The goals of this Conference on “Signalling by Adhesion Receptors” are to increase our understanding of how cells sense and respond to signals from the extracellular matrix and neighboring cells, and how they convert those signals into changes in cell decision making in differentiation, cell movement, and cell-cell interactions in normal and disease states. Answers to these problems are central to understanding the mechanics of cell movements and interactions during embryogenesis and diseases such as metastatic cancer. The meeting will including 22 invited and 16 speakers chosen from submissions and a total of ~170 participants for the five day Conference. The Conference provides a unique forum to compare, contrast and integrate information from the latest studies of a diversity of adhesion receptors and the cellular mechanisms linking them to intracellular signaling pathways and the cytoskeleton. This GRC on Signaling by Cell Adhesion Receptors is uniquely positioned at the nexus of cell adhesion, signaling and fate, and therefore attracts international leaders and students from a diversity of disciplines including developmental biologists and clinicians interested in 3-D tissue organization and disease processes, cell biologists and biochemists interested in cellular mechanisms, and biophysicists and bio-engineers interested in measuring adhesion forces and fabricating cell microenvironments. The crosstalk and cross-fertilization of ideas between scientists with these different research interests and expertise will contribute greatly to the impact of the Conference across these fields.