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Conference Program
 
Cancer Nanotechnology
From Basic Concepts to Clinical Applications
July 17-22, 2011
Colby College
Waterville, ME
Chair:
Piotr Grodzinski

Vice Chair:
James R. Baker

The new Gordon Research Conference on "Cancer Nanotechnology" will allow for further development of a multi-disciplinary research community representing a broad range of disciplines including biology, chemistry, physics, engineering, medicine, and regulatory affairs and supporting the new field of cancer nanotechnology. The ultimate goal of the conference will be to accelerate implementation of nanotechnology innovations into cancer research and its clinical practice.

Cancer is a complex disease. In contrast to dramatic reversals in death rates from heart disease, stroke, and infectious disease during the past 50 years, the death rate from cancer has declined only marginally over the past several decades. This occurred, despite high level of efforts in both basic research and the development of new clinical treatments. It can be argued that, non-traditional, paradigm shifting ideas and approaches are needed in order to improve this unfortunate trend. In recent years, nanotechnology has emerged as a "disruptive technology" with a potential to generate new diagnostic and therapeutic products and as a result improve cancer outcomes. Novel and multi-functional nanodevices could be capable of detecting cancer at its earliest stages, delivering anticancer drugs specifically to malignant cells, and determining if these drugs are effective. Functionalized nanoparticles could deliver multiple therapeutic agents to tumor sites in order to simultaneously attack multiple points in the pathways involved in cancer. Several of these concepts have been already demonstrated in academic laboratories and are gradually finding their ways into translational world.

The field of cancer nanotechnology is unique. It combines disparate research communities of physical scientists, engineers, and technologists working at the nanoscale with cancer biologists and oncologists specializing in the diagnosis, prevention, and treatment of cancer. It is common that implementation of new technology discoveries into medical world occurs only when these technologies mature and final medical product is developed. This sequential approach is detrimental to overall progress, but often persists since academic discovery still occurs largely in the single-discipline departments. The recent efforts of funding agencies and academic institutions have centered around the development of multi-disciplinary programs and institutes attempting to break these single-discipline barriers and house scientists representing several fields in one location to work on hard problems together. For example, the National Cancer Institute (NCI) has founded the NCI Alliance for Nanotechnology in Cancer - the network of large academic centers performing basic and translational cancer research, Massachusetts Institute of Technology (MIT) is in the process of constructing David Koch Institute for Integrative Cancer Research, Institute of Bioengineering and Nanotechnology has been established in Singapore.

