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Cancer Genetics & Epigenetics
January 23-28, 2011
Ventura Beach Marriott
Ventura, CA
Chairs:
Kristian Helin & Bruno Amati

Vice Chair:
Joseph F. Costello

Cancer initiation and progression are driven by a series of genetic and epigenetic alterations that cause either activation (gain-of-function) of oncogenes, or inactivation (loss-of-function) of tumor suppressor genes, - both accompanied by broad alterations in genome utilization and gene expression programs. The nature of these alterations and the mechanisms that lead to such genomic changes is the focus of this GRC series. The field has seen a dramatic shift in the past decade from a pure genetic to a mixed genetic/epigenetic explanation of cancer. Another dramatic shift has consisted in the emergence of increasingly powerful technologies for genome-wide analysis of genetic, epigenetic, or other mechanistic alterations. These changes will have far-reaching implications for our capacity to understand the causes of disease, to decipher the pathways and molecules involved, as well as to devise new strategies for prevention and treatment. Sessions in the meeting will be devoted to the recent developments in cancer genomics and epigenomics, to the emerging roles of non-coding RNA species, as well as to recent advances in modeling cancer development and therapy.

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Genetic and Epigenetic Pathways of Cancer
Discussion Leader: Kristian Helin (University of Copenhagen)
7:40 pm - 8:10 pmJoe Gray (Lawrence Berkeley National Laboratory)
"Therapeutic insights from an integrated genomics"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmFrank McCormick (UCSF)
"Exploiting Cancer Mutations for Therapy"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pmPeter A. Jones (USC)
"The nucleosome - integrator and executor of epigenomic information"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic and Molecular Alterations in Cancer
Discussion Leader: Joe Costello (UCSF)
9:00 am - 9:30 am Jim Downing (St. Jude Children’s Research Hospital)
"The Molecular Pathology of Acute Leukemia"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Helene McMurray (University of Rochester)
"System-wide control of malignant cell transformation by cooperating oncogenic mutations"
9:55 am - 10:00 am Discussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:45 am Wei Du (University of Chigago)
"Targeting Rb mutant cancer by inactivating TSC2"
10:45 am - 10:50 am Discussion
10:50 am - 11:20 amTom Look (Harvard Medical School)
"Autocrine MET activation induced by aberrant expression of HGF provides a therapeutic target in acute myeloid leukemia"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Diwakar Pattabiraman (University of Queensland)
"Requirement of MYB-CBP/p300 interaction for the development of acute myeloid leukemia"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pm Richard Houlston (Institute for Cancer Research)
"What have association studies taught us about inherited susceptibility to cancer"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic and Molecular Alterations in Cancer
Discussion Leader: Karen Cichowski (Harvard Medical School)
7:30 pm - 8:00 pmPier Giuseppe Pelicci (European Institute of Oncology)
"Regulation of self renewal in cancer stem cells"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:25 pm Craig Ceol (University of Massachusetts Medical School)
"The SETDB1 histone methyltransferase is recurrently amplified in and accelerates the formation of melanoma"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm Axel Behrens (LRI, Cancer Research UK)
"Transcriptional control in stem cells and cancer"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmKatherine A. Jones (Salk Institute)
"The SKIP transcription elongation/splicing factor is required for cancer cell survival"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntegrative Cancer Genetics and Epigenetics
Discussion Leader: Katherine A. Jones (Salk Institute)
9:00 am - 9:30 amJoe Costello (UCSF)
"Mono-allelic epigenetic regulation in the genome of stem cells and tumors"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Avnish Kapoor (Mount Sinai School of Medicine)
"The histone variant macroH2A suppresses melanoma progression through regulation of CDK8"
9:55 am - 10:00 am Discussion
10:00 am - 10:15 am Adele Murrell (University of Cambridge)
"5’hydroxymethylation potentially an intermediate step in DNA demethylation at selected foci during colorectal cancer progression"
10:15 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amJean-Pierre Issa (MD Anderson Cancer Center)
"The DNA methylation/chromatin (dis)connection"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Scott Diede (Fred Hutchinson Cancer Research Center)
"DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pm Karen Cichowski (Harvard Medical School)
"PRC2 proteins and cancer"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCancer Epigenomics
Discussion Leader: Gigi Lozano (MD Anderson Cancer Center)
7:30 pm - 8:00 pmPeter Laird (USC)
"Mining the Cancer Methylome"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmSusan Clark (The Garvan Institute of Medical Research)
"Epigenetics: Layers of change above the cancer genome"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmKristian Helin (University of Copenhagen)
"Functional roles of TET proteins and 5-hydroxymethylcytosine in stem cells and cancer"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMouse Models for Cancer
Discussion Leader: Susan Clark (The Garvan Institute of Medical Research)
9:00 am - 9:30 amAnton Berns (The Netherlands Cancer Institute)
"Mouse models for small cell lung cancer. Functional role of tumor heterogeneity"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Elisa Orrichio (Memorial Sloan-Kettering Cancer Center)
"The soluble Eph-receptor A7 is a tumor suppressor gene in follicular lymphoma and readily restored for therapy"
9:55 am - 10:00 am Discussion
10:00 am - 10:15 am Jan-Hermen Dannenberg (The Netherlands Cancer Institute)
"Hdac1 and Hdac2 levels are critical for hematopoietic lineage determination and suppression of T-cell lymphomagenesis"
10:15 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 amGigi Lozano (MD Anderson Cancer Center)
"Modifiers of the p53 tumor suppressor pathway"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Mallika Singh (Genentech)
"Assessing therapeutic responses in pancreatic cancer using genetically engineered mouse models"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pmAlan Clarke (Cardiff School of Biosciences)
"Modelling epigenetic and genetic modulators of colorectal cancer in the mouse"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmThe Role of ncRNA in Cancer
Discussion Leader: Joe Nevins (Duke University)
7:30 pm - 8:00 pm Carlo Croce (The Ohio State University)
"Causes and Consequences of MicroRNA Dysregulation in Cancer"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:25 pm Ferdinandos Skoulidis (University of Cambridge)
"Germline Brca2 heterozygosity promotes KrasG12D - driven carcinogenesis in a murine model of familial pancreatic cancer"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm Dimitrios Illiopoulos (Harvard Medical School)
"Epigenetic networks and miRNAs in cancer stem cells"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmFrank Slack (Yale University)
"MicroRNAs as oncogenes and tumor suppressors"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCancer Transcriptome and Genome Profiling
Discussion Leader: En Li (Novartis Institutes for Biomedical Research)
9:00 am - 9:30 amJoe Nevins (Duke University)
"Utilizing Pathway Signatures to Dissect the Heterogeneity of Breast and Lung Cancer"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Adrian Dubuc (Hospital for Sick Children, Toronto)
"Medulloblastoma genomics and epigenomics converge on neuronal differentiation"
9:55 am - 10:00 am Discussion
10:00 am - 10:15 am Sandeep Dave (Duke University)
"Whole genome and exome sequencing defines the genetic landscape of diffuse large B cell lymphoma"
10:15 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 am Vessela Kristensen (Oslo University)
"Genetic and epigenetic interactions in the development of breast cancer"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Heinz G. Linhart (DKFZ, Heidelberg)
"Genes targeted by Dnmt3b in the mouse intestinal mucosa correspond to genes methylated in human colon cancer"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pm Bruno Amati (European Institute of Oncology)
"Identification of Myc-regulated genes during mitogenic stimulation and in lymphoma onset"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Targeted Anti-Cancer Therapies
Discussion Leader: Bruno Amati (European Institute of Oncology)
7:30 pm - 8:00 pm En Li (China Novartis Institutes for Biomedical Research)
"Targeting Epigenetic Mechanisms in Cancer"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmRicky Johnstone (The Peter MacCallum Cancer Institute)
"Targeting the epigenome using histone deacetylase inhibitors to induce tumor cell apoptosis and anti-cancer responses"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmFred De Sauvage (Genentech)
"Development of Hedgehog Pathway Inhibitors"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
 
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