Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Atherosclerosis
Understanding the Pathophysiology and Identifying New Modes of Prevention
June 19-24, 2011
Salve Regina University
Newport, RI

The 2011 Gordon Conference on Atherosclerosis will be held June 19-24, at Salve Regina University in the famous coastal city and yachting harbor of Newport, Rhode Island. This conference will present cutting-edge research on the molecular, cellular, immunological, structural and therapeutic aspects of atherosclerotic plaque formation and regression. The Conference will feature a wide range of topics, including: vascular biology and matrix dysfunction; adaptive immunity, innate immunity and inflammation in atherosclerosis; HDL function and plaque regression; genetics, genomics, and novel mechanisms in atherosclerosis; biomarkers, cardiometabolic disease, and the vulnerable patient; and, innovations in therapeutics. Invited speakers and discussion leaders will represent a spectrum of scientific and medical disciplines, including biochemistry, lipid metabolism, lipidomics, proteomics, molecular genetics, bioengineering, immunology, vascular biology, cell biology, endocrinology, cardiology, and imaging. They will be from several countries, and there will be will opportunities for junior scientists and graduate students to present their work in poster format and to exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for attendees to network and brainstorm, thereby promoting cross-disciplinary collaborations in the various research areas that will be highlighted.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEndothelial and Smooth Muscle Cell Dysfunction in Vascular Disease Pathogenesis
Discussion Leaders: William Sessa (Yale Univ. School of Med.) and Elaine Raines (Univ. of Washington)
7:40 pm - 8:00 pmWilliam Sessa (Yale Univ. School of Med.)
"Novel Mechanisms Controlling Vascular Function"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmGeorge King (Harvard Medical School)
"Loss of Endothelial Cell Insulin Signaling and Atherosclerosis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmMartin Bennett (Addenbrooke's Centre for Clinical Investigation)
"Smooth Muscle Cell Apoptosis"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmOlga Stenina (Cleveland Clinic)
"Thrombospondin 4 and Atherosclerosis"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMacrophage Biology in Atherosclerosis
Discussion Leaders: Edward Fisher (NYU School of Medicine) and David Greaves (Sir William Dunn School of Pathology)
9:00 am - 9:20 amDavid Greaves (Sir William Dunn School of Pathology)
"Novel Regulation of Macrophage Inflammation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAjay Chawla (Stanford Univ. School of Medicine)
"Diabetes, Nuclear Receptors, and M1/M2 Macrophages"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 11:50 amIsrael Charo (Gladstone Institute of Cardiovascular Disease)
"Chemokines and Atherosclerosis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amGwendalyn Randolph (Mt. Sinai School of Medicine)
"Macrophage Heterogeneity and Trafficking in Atherosclerosis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amCatherine (Lynn) Hedrick (La Jolla Inst. for Allergy and Immunology)
"Nuclear Receptors in Innate Immunity"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmEsther Lutgens (Maastricht University Medical Center)
"CD40-CD40L in Atherosclerosis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmLazar Bojic (Univ. of Western Ontario)
"Inhibition of VLDL-induced macrophage inflammation by activation of PPAR delta"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdaptive Immunity in Atherosclerosis
Discussion Leader: Goran Hansson (Karolinska Institute)
7:30 pm - 7:50 pmAndrew Lichtman (Brigham and Womens Hospital)
"T Cells and Atherosclerosis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmGoran Hansson (Karolinska Institute)
"Antigen Specificity in Cell Immune Responses in Atherosclerosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKlaus Ley (La Jolla Inst. for Allergy and Immunology)
"Trafficking of Adaptive Immune Cells in Atherosclerosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmGiuseppina Caligiuri (INSERM)
"Pecam, T cells, and Atherosclerosis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMansori Aikawa (Brigham and Women's Hosp.)
"Dll4-Notch Signaling Promotes Macrophage Activation and Cardiometabolic Disorders"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmClinical Perspectives, Biomarkers, and the Vulnerable Patient
Discussion Leaders: Stan Hazen (Cleveland Clinic) and Peter Libby (Harvard Medical School)
9:00 am - 9:20 amThomas Wang (Mass. General Hospital)
"Lessons from the Framingham Heart Study"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amFrank Sacks (Harvard School of Public Health)
"Apolipoprotein C-III, Atherosclerosis, and Coronary Heart Disease"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amStephan Baldus (University Hospital Hamburg)
"Myeloperoxidase and Coronary Artery Disease"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:00 amPeter Libby (Harvard Medical School)
"Molecular Imaging to Detect the Vulnerable Patient"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amKarine Clement (INSERM)
"Obesity, Coronary and Cardiac Diseases: Implications of Adipose Inflammation and Tissue Remodeling"
11:30 pm - 11:40 amDiscussion
11:40 am - 12:00 pmClay Semenkovich (Washington Univ. School of Medicine)
"Novel Therapies for Metabolic Syndrome"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSteven Rosenberg (CardioDx)
"Development, Clinical Validation, and Initial Outcomes with a Gene Expression Test for Obstructive Coronary Artery Disease"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInnate Immunity and Inflammation in Atherosclerosis
Discussion Leader: Kathryn Moore (NYU Medical Center)
7:30 pm - 7:50 pmMichael Fessler (National Institute of Environmental Health Sciences)
"Inflammation Cross Talk with Reverse Cholesterol Transport"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAntonio Castrillo (Instituto Investigaciones Biomedicas ‘Alberto Sols’ Consejo Superior)
"Apoptotic Cell Clearance and LXRs"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmFilip Swirski (Mass. General Hospital)
"Spleen Monocyte Reservoir and Atherosclerosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmFrederick Sheedy (NY University School of Medicine)
"CD36: The Toll-Gate for Inflammasome Activation in Atherosclerosis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMireille Ouimet (Ottawa Heart Institute)
"Autophagy Regulates Cholesterol Efflux in Macrophage Foam Cells"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHDL Function and Plaque Regression
Discussion Leaders: John Chapman (INSERM) and Alan Tall (Columbia Univ.)
9:00 am - 9:20 amDan Rader (Univ. of Pennsylvania)
"HDL/TG Genes and Reverse Cholesterol Transport"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amEdward Fisher (NYU School of Medicine)
"Regression of Atherosclerosis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amRyan Temel (Wake Forest University School of Medicine)
"Non-Biliary Reverse Cholesterol Transport"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:00 amAlan Tall (Columbia Univ.)
"Cholesterol Efflux Pathways and Myeloid Cell Proliferation"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amMary Sorci-Thomas (Wake Forest University School of Medicine)
"HDL and Immune Functions"
11:30 pm - 11:40 amDiscussion
11:40 am - 12:00 pmStan Hazen (Cleveland Clinic)
"Novel HDL Functions"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmChristian Besler (University Hospital Zurich)
"Endothelial-Protective Effects of HDL that are Impaired in Patients with Coronary Disease"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmGenetics and Genomics I, and Keynote Address
Discussion Leaders: Jonathan Smith (Cleveland Clinic) and Daniel Teupser (University Hospital Leipzig)
7:30 pm - 7:50 pmDaniel Teupser (University Hospital Leipzig)
"QTL Mapping of the Plasma Proteome (pQTL)"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmArya Mani (Yale School of Medicine)
"Coronary Artery Disease: Identifying a Disease Gene and Understanding its Function"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmRalph Burkhardt (University of Leipzig)
"TRIB1"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKeynote Lecture: Sek Kathiresan (Mass. General Hospital)
"Exome Sequencing, Rare Variants, and Risk for Early-Onset Myocardial Infarction"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetics and Genomics II
Discussion Leaders: Sek Kathiresan (Mass. General Hospital) and Dan Rader (Univ. of Pennsylvania)
9:00 am - 9:20 amAxel Visel (Lawrence Berkeley National Laboratory)
"9p21 Locus and Enhancers in the Heart"
9:20 am - 9:30 amDiscussion
9:30 am - 9:45 amLesca Holdt (University Hospital Leipzig)
"9p21 Locus Studies in Humans"
9:45 am - 9:55 amDiscussion
9:55 am - 10:10 amJ. Brian Kim (UCLA)
"The effect of 9p21 risk locus neighboring genes on atherosclerosis in mice"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:00 amChris O'Donnell (NHLBI Framingham Heart Study)
"Framingham in the Genomic Era"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amDanish Saleheen (University of Cambridge)
"Emerging biological pathways and CHD risk - use of genetic and biomarker studies to assess causal relevance"
11:30 pm - 11:40 amDiscussion
11:40 am - 11:50 amNehal Mehta (Univ. of Pennsylvania)
"Chr10q11 Atherosclerosis Locus Modulation of Plasma and Adipose CXCL12 to in vivo Inflammation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmKiran Musunuru (Mass. General Hospital)
"SORT1"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmNew Directions in Therapeutics
Discussion Leader: Philip Barter (The Heart Research Institute, Sydney)
7:30 pm - 7:50 pmKathryn Moore (NYU Medical Center)
"miR33 Antagonism"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPhilip Barter (The Heart Research Institute, Sydney)
"CETP Inhibition as an Anti-Atherosclerosis Strategy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmViktoria Gusarova (Regeneron Pharmaceuticals)
"PCSK9 inhibition therapy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmTom Schall (ChemoCentryx)
"CXCR7 inhibition"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmZhaosha Li (Leiden)
"Niacin Reduces Hepatic and Plasma CETP Levels by Diminishing Liver Macrophage Content in CETP Transgenic Mice"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter