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Protein Folding Dynamics
Gordon Research Conference

Dates

January 10-15, 2010

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Susan Marqusee

Vice Chair:
Dave Thirumalai

Meeting Description

The 2010 Gordon Research Conference on Protein Folding Dynamics will provide an exciting forum to discuss new developments in both theoretical and experimental studies in protein folding dynamics. An understanding of Protein Folding Dynamics - the dynamical and energetic features encoded in a polypeptide sequence - is an essential component to deciphering the subtleties encoded in the genome; elucidating issues of protein function, design and the origin of misfolding diseases. Emerging developments in fast spectroscopy, single molecule techniques, simulation approaches and molecular and cellular biology together with established experiments utilizing NMR and other visible spectroscopy are fueling investigations with increasingly more quantitative detail. Consequently, protein folding, engages a highly multi- and interdisciplinary group of scientists working at the forefront of research in biological and biophysical methodologies and theory; few other fields see such a successful blend of physical and biological sciences. The Gordon Research Conference in Protein Folding Dynamics was established specifically to bring experiment and theory together to explore advances in the field. Invited speakers will present cutting edge research, looking at the folding process (in solution, in the crowded cellular environment, and at the ribosome during protein synthesis) as well as the fluctuations needed to provide important cellular processes such as molecular motors and signaling. In addition to the invited presentations from leaders in the field, the conference will provide opportunities for junior scientists and graduate students to present their work via abstract-selected presentations and posters. Graduate students and post-doctoral fellows are encouraged to attend the accompanying Gordon Research Seminar in Protein Folding Dynamics which will include an overview of the field as well as an opportunity to present research results.

Related Meeting

This GRC was held in conjunction with the "Protein Folding Dynamics" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lectures
Discussion Leader: Harold Scheraga (Cornell University)
7:40 pm - 8:15 pm Charlie Brooks (University of Michigan)
"Simulation studies of protein folding from conformational networks to protein function"
8:15 pm - 8:30 pm Discussion
8:30 pm - 9:05 pm Bill Eaton (National Institutes of Health)
"Ultrafast protein folding: from ensembles to single molecules"
9:05 pm - 9:20 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNavigating the Energy Landscape
Discussion Leader: Sheena Radford (University of Leeds)
9:10 am - 9:35 am Doug Barrick (Johns Hopkins University)
"Measurement of long-range coupling energetics and contribution to protein folding kinetics"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Dan Raleigh (SUNY Stony Brook)
"Unfolded states under native conditions: Not a random coil"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break / Group Photo
10:45 am - 11:10 am Peter Wolynes (University of California, San Diego)
11:10 am - 11:15 am Discussion
11:15 am - 11:30 am Wei Wang (Nanjing University)
"Protein Folding Mediated by Cofactors"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Mikael Oliveberg (Stockholm University)
"Functional frustration in the ALS-associated protein SOD1"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Machines: Dynamics and Function
Discussion Leader: Jose Onuchic (University of California, San Diego)
7:40 pm - 8:05 pm Klaus Schulten (University of Illinois, Urbana-Champaign)
"Microsecond molecular dynamics simulations of protein folding - successes, failures, and challenges"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Changbong Hyeon (Chung-Ang University, Korea)
"Understanding the principles of molecular nanomachines"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Lorna Dougan (University of Leeds)
"Identifying the role of the solvent environment in protein folding"
9:15 pm - 9:25 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFluctuations in the native state
Discussion Leader: Ken Dill (University of California, San Francisco)
9:10 am - 9:35 am Jaime Fraser (University of California, Berkeley)
"Hidden Alternate Structures Essential For Catalysis"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am Riina Tehver (University of Maryland)
"Myosin V Allostery: Link between the Dynamics and its Supporting Architecture"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:05 am Hue Sun Chan (University of Toronto)
"Interplay of Native Topology and Nonnative Interactions in Cooperative and Noncooperative Protein Folding"
11:05 am - 11:15 am Discussion
11:15 am - 11:45 am Jane Dyson (The Scripps Research Institute)
"NMR Studies of Protein Folding Dynamics"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Ivet Bahar (University of Pittsburgh)
"Functional Dynamics of Proteins: Learning from Ensembles of Structures and Network Models"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrom Evolution to Pathways and Design
Discussion Leader: Jane Clarke (Cambridge University)
7:40 pm - 8:05 pm Eugene Shakhnovitch (Harvard University)
"Effect of protein folding on fitness landscape"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Frances Arnold (California Institute of Technology)
"How proteins adapt: lessons from laboratory evolution"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Tobin Sosnick (University of Chicago)
"Using the folding process to improve protein structure prediction"
9:15 pm - 9:25 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFolding in vivo and off the ribosome
Discussion Leader: Joan Shea (University of California, Santa Barbara)
9:10 am - 9:35 am Andreas Mastoushek (Northwestern University)
"Substrate selection by the proteasome"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am Patricia Clark (University of Notre Dame)
"The Influence of Translation on Protein Folding"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:05 am Judith Frydman (Stanford University)
"Mechanisms of chaperone-assisted protein folding in the eukaryotic cytosol"
11:05 am - 11:15 am Discussion
11:15 am - 11:45 am George Lorimer (University of Maryland)
"Allosteric states and chaperonin assisted protein folding"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Johannes Buchner (Technische Universitaet München)
"Functional principles of molecular chaperones"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmPushing the Limits
Discussion Leader: Matthias Reif
7:40 pm - 8:05 pm Vijay Pande (Stanford University)
"Insights from all-atom simulations of folding on the millisecond timescale and beyond"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Ruxandra Dima (University of Cincinnati)
"Exploring factors that determine the mechanical response of proteins: from globular proteins to protofilaments"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Josh Wand (University of Pennsylvania)
"Scraping the bottom of the funnel: dynamics, entropy and solvation in the native state"
9:15 pm - 9:25 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMisfolding and Aggregation
Discussion Leader: Jennifer Lee (National Institutes of Health)
9:10 am - 9:35 am Phillip Geissler (University of California, Berkeley)
"Solvation, sterics, and side chains: Fluidity within proteins' native states"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am Zoya Ignatova (University of Potsdam)
"Natural osmolytes modulate the aggregation pathway of polyglutamine proteins"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:05 am Yuji Goto (Osaka University)
"Amyloid fibril growth visualized by thioflavin T fluorescence and probed by H/D exchange"
11:05 am - 11:15 am Discussion
11:15 am - 11:45 am John Straub (Boston University)
"Exploring the role of sequence and environment in the early stages of the protein aggregation pathway"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Rob Tycko (National Institutes of Health)
"Characterization of Unfolded, Partially Folded, and Misfolded Proteins by Solid State NMR"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein Energetics and Cosolvents
Discussion Leader: Walter Englander (University of Pennsylvania)
7:40 pm - 8:10 pm Rohit Pappu (Washington University, St. Louis)
"Conformational equilibria and 'phase' diagrams of intrinsically disordered polypeptides"
8:10 pm - 8:25 pm Discussion
8:25 pm - 8:40 pm Ruhong Zhou (IBM Thomas J. Watson Research Center)
"Action of Urea: Molecular Picture of Protein Chemical Denaturing from Large Scale Simulations"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm George Makhatadze (Rensselaer Polytechnic Institute)
"Protein Stability and Cooperativity: Effects of Different Denaturing Factors"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1R13GM090605-01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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