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Conference Program
 
Genetic Toxicology
July 10-15, 2011
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Genetic toxicology represents the study of genetic damage, the agents that induce such damage, and the biological mechanisms that respond to the consequences of genetic damage. Genotoxic agents are abundant in the environment and are often linked to human activity. The effects these agents have on humans include many common diseases, such as cancer. The response to genetic damage interfaces closely with many aspects of cellular metabolism, such as DNA repair and recombination, replication, transcription, cell cycle regulation and cell death. The interplay between genetic damage and cellular function will be a central focus of the conference.

The 2011 Gordon Research Conference on Genetic Toxicology will bring together a broad spectrum of scientists with the aim of disseminating current advances and stimulating debate to address future developments. Genetic toxicology ranges from basic research to applied research and includes a variety of disciplines (including structural, molecular and cellular biology, genetics, biochemistry, epidemiology, toxicology, toxicogenomics and hazard assessment). Bringing together basic and applied scientists from academia, industry and government is essential to drive this important field forward. Scientists can therefore use this conference as a forum to exchange ideas and discuss cross-disciplinary collaborations and research opportunities.

Participants will include those at the cutting edge of basic research and those driving technology developments within applied areas. In keeping with the ethos of Gordon Research Conferences, while information will be disseminated by speaker and poster presentations, vigorous discussion will be the key focus. Designated discussion leaders, recognized for their skills in each particular area, will guide the audience-based discussions. Special consideration will be given to strategies to improve interactions of junior and senior scientists during the conference.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lectures: Mechanisms of DNA Synthesis and Repair
Discussion Leader: Jessica Downs (University of Sussex)
7:40 pm - 8:20 pm Samuel Wilson (NIEHS/NIH)
"Structural Insight in Base Excision Repair"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Josef Jiricny (University of Zurich)
"The Mismatch Repair Interactome"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndogenous Damage and Cell Signalling
Discussion Leader: Penny Jeggo (University of Sussex)
9:00 am - 9:20 am Penny Jeggo (University of Sussex)
"The benefit of relaxation: how ATM achieves it"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Duaa Mohammad (MIT)
"DNA damage signaling pathways, chromatin structure, and post-transcriptional control of gene expression"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:50 am John Tainer (Scripps/LBNL)
"Damage Recognition and Signaling by Mre11-Rad50-Nbs1-ATM and TFIIH-CAK Kinase Complexes Control Biological Outcomes of DNA Damage"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am John Rouse (MRC PPU, University of Dundee)
"Forks and molecular knives in DNA repair"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Cynthia McMurray (Lawrence Berkeley National Laboratory)
"ATP hydrolysis by Rad50 switches MRE11 from an endonuclease to an exonuclease"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Timothy Humphrey (University of Oxford)
"Suppressing Break-Induced Loss of Heterozygosity"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCell Cycle Responses to Genotoxicity
Discussion Leader: Kevin Hiom (Dundee Cancer Centre, University of Dundee)
5:30 pm - 5:50 pm Kevin Hiom (Dundee Cancer Centre, University of Dundee)
"Understanding the contribution of BRCA1 to maintenance of genome stability"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Laurence Pearl (University of Sussex)
"Recognition and repair of DNA strand breaks"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Helle Ulrich (London Research Institute)
"Mechanistic analysis of ubiquitin-dependent DNA damage bypass"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Michael Resnick (NIEHS, NIH)
"Resection and coordination at random double strand breaks"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndogenous Damage and DNA Repair
Discussion Leader: Keith Caldecott (University of Sussex)
9:00 am - 9:20 am Keith Caldecott (University of Sussex)
"PARP3 is a novel component of mammalian DNA double strand break repair"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Ben van Houten (University of Pittsburgh)
"Alterations in mitochondrial dynamics affects cell cycle control and genome stability"
9:50 am 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Aidan Doherty (University of Sussex)
"Orchestration of DNA Double-Strand Break Repair Processes by NHEJ Polymerases"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Dragony Fu (MIT)
"Mammalian AlkB dioxygenases: novel functions in the DNA damage response and cell death"
11:20 am - 11:25 am Discussion
11:25 am - 11:45 am Susan Lees-Miller (University of Calgary)
"XLF interactions with XRCC4 create an extended grooved scaffold for DNA ligation and double-strand break repair"
11:45 am - 11:50 pm Discussion
11:50 pm - 12:05 pm Sherif El-Khamisy (University of Sussex)
"Breaking and sealing one strand of DNA: a role for SUMO"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Melanie Blasius (Gurdon Institute)
"The roles of the Chk1 kinase in the DNA-damage response and beyond"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMutagenesis and Lesion Bypass - I
Discussion Leader: Alan Lehmann (University of Sussex)
5:30 pm - 5:50 pm Alan Lehmann (University of Sussex)
"Regulation of pol eta by post-translational modifications"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Julian Sale (MRC LMB)
"Structured DNA and epigenetic instability"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Robert Fuchs (CNRS, Marseille)
"The switches between replicative and TLS polymerases: an integrated view of Translesion Synthesis in E. coli"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Alba Guarne (McMaster University)
"Structural insights into the molecular mechanisms that regulate the endonuclease activity of MutL"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMutagenesis and Lesion Bypass - II
Discussion Leader: Tom Kunkel (NIEHS, NIH)
9:00 am - 9:20 am Tom Kunkel (NIEHS, NIH)
"Generating and Correcting Leading- and Lagging-Strand DNA Replication Errors in Yeast"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Roger Woodgate (NICHD, NIH)
"Properties of E. coli PolVMut"
9:50 am 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Wei Yang (NIDDK, NIH)
"Molecular mechanism for DNA lesion recognition and repair"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Joann Sweasy (Yale University)
"Base Excision Repair Plymorphisms and Cancer"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Jeffrey Miller (UCLA)
"Finding mutators in Bacillus anthracis to discover the components of mismatch repair"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Nigel Savery (University of Bristol)
"Damage-detection during bacterial transcription coupled DNA repair"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmEnvironmental and Genotoxic Stress
Discussion Leader: Laurence Loeb (University of Washington)
5:30 pm - 5:50 pm Lawrence Loeb (University of Washington)
"Human Cancers Express a Mutator Phenotype: Origin, Consequences and Targeting"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm David Phillips (ICR, UK)
"Complexities of cellular responses to genotoxicants"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Simon Reed (Cardiff University)
"An 'Omics' approach to measuring DNA damage and repair: from technique to translation"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Geoff Baldwin (Imperial College London)
"Network behavior in the BER system of the human pathogen Neisseria meningitidis"
7:20 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin Responses to Genotoxicity
Discussion Leader: Genevieve Almouzni (Institut Curie)
9:00 am - 9:20 am Genevieve Almouzni (Institut Curie)
"Variation on the theme of Chromatin Assembly"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Wim Vermeulen (Erasmus MC)
"responseIdentification of a novel transcription-coupled repair factor by an unbiased UV-induced ubiquitinome screen"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Michael Smerdon (Washington State University)
"Accessibility of DNA Lesions in Chromatin"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Zdenko Herceg (IARC)
"Role of histone acetylation in DNA damage response and chromatin-based processes"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Aaron Goodarzi (University of Calgary)
"ATM and PP4 control KAP-1 phosphorylation to form a molecular switch that regulates CHD3 nucleosome remodeling during the DNA double strand break response"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Alex Pines (Leiden University Medical Center)
"Recruitment of chromatin remodeling proteins at pre-incision stage of nucleotide excision repair by DDB2"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmReplication and Links to Genotoxicity
Discussion Leader: Anthony Carr (University of Sussex)
5:30 pm - 5:50 pm Anthony Carr (University of Sussex)
"Analysis of recombination-mediated replication restart"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Marco Foiani (IFOM, Milan)
"The replication checkpoint protects fork stability by releasing topological tension at nuclear pore gated genes"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Steve Kowalczykowski (UC Davis)
"Mechanism of DNA-break repair: roles of BLM and BRCA2"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Katharina Schlacher (MSKCC)
"Replication fork protection provides a mechanistic link between breast cancer and Fanconi anemia susceptibility"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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