Gordon Research Conferences
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Conference Program
 
Cartilage Biology & Pathology
March 6-11, 2011
Ventura Beach Marriott
Ventura, CA

The 2011 Gordon Conference on Cartilage Biology and Pathology will present cutting-edge research on the molecular and cellular aspects of cartilage formation, maintenance, repair and disease. Topics for discussion have been selected with a view to balance translational and basic research and to stimulate work related to repair, and regeneration geared toward major diseases of cartilage. The Conference program covers areas of active research and includes progress in understanding cartilage evolution and development, signaling mechanisms in chondrocytes, growth plate, and articular cartilage, genetic mechanisms of cartilage disease, metabolic and immune influences on cartilage, degenerative cartilage disorders, and repair, regeneration and tissue engineering strategies in disorders of cartilage. The last session of the meeting will be devoted to research that defines new directions and technologies, challenges and opportunities.

Discussion leaders and invited speakers, representing a variety of scientific disciplines, are encouraged to present cutting edge science, keep reviews of published data short and emphasize new data and ideas. The Conference will provide opportunities for new investigators, postdoctoral trainees and graduate students to present their work in poster sessions and to exchange ideas with experienced investigators who are at the forefront in their fields. The programmed discussion sessions will include talks selected from submitted poster abstracts. The collegial atmosphere and opportunities for informal gatherings in the afternoons and evenings will promote brainstorming around new and old scientific problems and set the stage for the kind of cross-disciplinary collaborations that are needed to move research on cartilage forward and in new directions.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmDevelopment / Evolution of Cartilage
Discussion Leader: Andrea Vortkamp (University of Duisberg-Essen, Germany)
7:40 pm - 8:05 pmShigeru Kuratani (RIKEN Center for Developmental Biology, Japan)
"Craniofacial development of the cyclostome and evolution of the vertebrate body plan"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:40 pmRich Schneider (University of California, San Francisco, USA)
"Mechanisms of Cartilage Patterning During Development and Evolution"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:15 pmVeronique Lefebvre (Cleveland Clinic and Case Western Reserve, USA)
"Roles and regulation of Sox genes in chondrogenesis"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling and Control Mechanisms in Cartilage
Discussion Leader: Ernestina Schipani (Massachusetts General Hospital, USA)
9:00 am - 9:20 amMathew Hilton (University of Rochester, USA)
"Multiple Roles of the Notch Signaling Pathway During Chondrogenesis and Chondrocyte Maturation"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amXiangli Yang (Vanderbilt University, USA)
"ATF4 in chondrocytes regulates osteoblast function"
9:50 am - 10:00 am Discussion
10:00 am Group Photo / Coffee Break
10:30 am - 10:55 amHank Kronenberg (Massachusetts General Hospital, USA)
"How PTHrP regulates growth plate chondrocytes"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amHiroshi Asahara (NRICHD, Japan, and The Scripps Research Institute, USA)
"Transcription and RNA network regulating locomotive system development and homeostasis"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmChris Murphy (Imperial College, UK)
"MicroRNAs - aiming for targets"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic Analysis of Skeletal and Metabolic Disorders
Discussion Leader: Philip Beales (University College London, UK)
7:30 pm - 7:50 pmDeborah Krakow (University of California, Los Angeles, USA)
"FGFs and skeletal dysplasia"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmDaniel Cohn (Cedars-Sinai Medical Center, Los Angeles, USA)
"Type XI collagen defects in fibrochondrogenesis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmBrendan Lee (Baylor College of Medicine, USA)
"Novel signaling mechanisms during chondrogenesis"
8:50 pm - 9:00 pm Discussion
9:10 pm - 9:20 pmShireen Lamande (Royal Children’s Hospital, Australia)
"Mutations in TRPV4 cause an inherited arthritis of hands and feet"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCartilage Organization
Discussion Leader: Regis O’Keefe (University of Rochester, USA)
9:00 am - 9:20 amDick Heinegard (Lund University, Sweden)
"Implications of differences in molecular constituents within and between cartilages"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Kevin Jones (University of Utah, USA)
"Chondrocyte polarity in osteochondromagenesis and malignant transformation"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 amAtilla Aszodi (Ludwig-Maximillians-University, Germany)
"Mechanisms controlling chondrocyte polarity"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amYingzi Yang (National Institutes of Health, USA)
"Wnt5a controls directional growth of the cartilage by acting as a global cue to establish planar cell polarity"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmJessica Bertrand (Queen Mary University, UK)
"NPP1 deficient mice exhibit OA-like changes and cartilage remodeling into bone"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCellular Stress in Cartilage
Discussion Leader: Linda Sandell (Washington University, USA)
7:30 pm - 7:50 pmBen Alman (University of Toronto, Canada)
"From development to pathology: Hedgehog signalling in cartilage neoplasia and osteoarthritis"
7:50 pm - 8:05 pm Discussion
8:05 pm - 8:25 pmMike Briggs (University of Manchester, UK)
"Mechanisms of chondrocyte stress caused by mutations in COMP and MATN3"
8:25 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmFrank Beier (University of Western Ontario Canada)
"Stress pathways in endochondral ossification and osteoarthritis"
9:00 pm - 9:15 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDegenerative Disorders
Discussion Leader: Danny Chan (University of Hong Kong)
9:00 am - 9:20 amMakarand Risbud (Thomas Jefferson University, USA)
"Molecular Mediators of TNF-alpha and IL-1beta Action on the Nucleus Pulposus Cells: Implications in Degenerative Disc Disease"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amLinda Sandell (Washington University, USA)
"Genetic Mouse Models for Cartilage Repair and Degeneration"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 amErnestina Schipani (Massachusetts General Hospital, USA)
"HIF and VHL in cartilage: a tale of paradoxes"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amHiroshi Kawaguchi (University of Tokyo, Japan)
"Endochondral ossification signals as potential therapeutic targets for osteoarthritis"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmThomas Pap (University Hospital Munster, Germany)
"Regulation of chondrocyte metabolism and cartilage breakdown by syndecans"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmInflammatory Mechanisms
Discussion Leader: Roy Black (Amgen, Seattle, USA)
7:30 pm - 7:40 pmRoy Black (Amgen, Seattle, USA)
"Blocking the LRP-1-mediated clearance of TIMP-3 prevents cytokine-induced cartilage degradation"
7:40 pm - 7:50 pm Discussion
7:50 pm - 8:10 pmKonstantin Taganov (Regulus Therapeutics, Carlsbad, USA)
"microRNA-146A is a Significant Brake on Autoimmunity Myeloproliferation and Cancer in Mice"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:40 pmJoyce Wu (Harvard University, USA)
"A link between gut microbiota, mucosal immunity and autoimmune arthritis"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmRu Liu-Bryan (University of California, San Diego, USA)
"Innate Immunity in chondrocyte function and differentiation"
9:15 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRepair, Regeneration, Tissue Engineering
Discussion Leader: Rocky Tuan (University of Pittsburgh, USA)
9:00 am - 9:20 amRegis O’Keefe (University of Rochester, USA)
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Bjorn Olsen (Harvard University, USA)
"Mesenchymal stem-like cells from vascular endothelium - the good and the bad"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 amSamuel Stupp (Northwestern University, USA)
"Bioactive Nanostructures for the Regeneration of Tissues"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amDaisuke Sakai (Tokai University, Japan)
"Identification and characterization of stem/progenitor population from nucleus pulposus of the intervertebral disc"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmRita Kandel (University of Toronto, Canada)
"Engineering intervertebral discs"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEnabling Technologies for Cartilage Research
Discussion Leader: Bjorn Olsen (Harvard University, USA)
7:30 pm - 7:55 pmJohn Loughlin (Newcastle University, UK)
"Osteoarthritis susceptibility loci emerging from genome-wide association scans"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Faisal Aldaye (Harvard University, USA)
"A structurally and functionally tunable DNA extracellular matrix"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Shinsuke Ohba (Univeristy of Tokyo, Japan)
"Application of ChIP-Seq combined with a novel genetic tool to skeletal biology"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (I1 R13AR061167-01) from NIAMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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