Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
High Throughput Chemistry & Chemical Biology
June 19-24, 2011
Colby-Sawyer College
New London, NH

Related Meeting Information
The High Throughput Chemistry & Chemical Biology Gordon Research Conference was held in conjunction with the High Throughput Chemistry & Chemical Biology Gordon Research Seminar. Please refer to the High Throughput Chemistry & Chemical Biology GRS web page for more information.

Dear Colleagues,

High throughput chemistry and chemical biology is a dynamic, rapidly evolving field that plays a critical role in molecular probe development and drug discovery. This scientific community has contributed vigorously to the evolution of the drug discovery process emphasizing accelerated lead generation / lead optimization strategies, high throughput technologies, and chemical biology. This year’s program will feature cutting edge talks bridging the disciplines of organic synthesis, catalysis, medicinal chemistry, and chemical biology as applied towards high speed synthesis, parallel chemistry approaches, rapid generation of structure-activity relationships, and the discovery of small molecule probes to study the role of newly discovered protein targets and molecular pathways in disease initiation and progression.

A review of the 2010 program will give you an idea of the range of topics typically covered. Participants are encouraged to present posters. Three poster winners are selected at each meeting to present lectures at the following conference.

I am especially pleased to announce that the 2nd Gordon Research Seminar (GRS) for our conference will be held the weekend prior to the GRC, June 18-19. The GRS leaders are postdoctoral fellows Dr. William C. Pomerantz (University of Michigan) and Dr. Anand Singh (Burnham Institute of Medical Research).

High Throughput Chemistry and Chemical Biology GRC and GRS will continue the tradition of excellent science in a relaxed atmosphere. I encourage the application and attendance of scientists from diverse backgrounds and experiences, including women, minorities, graduate students, post docs, academic, and industrial researchers to the conference. Corporate funding is vital to support our invited speakers and conference operations to insure that we continue to meet the needs of the drug discovery and probe development community. I look forward to seeing you at the conference in June. Thank you for your interest and support.

Roland E. Dolle, Ph.D.
2011 GRC Conference Chair
High Throughput Chemistry & Chemical Biology