It is clear that establishing the regular discussion forum for the scientists and clinicians working in cancer nanotechnology will be highly beneficial. The model of Gordon Research Conferences, providing forums for the presentation and discussion of frontier, multi-disciplinary research, is ideal. Because of the lack of a common language among the scientists from so many different fields, longer meetings with large blocks of time dedicated to discussions, rather than series of presentations held at 'traditional' conferences, are favored for establishing such forum.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:50 pmWelcome / Introductory Comments by Drs. Grodzinski and Baker
7:50 pm - 9:30 pmNanotechnology - Benefits to Cancer Research and Oncology
Discussion Leader: James Heath (California Institute of Technology, USA)
7:50 pm - 8:05 pmLarry Norton (Memorial Sloan-Kettering Cancer Center, USA)
"Cancer as a Disease of Cell Mobility: Theoretical and Practical Implications"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmDavid Walt (Tufts University, USA)
"Single Molecule and Single Cell Analysis for Cancer Diagnostics"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmKazunori Kataoka (University of Tokyo, Japan)
"Supramolecular Nanodevices from Smart Block Copolymers for Gene and Drug Delivery"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmRuth Duncan (Cardiff University, United Kingdom)
"Multifunctional Nano-therapeutics: How Discovery and Science Policy Enable Clinical Development"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRecognizing the Disease Early - In vitro Nanotechnology Assays
Discussion Leader: David Walt (Tufts University, USA)
9:00 am - 9:20 amJames Heath (California Institute of Technology, USA)
"Single Cell Technologies for Clinical Diagnostics and Fundamental Onclogy Studies"
9:20 am - 9:40 amDiscussion
9:40 am - 9:50 amDaniel Heller (Massachusetts Institute of Technology, USA)
"Real-Time Molecular Detection and Identification of ROS Activity via Carbon Nanotube Optical Biosensors"
9:50 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:50 amFrancois Berger (Universite Joseph Fourier, France)
"Reaching Inaccessible Tumors Territories: Micro Nanoharvesting Devices for Deep Proteome and Peritumoral Exploration"
10:50 am - 11:10 amDiscussion
11:10 am - 11:30 amMolly Stevens (Imperial College, England)
"Peptide Functionalized Nanoparticles for Detection of Cancer-related Enzymes"
11:30 am - 11:50 amDiscussion
11:50 am - 12:10 pmVladimir Zharov (University of Arkansas for Medical Sciences, USA)
"In Vivo Blood Test for Multiplex Detection Circulating Tumor Cells Targeted by Ultrasharp Rainbow Nanoparticles"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPros and Cons of Multifunctionality in Nanotechnology Delivery Platforms
Discussion Leader: Ruth Duncan (Cardiff University, United Kingdom)
7:30 pm - 7:50 pmSonke Svenson (Cerulean Pharma, Inc., USA)
"Docetaxel Nanoparticles - Improved Therapeutic Window for an Established Anticancer Drug"
7:50 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmJeff Brinker (University of New Mexico, USA)
"Less is More: Achieving Complex Functionality in Simple Porous Nanoparticles"
8:30 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmJoseph DeSimone (University of North Carolina, Chapel Hill, USA)
"Co-opting Moore's Law: Vaccines and Therapeutics from a Wafer"
9:10 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNanoparticle-based Therapies
Discussion Leader: Vladimir Torchilin (Northeastern University, USA)
9:00 am - 9:20 amHamid Ghandehari (University of Utah, USA)
"Polymer-Peptide Conjugates for Targeted Delivery to Sites of Tumor Angiogenesis"
9:20 am - 9:40 amDiscussion
9:40 am - 9:50 amClemens Burda (Case Western Reserve University, USA)
"Peptide Targeting of Gold Nanoparticle -PDT Drug Conjugates to Improve Drug Accumulation and PDT Efficacy in Brain Tumors"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amEsther Chang (Georgetown University, USA)
"Systemic Delivery of Cancer Therapeutics into Cancer Stem Cells via Targeted Nanoparticles"
10:50 am - 11:10 amDiscussion
11:10 am - 11:30 amCostas Hadjipanayis (Emory University, USA)
"Targeting Glioblastoma with EGFR-Bioconjugated Iron-Oxide Nanoparticles after Convection-Enhanced Delivery"
11:30 am - 11:50 amDiscussion
11:50 am - 12:10 pmP. Jack Hoopes (Dartmouth College, USA)
"The Importance of Tumor Model and EPR Effect Variability on Tumor NP Biodistribution and Treatment Effect"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImproved Resolution and Multi-Modality - In vivo Nanoimaging Contrast Agents
Discussion Leader: Jeff Bulte (Johns Hopkins University, USA)
7:30 pm - 7:45 pmMarcus Textor (ETH Zürich, Switzerland)
"Functionalization of Magnetic Iron Oxide Nanoparticles and Liposome-Nanoparticle Constructs for MRI Contrast Agent and Triggered Release Application"
7:45 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmJianghong Rao (Stanford University, USA)
"New Approaches to Synthesizing Nanoprobes for Cancer Imaging"
8:25 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmDan Meyer (General Electric, USA)
"Preclinical Development of a New Iron Oxide Nanoparticle Agent for MR Imaging in Oncology"
9:05 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBenefits of Multifunctionality - Targeting, Imaging and Delivery
Discussion Leader: Fatih Uckun (Children's Hospital Los Angeles, USA)
9:00 am - 9:20 amMatt Trau (University of Queensland, Australia)
"Lab on a Nanoparticle: Molecular Circuits and Transducers on the Surface of Colloidal Particles"
9:25 am - 9:40 amDiscussion
9:40 am - 10:00 amKimberly Kelly (University of Virginia, USA)
"Molecular Imaging and Targeted Therapy in Pancreatic Cancer"
10:00 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:05 amMark Banaszak Holl (University of Michigan, USA)
"Nanotechnology, Cell Membrane Disruption, and Non-viral Gene Delivery"
11:05 am - 11:20 amDiscussion
11:20 am - 11:40 amShuming Nie (Emory University, USA)
"Nanotechnology for Cancer Molecular Imaging, Targeted Therapy, and Image-Guided Surgery"
11:40 am - 11:55 amDiscussion
11:55 am - 12:15 pmKeith Paulsen (Dartmouth College, USA)
"Magnetic Hyperthermia"
12:15pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmNanotechnology Tools to Elucidate Cancer Biology
Discussion Leader: Yi Yan Yang (Institute of Bioengineering, Singapore)
7:30 pm - 7:45 pmYi Yan Yang (Institute of Bioengineering, Singapore)
"Self-Assembled Biodegradable Nanostructures as Delivery Carriers for Cancer Therapy"
7:45 pm - 8:00 pmDiscussion
8:00 pm - 8:15 pmMichelle Bradbury (Memorial Sloan Kettering Cancer Center, USA)
"Multimodal Core-Shell Silica Nanoparticles: Linking Cancer Biology to Nanomedicine"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmBrenda Farrell (Baylor College of Medicine, USA)
"Force Measurements at a Leading Edge of a Cell"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmMuhammad Yousaf (University of North Carolina, Chapel Hill, USA)
"Liposome Fusion for Controlling Dynamic Cell Assemblies"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPre-Clinical Characterization of Nanomaterials - Knowledge and Responsibility
Discussion Leader: Kenneth Dawson (University College Dublin, Ireland)
9:00 am - 9:20 amYuliang Zhao (Chinese Academy of Sciences, China)
"Pre-clinical Characterization of Nanomaterials: Mechanisms for Toxicity and Anticancer Activity of Nanomaterials"
9:20 am - 9:40 amDiscussion
9:40 am - 9:50 amZoran Popovic (TU Dresden, Germany)
"Shape Controlled Transvascular Flux of Nanoparticles in Solid Tumors"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amScott McNeil (Nanotechnology Characterization Laboratory, USA)
"Structure-Activity Relationship (SAR) Studies on Nanomaterial Physicochemical Properties and Biocompatibility"
10:50 am - 11:10 amDiscussion
11:10 am - 11:30 amNeil Desai (Abraxis Bioscience, LLC, USA)
"Abraxane and the Nab Technology Platform"
11:30 am - 11:50 amDiscussion
11:50 am - 12:10 pmAgnes Pottier (Nanobiotix, France)
"NanoXRay: From Concept of Radioenhancement to Usable Product in Clinic"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNucleic Acid-based Nanotherapeutics
Discussion Leader: Leaf Huang (University of North Carolina, Chapel Hill)
7:30 pm - 7:50 pmAlexander Stegh (Northwestern University, USA)
7:50 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmLeaf Huang (University of North Carolina, Chapel Hill)
"Nanoparticles Escaping RES and Endosome for Efficient Cytoplasmic Delivery"
8:30 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmThomas Schluep (Calando Pharmaceuticals)
"Systemic Delivery of siRNA with Targeted Nanoparticles in Man"
9:10 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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