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Molecular Membrane Biology
July 10-15, 2011
Proctor Academy
Andover, NH
Chair:
Charlie Barlowe

Vice Chair:
Francis Barr

The 2011 Molecular Membrane Biology Gordon Conference will cover recent advances in organelle structure, function and biogenesis, including protein trafficking, autophagy, mitochondrial dynamics, and lipid biology. The field of membrane biology is entering an exciting phase as insights on molecular mechanism are enhancing our understanding of important biological processes such as signal transduction, development, host-pathogen interactions and familial diseases. Current progress is advancing through multidisciplinary approaches and an explosion of new methodology including high throughput screening, super-resolution microscopy and advanced biophysical methods. These and other late-breaking discoveries will be covered at the 2011 conference. In addition to invited speakers, sixteen short talks will be selected from submitted abstracts and poster sessions are planned to promote discussion of the most recent developments. Applicants are encouraged to submit a brief abstract describing their current studies and to indicate whether they wish to present a poster or to be considered for a talk. The meeting program will be finalized in mid-April and we request that applicants who would like their abstracts considered for a talk to apply by April 4, 2011.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:00 pmAt the Frontier in Molecular Membrane Biology
Discussion Leader: Charlie Barlowe (Dartmouth)
7:45 pm - 8:35 pmPeter Walter (University of California San Francisco)
"The unfolded protein response in health and disease"
8:35 pm - 9:00 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMembrane Bending and Fusion
Discussion Leader: Jodi Nunnari (University of California Davis)
9:00 am - 9:20 amTom Rapoport (Harvard Medical School)
"How the ER gets into shape"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJames McNew (Rice University)
"Molecular analysis of membrane fusion by the GTPase atlastin"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMarijn Ford (University of California Davis)
"Molecular mechanisms of mitochondrial behavior"
10:20 am -10:30 amDiscussion
10:30 amGroup Photo / Coffee Break
11:00 am - 11:20 amSandy Schmid (Scripps Research Institute)
"A tale of two dynamins"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amBill Wickner (Dartmouth)
"Protein:lipid interplay for membrane fusion"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pmDaniel Kuemmel (Yale University)
"Structural basis for clamping of membrane fusion by complexin"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmWei Guo (University of Pennsylvania)
"Membrane remodeling by the exocyst component Exo70"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMembrane Coats
Discussion Leader: Sandy Schmid (Scripps Research Institute)
7:30 pm - 7:50 pm David Owen (University of Cambridge)
"Selecting cargo for clathrin mediated endocytosis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Randy Schekman (University of California Berkeley)
"Accommodation of large cargo by the COPII coat"
8:20 pm - 8:30pm Discussion
8:30 pm - 8:40 pm Jeroen Strating (Heidelberg University)
"Functional studies of coatomer using recombinant coatomer subcomplexes"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Max Nachury (Stanford University)
"Trafficking of signaling receptors to and from the primary cilium"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Dusanka Deretic (University of New Mexico)
"Mechanism for coupling of cargo recognition with cargo destination in delivery to the primary cilium"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmER in Health and Disease
Discussion Leader: Randy Schekman (University of California Berkeley)
9:00 am - 9:20 am Bob Keenan (University of Chicago)
"Tail-anchored membrane protein biosynthesis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Ineke Braakman (University of Utrecht)
"Protein folding in the Endoplasmic Reticulum"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Liz Miller (Columbia University)
"High throughput yeast genetics reveals novel aspects of ER quality control"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 am Sima Lev (Weizmann Institute)
"The Conserved Oligomeric Golgi (COG) complex and its role in retrograde trafficking"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Aki Nakano (RIKEN)
"High-resolution live imaging of cargo delivery from ER exit sites to the Golgi apparatus"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Jon Audhya (University of Wisconsin)
"Regulation of COPII recruitment at ER exit sites"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Bill Balch (Scripps Research Institute)
"Trafficking, vesicles and proteostasis"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLeading Edges of Membrane Biology I
Discussion Leader: Suzanne Pfeffer (Stanford University)
7:30 pm - 7:50 pm Jay Groves (University of California Berkeley)
"Spatial organization and the mechanics of signal transduction in cell membranes"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Jeanne Stachowiak (Sandia National Laboratories)
"Epsin1 bends lipid membranes by molecular crowding"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm Usha Acharya (University of Massachusetts Medical School)
"Sphingolipids regulate intracellular trafficking to maintain photoreceptor homeostasis"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Fred Hughson (Princeton University)
"CATCHR-family complexes: structure and mechanism"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Susan Ferro-Novick (University of California San Diego)
"Coats, tethers, Rabs and SNAREs work together to mediate the specificity of vesicle traffic"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOrganelle Structure and Function
Discussion Leader: Fred Hughson (Princeton University)
9:00 am - 9:20 am Janet Shaw (University of Utah)
"Mechanisms of mitochondrial membrane dynamics"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Gia Voeltz (University of Colorado)
"A 3D analysis of yeast ER structure reveals how ER Domains are organized by membrane curvature"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Federica Brandizzi (Michigan State University)
"Integrity of the plant Golgi"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 am Graham Warren (University of Vienna)
"Biogenesis of the Golgi"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Greg Lavieu (Yale University)
"Real-time imaging of inter-Golgi transport supports a bi-directional vesicular transport model"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pm Anne Spang (University of Basel)
"Novel roles for the ArfGEFs in C. elegans"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Maya Schuldiner (Weizmann Institute)
"Towards creation of a traffickome: a novel approach to pair secretory cargo receptors with their cargo"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmLeading Edges of Membrane Biology II
Discussion Leader: Peter Novick (University of California San Diego)
7:30 pm - 7:50 pm Jonathan Weissman (University of California San Francisco)
"Towards a comprehensive view of the mammalian endocytic machinery"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Amy Kiger (University of California San Diego)
"Coordination of phosphoinositide and Rab GTPase regulation and functions"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Suzanne Pfeffer (Stanford University)
"Transport vesicle tethering at the TGN"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Svetlana Dokudovskaya (IGR-Villejuif)
"A novel conserved coatomer-related complex"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Jodi Nunnari (University of California Davis)
"MitOS is a conserved mitochondrial skeletal structure"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndosomes and Autophagy
Discussion Leader: Beverly Wendland (Johns Hopkins University)
9:00 am - 9:20 am Jennifer Lippincott-Schwartz (National Institutes of Health - NICHD)
"Anatomy of cytokinetic membrane abscission by ESCRTs"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Scott Emr (Cornell University)
"TORC1 regulates endocytosis via a kinase signaling cascade and phosphoinhibition of a Ub ligase adaptor"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am James Hurley (National Institutes of Health - NIDDK)
"New ways for ESCRTs to get to endosomes"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 am Tamotsu Yoshimori (Osaka University)
"Autophagosome Formation: between the ER and Mitochondria"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Liz Conibear (University of British Columbia)
"New regulators of the AP-1 complex"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Peter Van Der Sluijs (University Medical Center Utrecht)
"Munc13-4 rab27 complex is required for tethering secretory lysosomes at the plasma membrane"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Heike Folsch (Northwestern University)
"Regulation of AP-1B function in polarized epithelial cells"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSmall GTPases in Membrane Dynamics
Discussion Leader: Francis Barr (University of Oxford)
7:30 pm - 7:50 pm Rodger Goody (Max-Planck-Dortmund)
"Learning about vesicular transport from bacteria"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Chris Fromme (Cornell University)
"Regulation of Arf GTPase activation and effector function at the trans-Golgi network"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Barth Grant (Rutgers University)
"Basolateral recycling in a C. elegans polarized epithelium: RAB-10 and its effectors"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Stefan Eimer (ENI-Gottingen)
"Regulation of RAB-2 GTPase involved in dense-core vesicle maturation"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Peter Novick (University of California San Diego)
"Regulation of membrane traffic by networks of Rab GTPases"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by 1 R13 GM 097961-01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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