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Synaptic Transmission
July 25-30, 2010
University of New England
Biddeford, ME
Chair:
Pablo E. Castillo

Vice Chair:
Felix E. Schweizer

Synaptic transmission underlies nearly every aspect of nervous system function and is relevant to most neuropsychiatric conditions. It has become increasingly clear that the communication between neurons is a highly complex, dynamically regulated process, and that a comprehensive understanding of such a process requires a multidisciplinary approach and the complementary use of cutting-edge techniques. The Gordon Research Conference on Synaptic Transmission, established in 1998, highly successful and widely attended since then, has developed into the quintessential biannual meeting covering all aspects of synaptic communication. The 2010 Conference will present major recent advances on a wide range of topics related to synaptic transmission including, the molecular basis of transmitter release, postsynaptic signaling and receptor trafficking, local protein synthesis and synaptic function, synaptic plasticity, trans-synaptic signaling, as well as synaptic dysfunction as a mechanism of brain disorders. The Conference will bring together a diverse group of investigators who are at the forefront of their field, and will provide ample opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with world-class leaders in the field. Some poster presenters will be selected for short talks. In addition, keynote lectures will be delivered by two outstanding scientists whose work on synapses is both highly influential and complementary. The collegial atmosphere of Gordon Research Conferences, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an ideal venue to discuss the most exciting discoveries in the field. The Conference bridges across disciplines by bringing together experts in different areas, and fosters future developments by promoting the interaction between senior and junior investigators. The GRC on Synaptic Transmission will be held at the modern University of New England Campus on the scenic US Atlantic coast in Biddeford, Maine.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKEYNOTE LECTURES: SYNAPSES AT CENTER STAGE OF BRAIN FUNCTION AND DISEASE
Discussion Leader: Pablo E. Castillo (Albert Einstein College of Medicine, USA)
7:40 pm - 8:20 pm Thomas C. Südhof (Stanford University, USA)
"Molecular dissection of active zone function in neurotransmitter release"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Susumu Tonegawa (MIT, USA - RIKEN/BSI, Japan)
"Hippocampal Circuits for Learning and Memory"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTRANSMITTER RELEASE
9:00 am - 9:05 am Discussion Leader: Peter Jonas (Institute of Science and Technology, Austria)
"Introductory remarks"
9:05 am - 9:30 am Erwin Neher (Max-Plank Institute, Germany)
"What limits neurotransmitter release during sustained synaptic activity: Availability of vesicles or refractoriness of release sites?"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Ling-Wang Wu (NIH, USA)
"Multiple modes of exo- and endocytosis at the calyx of Held nerve terminal"
10:10 am - 10:25 am Discussion
10:25 am Coffee Break
10:55 am - 11:20 am Ralf Schneggenburger (EPFL, Switzerland)
"Molecular targeting of a large CNS synapse yields new insights into transmitter release and active zone function"
11:20 am - 11:35 am Discussion
11:35 am - 11:50 am Stefan Hallerman (University of Leipzig, Germany)
"Bassoon speeds vesicle reloading at a central excitatory synapse"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Nicholas Oesch (NIH, USA)
"Release probability and vesicle replenishment regulate responses at a ribbon synapse"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmPOSTSYNAPTIC SIGNALING AND RECEPTOR TRAFFICKING
7:30 pm - 7:35 pm Discussion Leader: Katherine Roche (NIH, USA)
"Introductory remarks"
7:35 pm - 8:00 pm Daniel Choquet (CNRS, France)
"Linking excitatory transmission with AMPAR surface diffusion"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Susumu Tomita (Yale University, USA)
"Roles of glutamate receptor auxiliary subunits in synaptic transmission"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Josef Kittler (University College of London, UK)
"Rapid Synaptic Delivery of GABAA Receptors and the Tuning of Inhibitory Transmission"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLONG-TERM SYNAPTIC PLASTICITY
9:00 am - 9:05 am Discussion Leader: Alison Barth (Carnegie Mellon University, USA)
"Introductory remarks"
9:05 am - 9:30 am Ryohei Yasuda (Duke University, USA)
"Imaging signal transduction in single dendritic spines"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Julie Kauer (Brown University, USA)
"TRPV1 channels in LTD"
10:10 am - 10:25 am Discussion
10:25 am Coffee Break
