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Conference Program
 
Pineal Cell Biology
Mechanisms of Circadian Rhythmicity and Melatonin Action
February 7-12, 2010
Hotel Galvez
Galveston, TX
Chair:
David R. Weaver

Vice Chair:
Debra J. Skene

The Gordon Research Conference on Pineal Cell Biology will be held February 7-12, 2010 at the Hotel Galvez, in Galveston, Texas, USA. As usual, this will be a broadly interdisciplinary meeting, in an exciting new venue on Galveston Island.

Topics to be covered include:

Molecular and cellular biology of pineal gland development; Circadian regulation of melatonin production in the pineal and retina; The role of the pineal hormone, melatonin, in internal dissemination of circadian time; Circadian clock mechanisms; Melatonin actions on recognized target sites/functions (circadian and photoperiodic actions), and new/ emerging effects of melatonin; Circadian clock functions in the retina and pineal. Virtually all aspects of circadian and seasonal rhythms are of interest to this community.

Levels of analysis include molecular and cellular studies, pharmacology, physiology and animal behavior, and human studies.

Young scientists at the graduate and post-doc level will be actively integrated as speakers, through poster presentations and by selection of some posters authored by Trainees for “Hot Topics” oral presentations; trainees are strongly encouraged to apply.

A limited number of scholarships will be awarded as Trainee Poster Awards. These scholarships will provide registration fee reduction for Trainees whose posters were selected on a competitive basis.

In addition, limited funds are available to defray registration expenses of individuals from underrepresented groups, including Trainees, women, under-represented minorities, individuals with disabilities, and individuals from geographic regions poorly represented at the Conference.

Inquiries regarding scholarships should be directed to David.weaver@umassmed.edu.

Stimulating poster sessions will occur. The poster sessions are an excellent opportunity for younger scientists to present their work. All registrants are welcome to present a poster. Abstracts (for programming purposes; title, authors, institution, text up to 400 words) should be submitted to the conference Vice-Chair, Debra Skene (D.Skene@surrey.ac.uk ) by January 17, 2010.

This announcement will be updated as additional information develops.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:00 pmREGULATION OF MELATONIN PRODUCTION
7:40 pm - 7:50 pmDiscussion Leader: Helena Illnerova, Ph.D (Institute of Physiology, Prague)
7:50 pm - 8:10 pmAnthony K. Ho, Ph.D (University of Alberta, Edmonton)
"The role of Sik/Torc signaling pathway in regulating gene expression in the rat pineal gland"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:40 pmJorg H. Stehle, Ph.D (University of Frankfurt, Germany)
"Illuminating molecular details of dynamics in the human pineal gland"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:00 pm General Discussion
9:00 pm - 9:30 pmHOT TOPICS SESSION #1
(Speakers selected from posters)
Discussion Leader: David C. Klein (NICHD, NIH, Bethesda, MD)
9:00 pm - 9:10 pm Samuel Clokie (NICHD, NIH, Bethesda, MD)
"miRNAs in the rodent pineal gland"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Dave Lanoix (INRS-Institut Armand-Frappier, Laval, Quebec, Canada)
"Protective effects of human placental melatonin in normal pregnancy"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCIRCADIAN CLOCKS IN THE RETINA
9:00 am - 9:10 amDiscussion Leader: Gianluca Tosini (Morehouse School of Medicine, Atlanta, GA, USA)
9:10 am - 9:30 amDoug McMahon (Vanderbilt University, Nashville TN)
"Keeping an Eye on the Time and Keeping the Eye on Time: Mechanisms of a Retinal Circadian Clock"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 amChad R. Jackson (Emory University, Atlanta, GA)
"Rhythmic Regulation of Retinal Gene Expression by Dopamine"
10:00 am - 10:10 am Discussion
10:10 am - 10:25 am Coffee Break
10:25 am - 10:45 amJoseph C. Besharse (Medical College of Wisconsin, Milwaukee, WI)
"Circadian Regulation of Photoreceptor Outer Segment Turnover"
10:45 am - 10:55 am Discussion
10:55 am - 11:15 amChristophe P. Ribelayga (The University of Texas Medical School at Houston, Houston, TX)
"Identification of a circadian clock-controlled rod pathway in the mammalian retina"
11:15 am - 11:25 am Discussion
11:25 am - 11:45 amCara M. Altimus (Johns Hopkins University, Baltimore, MD)
"Cellular dissection of circadian photoreception"
11:45 am - 11:55 am Discussion
11:55 am - 12:15 pm P. Michael Iuvone (Emory University School of Medicine, Atlanta, GA)
"A novel role for N-acetylserotonin"
12:15 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNEW DEVELOPMENTS IN PINEAL DEVELOPMENTAL BIOLOGY
7:30 pm - 7:35 pmDiscussion Leader: Maria Serón-Ferré (Universidad de Chile, Santiago, Chile)
7:35 pm - 7:55 pmJoshua T. Gamse (Vanderbilt University, Nashville, TN)
"Melatonin controls the onset of gene expression in the developing zebrafish brain"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmMargaret J. Ochocinska (NICHD, NIH, Bethesda, MD)
"NeuroD1 control of gene expression in the mammalian pineal and retina"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:45 pmDiego Bustos (NICHD, NIH, Bethesda, MD)
"The biology of eyes absent homolog 2 (Drosophila) in the pineal gland"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmMartin F. Rath (University of Copenhagen, Copenhagen, Denmark)
"Homeobox genes in the developing and adult pineal gland"
9:20 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm General Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCIRCADIAN CLOCKS, MELATONIN AND METABOLISM I
9:00 am - 9:10 amDiscussion Leader: Andrew Loudon (University of Manchester, Manchester, UK)
9:10 am - 9:30 amEleanor M. Scott (University of Leeds, Leeds UK)
"Clock Gene Polymorphisms and Obesity"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 amHélène Duez (Institut Pasteur de Lille, Lille, France)
"The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amCoffee Break
10:25 am - 10:45 amAkhilesh B. Reddy (University of Cambridge Metabolic Research Labs, Cambridge, UK)
"Circadian Regulation of Molecules and Metabolism"
10:45 am - 10:55 amDiscussion
10:55 am - 11:15 amFrank A.J.L. Scheer (Harvard Medical School/BWH, Boston, MA)
"Adverse Metabolic and Endocrine Consequences of Circadian Misalignment in Humans"
11:15 am - 11:25 am Discussion
11:25 am - 11:45 amHindrik Mulder (Lund University Diabetes Center, Malmö, Sweden)
"Melatonin Receptors, Islet Biology, and Type 2 Diabetes"
11:45 am - 11:55 am Discussion
11:55 am - 12:05 pm Hot Topics Speaker (selected from the posters)
Ariel Poliandri (Imperial College London, London, UK)
"Receptor Interacting Protein 140 regulates the circadian clock by co-activation of Retinoid-Related Orphan Receptor alpha"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCELLULAR MECHANISMS OF MELATONIN ACTION
7:30 pm - 7:40 pmDiscussion Leader: Margarita L. Dubocovich (School of Medicine and Biomedical Sciences, University at Buffalo)
7:40 pm - 8:00 pmPaula A. Witt-Enderby (Duquesne University, Pittsburgh, PA)
"Melatonin and Hormone Replacement Therapy in a Preclinical Model of Mammary Cancer"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmVincent M. Cassone (University of Kentucky, Lexington, KY)
