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Conference Program
 
Cilia, Mucus & Mucociliary Interactions
February 13-18, 2011
Ventura Beach Marriott
Ventura, CA

The interactions between beating cilia, mucus, and fluids with varying viscoelastic properties play a fundamental role in human biology. Mucociliary clearance is now recognized as a key component of human innate immune defense mechanisms. Although classic mucociliary interactions are predominant in respiratory epithelium, they also occur in multiple other organ systems. In the respiratory tract, a deficiency in any part of these processes (mucous, cilia, fluids) impacts multiple disease states, including primary ciliary dyskinesia, Cystic Fibrosis, asthma and chronic rhinosinusitis. Primary individual alterations in ciliary-fluid interactions can also lead to pathology in ciliopathies. Collectively, the fields of cilia, mucus and mucociliary interactions represent different scientific disciplines that are highly relevant to each other, yet rarely combined into a common scientific meeting. The 2011 Gordon Research Conference on Cilia, Mucus and Mucociliary Interactions will feature a wide range of topics on Development, signaling and transcriptional control of ciliary and mucous components, Fundamental processes in mucins and cilia, Structure-function relationships in cilia and mucus, Genetic approaches to mucociliary diseases, Diseases of cilia and mucus, Mucociliary interactions, and Cilia and fluid interactions. The Conference will bring together a collection of investigators from a variety of scientific disciplines (including biochemistry, molecular, cell and structural biology, physiology, molecular genetics, and imaging) that are at the forefront of their fields. Additionally, the conference will provide opportunities for junior scientists and graduate students to present their work and exchange ideas with leaders in the fields. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, will serve as a forum where basic and clinical researchers from diverse disciplines can meet, interact, and bring cross-disciplinary understanding and new basic findings to the translational stage, with the ultimate goal of improving diagnosis and treatment for diseases and disorders involving both cilia and mucus.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmTowards Integrating Cilia, Mucins, and Mucociliary interactions: Prospects and Themes
Discussion Leaders: Peter Satir (Albert Einstein) and Sandra Gendler (Mayo Clinic, Phoenix)
7:35 pm - 7:40 pmPeter Satir (Albert Einstein) and Sandra Gendler (Mayo Clinic, Phoenix)
"Introduction"
7:40 pm - 8:05 pmGregory J. Pazour (Univ. Mass.)
"Motile and primary cilia in biology and disease"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmDavid Thornton (Univ. of Manchester, UK)
"From mucins to mucus"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmRichard Boucher (Univ. of North Carolina, Chapel Hill)
"Mucociliary interactions: views from the respiratory tract"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevelopment of Cilia and of Secretory Cells
Discussion Leaders: Mary Porter (Univ. Minnesota, Minneapolis) and Burton Dickey (MD Anderson Cancer Ctr, Houston)
9:00 am - 9:05 amMary Porter (Univ. Minnesota, Minneapolis)
"Introduction - cilia and development"
9:05 am - 9:25 amChristopher Kintner (Salk Institute, La Jolla)
"Developmental signals specify different cilia subtypes in Xenopus"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 amEszter K. Vladar (Stanford)
"Planar Cell Polarity Orients Respiratory Cilia"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Group Photo / Coffee Break
10:25 am - 10:45 amSteven Brody (Washington Univ., St. Louis)
"Relationships between primary and motile ciliogenesis in developing and injured airway epithelium"
10:45 am - 10:55 am Discussion
10:55 am - 11:00 amBurton Dickey (MD Anderson Cancer Ctr)
"Introduction - secretory cells and development"
11:00 am - 11:20 amWellington Cardoso (Boston Univ.)
"Notch signaling modulates the balance between ciliated and secretory cells"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amJeffrey Whitsett (Cincinnati Children’s Hospital)
"Transcriptional regulation of goblet cell differentiation"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmScott Randell (Univ. North Carolina, Chapel Hill)
"Micro RNA regulation of human airway epithelial phenotypes"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A (1st viewing)
6:00 pmDinner
7:30 pm - 9:30 pmSignaling and regulation in Cilia and Mucins
Discussion Leaders: Susan Dutcher (Washington Univ., St. Louis) and Yin Chen (University of Arizona)
7:30 pm - 7:35 pmSusan Dutcher (Washington Univ., St. Louis) and Yin Chen (University of Arizona)
"Introduction"
7:35 pm - 7:55 pmWallace Marshall (Univ. CA, San Francisco)
"Ciliary Length Control Systems"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmZhaoxia Sun (Yale Univ.)
"Cilia in the TSC/mTOR pathway"
8:30 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Christopher Evans (MD Anderson Cancer Center, Houston)
"Life (and Death) without Muc5ac and Muc5b in murine airways"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pmIsabelle Van Seuningen (Inserm, Lille, France)
"Epigenetic regulation of mucin genes: a new family of biomarkers in lung cancers"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFundamental Processes: Mucins and Cilia
Discussion Leaders: K.C. Kim (Temple Univ.) and Maureen WIrschell (Emory)
9:00 am - 9:05 amK.C. Kim (Temple Univ.)
"Introduction - Mucins"
9:05 am - 9:25 amBradley Schroeder (Univ. CA, San Francisco)
"Specialized ER proteins with critical roles in mucin production"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 amMehmet Kesimer (Univ. North Carolina, Chapel Hill)
"Unfolding a secreted mucin"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Coffee Break
10:25 am - 10:45 amGunnar C. Hansson (Univ. Gothenburg, Sweden)
"Intestinal mucin function and organization in relation to CFTR and the respiratory tract"
10:45 am - 10:55 am Discussion
10:55 am - 11:00 amMaureen Wirschell (Emory)
"Introduction - Cilia"
11:00 am - 11:20 amWinfield Sale (Emory Univ.)
"Regulation of cilia function in Chlamydomonas"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amElizabeth Smith (Dartmouth College)
"Calcium and regulation of ciliary motility"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmRebecca Burdine (Princeton)
"Cilia structure and function in zebrafish development"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A (2nd viewing)
6:00 pmDinner
7:30 pm - 9:30 pmGenetic Approaches in Ciliopathies and Mucociliary Diseases
Discussion Leaders: Heymut Omran (Univ. Freiburg) and Judith Voynow (Duke Univ.)
7:30 pm - 7:35 pm Heymut Omran (Univ. Freiburg) and Judith Voynow (Duke Univ.)
"Introduction"
7:35 pm - 7:55 pmKhalid Fakhro (Yale Univ.)
"Genetics of human heterotaxy"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pmPhilip L. Beales (University College, London)
"Craniofacial and skeletal patterning in ciliopathies"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pmMaimoona Zariwala (Univ. North Carolina, Chapel Hill)
"Use of Whole-Exome Sequencing to Define Genetic Causes of Primary Ciliary Dyskinesia"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmDavid Schwartz (National Jewish Health, Denver)
"Genetic studies implicate MUC5B in idiopathic pulmonary fibrosis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMucociliary Diseases, Submucosal Glands and Mucus
Discussion Leaders: Judith Voynow (Duke Univ.) and Stephen Ballard (Univ. South Alabama)
9:00 am - 9:05 amJudith Voynow (Duke)
"Introduction - models of mucociliary diseases"
9:05 am - 9:25 amLarry Ostrowski (Univ. North Carolina, Chapel Hill)
"Pathogenesis and Treatment of Primary Ciliary Dyskinesia in a novel mouse model"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 amMichael Welsh (Univ. Iowa)
"Airway alterations in the CF pig model"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Coffee Break
10:25 am - 10:45 amJohn Engelhardt (Univ. Iowa)
"Airway alterations in the CF ferret model"
10:45 am - 10:55 am Discussion
10:55 am - 11:00 amStephen Ballard (Univ. South Alabama)
"Introduction - Submucosal glands and mucus"
11:00 am - 11:20 amJeff Wine (Stanford Univ.)
"Submucosal Glands, Mucus, and Cystic Fibrosis"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Walter Finkbeiner (UCSF)
"Characterization of Native and Cultured Human Tracheobronchial Gland Serous and Mucous Cells"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Silvia Kreda (UNC)
"Rho signaling and VAMP8 are important mediators of airway goblet cell mucin secretion"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmKen Adler (North Carolina State Univ.)
"Circumvention of mucin hypersecretion by peptide inhibition"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B (1st viewing)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmStructure-Function Interactions in Cilia and Mucus
Discussion Leaders: Stephen King (Univ. Conn) and C.W. Davis (Univ. North Carolina, Chapel Hill)
7:30 pm - 7:50 pmDaniela Nicastro (Brandeis Univ.)
"CryoEM tomography: The axonemal dynein regulatory complex and nexin link"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pmMary Porter (U. Minnesota)
"Conserved subunits required for assembly of the nexin-DRC link and regulated microtubule sliding"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pmChris O'Callaghan (Univ. Leicester, UK)
"The interaction of cilia with pathogens"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Diego Preciado (Children's National, Washington DC)
"Bacterial Lysate Induction of Cxcl2 and Middle Ear Mucosal Metaplasia in Mice"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Richard Cone (Johns Hopkins Univ.)
"Barrier properties of mucus"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMucociliary Interactions
Discussion Leaders: Justin Hanes (Johns Hopkins Univ.) and Michael Rubinstein (Univ. N. Carolina, Chapel Hill)
9:00 am - 9:05 amJustin Hanes (Johns Hopkins Univ.)
"Introduction to Mucus Fundamentals"
9:05 am - 9:15 amYing-Ying Wang (Johns Hopkins University)
"Muco-inert nanoparticles reveal highly conserved microstructure of human mucus across entire physiological pH range"
9:15 am - 9:20 am Discussion
9:20 am - 9:40 amJohn Fahy (Univ. CA, San Francisco)
"Mechanisms of pathologic mucus formation in airway disease: roles for proteases and lectins"
9:40 am - 9:50 am Discussion
9:50 - 10:10 am Paul Quinton (Univ. CA, San Diego)
"A new intersection of electrolytes and mucus"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 10:45 amMichael Rubinstein (Univ. N. Carolina, Chapel Hill)
"Introduction to Mucus Interactions with Cilia"
10:45 am - 10:55 amLiheng Cai (Univ N.Carolina, Chapel Hill)
"New Insights on the Structure of Periciliary Layers of Lungs"
10:55 am - 11:00 am Discussion
11:00 am - 11:20 amSusan Suarez (Cornell Univ.)
"Sperm interactions with mucus and cilia"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amPanteleimon Rompolas (Univ. Conn.)
"Planarians as a molecular genetic system for analyzing cilia and force production against secreted mucus"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Richard Superfine (Univ. North Carolina, Chapel Hill)
"Modeling mucociliary interactions for the generation of flow"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B (2nd viewing)
6:00 pmDinner
7:30 pm - 9:30 pmLife at the Interface: Cilia and Fluid Interactions
Discussion Leader: Martina Brueckner (Yale Univ. New Haven)
7:30 pm - 7:35 pmMartina Brueckner (Yale Univ., New Haven)
"Introduction"
7:35 pm - 7:55 pmHiroshi Hamada (Osaka Univ., Japan)
"Fluid dynamics at the node, left-right development"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmIain Drummond (Harvard Univ.)
"Fluid movement in the developing kidney"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmSergio Gradilone (Mayo Clinic, Rochester)
"Cholangiocyte primary cilia: Key sensory organelles in biliary tree fluid"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmMatthias Salathe (Univ. Miami)
"New paradigms for regulation of ciliary function by secretions"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL106870-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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