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Chemistry and Biology of Tetrapyrroles
Gordon Research Conference

Dates

July 25-30, 2010

Location

Salve Regina University
Newport, RI

Organizers

Chair:
Angela Wilks

Vice Chair:
Harry A. Dailey

Meeting Description

The objective of the Chemistry & Biology of Tetrapyrroles Gordon Conference is to bring together researchers from diverse disciplines that otherwise would not interact. By bringing biologists, chemists, engineers and clinicians with a common interest in tetrapyrroles the conference provides a forum for cross-disciplinary ideas and collaboration. The perspective provided by biologists, chemists, and clinicians working in fields such as newly discovered defects in human porphyrin metabolism, the myriad of strategies for light harvesting in photosynthetic organisms, novel tetrapyrroles that serve as auxiliary chromophores or enzyme cofactors, synthetic strategies in the design of novel tetrapyrrole scaffolds, and tetrapyrrole based cell signaling and regulatory systems, makes this conference unique in the field. Over the years the growing evidence for the role of tetrapyrroles and their reactive intermediates in cell signaling and regulation has been of increasing importance at this conference. The 2010 conference on Chemistry & Biology of Tetrapyrroles will focus on many of these new frontiers as outlined in the preliminary program listed below.

Speakers will emphasize unpublished results and new findings in the field. The oral sessions will be followed by the highly interactive afternoon poster sessions. The poster sessions provide all conferees with the opportunity to present their latest research and to exchange ideas in a more informal setting. As in the past, this opportunity will continue during the nightly social gathering that takes place in the poster hall following the evening lectures. All conferees are encouraged to submit and present posters. At the conference the best poster in the areas of biology, chemistry and medicine will be selected by a panel of previous conference chairs.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmHEME DEGRADATION: OXIDATIVE STRESS AND CELLULAR FUNCTION
Discussion Leader: Paul R. Ortiz de Montellano (University of California at San Francisco, USA)
7:40 pm - 8:20 pmStephen W. Ragsdale (University of Michigan, USA)
"Thiol-disulfide redox switches that regulate heme-binding to proteins"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pmMahin D. Maines (University of Rochester, USA)
"Human biliverdin reductase; a bridge at the crossroads of multiple signal transduction pathways"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHEME BIOSYNTHESIS: GENES, PROTEINS AND DISEASE
Discussion Leader: Jean Charles Deybach (University of Paris, FRANCE)
9:00 am - 9:40 amBarry H. Paw (Harvard Medical School, USA)
"Mitoferrin solute carriers and their role in vertebrate heme synthesis in the mitochondria"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo (10:15 am)
10:30 am - 11:10 amSharon D. Whatley (University of Cardiff, UK)
"Molecular basis of human protoporphyria"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmJohn D. Phillips (University of Utah, USA)
"Efficient decarboxylation: What works and why"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLIGHT HARVESTING PIGMENTS: STRUCTURE, FUNCTION AND REGULATION
Discussion Leader: Alison Smith (University of Cambridge, UK)
7:30 pm - 8:10 pmJesse Woodson (Salk Institute, USA)
"Tetrapyrroles and chloroplast to nucleus communication in Arabidopsis"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmMatthew J. Terry (University of Southampton, UK)
"Regulation of chlorophyll synthesis by light and plastid signals"
9:10 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTETRAPYRROLE ENZYMES: CATALYSIS AND REACTIVITY
Discussion Leader: Gloria Ferreira (University of Southern Florida, USA)
9:00 am - 9:40 amJennifer L. DuBois (University of Notre Dame, USA)
"Making Dioxygen using Heme : O-O Bond Formation by Chlorite Dismutase"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amMartin J. Warren (University of Kent, UK)
"Putting tetrapyrroles in their place - the assembly of an organelle specifically for cobalamin dependent enzymes"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmC.S. Raman (University of Maryland, Baltimore, USA)
"How do novel functions evolve from existing heme protein scaffolds?"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTETRAPYRROLES: NEW METHODOLOGIES IN CATALYSIS AND CHEMISTRY
Discussion Leader: Kevin Smith (Louisiana State University, USA)
7:30 pm - 8:10 pmSilviu Balaban (Karlsruhe Institute of Technology, Germany)
"Biomimetic Light-harvesting"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmR. David Britt (University of California at Davis, USA)
"Multifrequency EPR studies of biliverdin-derived radical intermediates in the bilin reductase enzyme pcyA"
9:10 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHEME TRANSPORTERS, SENSORS AND REGULATORS
Discussion Leader: Bill Lanzilotta (University of Georgia, USA)
9:00 am - 9:40 amCarla V. Finkielstein (Virginia Polytechnic Institute, USA)
"Cross-talk mechanisms link circadian pathways to metabolic conditions"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amStuart J. Ferguson (University of Oxford, UK)
"Complexity and Diversity in making the thioether bonds to heme in c-type cytochromes"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmMark R. O’Brian (SUNY at Buffalo)
"Heme-mediated control of metal homeostasis"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTETRAPYRROLES AS IMAGING AND THERAPEUTIC MOLECULES
Discussion Leader: Graça H. Vicente (Louisiana State University, USA)
7:30 pm - 8:10 pmZeev Gross (Technion-Israel Institute of Chemistry, Israel)
"Metalocorroles for cellular and whole animal imaging and as therapeutic molecules"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmGang Zheng (University of Toronto, Canada)
"New roles for porphyrins in molecular imaging and therapy"
9:10 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHEME IN INFECTIOUS DISEASE
Discussion Leader: Eric Skaar (Vanderbilt University, USA)
9:00 am - 9:40 amCecile Wandersman (Institute Pasteur, France)
"Iron extraction from heme: hammer or forceps"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amBernard Meunier (Palumed, FRANCE)
"Heme as trigger and target for trioxane-containing antimalarial drugs"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmAmanda G. Oglesby (University of Colorado at Denver, USA)
"Heme regulation in Pseudomonas aeruginosa"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:15 pmKEYNOTE ADDRESS
Discussion Leader: Nicole Frankenburg-Dinkel (Ruhr-University, Bochum, Germany)
8:00 pm - 8:50 pmJ. Clark Lagarias (University of California at Davis, USA)
"Lord of the broken rings: From near UV to near IR and back again"
8:50 pm - 9:15 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 DK88398-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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