"The Pineal Gland Regulates Bird Song Control Structures and Song Behavior"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmStephano Comai (McGill University, Montreal, Canada)
"Role of MT2 Receptors in Sleep Regulation"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:40 amCIRCADIAN CLOCKS, MELATONIN AND METABOLISM II
9:00 am - 9:10 amDiscussion Leader: Paul D. Heideman (College of William and Mary, Williamsburg, VA)
9:10 am - 9:30 amTakashi Yoshimura (Nagoya University, Nagoya, Japan)
"Photoperiodic Transduction in the Mediobasal Hypothalamus"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 amSandrine M. Dupré (University of Manchester, Manchester, UK)
"Photoperiodic Control of Pars Tuberalis Gene Expression"
10:00 am - 10:10 am Discussion
10:10 am - 10:25 am Coffee Break
10:25 am - 10:45 amValérie Simonneaux (University of Strasbourg, Strasbourg, France)
"Melatonin regulation of seasonal reproduction in rodents"
10:45 am - 10:55 am Discussion
10:55 am - 11:15 amTimothy J. Bartness (Georgia State University, Atlanta, GA)
"Photoperiodic Control of Adipose Tissues"
11:15 am - 11:25 am Discussion
11:25 am - 11:45 am David A. Bechtold (University of Manchester, Manchester, UK)
"GPR50: Role in Metabolic Regulation and Torpor"
11:45 am - 11:55 am Discussion
11:55 am - 12:00 pm General Discussion
12:00 pm - 12:30 pmHOT TOPICS SESSION #2
(Speakers selected from posters)
Discussion Leader: Megan M. Mahoney (University of Illinois, Urbana, IL)
12:00 pm - 12:10 pm Caroline Ancel (INCI, Strasbourg, France)
"The role of RFRP peptides in the seasonal regulation of reproduction in the Syrian hamster"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Le Yu (University of Edinburgh, Edinburgh, Scotland)
"Technologies to identify melatonin regulated genes in the sheep pars tuberalis using next generation transcriptome sequencing"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMELATONIN, CIRCADIAN CLOCKS, AND CNS DISEASES
7:30 pm - 7:40 pmDiscussion Leader: Elizabeth S. Maywood (MRC-LMB, Cambridge UK)
7:40 pm - 8:00 pmSarah H. Elsea (Virginia Commonwealth University School of Medicine, Richmond, VA)
"To Sleep, Perchance to Dream... not in Smith-Magenis Syndrome"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmJames Olcese (FSU College of Medicine, Tallahassee, FL)
"Melatonin Supplementation as a Neuroprotective Strategy in a Transgenic Model of Alzheimer Dementia"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmBeth A. Malow (Vanderbilt University Medical Center, Nashville TN)
"Treating Insomnia in Children with Autism Spectrum Disorders: The Promise of Melatonin"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:40 amMELATONIN EFFECTS ON SLEEP AND CIRCADIAN RHYTHMS
9:00 am - 9:10 amDiscussion Leader: Debra J. Skene (University of Surrey, Guildford, UK)
9:10 am - 9:30 amIrina V. Zhdanova (Boston Univ. Med. School, Boston, MA)
"What Can Melatonin Do Without the SCN?"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 amPhyllis C. Zee (Northwestern University, Evanston, IL)
"Melatonin, Circadian Rhythms and Sleep in Humans"
10:00 am - 10:10 am Discussion
10:10 am - 10:25 am Coffee Break
10:25 am - 10:45 amCharmane I. Eastman (Rush University Medical Center, Chicago, IL)
"Melatonin Phase Response Curves"
10:45 am - 10:55 am Discussion
10:55 am - 11:15 amKenneth P. Wright, Jr (University of Colorado, Boulder, CO)
"Melatonin, Thermoregulation and Sleep"
11:15 am - 11:25 am Discussion
11:25 am - 11:40 am General Discussion
11:40 am - 12:30 pmHOT TOPICS SESSION #3
(Speakers selected from posters)
Discussion Leader: Samer Hattar (Johns Hopkins School of Medicine, Baltimore MD)
11:40 am - 11:50 am Steven Hill (Tulane University School of Medicine, New Orleans, LA)
"Conditional expression of the MT1 melatonin receptor impedes mammary gland development in mice"
11:50 am - 11:55 am Discussion
11:55 am - 12:05 pm Rodrigo Lacruz (University of Southern California, Los Angeles, CA)
"Hard tissue rhythms: The long and short of it in organismal biology"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Anastasia Saade (Cochin Institute- Orsay University, Paris, France)
"Impact of circadian protein networks on hippocampus plasticity"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmWHEN LIGHT INTERRUPTS THE NIGHT: DYING FOR DARKNESS
Discussion Leader: George C. Brainard (Thomas Jefferson University, Philadelphia, PA)
7:30 pm - 7:50 pmJennifer A. Evans (Morehouse School of Medicine, Atlanta, GA)
"Circadian plasticity is enhanced by dim light at night"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pmAlec J. Davidson (Morehouse School of Medicine, Atlanta, GA)
"Adverse Health Consequences of Circadian Disruption in Mice"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pmRichard G. Stevens (University of Connecticut Health Center, Farmington, CT)
"Light at Night, Circadian Disruption, and Breast Cancer"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pmTill Roenneberg (Ludwig-Maximilians-University, Munich, Germany)
"Light at Night: A Health Risk Factor or a Health Risk Predictor?"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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