Conference Program
 
Plasminogen Activation & Extracellular Proteolysis
February 14-19, 2010
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chairs:
Thomas H. Bugge & Vincent Ellis

Vice Chair:
Bradford S. Schwartz
Application Deadline
Applications are no longer being accepted for this meeting. If you have been instructed to apply by the Conference Chair, please contact your Conference Coordinator for further instructions.
Related Meeting Information
The Plasminogen Activation & Extracellular Proteolysis Gordon Research Conference will be held in conjunction with the Plasminogen Activation & Extracellular Proteolysis Gordon-Kenan Research Seminar. Those interested in attending both meetings must submit an application for the GKRS in addition to an application for the GRC. Please refer to the Plasminogen Activation & Extracellular Proteolysis GKRS web page for more information.

The plasminogen activation system and other proteolytic system that operate in the pericellular environment are essential regulators of cell signaling and extracellular matrix remodeling during development, homeostasis, tissue remodeling, and tissue regeneration. Furthermore, the aberrant activity of these proteolytic systems is intimately associated with the genesis or progression of some of the most important human diseases, including cardiovascular disease, central nervous system disorders, and cancer. With their extracellular location and documented causal roles in pathogenesis, these proteolytic systems provide excellent targets for pharmacological intervention aimed at improving human health. The GRC brings together the leading researchers in this area for a highly interactive and informative meeting in a casual atmosphere. Topics will include thrombolysis and fibrinolysis, vascular biology, central nervous system function and dysfunction, tissue homeostasis and regeneration, hematopoiesis, stem cell biology, metabolism and obesity, tumor biology, angiogenesis, and more.

Students and Postdoctoral Fellows will serve as Co-Discussion Leaders of all Sessions. Eight to ten talks will be selected from the submitted abstracts. The deadline for abstract submission is January 14, 2010. In addition to oral presentations, there will be two Poster Sessions that will feature prizes for best presentations by Students and Postdoctoral Fellows. Minorities can seek support for participation through a Carl Storm Underrepresented Minority Fellowship.

As a new feature, a Gordon-Kenan Research Seminar (GRS), specifically for Students and Postdoctoral Fellows within this field, will be held in immediate conjunction with the GRC. Please join us in 2010!

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThrombolysis, Fibrinolysis & Hemostasis
Discussion Leaders: Nuala Booth (University of Aberdeen, Aberdeen, United Kingdom) & Nishamol Geetha (Medical University of Vienna, Vienna, Austria)
7:35 pm - 7:40 pm Introduction
7:40 pm - 8:20 pm Bruce Beutler (Scripps Research Institute, La Jolla, California)
"Forward Genetics in the Mouse: from Phenotype to Function"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Jay Degen (Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio)
"Thrombin and Inflammatory Processes"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Edward Plow (The Cleveland Clinic Foundation, Cleveland, Ohio)
"Regulation of Tailed and Untailed Plasminogen Receptors"
9:20 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCNS Function and Dysfunction
Discussion Leaders: Katerina Akassoglou (Gladstone Institute of Neurological Disease, San Francisco, California) & Loic Doeuvre (INSERM, Caen, France)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am Katerina Akassoglou (Gladstone Institute of Neurological Disease, San Francisco, California)
"Molecular Determinants of Neurovascular Dynamics"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Robert Medcalf (Monash University, Melbourne, Australia)
"t-PA, the Blood Brain Barrier and Traumatic Brain Injury"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Daniel Lawrence (University of Michigan Medical School, Ann Arbor, Michigan)
"tPA and PDGF in the CNS"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Sidney Strickland (The Rockefeller University, New York, New York)
"A Possible Role for Fibrin in Alzheimer's Disease"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm Manuel Yepes (Emory University, Atlanta, Georgia)
"Tissue-type plasminogen activator: an endogenous neuroprotectant in the CNS"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCardiovascular Health and Disease
Discussion Leaders: Qingyu Wu (The Cleveland Clinic Foundation, Cleveland, Ohio) & Ida Katrine Lund (Finsen Laboratory, Copenhagen, Denmark)
7:30 pm - 7:35 pm Introduction
7:35 pm - 8:00 pm Qingyu Wu (The Cleveland Clinic Foundation, Cleveland, Ohio)
"The Cardiac Membrane Protease Corin in Hypertensive and Heart Disease"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm David Dichek (University of Washington, Seattle, Washington)
"New Roles for uPA in Vascular Pathology"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Katherine Hajjar (Weill Medical College of Cornell University, New York, New York)
"The Annexin A2 System and Vascular Homeostasis"
9:15 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInfection, Inflammation and Immunity
Discussion Leaders: David Ginsburg (University of Michigan Medical School, Ann Arbor, Michigan) & Mercedes Valls Seron (Academic Medical Center, Amsterdam, Netherlands)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am David Ginsburg (University of Michigan Medical School, Ann Arbor, Michigan)
"Hemostasis in Host Defense during Group A Streptococcal Infection"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Mark Walker (School of Biological Sciences, University of Wollongong, Wollongong, Australia)
"Interplay between Human Plasminogen, Wildtype and Hyperinvasive Group A streptococci"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Hongmin Sun (University of Missouri, Columbia, Missouri)
"Generating Novel Antimicrobial Reagents in Streptococcal Infection by Decreasing Bacterial Plasminogen Activator Streptokinase"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Aime K. Zaas (Duke University Medical Center, Durham, North Carolina)
"Plasminogen Polymorphisms and Risk of Invasive Fungal Infection: A Case Study of Plasminogen's Role in Host Defense"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm Marcelo Jacobs-Lorena (Johns Hopkins School of Public Health, Baltimore, Maryland)
"Plasminogen plays a Critical Role for Development of the Malaria Parasite in its Mosquito Vector"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTissue Homeostasis & Regeneration
Discussion Leaders: Toni Antalis (University of Maryland School of Medicine, Baltimore, Maryland) & Stine Friis (University of Copenhagen, Copenhagen, Denmark)
7:30 pm - 7:35 pm Introduction
7:35 pm - 8:00 pm Toni Antalis (University of Maryland School of Medicine, Baltimore, Maryland)
"Membrane Serine Proteases in Tissue Homeostasis and Healing"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Andreas R. Janecke (Innsbruck Medical University, Innsbruck, Austria)
"Loss of Function of Serine Protease Inhibitor SPINT2 causes a Human Syndrome of Congenital Malformations and Sodium Diarrhea"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Pura Munoz-Canoves (University Pompeu Fabra and ICREA, Barcelona, Spain)
"The Plasminogen Activation/Fibrinolytic System in Muscular Dystrophy"
9:15 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cell Biology & Hematopoiesis
Discussion Leaders: Lindsay Miles (Scripps Research Institute, La Jolla, California) & Nathaniel C. Noyes (University of Maryland School of Medicine, Baltimore, Maryland)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am Lindsay Miles (Scripps Research Institute, La Jolla, California)
"Progenitor Cells as a Source of a Novel Plasminogen Receptor"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Marc Tjwa (Goethe University & University Hospital Frankfurt, Frankfurt, Germany)
"Role of the Plasminogen System in the Regulation of Hematopoiesis"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Birgitte Rønø (Finsen Laboratory, Copenhagen, Denmark)
"Plasmin-mediated Fibrinolysis is Required for Hematopoietic Stem Cell Mobilization"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Peter Andreasen (University of Aarhus, Aarhus, Denmark)
"The Plasminogen Activation System in Bony Fish"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm Karin Finberg (Duke University Medical Center, Durham, North Carolina)
"TMPRSS6: An Essential Regulator of Mammalian Iron Homeostasis"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
12:30 pm - 6:00 pmFree Time / Afternoon Excursion to Santa Barbara (Optional)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmLate Breaking Topics from Abstracts
Discussion Leaders: Vincent Ellis (University of East Anglia, Norwich, United Kingdom), Bradford Schwartz (University of Illinois, Urbana, Illinois) & Molly Rose Darragh (University of San Francisco, San Francisco, California)
7:30 pm - 7:40 pm Jared M. Lucas (Fred Hutchinson Cancer Center, Seattle, Washington)
"Identification of Substrates for the Type II Transmembrane Serine Protease TMPRSS2 Involved in Prostate Cancer Metastasis"
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pm Hiroaki Kataoka (University of Miyazaki, Miyazaki, Japan)
"Roles of HAI-1 in Epithelial Integrity and Invasion of Carcinoma Cells"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Moon G. Kim (Inha University, Incheon, South Korea)
"Regulation of Endothelial Tie2 Signaling by a Extracellular Protease, Epithin (PRSS14)"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm Li Zhang (University of Maryland School of Medicine, Baltimore, Maryland)
"Protection of Mice from Endotoxemia-induced Death by Activated Protein C Requires Leukocyte Integrin CD11b and Protease Activated Receptor-1"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Zhi Xu (University of Notre Dame, South Bend, Indiana)
"Plasminogen Activator Inhibitor-1 Stimulates Macrophage Activation Through Toll-like Receptor-4"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Revu Ann Alexander (Medical University of Vienna, Vienna, Austria)
"VEGF-Induced Initial Endothelial Cell migration Requires Urokinase Receptor for Integrin Redistribution"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Eduardo Angles-Cano (INSERM, Caen, France)
"Plasmin-Induced Release of Neuronal Microparticles: Biomarkers of Neuronal Outcome and Proteolytic Messengers"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Sarah Netzel-Arnett (University of Maryland School of Medicine, Baltimore, Maryland)
"Targeting PAI-2 Prosurvival Pathways for Enhanced Stem Cell Based Therapy"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTumor Biology and Angiogenesis
Discussion Leaders: Sharon Stack (University of Missouri, Columbia, Missouri) & Irina Beloglazova (Institute of Experimental Cardiology, Moscow, Russia)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am Sharon Stack (University of Missouri, Columbia, Missouri)
"uPAR/Integrin Association and Altered MicroRNA Regulation in Oral Cancer"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Jim Quigley (Scripps Research Institute, La Jolla, California)
"Activation of uPA contributes functionally to Angiogenesis and the Dissemination of Human Fibrosarcoma and Prostate Carcinoma Cells"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Francesco Blasi (FIRC Institute of Molecular Oncology, Milan, Italy)
"Urokinase Receptor, Stem Cells and Cancer"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Steve Gonias (University of California, San Diego, California)
"Molecular Mechanisms by which uPAR Promotes Cancer Progression"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm Michael Ploug (Finsen Laboratory, Copenhagen, Denmark)
"The Urokinase Receptor. From Crystal Structure to in vivo Imaging"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:00 pmFree Time
5:00 pm - 6:00 pmFarewell Reception
6:00 pmDinner
7:30 pm - 9:30 pmProteases and Endocytic Receptors
Discussion Leaders: Dan Lawrence (University of Michigan Medical School, Ann Arbor, Michigan) & Gian Marua Sarra Ferraris (Institute of Molecular Oncology, Milan, Italy)
7:30 pm - 7:35 pm Introduction
7:35 pm - 8:00 pm Dudley Strickland (University of Maryland School of Medicine, Baltimore, Maryland)
"Regulation of inflammation and vascular remodeling by LRP1"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Joyce Chan (Amgen Inc., South San Francisco, California)
"Targeting of the Serine Protease, PCSK9, for the Treatment of Hypercholesterolemia"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Niels Behrendt (Finsen Laboratory, Copenhagen, Denmark)
"The Composite Function of Proteolytic and Endocytic Processes in Matrix Turnover and Cancer Invasion"
9:15 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this conference was made possible (in part) by 1 R13 HL 098974-01 from the National Institutes of Health, National Heart Lung and Blood Institute.
Last Updated: February 9, 2010