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Carbohydrates
Gordon Research Conference

Dates

June 19-24, 2011

Location

Colby College
Waterville, ME

Organizers

Chairs:
Robert J. Woods & Nicola Pohl

Vice Chairs:
Joseph J. Barchi & George O'Doherty

Meeting Description

The Carbohydrates Gordon Research Conference (GRC) brings together a diverse group of scientists who work in the broad area of “glycoscience”, a term that encompases the fields of carbohydrate chemistry, carbohydrate biochemistry, and glycobiology. Compared to other meetings in the glycoscience area, the Carbohydrates GRC differs in that it does not focus on a single class of glycoconjugate nor principally on the biology of glycoconjugates. Instead, this meeting serves as a forum for the presentation and critical discussion of the newest ideas and emerging concepts in the entire glycoscience area, with a focus on the molecular aspects of carbohydrate-containing compounds and their interactions with other molecules. The specific aims of this meeting will be to:

  1. Bring together established and young investigators, including students and postdoctoral scholars, who work on the chemistry and biochemistry of carbohydrates;
  2. Present the current state of carbohydrate synthetic, computational, and analytical tools with an emphasis on illustrating their abilities and limitations through applied examples in areas such as the development of diagnostics, vaccines, and other therapeutics, as well as with cutting-edge examples from academia; and
  3. Highlight emerging research areas and build interdisciplinary collaborations between synthetic chemists, analytical chemists, computational chemists, biologists, bioinformaticists, and chemical biologists to best tackle the obstacles to understanding the structure and functions of, and therapeutic and diagnostic interventions based on, carbohydrate interactions.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGlycomimetics
Discussion Leader: George O'Doherty (Northeastern University)
7:35 pm - 8:05 pmJohn Magnani (Glycomimetics, Inc.)
"GMI-1070: A Small Molecule Glycomimetic Antagonist of the Selectins in Phase II Clinical Trials for Vaso-occlusive Crisis in Sickle Cell Disease"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmPaul Murphy (National University of Ireland)
"Anomerization and the Synthesis of Glycomimetics"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmBeat Ernst (University of Basel)
"Lectins as Therapeutic Targets"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmConformational Analysis/NMR Spectroscopy
Discussion Leader: Joseph Barchi (NCI Frederick)
9:00 am - 9:30 amJulie Bouckaert (Vrije Universiteit Brussel)
"Structural and Thermodynamic Basis of Mannose Binding to the Type-1 Fimbrial Adhesin of Escherichia coli"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amChristoph Rademacher (Scripps Research Institute)
"NMR Experiments Guiding the Design of Multivalent Inhibitors Against Norovirus Cell Entry"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break / Group Photo
10:50 am - 11:20 amMari DeMarco (Washington University)
"3D Structure Determination of Dynamic Glycolipids in Biologically Relevant Environments: Challenges & Methods"
11:20 am - 11:30 amDiscussion
11:30am - 11:50 amSelected Poster Talks
11:50 am - 12:30 pmRoundtable Topic Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSynthetic Carbohydrate Chemistry
Discussion Leader: Alexei Demchenko (University of Missouri)
7:30 pm - 8:00 pmBeatrice Collet (LuCella Biosciences, Inc.)
"Automated Oligosaccharide Synthesis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmTakashi Takahashi (Tokyo Institute of Technology)
"Synthesis of Biologically Important Oligosaccharides Toward Chemical Glycobiology Study"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDavid Crich (University of Illinois)
"Methodology Development and Physical Organic Chemistry: A Powerful Combination for Glycochemistry"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynthetic Carbohydrate Chemistry
Discussion Leader: France-Isabelle Auzanneau (Guelph University)
9:00 am - 9:30 amReko Leino (Åbo Akademi University)
"Towards Immunostimulatory Oligosaccharides"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amHien Nguyen (University of Iowa)
"Stereocontrolled Synthesis of 1,2-Cis-2-Aminosugars and Glycosyl Ureas"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:20 amCristina De Meo (Southern Illinois University)
"Chemical Sialylation: Traditional Challenges and Recent Advancements'"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected Poster Talks
11:40 am - 12:30 pmRoundtable Topic Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Glycobiology
Discussion Leader: Nicola Pohl (Iowa State University)
7:30 pm - 8:00 pmSuzanne Walker (Harvard Medical School)
"Structure and Inhibition of Human O-GlcNac Transferase"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmChris Cairo (University of Alberta)
"Substrate Specificity and Inhibition of Human Neuraminidase 3 (NEU3)"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAnna-Maria Papini (University of Florence)
"The 'Chemical Reverse Approach' to Develop Glycopeptides as Synthetic Antigens Characterizing Autoantibodies as Biomarkers of Immune-mediated Neurodegenerative Diseases"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemical Glycobiology
Discussion Leader: Xi Chen (UC Davis)
9:00 am - 9:30 amJennifer Kohler (UT Southwestern Medical Center)
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amBen Davis (University of Oxford)
"Sugars and Proteins"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:10 amDaniel Kahne (Harvard University)
"Lipopolysaccharide Transport and Assembly in Escherichia coli"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amSelected Poster Talks
11:40 am - 12:30 pmRoundtable Topic Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmGlycoinformatics / Computational Simulations
Discussion Leader: Robert Woods (University of Georgia)
7:30 pm - 8:00 pmNicolle Packer (Macquarie University)
"UniCarb: Getting It All Together"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDavid F. Green (Stony Brook University)
"Carbohydrate-recognition by Anti-viral Lectins: New Insights from Computational Models"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmPeter Kasson (Stanford University)
"Receptor Binding by Influenza Virus: Using Computational Techniques to Extend Structural Data"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVaccines
Discussion Leader: Willie Vann (FDA)
9:00 am - 9:30 amAndre Nikolaev (University of Dundee)
"From Phosphosaccharide Chemistry to Potential Anti-parasite and Anti-bacterial Carbohydrate Vaccines"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amGeert-Jan Boons (University of Georgia)
"Carbohydrate-Based Multicomponent Vaccines"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:20 amFrancesco Berti (Novartis)
"Structural Characterization of Carbohydrate-Based Conjugate Vaccines"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected Poster Talks
11:40 am - 12:30 pmRoundtable Topic Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEmerging Applications in Glycoanalytics
Discussion Leader: Mingdi Yan (Portland State University)
7:30 pm - 8:00 pmJohn Nolan (LaJolla BioEngineering Institute)
"Quantitative, Multiplexed Measurement of Glycan-Receptor Interactions"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDavid Clemmer (Indiana University)
"Developing Ion Mobility/Photodissociation/Mass Spectrometry Techniques for the Analysis of Carbohydrate Mixtures"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJohn Klassen (University of Alberta)
"Characterization of Protein-Carbohydrate Interactions Using Mass Spectrometry"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13RR032272-01 from the National Center for Research Resources. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names,commercial practices, or organizations imply endorsement by the U.S. government.
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