| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote lecture |
| 3:45 pm - 4:15 pm | Donald McDonald (UCSF, CA, USA)
"Angiogenesis in Tumors and Inflammation: Similarities and Differences" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Tumor Vascularization and its Role in Tumor Progression |
| Discussion Leader: Lena Claesson-Welsh (Uppsala University, Sweden) & Claire Clarkin (King's College, London, UK) |
| 7:30 pm - 7:50 pm | Brad St.Croix (NCI, Frederick, MD, USA)
"Functional Analysis of Tumor Endothelial Markers in Development and Disease" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Maximilliano Mazzone (Vesalius Research Center, Leuven; Belgium)
"Targeting PHD2 oxygen sensor: a new avenue in anti-angiogenic therapy" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Lisette Acevedo (UCSD, CA, USA)
"Semaphorin 3A promotes metastatic disease" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Sònia Tugues (Uppsala University, Sweden)
"Role of endogenous Histidine Rich Glycoprotein (HRG) in regulation of the tumor microenvironment" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Mario Squadrito (Instituto San Raffaele, Milan, Italy)
"MicroRNA regulation of pro-angiogenic macrophages" |
| 9:25 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Vascular plasticity in health and disease |
| Discussion Leader: Donald McDonald (UCSF, CA, USA) & Lisette Acevedo (UCSF, CA, USA) |
| 9:00 am - 9:20 am | Carlos Fernández-Hernando (NY School of Medicine, New York, USA)
"Role of endothelial caveolin-1 in the progression of atherosclerosis" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:45 am | Ivan Lobov (Regeneron, Tarrytown, NY, USA)
"The Dll4/Notch pathway controls post-angiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:05 am | Claire Clarkin (King's College, London, UK)
"Human islet mesenchymal cells detrimentally influence endothelial cell survival and function" |
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:25 am | Filip Roudnicky (ETH Zurich, Switzerland)
"Laser capture microdissection of vascular endothelial cells from muscle invasive bladder cancer identifies endocan as a bladder cancer endothelium specific marker" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:45 am | Amir Assadi (University of Wisconsin, WI, USA)
"Predicting functionalities of organ-specific angiogenesis related genes in endothelial cells" |
| 10:45 am - 10:50 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:40 pm | Vascular targeting |
| Discussion Leader: Maximilliano Mazzone (Vesalius Research Center, Leuven; Belgium) & Ivan Lobov (Regeneron Pharmaceuticals, Tarrytown) |
| 1:30 pm - 1:50 pm | Ronald J Buckanovich (Michigan Medical Center, Michigan, USA)
"A Model of Human Tumor Vasculature in Mice to Test Anti-vascular Therapeutics" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:15 pm | Elise Langenkamp (UMCG, Groningen, The Netherlands)
"VEGFR2 inhibition in Lewis Lung Carcinoma induces vascular stabilization" |
| 2:15 pm - 2:20 pm | Discussion |
| 2:20 pm - 2:35 pm | Barbara Sennino (UCSF, CA, USA)
"Inhibition of c-Met together with VEGF signaling suppresses tumor invasion and metastasis and prolongs survival"
|
| 2:35 pm - 2:40 pm | Discussion |
| 2:40 pm - 3:00 pm | Concluding Remarks, Poster Awards, and Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |