The Gordon-Kenan Research Seminar on Physical Virology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas relevant to the area of virus-inspired systems.
Virus capsids, in particular, have properties that have elicited an increased interest for various applications of potential technological importance, e.g., responsiveness to environmental changes, the ability to spontaneously and efficiently self-assemble in vitro or in vivo with sub-nanometer accuracy, and the possibility of structural engineering using established molecular biology methods.
The focus of this meeting is on:
- providing a non-intimidating forum for the discussion of physical, biological, and materials perspectives that are rapidly shaping the field of viruses as physical functional systems, and
- providing career mentorship by addressing the challenges and opportunities related to interdisciplinary research, including:
- how to create one’s niche in a diverse field
- what types of jobs are available to applicants with an interdisciplinary background
- how the continuous evolution of this field might impact future career prospects
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Seed funding for this new Gordon Research Seminar has been provided by the Kenan Institute for Engineering, Technology and Science at North Carolina State University.
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| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Lecture |
| 3:45 pm - 4:15 pm | Mavis Agbanje-McKenna (Univ. of Florida, Gainesville)
"Physical Virology: Visualizing essential steps in a viral life cycle" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Probing virus assembly |
| Discussion Leaders: Hazel Levy (Harvard Medical School), Kelly Lee (Univ. of Washington) |
| 7:30 pm - 7:50 pm | Michael Bruckman (Naval Research Labs)
"The role of hexa-histidine in directed nano assemblies of Tobacco Mosaic Virus coat protein and gold nanoparticles" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Juliana Cortines (University of Connecticut)
"Defining the interaction sites between bacteriophage P22 scaffolding and coat proteins" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Chao Chen (Indiana University)
"When HBV meets SRPK: probing capsid assembly and signaling" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Melanie Brasch (University of Twente, Netherlands)
"Encapsulation in CCMV: container and contents shaping each other" |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Career Panel / Virus structure and infectivity |
| Discussion Leaders: Walid Maaty (Montana State University), Rudolf Podgornik (University of Ljubljana, Slovenia) |
| 9:00 am - 9:45 am | Mentoring Component: Challenges and Opportunities in Interdisciplinary Research |
| Panel participants: |
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- Nicole Steinmetz (Assistant Professor, Case Western Reserve University)
- Kelly Lee (Assistant Professor, University of Washington)
- Junghae Suh (Assistant Professor, Rice University)
- Joseph Wang (Postdoc, Indiana University)
- Park, Eun-Chung (Program Officer, NIH/NIAID)
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| 9:45 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Thibault Lagache (École Normale Supérieure, France)
"Modeling the endosomal step of viral infection - Influenza as an example of enveloped viruses" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Joshua Powell (Oregon State University)
"Mutagenesis of the coat protein N-terminus of TYMV results in infectious virions that are either more or less resistant to disassembly" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 3:00 pm | Biomedical applications of viruses |
| Discussion Leader: Antonette Bennett (University of Florida, Gainesville) |
| 1:30 pm - 1:50 pm | Francis Galaway (University of Leeds, UK)
"Use of an RNA phage capsid as a regulatory RNA delivery system" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | David Morris (University of Alabama-Birmingham)
"Virus capsids as targeted nanoparticle drug delivery system" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |