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Enzymes, Coenzymes & Metabolic Pathways
July 10-15, 2011
Waterville Valley Resort
Waterville Valley, NH
Chairs:
James T. Stivers & Anne-Frances Miller

Vice Chairs:
Gregory D. Reinhart & Steven Rokita

This conference will integrate fundamental and applied aspects of modern enzymology. A broad cross section of academic and industrial research will be merged into program that will showcase the most innovative current thinking in enzymatic reaction mechanisms and in applied enzymology. The meeting will bring together a vibrant mix of established and new academic investigators with students and industrial researchers with the aim of stimulating dialogue among experts of diverse approaches and applications of enzymology. This year’s meeting will include sessions on single molecule enzymology, nucleic acid processing and modification, enzymatic energy transduction, macromolecule dynamics, epigenetic mechanisms, metabolic engineering, enzymological events & metabolic changes associated with aging or disease, and redox metalloenzymes.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
5:00 pm - 6:00 pmReception
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmENZYMOLOGICAL AND METABOLIC CHANGES ASSOCIATED WITH AGING AND DISEASE
Discussion Leader: Barbara Gerratana (National Institutes of Health)
7:40 pm - 8:10 pm L. Guarente (M.I.T.)
"NAD-dependent deacetylation regulating aging and disease"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Benjamin Tu (University of Texas Southwestern Med. Ctr)
"Metabolic signals that drive cell growth and proliferation"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Eyal Gottleib (Beatson Institute for Cancer Research)
"From metabolomics to system biology: identifying new targets for cancer treatment"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmENZYMOLOGY OF EPIGENETICS
Discussion Leader: Yujun George Zheng (Georgia State University)
9:00 am - 9:30 am Victoria Richon (Epizyme, Inc.)
"Histone methyltransferases: A new target class for cancer drug discovery"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Phil Cole (Johns Hopkins University)
"Regulation of CK2 by post-translational modifications"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Group Photo / Coffee Break
10:50 am - 11:20 am Hening Lin (Cornell University)
"The enzymatic activity of sirtuins uncovers new protein posttranslational modifications"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pm Chuan He (University of Chicago)
"Enzyme catalyzed oxidative modification and demodification of nucleic acids"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Yan Zhang (UT, Austin)
"Dephosphorylation Regulation of RNA polymerase II in Eukaryotic Transcription"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSINGLE MOLECULE METHODS
Discussion Leader: Kevin Dalby (University of Texas Austin)
7:30 pm - 8:00 pm Eric Greene (Columbia University)
"Single molecule imaging of DNA mismatch repair mechanisms"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Carlos Bustamante (UC Berkeley)
"Grabbing the Cat by the Tail: Discrete Steps by a DNA Packaging Motor and the Inter-Subunit Coordination in a Ring-ATPase"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Sunney Xie (Harvard University)
"Single Molecule Enzymology: From in vitro to live cell studies"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMACROMOLECULE DYNAMICS
Discussion Leader: Albert Mildvan (Johns Hopkins University)
9:00 am - 9:30 am Engin Serpersu (Department of Biochemistry Cellular & Molecular Biology, U. Tennessee)
"Antibiotic selection by promiscuous aminoglycoside modifying enzymes is thermodynamically achieved through protein flexibility and control of solvent rearrangement"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Bob Callender (Albert Einstein College of Medicine)
"Atomic Motion Encoding Function in lactate dehydrogenase"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Anne McDermott (Columbia University)
"Conformational exchange in enzymatic processes: seeing a protein's moves through NMR"
11:10 am - 11:20 am Discussion
11:20 am - 11:35 am Ellen Moomaw (Kennesaw State University)
"Ceriporiopsis subvermispora Bicupin Oxalate Oxidase"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Raul Perez-Jimenez (Columbia University)
"Single-Molecule Paleoenzymology: A Journey Back in Time"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Jane Jackman (Ohio State University)
"Mechanism and biological relevance of 3'-5' nucleic acid synthesis reactions catalyzed by tRNAHis guanylyltransferase (Thg1) superfamily enzymes"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMETABOLIC ENGINEERING
Discussion Leader: John Tomashek (Iogen Corp.)
7:30 pm - 8:00 pm Kristala Prather (M. I. T.)
"A platform pathway for the production of value-added chiral hydroxyacids"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Shota Atsumi (U. C. Davis)
"Synthetic biology and metabolic engineering approaches to produce biofuels from sugar and CO2"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Christina Smolke (Stanford)
"Molecular tools for advancing metabolic network design"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNUCLEIC ACIDS PROCESSING AND MODIFICATION
Discussion Leader: Patrick O'Brien (University of Michigan)
9:00 am - 9:30 am Barbara Golden (Purdue University)
"The HDV ribozyme has a hybrid engine"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Rick Russell (University of Texas Austin)
"How do DEAD-box 'helicase' proteins function as general RNA chaperones?"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Carol Fierke (University of Michigan)
"Mechanism and Substrate Selectivity of Ribonuclease P"
11:10 am - 11:20 am Discussion
11:20 am - 11:35 am Emily Parker (University of Canterbury)"Allosteric regulation of the shikimate pathway"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Siddhesh Kamat (Texas A & M)
"In vitro reconstitution of the C-P Lyase Pathway of E. coli"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Peter Bernhardt (UC, San Diego)
"A Stereoselective Vanadium-Dependent Chloroperoxidase in Bacterial Antibiotic Biosynthesis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmENZYMATIC ENERGY TRANSDUCTION
Discussion Leader: Jesse Chen (Millennium Pharmaceuticals)
7:30 pm - 8:00 pm Sheila Ferguson-Miller (Michigan State)
"Role of conformational change and conserved water in the cytochrome c oxidase proton pump"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Robert Gennis (University of Illinois)
"The superfamily of heme-copper oxygen and NO reductases"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm P. Leslie Dutton (U. Penn)
"Electronics of cytochrome bc1/b6f energy conversion catalysis"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMETALLOENZYMES AND REDOX CATALYSIS
Discussion Leader: Pinghua Liu (Boston University)
9:00 am - 9:30 am J. Marty Bollinger (Penn State University)
"The expanding catalytic repertoire of enzymes with carboxylate-bridged dimetal cofactors"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Lindsay Eltis (U. British Columbia)
"Mycobacterium tuberculosis reveals the unappreciated diversity of Reiske-type oxygenases"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 Coffee Break
10:50 am - 11:20 am Cathy Drennan (M.I.T.)
"Shake, Rattle, & Roll: Capturing Snapshots of Metalloenzymes in Action"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pm Dan Kosman (SUNY Buffalo)
"How Multicopper Ferroxidases Coax Fe(II) to Part with an Electron without Getting Rusty"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Pablo Sobrado (Virginia Tech)
"Flavin dependent-monooxygenases in Mycobacterial and Fungal Siderophore Biosynthesis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTOPICS IN ENZYME CATALYSIS
Session in Honour of Al Mildvan
Discussion Leader: Christian Whitman (University of Texas at Austin)
7:30 pm - 8:10 pm Steve Withers (U British Columbia)
"New mechanisms for breakdown and rearrangement of glycosides"
8:10 pm - 8:20 pm Discussion
8:20 pm - 9:00 pm Chris Walsh (Harvard University)
"How Aspergilli make peptidyl alkaloid scaffolds from anthranilate"
9:00 pm - 9:10 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
 
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