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Neurotrophic Factors
Gordon Research Conference

Dates

June 5-10, 2011

Location

Salve Regina University
Newport, RI

Organizers

Chair:
Carlos Ibanez

Vice Chair:
Rosalind A. Segal

Meeting Description

Neurotrophic factors play essential roles in the developing and mature nervous system. Now more than 50 years old, this field of study continues to contribute breakthrough discoveries regarding the fundamental biology of cell-cell communication and the development and maintenance of the most complex and elegant biological machine - the brain. Neurotrophic factors influence cell proliferation, survival, differentiation, migration, axon and dendrite growth, synaptic plasticity and the interactions of neuronal and glial cells. They play critical roles in complex behaviors including feeding, anxiety, depression and learning. Studies of neurotrophic factors may have important implications for the treatment of a variety of neurological diseases including disorders of neural development and as well as diseases of the differentiated nervous system including Alzheimer's disease, Down syndrome, Parkinson's disease, Huntington's disease, epilepsy, stroke, and peripheral neuropathies. No venue for this field provides a better opportunity to learn of recent advances, and to encourage collaborations among scientists and students, than the Neurotrophic Factors Gordon Conferences. The 10th meeting promises to be just as exciting, featuring many different neurotrophic factors and their roles in neurogenesis, neuronal migration, axon guidance, survival, plasticity, behavior and disease. Emphasis will be placed on the most recent developments. Newly emerging hypotheses will be addressed, and opportunities to discuss groundbreaking work will be plentiful. Poster sessions and “Hot Topics” sessions will highlight cutting edge studies and enhance interactions. We envision this meeting as catalyzing important new efforts to translate neuroscience advances into effective new treatments for disorders of the nervous system.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:10 pmNeurotrophic Factor Signaling Mechanisms I
Discussion Leader: Mark Bothwell (University of Washington, Seattle, USA)
7:40 pm - 8:10 pmMoses Chao (Skirball Institute, New York, UK)
"Convergence of Trk and glucocorticoid receptor signaling"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmChenghua Gu (Harvard Medical School)
"Molecular mechanisms underlying pathway-sepcific synapse formation in the striatum"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmPhilippe Bastiaens (Max Planck Institute of Molecular Physiology, Dortmund, Germany)
"Spatial organization of growth factor signaling: bridging scales"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurotrophic Factors and Synapse Formation
Discussion Leader: Louis Reichardt (University of San Francisco, San Francisco)
9:00 am - 9:30 amMichela Matteoli (University of Milan, Milan, Italy)
"From filopodia to synapses: BDNF and the actin cytoskeleton"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amMike Greenberg (Harvard Medical School, Boston, USA)
"Transcriptional mechanisms of synaptic connectivity"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:30 amHasashi Umemori (University of Michigan, Ann Arbor, USA)
"Secreted factors as synaptic organizers"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmPatricia Salinas (University College London, London, UK)
"Dynamic regulation of synaptic structure and function by Wnt signaling"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNeurotrophic Factors and Stem Cells
Discussion Leader: Elizabeth Coulson (The University of Queensland)
7:30 pm - 8:00 pmPatrik Ernfors (Karolinska Institute, Stockholm, Sweden)
"Cell diversification in the neural crest"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmFiona Doetsch (Columbia University, New York, USA)
"Stem cells and their niche in the adult mammalian brain"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmYves-Alain Barde (Biozentrum, Basel, Switzerland)
"Revisiting the function of the Trk receptors using engineered embryonic stem cells"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurotrophic Factor Signaling Mechanisms II
Discussion Leader: Lloyd Greene (Columbia University, New York, USA)
9:00 am - 9:30 amWilma Friedman (Rutgers University, Newark, USA)
"Proneurotrophin regulation of neuronal death in the brain after seizures"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amBarbara Hempstead (Weill Cornell Medica Colege, New York, USA)
"Pro-neurotrophin signaling mechanisms"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amNeil McDonald (Cancer Research UK, London, UK)
"Architecture and regulation of the RET receptor tyrosine kinase"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmRüdiger Klein (Max-Planck-Institute of Neurobiology, Munich-Martinsried, Germany)
"New roles for GDNF/Ret signaling: Axon guidance versus trophic support"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNeurotrophic Factors in Axonal Growth
Discussion Leader: Philip A. Barker (McGill University)
7:30 pm - 8:00 pmTom Südhof (Stanford University, Stanford, USA)
"How synapses are specified - neurexins, neuroligins, and their partners"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmFreda Miller (University of Toronto, Toronto, Canada)
"p75NTR signaling in axonal growth and degeneration"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAlun Davies (Cardiff University, Cardiff, UK)
"ProNGF selectively regulates axon growth from a subset of NGF-dependent neurons"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurotrophic Factors in Circuit Formation and Plasticity
Discussion Leader: Martha Constantine-Paton (McGovern Institute, Boston, USA)
9:00 am - 9:30 amCarol Mason (Columbia University, New York, USA)
"Factors controlling axon guidance and connectivity in the visual system"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amSilvia Arber (Biozentrum, Basel, Switzerland)
"Assembling antagonistic motor maps in spinal circuits"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amHitoshi Sakano (Univeristy of Tokyo, Tokyo, Japan)
"Neural map formation in the mouse olfactory system"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmElly Nedivi (The Picower Institute, Boston, USA)
"The role of CPG15, a non-conventional neurotrophic factors, in activity-dependent circuit refinement"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmNeurotrophic Factors and Cortical Development
Discussion Leader: Susana Cohen-Cory (University of California, Irvine, USA)
7:30 pm - 8:00 pmPaola Arlotta (Harvard University, Boston, USA)
"Molecular development of corticospinal motor neurons and building of local microcircuitry in the cerebral cortex"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmBeatriz Rico (Instituto de Neurociencias, Alicante, Spain)
"Neurotrophic factors and GABA cricuitry development"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmOscar Marín (Instituto de Neurociencias, Alicante, Spain)
"Chemokine signaling in neuronal migration"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurotrophic Factors and Development
Discussion Leader: Bai Lu (GlaxoSmithKline, Shanghai, China)
9:00 am - 9:30 amDavid Ginty (Johns Hopkins University, Baltimore, USA)
"Development and organization of neural circuits that underlie the sense of touch"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amBen Barres (Stanford University, Stanford, USA)
"Do CNS astrocytes require neurotrophic signals to survive?"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amRejji Kuruvilla (Johns Hopkins University)
"Neurotrophin trafficking in axonal growth"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmFrancisca C. Bronfman (Universidad Catolica de Chile)
"cJun N-terminal kinase regulates internalization to multivesicular bodies of the p75 neurotrophin receptor and retrograde apoptotic killing of sympathetic neurons"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmNeurotrophic Factors in Injury and Disease
Discussion Leader: Susan Patterson (University of Colorado, Boulder, USA)
7:30 pm - 8:00 pmMike Fainzilber (Weizmann Institute, Rehovot, Israel)
"Growing to extremes - from injury signaling to length sensing in axons"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmWilliam Mobley (Univeristy of California, San Diego, USA)
"Axonal trafficking defects in diseased neurons"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMart Saarma (University of Helsinki, Helsinki, Finland)
"CDNF/MANF factors: biology and therapeutic potential"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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