and poster presentations, with some poster presentations being selected for short talks. This program will be complemented by the new addition of a Gordon Research Seminar immediately preceding this meeting, providing additional opportunities for postdocs and graduate students to present their research in talks and posters. Combined with time for informal discussions throughout the meeting, this conference will provide ample chances for integration and cross-disciplinary collaborations in this exciting area.

Kevin Gardner, chair
Christian Fankhauser, vice-chair


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:50 pm Opening Remarks: Kevin Gardner (UT Southwestern Medical Center)
7:40 pm - 9:30 pmVISUAL RHODOPSINS: MODELS FOR GPCR SIGNALING
Discussion Leader: Oliver Ernst (Charité - Universitätsmedizin Berlin)
7:50 pm - 8:20 pmOliver Ernst (Charité - Universitätsmedizin Berlin)
"Structural and spectroscopic studies on rhodopsin activation and interaction with G protein"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:50 pmKevin Ridge (UT Houston Medical School)
"Structural Studies of Visual Pigment Activation, Signaling, and Desensitization"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmGebhard Schertler (ETH Zürich)
"Structure of a constitutively active rhodopsin mutant: Insights into receptor activation"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPHYTOCHROME STRUCTURE/FUNCTION RELATIONSHIPS
Discussion Leader: J. Clark Lagarias (UC Davis)
9:00 am - 9:30 amJ. Clark Lagarias (UC Davis)
"Molecular Mechanisms of Light Perception by Phytochromes: Exploiting Constitutive Alleles to Regulate Plant Development"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amRichard Vierstra (University of Wisconsin - Madison)
"Atomic Perspectives on Phytochrome Photoconversion"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break / Group Photo
10:45 am - 11:10 amLars-Oliver Essen (Phillips Universität - Marburg)
"Cph1 & Cph2: Two families of cyanobacterial photochromes"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amAndrew Ulijasz (University of Wisconsin - Milwaukee)
"The Cyanochromes: Phytochrome-Like Photoreceptors With An Unusual Blue-Green Twist"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Speaker to be selected from GRS talks (TBA)
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCRYPTOCHROMES
Discussion Leader: Alfred Batschauer (Phillips Universität - Marburg)
5:30 pm - 5:35 pmAlfred Batschauer (Phillips Universität - Marburg)
"Open challenges in cryptochromes"
5:35 pm - 6:00 pmMargaret Ahmad (CNRS)
"Cryptochrome photoreceptor mechanisms of light activation"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmSteven Reppert (UMass Medical Center)
"Monarch butterfly cryptochromes mediate magnetoreception through an unconventional photochemical mechanism"
6:35 pm - 6:45 pm Discussion
6:45 pm - 7:10 pmDongping Zhong (Ohio State University)
"Ultrafast dynamics and anionic states of the flavin cofactor in cryptochrome"
7:10 pm - 7:20 pm Discussion
7:20 pm - 7:25 pm Speaker TBA: Promoted poster talk (TBA)
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMICROBIAL RHODOPSINS
Discussion Leader: Hartmut Luecke (UC Irvine)
9:00 am - 9:05 amHartmut Luecke (UC Irvine)
"Open challenges in microbial rhodopsins"
9:05 am - 9:30 amJohn Spudich (UT Houston Medical School)
"Microbial rhodopsins: Receptors, channels, and pumps from a single design"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amKlaus Gewert (Ruhr Universität - Bochum)
"Proton transfer via protein bound water molecules"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:10 amJoachim Heberle (Free University of Berlin)
"The vibrations of channelrhodopsin-2"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amPeter Hegemann (Humboldt University)
"Tailoring the Channelrhodopsin properties"
11:45 am - 11:55 am Discussion
11:30 am - 12:10 pmEd Boyden (MIT)
"Tools for controlling neural and biological processes enabled by ecological diversity of microbial opsins"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmBLUF DOMAINS
Discussion Leader: Ilme Schlichting (Max Planck Institute for Medical Research, Heidelberg)
5:30 pm - 6:00 pmIlme Schilchting (Max Planck Institute for Medical Research, Heidelberg)
"BLUF proteins: On downstream signaling"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmCarl Bauer (Indiana University)
"Defining dark and lit state of the BLUF photoreceptors AppA and PixD"
6:35 pm - 6:45 pm Discussion
6:45 pm - 7:10 pmMineo Iseki (Hayama Center for Advanced Studies)
"Single molecule studies of the structure and function of photoactivated adenylyl cyclase (PAC), a sensor for photomovement in Euglena"
7:10 pm - 7:20 pm Discussion
7:20 pm - 7:25 pm Speaker TBA: Promoted poster talk (TBA)
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBIOPHYSICAL METHODS AS APPLIED TO PHOTOSENSORS
Discussion Leader: Klaas Hellingwerf (University of Amsterdam)
9:00 am - 9:05 amKlaas Hellingwerf (University of Amsterdam)
"Open challenges for novel biophysical applications to photosensors"
9:05 am - 9:30 amKeith Moffat (University of Chicago)
"Optogenetics: The structure and function of natural and engineered photoreceptors"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amTom Sakmar (Rockefeller University)
"Using genetically-encoded non-natural amino acids to study rhodopsin structure and function"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:10 amWayne Hubbell (UCLA)
"Protein flexibility in signal transduction: A view from the EPR time window"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amMarloes Groot (Vrije Universiteit, Amsterdam)
"The role of the protein in the isomerization reaction of photoactive yellow protein"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pmJocelyne Vreede (University of Amsterdam)
"Predicting the reaction coordinates of millisecond light-induced conformational changes in Photoactive Yellow Protein"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmPHOTOSENSORY COMPONENTS OF BIOLOGICAL CLOCKS
Discussion Leader: Jay Dunlap (Dartmouth University School of Medicine)
5:30 pm - 5:35 pmJay Dunlap (Dartmouth University School of Medicine)
"Open challenges in biological clocks"
5:35 pm - 6:00 pmAmita Seghal (University of Pennsylvania)
"Photic entrainment of the circadian clock in Drosophila"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmDave Somers (Ohio State University)
"Post-translational regulation of the circadian clock"
6:35 pm - 6:45 pm Discussion
6:45 pm - 7:10 pmSamer Hatter (Johns Hopkins University)
"Vision beyond image formation: The role of melanopsin cells in regulating mammalian physiology"
7:10 pm - 7:20 pm Discussion
7:20 pm - 7:25 pm Speaker TBA: Promoted poster talk (TBA)
7:25 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLOV DOMAINS: STRUCTURE, MECHANISM AND ENGINEERING
Discussion Leader: Aba Losi (University of Parma)
9:00 am - 9:30 amAba Losi (University of Parma)
"News and views for prokaryotic LOV proteins: From signaling to phylogeny"
9:30 am - 9:35 am Discussion
9:35 am - 10:00 amJohn Christie (University of Glasgow)
"Application of LOV domains as fluorescent reporters"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break
10:35 am - 11:00 amMasamitsu Wada (Kyushu University)
"Factors controlling the existence of chlorplast actin filaments involved in chloroplast movement"
11:00 am - 11:05 am Discussion
11:05 am - 11:30 amAndreas Möglich (University of Chicago)
"Signal integration in PAS histidine kinases"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pm Hartmut Luecke (UC Irvine)
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:25 pm Wolfgang Gärtner (Max Planck Institute for Bioinorganic Chemistry, Mülheim)
"Novel LOV domain proteins from screening data bases and environment"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmPHYTOCHROME SIGNALING
Discussion Leader: Eberhard Schaefer (University of Freiburg)
5:30 pm - 6:00 pmEberhard Schaefer (University of Freiburg)
"Early events in phy signaling and modeling of HIR"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmAkira Nagatani (Kyoto University)
"Structural basis of phytochrome A specific functions"
6:35 pm - 6:45 pm Discussion
6:45 pm - 7:10 pm Chris Voigt (UC San Francisco)
"Fast, high-resolution induction of signaling networks using light"
7:10 pm - 7:20 pm Discussion
7:20 pm - 7:25 pm Speaker TBA: Promoted poster talk (TBA)
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Last Updated: January 6, 2010