10:55 am - 11:20 am Indira Raman (Northwestern University, USA)
"Inhibitory control of excitatory synaptic plasticity in the cerebellar nuclei"
11:20 am - 11:35 am Discussion
11:35 am - 11:50 am Yasunori Hayashi (RIKEN/BSI, Japan)
"Sequential reorganization of synaptic components after LTP induction"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Camilla Bellone (University of Geneva, Switzerland)
"In utero exposure to cocaine impairs synaptic maturation of glutamatergic transmission in the VTA"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 8:55 pmRELEASE MACHINERY AND SYNAPTIC VESICLE FUNCTION
7:30 pm - 7:35 pm Discussion Leader: Felix Schweizer (UCLA, USA)
"Introductory remarks"
7:35 pm - 8:00 pm Ege Kavalali (UTSW Medical Center, USA)
"Deconstructing presynaptic trafficking machinery and neurotransmission"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Sandra Bajjalieh (University of Washington, USA)
"There and back again - regulating exocytosis via endocytosis"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:30 pmDATA BLITZ
Discussion Leader: Felix Schweizer (UCLA, USA)
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSYNAPTIC BASIS OF BRAIN DISORDERS
9:00 am - 9:05 am Discussion Leader: Robert C. Malenka (Stanford University, USA)
"Introductory remarks"
9:05 am - 9:30 am Nils Brose (Max-Plank Institute, Germany)
"SNARE protein recycling and synaptic vesicle priming"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Marina Wolf (Rosalind Franklin University, USA)
"Plasticity of AMPA receptor transmission: a key mechanism controlling the reactivity of nucleus accumbens neurons following cocaine withdrawal"
10:10 am - 10:25 am Discussion
10:25 am Coffee Break
10:50 am - 11:15 am Linda Van Aelst (Cold Spring Harbor Laboratory, USA)
"Rho Regulators in Synapse Development and Disease"
11:15 am - 11:30 am Discussion
11:30 am - 11:55 am Jie Shen (Harvard University, USA)
"Neurotransmission and Neurodegeneration"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:25 pm Helen Bateup (Harvard University, USA)
"Loss of Tsc1 in hippocampal neurons leads to defects in protein translation-dependent synaptic plasticity"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmSYNAPTIC INTEGRATION AND CIRCUITS
7:30 pm - 7:35 pm Discussion Leader: Bernardo Sabatini (Harvard University, USA)
"Introductory remarks"
7:35 pm - 8:00 pm Angus Silver (University College of London, UK)
"Desynchronization of an electrically coupled interneuron network with excitatory synaptic input"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Rachel Wilson (Harvard University, USA)
"Synaptic mechanisms of early olfactory processing"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Nelson Spruston (Northwestern University, USA)
"Persistent firing of inhibitory interneurons in the hippocampus"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSHORT-TERM PLASTICITY AND TRANS-SYNAPTIC SIGNALING
9:00 am - 9:05 am Discussion Leader: Roger Nicoll (UCSF, USA)
"Introductory remarks"
9:05 am - 9:30 am Chris McBain (NIH, USA)
"Short term dynamics maintain the balance of excitation:inhibition in the hippocampal mossy fiber circuit"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Wade Regehr (Harvard University, USA)
"Cerebellar LTP is Induced by a Localized Calcium Signal"
10:10 am - 10:25 am Discussion
10:25 am Coffee Break
10:55 am - 11:20 am Yukiko Goda (University College of London, UK)
"Trans-synaptic regulation of neurotransmitter release by N-cadherins"
11:20 am - 11:35 am Discussion
11:35 am - 12:00 pm Lu Chen (UC Berkeley, USA)
"Involvement of FMRP in RA-mediated synaptic signaling"
12:00 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Jason Pugh (Vollum Institute, USA)
"Activation of axonal GABAA receptors increases excitability and release probability"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pmSYNAPTIC FUNCTION AND LOCAL PROTEIN SYNTHESIS
7:30 pm - 7:35 pm Discussion Leader: Lu Chen (UC Berkeley, USA)
"Introductory remarks"
7:35 pm - 8:00 pm Kimberley Huber (UTSW Medical Center, USA)
"Translational control of synaptic plasticity and function by Fragile X Mental Retardation Protein"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Eric Klann (New York University, USA)
"Mechanisms of Translational Control in Synaptic Plasticity and Memory"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Claudia Bagni (University of Rome, Italy)
"Synaptic dysfunction in Mental Retardation: effects of altered local protein synthesis"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
The project described was supported by Award Number R13NS070310 from the National Institute Of Neurological Disorders And Stroke. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Neurological Disorders And Stroke or the National Institutes of Health.
 
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