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Proteoglycans
Gordon Research Conference

Development, Disease and Therapeutics

Dates

July 11-16, 2010

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Marian F. Young

Vice Chair:
Robert J. Linhardt

Meeting Description

The goal of the 2010 Gordon Research Conference on Proteoglycans will be to bring together leading national and international scientists to present their latest findings in proteoglycan research. Topics that will be discussed include mechanisms regulating the production and assembly of the proteoglycans core proteins as well as their turnover. The role of proteoglycans in development, skeletal pathology, cancer, stem cells, regenerative medicine, inflammation, cardiovascular disease, and angiogenesis will also be addressed. The most recent progress within these areas with attention to the generation of both novel tracking assays and treatment regimens for diseases caused by abnormal proteoglycan function will be presented. Particular emphasis will be given to new insights into basic molecular mechanisms and to translational efforts designed to understand the role of proteoglycans in human disease as well as their use in prevention and novel therapeutics.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmLate Breaking Developments / Frontiers in Proteoglycan Research in Health and Disease
7:40 pm - 7:45 pmDiscussion Leader: Renato Iozzo (Thomas Jefferson University, USA)
7:45 pm - 8:25 pmBjorn Olsen (Harvard, USA)
"Unexpected matrix diseases and novel therapeutic strategies"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:05 pmJeffrey Esko (University of California, USA)
"Proteoglycan-Mediated Delivery of High-Molecular Weight Cargo to Cells"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pmJeremy Turnbull (University of Liverpool, UK)
"Sequence-specific HS modulation of FGF signalling using functional glycoarrays and ES-MS sequencing strategies"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGAG Synthesis, Assembly and Function: Spanning the Phyla; Basic to Applied
Discussion Leader: Jeffrey Esko (University of California, USA)
9:00 am - 9:20 amHenry Roehl (University of Sheffield, UK)
"Essential role of ext/dackel and papst1/pinscher in skeletogenesis revealed using zebrafish"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amMaurizio Pacifici (Thomas Jeffereson University, USA)
"Heparan sulfate insufficiency and the pathogenesis of Hereditary Multiple Exostoses syndrome"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 amMyron Hinsdale (Oklahoma State University, USA)
"Renal dysfunction and reduced proteoglycans"
10:10 am - 10:15 am Discussion
10:15 am - 10:25 amKevin McCarthy (Louisiana State University Health Sciences Center, USA)
"Cell surface-associated glycosaminoglycan control of integrin expression: a novel mechanism explaining podocyte detachment in diabetes mellitus"
10:25 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:20 amHannes Bülow (Albert Einstein College of Medicine, USA)
"HS modifications define a functional code by differential control of ligand/receptor interaction"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 amJean Spencer (Boston University School of Medicine, USA)
"ChamP analysis of vascular heparan sulfate: domain patterns, binding motifs, and much more"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 amYoung In Oh (CalTech University, USA)
"Synthesis and biological activity of heparan sulfate biomimetic glycopolymers"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmBrett Crawford (Zacharon, USA)
"Development of Novel Therapies for Mucopolysaccharidosis"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Softball Match
Social Chair: Megan Lord (University of New South Wales, Australia)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAngiogenesis, Cardiovascular Biology and Pathology
Discussion Leader: Thomas Wight (Benaroya Research Institute USA)
7:30 pm - 7:50 pmJens Fischer (Universität Duisburg-Essen, Germany)
"Small leucine-rich proteoglycans in atherosclerotic lesions: Novel targets of pharmacologic treatment?"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pmBarbara Triggs-Raine (University of Manitoba, Canada)
"Cardiac pathology in a mouse model deficient in Hyaluronidase 2"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pmJane Grande Allen (Rice University, USA)
"Hylauronan and proteoglycans in collagenous engineered tissues and calcified heart valves"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pmJuliana L. Dreyfuss (Massachusetts Institute of Technology, USA)
"The role of heparan sulfate in choroidal neovascularization"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmSuneel Apte (Cleveland Clinic, USA)
"Versican proteolysis by ADAMTS proteases-Mechanisms and biological implications"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevelopment
9:00 am - 9:05 amDiscussion Leader: Matthew Hoffman (NIH, USA)
9:05 am - 9:25 amXinhua Lin (Cincinnati Children’s Hospital, USA)
"The role glipican protein core and attached GAG in biphasic activites in wnt and Hh signaling and distribution"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 amJorge Filmus (University of Toronto, Canada)
"The role of glypican-5 in rhabdomyosarcomas"
9:55 am - 10:05 am Discussion
10:05 am - 10:30 am Coffee Break
10:30 am - 10:50 amNancy Schwartz (University of Chicago, USA)
"Role of CSPGs in growth factor signaling"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amSarah Knox (NIH, USA)
"Role of proteoglycans and the parasympathetic nervous system during branching morphogenesis"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 amMartin Hudson (University of Kansas, USA)
"C. elegans axon branch formation is regulated by multiple proteoglycans"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 amTabea Dierker (University of Essen, Germany)
"Dual heparan sulfate functions in Sonic hedgehog solubilization and stabilization"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmBarbara Bartolini (University of Lund, Sweden)
"Dermatan sulfate epimerase 1 and 2: roles in the synthesis and sulfation of dermatan sulfate iduronic acid domains"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmThao Nguyen (University of Utah, USA)
"Modulating zebrafish heparanome to decipher heparan sulfate-FGF interactions in vivo"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Cricket Match
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cells: Identity and Function
Discussion Leader: Catherine Merry (University of Manchester, UK)
7:30 pm - 7:50 pmLianchun Wang (University of Georgia, USA)
"Heparan Sulfate Is Required For Cell Fate Commitment Of Embryonic Stem Cells"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmBruce Caterson (Cardiff University, UK)
"Chondroitin Sulphate Glycobiology in the Stem/Progenitor Cell Niche"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmBrian Bigger (University of Manchester, UK)
"Heparan sulphate storage and stem cell migration in disease"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmBecki Holley (University of Manchester, UK)
"Use of HS oligos to functionalize biomaterial scaffolds for ES cell culture and differentiation"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmLola Reid (University of North Carolina, NC)
"Lineage restriction of stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSkeletal Biology: Biomarkers and the Bone: Cartilage Interface
Discussion Leader: Tim Hardingham (University of Manchester, UK)
A. Genes and Development
9:00 am - 9:20 amShiro Ikegawa (Center for Genomic Medicine, Japan)
"From genome to skeletal diseases- recent advances in the association study of osteoarthritis and lumbar disc herniation and its association with ECM biology"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 amHideto Watanabe (Aichi Medical University)
"Versican facilitates chondrocyte differentiation and regulates joint morphogenesis"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 amAnders Aspberg (University of Copenhagen)
"Normal skeletal development but disturbed perineural net formation in knock-in mice with deleted aggrecan C-type lectin repeat"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 amJohn Whitelock (University of New South Wales, Australia)
"Heparan Sulfate dependent signaling of fibroblast growth factor (FGF) 18 by chondrocytederived perlecan"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
B. Signaling, Disease and Therapy
10:45 am - 10:55 am Andrea Vortkamp (University of Duisburg-Essen)
"Molecular characterization of osteochondroma development in mice"
10:55 am - 11:00 am Discussion
11:00 am - 11:10 amAgnes Berendsen (NIH, USA)
"A Novel Mechanism for Modulation of Canonical Wnt Signaling by the ECM Component, Biglycan"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 amMorten Karsdal (Nordic Bioscience, Denmark)
"Aggrecan degradation is associated with both reversible and irreversible tissue damage - Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics and separated in time ex vivo"
11:35 am - 11:50 am Discussion
11:50 am - 12:10 pmMartha Gray (MIT, USA)
"Molecular imaging of GAGs to monitor OA disease progression"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Soccer Match
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmInflammation: From Tolerance to Autoimmunity
Discussion Leader: Carol DeLa Motte (Cleveland Clinic, USA)
7:30 pm - 7:50 pmPaul Bollyky (Benaroya Research Institute, USA)
"The development of ECM-based tools for the induction of immune tolerance"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pmAkira Asari (Hyaluronan Reserch Institute, Japan)
"Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via toll-like receptor 4 in the intestinal epithelium"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Liliana Schaefer (University of Frankfurt, Germany)
"Biglycan signaling: Toll-like receptors, the NLRP3-inflammasome and beyond"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pmNicholas Shworak (Dartmouth Medical School, USA)
"Unique role of anticoagulant heparan sulfate in antithrombin anti-inflammatory signaling"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmRichard Stevens (Brigham and Women’s Hospital, USA)
"Mast cell-restricted serglycin proteoglycan-protease complexes in innate immunity, inflammation, and connective tissue remodelling"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCancer
Discussion Leader: Ralph Sanderson (University of Alabama, USA)
9:00 am - 9:20 amAndreas Friedl (USA)
"Regulation of Extracellular Matrix Fiber Organization and Carcinoma Cell Motility by Stromal Syndecan-1"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 amVivien J. Coulson-Thomas (Universidade Federal de San Paulo, Brazil)
"Fibroblast and prostate tumor cell cross-talk: fibroblast differentiation, TGFβ and extracellular matrix down-regulation"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 amIsrael Vlodavsky (Israel)
"Heparanase: one molecule with multiple functions in cancer and other diseases"
10:15 am - 10:25 am Discussion
10:25 am - 10:45 am Coffee Break
10:45 am - 10:55 amAnurag Purushothaman (University of Alabama, USA)
"Heparanase mediated loss of nuclear syndecan-1 enhances histone acetyltransferase activity and gene expression to promote an aggressive tumor phenotype"
10:55 am - 11:00 am Discussion
11:00 am - 11:10 amHassan Lemjabbar-Alaoui (University of California, San Francisco, USA)
"Pharmacologic Inhibition of Sulf-2 in lung cancer cells reverts transformed phenotype"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 amMelanie Simpson (University of Nebraska, USA)
"Hyaluronan accumulation or steroid sequestration: outcomes of aberrant glucuronidation"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Daniel Grass (Medical University of South Carolina, USA)
"Interactions between hyaluronan, CD44 and CD147 (emmprin; basigin) regulate properties of highly tumorigenic subpopulations of cancer cells"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmMartin Thelin (University of Lund, Sweden)
"Lentiviral vector-mediated downregulation of DS-epimerase 1 in a squamous cell carcinoma cell line results in increased cell size and altered golgi localization"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Soccer Match
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 7:40 pmPoster Awards
Leader: Robert Linhardt (Conference Vice Chair)
7:40 pm - 9:30 pmProteoglycans in Translational Research: Therapeutics
Discussion Leader: Robert Linhardt (Rensselaer Polytechnic Institute, USA)
7:40 pm - 7:55 pmRobert Mecham (Washington University School of Medicine, USA)
"Vascular extracellular matrix and vessel wall development"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:15 pmDavid McQuillan (Life Cell, USA)
"Matrix-Directed Regeneration of Soft Tissues"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:30 pmGlen Prestwich (University of Utah, USA)
"Therapeutic Uses of Sulfated Polysaccharide RAGE Antagonists: Novel Modulators of Inflammatory Response"
8:30 pm - 8:35 pm Discussion
8:35 pm - 8:45 pmAnders Malmstrom (University of Lund, Sweden)
"Mechanisms of Action for Tafoxiparin Belonging to a Novel Class of Heparin Derived Compounds - Low Anticoagulant Heparin (LAH) - on Human Labor"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:00 pmKuby Balagurunathan (University of Utah)
"Heparanomics: Biosynthesis, Structures and Functions"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:20 pmYu Yamaguchi (Burnham Institute for Medical Research, USA)
"HS-proteoglycan animal models of autism"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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