| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | New Applications of Heterocycles |
| Discussion Leader: David Lathbury (Albany Molecular Research Inc.) |
| 7:40 pm - 8:00 pm | Abigail Doyle (Princeton)
"Strategies and Methods for the Catalytic Functionalization of Heterocycles" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Armen Zakarian (UCSB)
"Strategies for the Synthesis of Maoecrystal V and other /ent/-Kauranoids" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Andrew Myers (Harvard University)
"Research Directed toward the Natural Antiproliferative Agent Cortistatin A leads to a New and Versatile Synthesis of Isoquinolines" [Lecture in Memory of Dr. David Gin] |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Heterocycle Formation and Catalytic Functionalizations |
| Discussion Leader: Ashton Hamme (Jackson State University) |
| 9:00 am - 9:25 am | Vy Dong (Toronto)
"A catalytic and enantioselective approach to lactones and lactams" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Jacqueline Milne (Amgen)
"Development and Investigation of Pd-catalyzed C-N Bond Formation: Application To the Synthesis of an Active Pharmaceutical Ingredient" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo (10:15 am) |
| 10:25 am - 10:50 am | Eric Ferreira (Colorado State)
"Metal-Catalyzed Directed Functionalizations via Heterocycle Formation" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:30 am | Takashi Ooi (Nagoya University)
"Molecular Design and Synthetic Applications of Chiral 1,2,3-Triazolium Salts" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:20 pm | Andrew Degnan (BMS)
"Heterocyclic Compounds for a New Treatment of Depression" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #1 (Convenor: David Lathbury) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Heterocycles in Natural Product Synthesis I |
| Discussion Leader: Sarah Reisman (Caltech) |
| 7:30 pm - 7:50 pm | Matthias Brewer (University of Vermont)
"Intramolecular cycloadditions as efficient approaches to polycyclic nitrogen heterocycles" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:25 pm | Neil Garg (UCLA)
"Studies toward the Synthesis of Heterocyclic Natural Products" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Brian Stoltz (Caltech)
"Heterocycles as a Driving Force for Discovery in Organic Chemistry" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Methodology for Heterocyclic Compounds |
| Discussion Leader: Brian M. Lawrence (Morehouse College) |
| 9:00 am - 9:20 am | Taichi Kano (Kyoto)
"Asymmetric α-functionalizations of aldehydes catalyzed by binaphthyl-based secondary amines" |
| 9:30 am - 9:35 am | Discussion |
| 9:35 am - 10:05 am | Thomas Colacot (JohnsonMatthey)
"Structure Activity Relationship in Pd-Catalyzed Heteroarylation" |
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:25 am | Poster Presenter 1 |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 10:50 am - 11:30 am | Mohammad Movassaghi (MIT)
"Complex Alkaloid Total Synthesis" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 12:25 pm | Jon Ellman (Yale University)
"New Carbon-Carbon Bond Forming Reactions for Heterocycle Synthesis and Elaboration" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Heterocycles in Natural Product Synthesis I |
| Discussion Leader: Martha Sarpong (GlaxoSmithKline) |
| 7:30 pm - 8:00 pm | Mike Kerr (Western Ontario)
"Total synthesis of heterocyclic natural products enabled by the use of donor-acceptor cyclopropanes" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Darren Dixon (Oxford)
"Catalysis and Cascades in Complex Alkaloid Natural Product Synthesis" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | John Wood (Colorado State University)
"Recent Efforts in the Synthesis of Oxindole-Containing Natural Products" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Heterocyclic Processes for Biological Applications |
| Discussion Leader: Javier Sardina (Santiago de Compostela) |
| 9:00 am - 9:20 am | Tom Selby (DuPont)
"Pyrimidinone-substituted Methylsulfonylisoxazolines: Potent Herbicidal Inhibitors of Very Long Chain Fatty Acid Biosynthesis" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Stefan France (Georgia Tech)
"Diastereoselective Synthesis of Pyrido[1,2-a]indole-based Alkaloids via Indium-Catalyzed Homo-Nazarov Cyclizations" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:25 am | Daniel Fandrick (Boehringer Ingelheim)
"Stereoselective Propargylations with a Propargyl Borolane and
application to Heterocyclic Scaffolds" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | Business Meeting: Part 1 |
| Nominations for the next Vice Chair |
| 10:40 am | Coffee Break |
| 11:00 am - 11:15 am | Poster Presenter 2 |
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 11:35 am | Poster Presenter 3 |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:25 pm | Gary Molander (UPenn)
"Organotrifluoroborates in the Service of Heterocyclic Synthesis" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #2 (Convenor: David Lathbury) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Heterocycles in Chemical Biology |
| Discussion Leader: Oladapo Bakare (Howard) |
| 7:30 pm - 7:50 pm | Herman Sintim (Maryland)
"Bacterial conversation stoppers- new methodologies for constructing next generation anti-infectives" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:35 pm | Margaret Brimble (Auckland)
"Synthesis of bioactive natural products that contain benzannulated spiroketal heterocycles" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Huw Davies (Emory)
"Stereoselective Synthesis of Heterocycles Using Rhodium Carbene Chemistry" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Synthesis of Biologically Active Heterocycles |
| Discussion Leader: Jason Herr (AMRI) |
| 9:00 am - 9:30 am | Eric A. Voight (Abbott)
"Synthesis of Pharmacologically Differentiated Heterocyclic TRPV1 Antagonists for the Treatment of Chronic Pain" |
| 9:30 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Brian Aquila (Astra Zeneca)
"The chemistry of AZD4877, a kinesin spindle protein inhibitor" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:25 am | Kevin Cole (Eli Lilly)
"A Novel Vanadium-Catalyzed Arylation in Process Development" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Business Meeting: Part 2 |
| Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 10:50 am - 11:00 am | Coffee Break |
| 11:00 am - 11:15 am | Poster Presenter 4 |
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 12:00 pm | Chris Vanderwal (UC Irvine)
"Complex Molecule Synthesis Inspired by the Zincke Ring-Openings of Pyridines" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:25 pm | Tobias Ritter (Harvard)
"Redox Catalysis with Iron and Palladium" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time / Optional Wine Tasting Social (4:00 pm - 6:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Exploring Chemical Space: Heterocycles |
| Discussion Leader: Rebecca Hoye (Macalester College) |
| 7:30 pm - 8:00 pm | Daniel Romo (Texas A&M)
"Natural Products as Enduring Forums for Synthetic Strategy and Biological Discovery" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 9:05 pm | Stuart Schreiber (Harvard)
"Using small-molecule probes to relate the genetic features of human cancers to drug efficacies" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | David Lathbury (Albany Molecular Research)
Vice Chair's Closing Remarks |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |