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Transglutaminases in Human Disease Processes
July 18-23, 2010
Davidson College
Davidson, NC
Chair:
Richard L. Eckert

Vice Chair:
Kapil Mehta

The 2010 Gordon Conference on "Transglutaminases in Human Disease Processes" is the first Gordon Conference to focus on this rapidly expanding field. The meeting will cover cutting-edge research on the biology of transglutaminases and the role of this family of enzymes in disease processes. Sessions will cover recent advances relating to the following topics:

  • Transglutaminases in cancer and inflammatory disease
  • Transglutaminases in celiac, neurodegeneration, and cardiovascular disease
  • Transglutaminases and intracellular signal transduction
  • Transglutaminase function in matrix remodeling and protein crosslinking
  • Transglutaminases as therapeutic targets
  • Transglutaminase regulation of cell survival and differentiation
  • Transglutaminases in industrial applications

This conference will bring together an international group of experts working in the rapidly expanding field with a goal of presenting and discussing the most recent advances in this field. Each talk will be structured to include ample time for discussion. Discussion will cover key issues of current relevance to the field and the implications of the work for future development of this area. There will be ample opportunity for informal discussion among attendees during the meeting. In particular this meeting is designed to provide an opportunity for young investigators to participate and interact with established experts in the field.

Contributors
SUNDAY
1:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pm - 7:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTransglutaminases and Human Disease Processes
7:40 pm - 7:50 pm Welcome Address from Conference Chair, Richard Eckert and Kapil Mehta, Vice-Chair
7:50 pm - 8:35 pm Keynote Lecture: Laszlo Fesus (University of Debrecen, Hungary)
"Transglutaminases in clinical research"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:20 pm Keynote Lecture: Martin Griffin (Aston University, UK)
"TG2-A novel extracellular scaffold protein with a sting in its tail"
9:20 pm - 9:30 pm Discussion
9:30 pm Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTransglutaminase and Cancer
9:00 am - 9:15 am Discussion Leader: Kapil Mehta (MD Anderson Cancer Center, USA)
"Transglutaminase 2: At crossroads of an oncogene and a tumor suppressor?"
9:15 am - 9:45 am Daniela Matei (Indiana University Cancer Center, USA)
"Tissue Transglutaminase - Mediated Metastasis in Ovarian Cancer"
9:45 am - 9:55 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 11:00 am Anupam Kumar (MD Anderson Cancer Center, USA)
"Tissue transglutaminase induces epithelial to mesenchymal transition and promotes cell survival and invasive functions in mammary epithelial cells"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Simone Beninati (University of Rome "Tor Vergata", ITALY)
"Differentiation Therapy of Cancer: biological and clinical significance of Transglutaminase"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Marc Antonyak (Cornell University, USA)
"A Novel Role for Tissue Transglutaminase in Cancer Cell Progression"
12:20 pm - 12:30 pm Discussion
12:30 pm - 1:15 pmLunch
1:15 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pm - 7:00 pmDinner
7:30 pm - 9:30 pmTransglutaminases Inhibitors and Substrates
7:30 pm - 7:45 pm Discussion Leader: Carlo Bergamini (University of Ferrara, ITALY)
"Transglutaminase Inhibitors and Substrates - Overview"
7:45 pm - 8:10 pm Soichi Kojima (Riken University, Tokyo, JAPAN)
"Controlling activities of nuclear TG2 and transcription factors"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Chaitan Khosla (Stanford University, USA)
"Chemical Probes for the Biology of Transglutaminase 2"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Kiyotaka Hitomi (Nagoya University, JAPAN)
"Identification of highly reactive substrate peptides for transglutaminases from random peptide library and their applications"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminases and Cell Signaling
9:00 am - 9:15 am Discussion Leader: Richard Eckert (University of Maryland-SOM, USA)
"TG1, TIG3 and cell signaling"
9:15 am - 9:45 am Ugra Singh (South Carolina Medical Center, USA)
"Targeting transglutaminase to prevent cell migration"
9:45 am - 9:55 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 11:00 am Richard Cerione (Cornell University, USA)
"Signaling to transglutaminase and its role in cell growth and migration"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Elisabetta Verderio (Nottingham Trent University, UK)
"Significance of syndecan-4-transglutaminase-2 interaction"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Shougang Zhuang (Brown University-SOM, USA)
"Transglutaminase-1 regulated cell proliferation and survival signaling pathways"
12:20 pm - 12:30 pm Discussion
12:30 pm - 1:15 pmLunch
1:15 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pm - 7:00 pmDinner
7:30 pm - 9:30 pmTransglutaminase and Renal and Vascular Systems
7:30 pm - 7:45 pm Discussion Leader: Alexey Belkin (University of Maryland-SOM, USA)
"Mechanism of transglutaminase secretion"
7:45 pm - 8:10 pm Tim Johnson (University of Sheffield, UK)
"TG2 in kidney fibrosis & scarring: a hot diagnostic & therapeutic target!"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Erik Bakker (Academic Medical Center, NETHERLANDS)
"Transglutamnases in blood pressure and blood flow induced small artery remodeling"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Zsuzsa Szondy (University of Debrecen, HUNGARY)
"Transglutaminase 2 is required for proper phagocytosis of apoptotic cells and to prevent autoimmunity"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminase and Neurological Disorders
9:00 am - 9:15 am Discussion Leader: Gail Johnson (University of Rochester, USA)
"The Protective Role of Transglutaminase 2 in Ischemic Cell Death"
9:15 am - 9:45 am Arthur J. Cooper (New York Medical College, USA)
"γ-Glutamylamines as Indices of Neurodegeneration"
9:45 am - 9:55 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 11:00 am Philippe Djian (Universite Paris Descartes)
"Does transglutaminase contribute to the aggregation of polyglutamine in neurological disease?"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Mauro Piacentini (University of Rome, "Tor Vergata", ITALY)
"Type 2 Transglutaminase in Huntington's Disease: a double-edged sword with clinical potential"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Anne-Marie van Dam (VU University Medical Center, Amsterdam, Netherlands)
"Local Tissue Transglutaminase Activity Directs Experimental Multiple Sclerosis Pathology"
12:20 pm - 12:30 pm Discussion
12:30 pm - 1:15 pmLunch
1:15 pm - 6:00 pmFree Time / Optional White Water Rafting excursion (additional fee required)
4:00 pm - 6:00 pmPoster Session
6:00 pm - 7:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmTransglutaminases and Celiac Disease
7:30 pm - 7:45 pm Discussion Leader: Siiri Iismaa (Chang Cardiac Center, AUSTRALIA)
"Transglutaminase 2 isoforms and neuroblastoma cell differentiation"
7:45 pm - 8:10 pm Carla Esposito (University of Salerno, ITALY)
"Relationship among tissue transglutaminase, anti-transglutaminase antibodies and gliadin peptides in celiac disease: biological effects and molecular studies"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm In-Gyu Kim (Seoul National University, KOREA)
"Transglutaminase 2 induces the differentiation of TH17 cells in response to tissue damage"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Ludvig Sollid (University of Oslo, NORWAY)
"Transglutaminase 2 and Celiac Disease"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminases and Differentiation (Types 1, 2 and 4)
9:00 am - 9:15 am Discussion Leader: Said El Alaoui (CovaLab)
"Overview on the isoenzyme-specific assays for transglutaminase 1, 2 and FXIII activities"
9:15 am - 9:45 am Haibing Jiang (University of Maryland-SOM, USA)
"Subcellular processing of TG1 and a new mechanism causing Autosomal Recessive Congenital Ichthyosis"
9:45 am - 9:55 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 11:00 am Wen G. Jiang (Cardiff University, UK)
"Transglutaminase-4 and the aggressive nature of human prostrate cancer"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Maria Nurminskaya (University of Maryland-SOM, USA)
"Cross-linking signaling pathways in osteochondral differentiation"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Diego Walther (Max Planck Institute, GERMANY)
"Protein monoaminylation: newly recognized functions of monoaminergic neurotransmitters"
12:20 pm - 12:30 pm Discussion
12:30 pm - 1:15 pmLunch
1:15 pm - 6:00 pmFree Time / Optional Wine Tasting and Tour excursion (additional fee required)
4:00 pm - 6:00 pmPoster Session
6:00 pm - 7:00 pmDinner
7:30 pm - 9:30 pmTransglutaminases and Differentiation
7:30 pm - 7:45 pm Discussion Leader: Soo-Youl Kim (National Cancer Center, Seoul, KOREA)
"A new paradigm of NF-κB: Transglutaminase 2"
7:45 pm - 8:10 pm Mari Kaartinen (McGill University, CANADA)
"TG2 and FXIIIA as regulators of matrix deposition and cell differentiation - lessons from the TG2/FXIIIA double knockout mice"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Daniel Aeschlimann (Cardiff University, UK)
"A new role of TG2 in epithelial-mesenchymal crosstalk"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:30 pm Selected Abstract Talks and Meeting Summary
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Last Updated: July 22, 2010
 
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