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff / Chair's Welcome by Roland Dolle (Cubist Pharmaceuticals)
7:40 pm - 9:30 pmFrontiers in Drug Discovery I
Discussion Leader: Craig Thomas (NIH/NHGRI)
7:40 pm - 8:20 pm Rishi Jain (Novartis)
"Chemical Biology: An Essential Tool for Pharma"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:20 pm P. Jeffery Conn (Vanderbilt University)
"Optimization and Functional Diversity of Allosteric Modulators of GPCRs"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChemical Biology: Probes and Pathways
Discussion Leader: Joseph Salvino (Alliance Discovery)
9:00 am - 9:25 am Kate Carroll (Scripps - Florida)
"Painting the Cysteine Chapel: New Tools to Probe Oxidation Biology"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Dirk Heerding (GlaxoSmithKline)
"Potent and Selective PDK1 Inhibitors Through Fragment Screening"
9:55 am - 10:05 am Discussion
10:05 am - 10:30 am Coffee Break
10:30 am - 11:00 am Jonathan Ellman (Yale University)
"A Substrate-Based Fragment Approach for Enzyme Inhibitor Discovery"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Karl Gademann (University of Basel)
"Controlling Biological Processes by Synthetic Natural Products"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Nathanael Gray (Dana Farber Cancer Institute)
"Three Strategies for Overcoming Kinase Inhibitor Resistance in Bcr-Abl, EGFR, PDGFR and B-Raf"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmDrug Discovery and Cheminformatics
Discussion Leader: Brian McGuinness (Venenum Biodesign)
7:30 pm - 7:55 pm Jason Lowe (Broad Institute)
"Diversity-Oriented Synthesis of a CNS-Focused Azetidine Library"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:35 pm Jake Wiener (J&J Pharmaceutical Research & Development)
"Intuitive Informatics Methods for Analyzing SAR in Complex Datasets: Application to a Cathepsin S Inhibitor Program"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:20 pm Bryan Roth (University of North Carolina, Chapel Hill)
"The Subterranean Pharmacology of Approved Medications"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHigh Throughput & Drug Discovery Technologies
Discussion Leader: Scott Wolkenberg (Merck)
9:00 am - 9:25 am Todd Graybill (GlaxoSmithKline)
"Hit Identification Using DNA-Encoded Libraries: A Case Study with Tachykinin Cell- Surface Receptor"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am David Nirschl (Bristol-Myers Squibb)
"Centralized Purification for Discovery Chemistry: Changing Drug Discovery One Compound at a Time"
10:00 am - 10:10 am Discussion
10:10 am - 10:30 am Coffee Break
10:30 am - 11:00 am Kevin Moeller (Washington University in St. Louis)
"Electrochemistry, Umpolung Reactions, and the Use of Microelectrode Arrays for Monitoring of Small Molecule-Receptor Interactions in 'Real-Time'"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Scott Harrison (Merck)
"Identification of the beta-Amyloid Plaque PET Ligand [18F]MK-3328 via Parallel Synthesis"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Thomas McMurry (Anchor Therapeutics)
"Discovery of Biased GPCR Agonists Based on Intracellular Domains"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmSynthetic Methodology and Chemical Neurobiology
Discussion Leader: Karin Worm (Avila Therapeutics)
7:30 pm - 7:55 pm Alan Rolfe (Kansas University) [2010 Poster Winner]
"Facilitated ROMP Protocols: From Mitsunobu to Flow"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:35 pm Tehshik Yoon (University of Wisconsin-Madison)
"Photocatalysis with Visible Light"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:20 pm Dirk Trauner (University of Munich)
"Optochemical Genetics"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDrug Discovery and Enabling Synthetic Chemistry
Discussion Leader: Richard Hartley (University of Glasgow)
9:00 am - 9:25 am J. Robert Merritt (Kean University)
"A CCR1 Antagonist for Autoimmune Diseases: from Combichem Hit to Lead, to Clinical Candidate, to Academics"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Jonathan Grob (Novartis)
"MIDA Boronates for Medicinal Chemistry: The Development of a Suite of Reactions Enabling Library Synthesis with MIDA Boronates"
10:00 am - 10:10 am Discussion
10:10 am - 10:30 am Coffee Break
10:30 am - 10:55 am Jin-Quan Yu (Scripps - San Diego)
"Diversity-Oriented Synthesis through Divergent C-H Functionalizations"
10:55 am - 11:05 am Discussion
11:05 am - 11:35 am Nick Terrett (Ensemble Therapeutics)
"Moving in New Circles: Exploiting Macrocycles for Drug Discovery"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Kevin Woller (Abbott)
"Reflections on 10 Years of HTOS at Abbott"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting: Part I
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences
7:30 pm - 9:30 pmSynthetic Chemistry and Catalysis
Discussion Leader: Robert Goodnow (Hoffman-La Roche)
7:30 pm - 7:55 pm Olugbeminiyi Fadeyi (Vanderbilt University) [2010 Poster Winner]
"A General Approach to Medium Ring Azabicycles: Progress Towards the Total Syntheses of Stemaphylline, Grandisines A & D, Verticillatin C and Cremastrine"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:35 pm Corey Stephenson (Boston University)
"Photoredox Catalysis: Enabling Chemical Synthesis with Visible Light"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:20 pm Tobias Ritter (Harvard University)
"Late-Stage Fluorination for PET Imaging"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting: Part II
Vice Chair Nominee Talks; Election of the next Vice Chair
9:00 am - 12:30 pmLead Finding for Oncology and Neurodegenerative Diseases
Discussion Leader: Sam Gerritz (Bristol-Myers Squibb)
9:00 am - 9:45 am Jeffery Kelly (Scripps - San Diego)
"Adapting Proteostasis to Ameliorate Loss- and Gain-of-Function Misfolding Diseases"
9:45 am - 10:00 am Discussion
10:00 am - 10:20 am Coffee Break
10:20 am - 11:10 am Paul Hergenrother (University of Illinois, Urbana Champaign)
"Elevated Protein Expression as a Target for Selective Anticancer Therapy"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Stephen Condon (TetraLogic Pharmaceuticals)
"The Discovery and Development of Smac Mimetics for the Treatment of Cancer"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Brent Stockwell (Columbia University)
"Probing Cell Death with Small Molecules"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmFrontiers in Drug Discovery II
Discussion Leader: Seung Bum Park (Seoul National University)
7:30 pm - 8:20 pm Alan Palkowitz (Lilly)
"Phenotypic Drug Discovery: A Globally Integrated Platform Approach for Innovation"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Richard L. Elliott (Bill & Melinda Gates Foundation)
"Drug Discovery for Neglected Diseases: Challenges and Opportunities"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
© 2013 Gordon Research Conferences. All Rights Reserved. Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter